Dirk Bumann Biozentrum University of Basel Biography Publications Institution JoVE Articles Dirk Bumann has not added a biography. If you are Dirk Bumann and would like to personalize this page please email our Author Liaison for assistance. Publications Revitalizing Antibiotic Discovery and Development Through in Vitro Modelling of In-patient Conditions Nature Microbiology. Jan, 2024 | Pubmed ID: 38177300 Zebrafish Larvae As an Model for Antimicrobial Activity Tests Against Intracellular Frontiers in Bioscience (Landmark Edition). May, 2023 | Pubmed ID: 37258480 Importance of Aspartyl Protease 5 in the Establishment of the Intracellular Niche During Acute and Chronic Infection of Toxoplasma Gondii Molecular Microbiology. Dec, 2022 | Pubmed ID: 36210525 Plant-Derived Catechols Are Substrates of TonB-Dependent Transporters and Sensitize Pseudomonas Aeruginosa to Siderophore-Drug Conjugates MBio. Aug, 2022 | Pubmed ID: 35770947 Making Antimicrobial Susceptibility Testing More Physiologically Relevant with Bicarbonate? Antimicrobial Agents and Chemotherapy. May, 2022 | Pubmed ID: 35435706 Tissue Compartmentalization Enables Persistence During Chemotherapy Proceedings of the National Academy of Sciences of the United States of America. Dec, 2021 | Pubmed ID: 34911764 Acquisition of Ionic Copper by the Bacterial Outer Membrane Protein OprC Through a Novel Binding Site PLoS Biology. Nov, 2021 | Pubmed ID: 34762655 Outer Membrane Permeability: Antimicrobials and Diverse Nutrients Bypass Porins in Proceedings of the National Academy of Sciences of the United States of America. Aug, 2021 | Pubmed ID: 34326266 Ferritin H Deficiency Deteriorates Cellular Iron Handling and Worsens Salmonella Typhimurium Infection by Triggering Hyperinflammation JCI Insight. Jul, 2021 | Pubmed ID: 34236052 Increased Production of Outer Membrane Vesicles by Salmonella Interferes with Complement-Mediated Innate Immune Attack MBio. Jun, 2021 | Pubmed ID: 34061589 Molecular Reprogramming and Phenotype Switching in Lead to High Antibiotic Persistence and Affect Therapy Success Proceedings of the National Academy of Sciences of the United States of America. Feb, 2021 | Pubmed ID: 33574060 Single-cell Reporters for Pathogen Responses to Antimicrobial Host Attacks Current Opinion in Microbiology. Feb, 2021 | Pubmed ID: 32810800 Regulation of Chaperone Function by Coupled Folding and Oligomerization Science Advances. Oct, 2020 | Pubmed ID: 33087350 Dynamics in Protein Translation Sustaining T Cell Preparedness Nature Immunology. Aug, 2020 | Pubmed ID: 32632289 Efficient Dual-negative Selection for Bacterial Genome Editing BMC Microbiology. May, 2020 | Pubmed ID: 32448155 Classical Activation of Macrophages Leads to Lipid Droplet Formation Without Fatty Acid Synthesis Frontiers in Immunology. 2020 | Pubmed ID: 32132994 Intestinal Epithelial NAIP/NLRC4 Restricts Systemic Dissemination of the Adapted Pathogen Salmonella Typhimurium Due to Site-specific Bacterial PAMP Expression Mucosal Immunology. May, 2020 | Pubmed ID: 31953493 Host Resistance Factor SLC11A1 Restricts Growth Through Magnesium Deprivation Science (New York, N.Y.). Nov, 2019 | Pubmed ID: 31753999 Antibiotic Chemotherapy Against Heterogeneous Pathogen Populations in Complex Host Tissues F1000Research. 