- JoVE DOUBLES SCIENCE EDUCATION VIDEO CONTENT IN 2017
June 15, 2017
- WAYNE STATE UNIVERSITY TEAM PUBLISHES METHOD IN JOVE VIDEO JOURNAL TO CREATE CUSTOMIZABLE BLOOD VESSELS USING 3D PRINTING
March 27, 2017
- JoVE Builds on Ten Years of Making Science Clearer, More Reproducible
January 30, 2017
- JoVE Expands Journal to Include Genetics, Biochemistry, and Cancer Research Videos
September 20, 2016
- JoVE is Expanding Science Education Collections to include Clinical Skills
June 15, 2016
- JoVE Named SIIA Content CODiE Award Finalist for Best Scholarly Publishing Information Solution
April 29, 2015
- Leading scientific video publisher introduces tool for systematic analysis of research output of individual scientists
March 16, 2015
- JoVE Quiz Extends Educational Value of Innovative Science Education (SE) video database
February 28, 2015
- JoVE Introduces Powerful Tool Linking Scientific Videos to 4.5 Million Research Articles
February 17, 2015
- New Mobile Offerings Extend Value of Leading Scientific Video Publication
February 2, 2015
Novel Technique Demonstrates Interactions Between Malaria Parasite and HIV
August 15, 2012
The World Health Organization estimates that in 2011 there were 216 million cases of malaria and 34.2 million people living with HIV. These diseases particularly afflict sub-Saharan Africa, where large incidence of co-infection result in high mortality rates. Yet, in spite of this global pandemic, interactions between the parasite that causes malaria, Plasmodium falciparum, and HIV-1 are poorly understood. However, a new video article in JoVE, the Journal of Visualized Experiments, that describes a novel technique to study the interactions between HIV-1 and P. falciparum in cultured human cells, will allow scientists to explore different parameters of co-infection by the two microbes.
The study is led by Dr. David Richard of the Centre Hospitalier Universitaire de Quebec (CHUQ). Dr. Richard explains, "We don't know much about what is happening at the cellular level when HIV-1-infected immune cells encounter the malaria parasite. Results obtained from the few studies exploring the interaction of these two diseases are sometimes conflicting. We hope that our model will allow us to thoroughly dissect these interactions in a simplified system."
Each disease attacks a different component of human blood, thus disturbing normal immune function. P. falciparum infect red blood cells and cause fever, shivering, vomiting, or convulsions in patients. HIV-1 causes acquired immune deficiency syndrome (AIDS) by infecting components of the immune system, including macrophages and helper T cells, and then replicates and destroys the host cells. By studying co-infection at different phases of each disease in vitro, scientists can better understand how different stages of malaria infection and HIV reproduction affect the onset and severity of the other disease. As such, Dr. Richard and his laboratory present a technique that investigates how P. falciparum-infected red blood cells affect the replication of HIV-1 in monocyte-derived macrophages.
Dr. Richard points out that, "by publishing in JoVE, you really see what is happening in the experiment. The visual representation helps succinctly explain a long procedure, and gives you a fuller picture of the schematic complexity." He hopes that this publication will give the scientific community the tools to look at the interactions on a cellular level, which would be an initial step in improving the quality of life for individuals infected by these deadly diseases. "This protocol provides a tool to examine the interactions between P. falciparium and HIV," states JoVE editor Dr. Charlotte Frank Sage, "Publication of the protocol in JoVE will allow researchers around the world to see a detailed demonstration of this system which will help in bring the technology to their laboratories."
Richard et. al.: http://www.jove.com/video/4166/an-vitro-co-infection-model-to-study-plasmodium-falciparum-hiv-1