Sandra Demaria Department of Radiation Oncology Weill Cornell Medical College Biography Publications Institution JoVE Articles Sandra Demaria has not added a biography. If you are Sandra Demaria and would like to personalize this page please email our Author Liaison for assistance. Publications Image-based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. A Report of the International Immuno-oncology Biomarker Working Group on Breast Cancer The Journal of Pathology. Mar, 2024 | Pubmed ID: 38230434 Pipeline to Identify Neoantigens Exposed by Radiation Methods in Cell Biology. 2023 | Pubmed ID: 37890930 Immunotherapy Targeting Different Immune Compartments in Combination with Radiation Therapy Induces Regression of Resistant Tumors Nature Communications. Aug, 2023 | Pubmed ID: 37620372 Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions: A Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer The Journal of Pathology. Aug, 2023 | Pubmed ID: 37608771 Immunologically Relevant Effects of Radiation Therapy on the Tumor Microenvironment Essays in Biochemistry. Sep, 2023 | Pubmed ID: 37199227 Quantitative Assessment of Mitophagy in Irradiated Cancer Cells Methods in Cell Biology. 2023 | Pubmed ID: 36710054 Perspectives in Immunotherapy: Meeting Report from the Immunotherapy Bridge, December 1st-2nd, 2021 Journal of Translational Medicine. Jun, 2022 | Pubmed ID: 35672823 Radiation Therapy-induced Remodeling of the Tumor Immune Microenvironment Seminars in Cancer Biology. Nov, 2022 | Pubmed ID: 35405340 Something Old and Something New to Unleash the Power of Natural Killer Cells Against Metastases Cancer Immunology Research. Jan, 2022 | Pubmed ID: 34815266 LTX-315-enabled, Radiotherapy-boosted Immunotherapeutic Control of Breast Cancer by NK Cells Oncoimmunology. 2021 | Pubmed ID: 34408925 Perspectives in Immunotherapy: Meeting Report from the Immunotherapy Bridge (December 2nd-3rd, 2020, Italy) Journal of Translational Medicine. Jun, 2021 | Pubmed ID: 34078406 Radiation Dose and Fraction in Immunotherapy: One-size Regimen Does Not Fit All Settings, So How Does One Choose? Journal for Immunotherapy of Cancer. Apr, 2021 | Pubmed ID: 33827904 Liver Metastasis Irradiation Can Restore Immunotherapeutic Responsiveness Trends in Immunology. Apr, 2021 | Pubmed ID: 33637449 The Role of Radiotherapy in the Age of Immunotherapy Japanese Journal of Clinical Oncology. Apr, 2021 | Pubmed ID: 33561212 Radiotherapy-exposed CD8+ and CD4+ Neoantigens Enhance Tumor Control The Journal of Clinical Investigation. Mar, 2021 | Pubmed ID: 33476307 Targeting Cancer Heterogeneity with Immune Responses Driven by Oncolytic Peptides Trends in Cancer. Jun, 2021 | Pubmed ID: 33446447 Potentiating Antitumor Efficacy Through Radiation and Sustained Intratumoral Delivery of Anti-CD40 and Anti-PDL1 International Journal of Radiation Oncology, Biology, Physics. Jun, 2021 | Pubmed ID: 32768562 Converging Focal Radiation and Immunotherapy in a Preclinical Model of Triple Negative Breast Cancer: Contribution of VISTA Blockade Oncoimmunology. Oct, 2020 | Pubmed ID: 33150045 Emerging Technologies for Local Cancer Treatment Advanced Therapeutics. Sep, 2020 | Pubmed ID: 33072860 Perspectives in Melanoma: Meeting Report from the "Melanoma Bridge" (December 5th-7th, 2019, Naples, Italy) Journal of Translational Medicine. Sep, 2020 | Pubmed ID: 32894202 Future of Radiation and Immunotherapy International Journal of Radiation Oncology, Biology, Physics. Sep, 2020 | Pubmed ID: 32819614 Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses Cancer Immunology Research. Aug, 2020 | Pubmed ID: 32532811 Immunogenic Cell Death Driven by Radiation-Impact on the Tumor Microenvironment Cancer Treatment and Research. 2020 | Pubmed ID: 32215874 Consensus Guidelines for the Definition, Detection and Interpretation of Immunogenic Cell Death Journal for Immunotherapy of Cancer. 03, 2020 | Pubmed ID: 32209603 The Abscopal Effect 67 Years Later: from a Side Story to Center Stage The British Journal of Radiology. May, 2020 | Pubmed ID: 32101479 Exercise Reduces Immune Suppression and Breast Cancer Progression in a Preclinical Model Oncotarget. Jan, 2020 | Pubmed ID: 32064049 CD73 Blockade Promotes Dendritic Cell Infiltration of Irradiated Tumors and Tumor Rejection Cancer Immunology Research. Apr, 2020 | Pubmed ID: 32047024 Immune Induction Strategies to Enhance Responses to PD-1 Blockade: Lessons from the TONIC Trial Journal for Immunotherapy of Cancer. Nov, 2019 | Pubmed ID: 31752991 The Great Debate at "Immunotherapy Bridge 2018", Naples, November 29th, 2018 Journal for Immunotherapy of Cancer. Aug, 2019 | Pubmed ID: 31416487 Baseline T Cell Dysfunction by Single Cell Network Profiling in Metastatic Breast Cancer Patients Journal for Immunotherapy of Cancer. Jul, 2019 | Pubmed ID: 31296256 Radiation Therapy and Anti-tumor Immunity: Exposing Immunogenic Mutations to the Immune System Genome Medicine. Jun, 2019 | Pubmed ID: 31221199 Transcriptomic Profiles Conducive to Immune-mediated Tumor Rejection in Human Breast Cancer Skin Metastases Treated with Imiquimod Scientific Reports. 