2019 | Pubmed ID: 31737252 Non-specific Interference of Cobalt with Siderophore-dependent Iron Uptake Pathways Metallomics : Integrated Biometal Science. Nov, 2019 | Pubmed ID: 31633703 Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter Baumannii Clinical Isolates MBio. Jul, 2019 | Pubmed ID: 31311879 Publisher Correction: Definitions and Guidelines for Research on Antibiotic Persistence Nature Reviews. Microbiology. Jul, 2019 | Pubmed ID: 31036919 Definitions and Guidelines for Research on Antibiotic Persistence Nature Reviews. Microbiology. Jul, 2019 | Pubmed ID: 30980069 Single-Cell Metabolism and Stress Responses in Complex Host Tissues Microbiology Spectrum. Mar, 2019 | Pubmed ID: 30953427 Publisher Correction: Clonal Analysis of Salmonella-specific Effector T Cells Reveals Serovar-specific and Cross-reactive T Cell Responses Nature Immunology. Apr, 2019 | Pubmed ID: 30862955 Quantitative Contribution of Efflux to Multi-drug Resistance of Clinical Escherichia Coli and Pseudomonas Aeruginosa Strains EBioMedicine. Mar, 2019 | Pubmed ID: 30852163 Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance While Maintaining Anti-Pathogen Immunity Immunity. Jan, 2019 | Pubmed ID: 30611611 A Multidisciplinary Approach Toward Identification of Antibiotic Scaffolds for Acinetobacter Baumannii Structure (London, England : 1993). Feb, 2019 | Pubmed ID: 30554842 Getting Drugs Through Small Pores: Exploiting the Porins Pathway in Pseudomonas Aeruginosa ACS Infectious Diseases. Oct, 2018 | Pubmed ID: 30039960 Clonal Analysis of Salmonella-specific Effector T Cells Reveals Serovar-specific and Cross-reactive T Cell Responses Nature Immunology. Jul, 2018 | Pubmed ID: 29925993 The Hepcidin-ferroportin Axis Controls the Iron Content of Salmonella-containing Vacuoles in Macrophages Nature Communications. May, 2018 | Pubmed ID: 29844422 TonB-Dependent Receptor Repertoire of Pseudomonas Aeruginosa for Uptake of Siderophore-Drug Conjugates Antimicrobial Agents and Chemotherapy. Jun, 2018 | Pubmed ID: 29555629 Correction for Wu Et Al., "Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages Via Modulation of NF-κB Signaling" Infection and Immunity. Mar, 2018 | Pubmed ID: 29463686 Editorial Overview: Bacterial Systems Biology Current Opinion in Microbiology. Oct, 2017 | Pubmed ID: 29241558 Structural Basis for Maintenance of Bacterial Outer Membrane Lipid Asymmetry Nature Microbiology. Dec, 2017 | Pubmed ID: 29038444 Heterogeneity of Salmonella-host Interactions in Infected Host Tissues Current Opinion in Microbiology. Oct, 2017 | Pubmed ID: 28988065 Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages Via Modulation of NF-κB Signaling Infection and Immunity. Dec, 2017 | Pubmed ID: 28874447 Intracellular Salmonella Metabolism Cellular Microbiology. Oct, 2017 | Pubmed ID: 28672057 Myeloperoxidase Targets Oxidative Host Attacks to Salmonella and Prevents Collateral Tissue Damage Nature Microbiology. Jan, 2017 | Pubmed ID: 28112722 A Novel Genome-Editing Platform for Drug-Resistant Acinetobacter Baumannii Reveals an AdeR-Unrelated Tigecycline Resistance Mechanism Antimicrobial Agents and Chemotherapy. Dec, 2016 | Pubmed ID: 27671072 Combining Shigella Tn-seq Data with Gold-standard E. Coli Gene Deletion Data Suggests Rare Transitions Between Essential and Non-essential Gene Functionality BMC Microbiology. Sep, 2016 | Pubmed ID: 27599549 Catechol Siderophores Repress the Pyochelin Pathway and Activate the Enterobactin