Chonnam National University 1 article published in JoVE Bioengineering 3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer Wonbin Park*1, Mihyeon Bae*1, Minseon Hwang1, Jinah Jang2, Dong-Woo Cho1, Hee-Gyeong Yi1,3 1Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 2Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), 3Department of Rural and Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National University Hypoxia is a hallmark of tumor microenvironment and plays a crucial role in cancer progression. This article describes the fabrication process of a hypoxic cancer-on-a-chip based on 3D cell-printing technology to recapitulate a hypoxia-related pathology of cancer.