06, 2019 | Pubmed ID: 31189943 Radiotherapy Induces Responses of Lung Cancer to CTLA-4 Blockade Nature Medicine. Dec, 2018 | Pubmed ID: 30397353 Tumor Mutational Burden is a Determinant of Immune-mediated Survival in Breast Cancer Oncoimmunology. 2018 | Pubmed ID: 30386679 Cytosolic DNA Sensing in Organismal Tumor Control Cancer Cell. Sep, 2018 | Pubmed ID: 30216189 Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect Trends in Immunology. Aug, 2018 | Pubmed ID: 30001871 Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory DsDNA from Irradiated Cancer Cells to DCs Cancer Immunology Research. Aug, 2018 | Pubmed ID: 29907693 SnapShot: CGAS-STING Signaling Cell. Mar, 2018 | Pubmed ID: 29570996 Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2018 | Pubmed ID: 29476019 Emerging Biomarkers for the Combination of Radiotherapy and Immune Checkpoint Blockers Seminars in Cancer Biology. Oct, 2018 | Pubmed ID: 29258856 Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells Cancer Immunology Research. Feb, 2018 | Pubmed ID: 29180535 The Future of Radiobiology Journal of the National Cancer Institute. Apr, 2018 | Pubmed ID: 29126306 Toward Precision Radiotherapy for Use with Immune Checkpoint Blockers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2018 | Pubmed ID: 28751442 Trial Watch: Immune Checkpoint Blockers for Cancer Therapy Oncoimmunology. 2017 | Pubmed ID: 29147629 Future Perspectives in Melanoma Research "Melanoma Bridge", Napoli, November 30th-3rd December 2016 Journal of Translational Medicine. 11, 2017 | Pubmed ID: 29145885 The Need for a Network to Establish and Validate Predictive Biomarkers in Cancer Immunotherapy Journal of Translational Medicine. Nov, 2017 | Pubmed ID: 29100546 Immune Recognition of Irradiated Cancer Cells Immunological Reviews. Nov, 2017 | Pubmed ID: 29027232 Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors Advances in Anatomic Pathology. Nov, 2017 | Pubmed ID: 28777143 Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research Advances in Anatomic Pathology. Sep, 2017 | Pubmed ID: 28777142 Cancer Immunotherapy: Opportunities and Challenges in the Rapidly Evolving Clinical Landscape European Journal of Cancer (Oxford, England : 1990). Aug, 2017 | Pubmed ID: 28623775 Heavy Metal to Rock the Immune Infiltrate Trends in Immunology. Aug, 2017 | Pubmed ID: 28602618 Activating Autophagy to Potentiate Immunogenic Chemotherapy and Radiation Therapy Nature Reviews. Clinical Oncology. Apr, 2017 | Pubmed ID: 27845767 Future Perspectives in Melanoma Research : Meeting Report from the "Melanoma Bridge". Napoli, December 1st-4th 2015 Journal of Translational Medicine. Nov, 2016 | Pubmed ID: 27846884 Trial Watch: Immunotherapy Plus Radiation Therapy for Oncological Indications Oncoimmunology. 2016 | Pubmed ID: 27757313 Melanoma and Immunotherapy Bridge 2015 : Naples, Italy. 1-5 December 2015 Journal of Translational Medicine. 07, 2016 | Pubmed ID: 27461275 Standardized Evaluation of Tumor-infiltrating Lymphocytes in Breast Cancer: Results of the Ring Studies of the International Immuno-oncology Biomarker Working Group Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. 10, 2016 | Pubmed ID: 27363491 Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Cancer Immunology Research. Jul, 2016 | Pubmed ID: 27197066 Subverting Misconceptions About Radiation Therapy Nature Immunology. Apr, 2016 | Pubmed ID: 27002831 Exercise in Regulation of Inflammation-Immune Axis Function in Cancer Initiation and Progression Oncology (Williston Park, N.Y.). Dec, 2015 | Pubmed ID: 26676894 Future Perspectives in Melanoma Research: Meeting Report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014 Journal of Translational Medicine. Nov, 2015 | Pubmed ID: 26619946 Local Radiotherapy and Granulocyte-macrophage Colony-stimulating Factor to Generate Abscopal Responses in Patients with Metastatic Solid Tumours: a Proof-of-principle Trial The Lancet. Oncology. Jul, 2015 | Pubmed ID: 26095785 Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids Maud Charpentier*1, Norma Bloy*1, Silvia C. Formenti1,2,3, Lorenzo Galluzzi1,2,4, Sandra Demaria1,5 1Department of Radiation Oncology, Weill Cornell Medical College, 2Sandra and Edward Meyer Cancer Center, 3Department of Medicine, Weill Cornell Medical College, 4Caryl and Israel Englander Institute for Precision Medicine, 5Department of Pathology and Laboratory Medicine, Weill Cornell Medical College JoVE 66680 Cancer Research
Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids Maud Charpentier*1, Norma Bloy*1, Silvia C. Formenti1,2,3, Lorenzo Galluzzi1,2,4, Sandra Demaria1,5 1Department of Radiation Oncology, Weill Cornell Medical College, 2Sandra and Edward Meyer Cancer Center, 3Department of Medicine, Weill Cornell Medical College, 4Caryl and Israel Englander Institute for Precision Medicine, 5Department of Pathology and Laboratory Medicine, Weill Cornell Medical College JoVE 66680 Cancer Research