Pathway in Pseudomonas Aeruginosa: an Opportunity for Siderophore-antibiotic Conjugates Development Environmental Microbiology. Mar, 2016 | Pubmed ID: 26718479 Heterogeneous Host-pathogen Encounters: Act Locally, Think Globally Cell Host & Microbe. Jan, 2015 | Pubmed ID: 25590757 PLEKHM1 Regulates Salmonella-containing Vacuole Biogenesis and Infection Cell Host & Microbe. Jan, 2015 | Pubmed ID: 25500191 Fast Sampling Method for Mammalian Cell Metabolic Analyses Using Liquid Chromatography-mass Spectrometry Nature Protocols. Jan, 2015 | Pubmed ID: 25474028 Identification of Protective Antigens for Vaccination Against Systemic Salmonellosis Frontiers in Immunology. 2014 | Pubmed ID: 25157252 Phenotypic Variation of Salmonella in Host Tissues Delays Eradication by Antimicrobial Chemotherapy Cell. Aug, 2014 | Pubmed ID: 25126781 Shigella Reroutes Host Cell Central Metabolism to Obtain High-flux Nutrient Supply for Vigorous Intracellular Growth Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 24958876 The Central Metabolism Regulator EIIAGlc Switches Salmonella from Growth Arrest to Acute Virulence Through Activation of Virulence Factor Secretion Cell Reports. Jun, 2014 | Pubmed ID: 24835993 Caspase-11 Activation Requires Lysis of Pathogen-containing Vacuoles by IFN-induced GTPases Nature. May, 2014 | Pubmed ID: 24739961 Disparate Impact of Oxidative Host Defenses Determines the Fate of Salmonella During Systemic Infection in Mice Cell Host & Microbe. Jan, 2014 | Pubmed ID: 24439899 Parallel Exploitation of Diverse Host Nutrients Enhances Salmonella Virulence PLoS Pathogens. 2013 | Pubmed ID: 23633950 Functional Identification of APIP As Human MtnB, a Key Enzyme in the Methionine Salvage Pathway PloS One. 2012 | Pubmed ID: 23285211 Immunity to Intracellular Salmonella Depends on Surface-associated Antigens PLoS Pathogens. 2012 | Pubmed ID: 23093937 Extensive in Vivo Resilience of Persistent Salmonella PloS One. 2012 | Pubmed ID: 22911873 Intestinal Inflammation Responds to Microbial Tissue Load Independent of Pathogen/non-pathogen Discrimination PloS One. 2012 | Pubmed ID: 22586458 Identification of Tumor-specific Salmonella Typhimurium Promoters and Their Regulatory Logic Nucleic Acids Research. Apr, 2012 | Pubmed ID: 22140114 Salmonella-induced Mucosal Lectin RegIIIβ Kills Competing Gut Microbiota PloS One. 2011 | Pubmed ID: 21694778 A Community Effort Towards a Knowledge-base and Mathematical Model of the Human Pathogen Salmonella Typhimurium LT2 BMC Systems Biology. 2011 | Pubmed ID: 21244678 Pathogen Proteomes During Infection: A Basis for Infection Research and Novel Control Strategies Journal of Proteomics. Oct, 2010 | Pubmed ID: 20797457 System-level Analysis of Salmonella Metabolism During Infection Current Opinion in Microbiology. Oct, 2009 | Pubmed ID: 19744878 Has Nature Already Identified All Useful Antibacterial Targets? Current Opinion in Microbiology. Oct, 2008 | Pubmed ID: 18804175 Author Spotlight: Unraveling Bacterial Responses to Antibiotics and Immune System in Tissues Jiagui Li1, Alaa Alhayek1, Heng Wang1, Dirk Bumann1 1Biozentrum, University of Basel JoVE 66469 Immunology and Infection
Author Spotlight: Unraveling Bacterial Responses to Antibiotics and Immune System in Tissues Jiagui Li1, Alaa Alhayek1, Heng Wang1, Dirk Bumann1 1Biozentrum, University of Basel JoVE 66469 Immunology and Infection