Aaron Ciechanover Biography Publications JoVE Articles Aaron Ciechanover has not added a biography. If you are Aaron Ciechanover and would like to personalize this page please email our Author Liaison for assistance. Publications Intracellular Protein Degradation: From a Vague Idea Through the Lysosome and the Ubiquitin-Proteasome System and Onto Human Diseases and Drug Targeting Neuro-degenerative Diseases. Feb, 2012 | Pubmed ID: 22327508 HUWE1 Ubiquitinates MyoD and Targets It for Proteasomal Degradation Biochemical and Biophysical Research Communications. Feb, 2012 | Pubmed ID: 22277673 FAT10 is a Proteasomal Degradation Signal That is Itself Regulated by Ubiquitination Molecular Biology of the Cell. Jan, 2012 | Pubmed ID: 22072791 Intracellular Protein Degradation: From a Vague Idea Thru the Lysosome and the Ubiquitin-proteasome System and Onto Human Diseases and Drug Targeting Biochimica Et Biophysica Acta. Jan, 2012 | Pubmed ID: 21435401 Switches, Excitable Responses and Oscillations in the Ring1B/Bmi1 Ubiquitination System PLoS Computational Biology. Dec, 2011 | Pubmed ID: 22194680 Innate and Adaptive Immunity: the 2011 Nobel Prize in Physiology or Medicine American Journal of Respiratory and Critical Care Medicine. Dec, 2011 | Pubmed ID: 22162893 Response to Health in the Occupied Palestinian Territory Lancet. Oct, 2011 | Pubmed ID: 22035555 On the Wings of Imagination Nature. Oct, 2011 | Pubmed ID: 21993824 The Predator Becomes the Prey: Regulating the Ubiquitin System by Ubiquitylation and Degradation Nature Reviews. Molecular Cell Biology. Sep, 2011 | Pubmed ID: 21860393 Ubiquitination and Degradation of Proteins Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21604134 PRAJA1 is a Ubiquitin Ligase for the Polycomb Repressive Complex 2 Proteins Biochemical and Biophysical Research Communications. May, 2011 | Pubmed ID: 21513699 Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2 The Journal of Biological Chemistry. Jun, 2011 | Pubmed ID: 21493713 Requirement of ATM-dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-strand Breaks Molecular Cell. Mar, 2011 | Pubmed ID: 21362549 Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination is Sufficient for Proteasomal Processing of the P105 NF-κB Precursor Advances in Experimental Medicine and Biology. 2011 | Pubmed ID: 21153313 Epstein-Barr Virus-encoded EBNA-5 Forms Trimolecular Protein Complexes with MDM2 and P53 and Inhibits the Transactivating Function of P53 International Journal of Cancer. Journal International Du Cancer. Feb, 2011 | Pubmed ID: 20473904 Regulation of the Polycomb Protein RING1B Ubiquitination by USP7 Biochemical and Biophysical Research Communications. Sep, 2010 | Pubmed ID: 20800574 Intracellular Protein Degradation: from a Vague Idea Through the Lysosome and the Ubiquitin-proteasome System and Onto Human Diseases and Drug Targeting Medicina. 2010 | Pubmed ID: 20447892 Regulation of the Polycomb Protein Ring1B by Self-ubiquitination or by E6-AP May Have Implications to the Pathogenesis of Angelman Syndrome Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20351251 The Ubiquitin System: Historical Perspective Proceedings of the American Thoracic Society. Feb, 2010 | Pubmed ID: 20160143 Degradation of Ubiquitin: the Fate of the Cellular Reaper Cell Cycle (Georgetown, Tex.). Feb, 2010 | Pubmed ID: 20107325 The 26 S Proteasome: from Basic Mechanisms to Drug Targeting The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19812037 ABIN-1 Negatively Regulates NF-kappaB by Inhibiting Processing of the P105 Precursor Biochemical and Biophysical Research Communications. Nov, 2009 | Pubmed ID: 19695220 Ubiquitin Degradation with Its Substrate, or As a Monomer in a Ubiquitination-independent Mode, Provides Clues to Proteasome Regulation Proceedings of the National Academy of Sciences of the United States of America. Jul, 2009 | Pubmed ID: 19581590 Interview with Aaron Ciechanover Biochemical and Biophysical Research Communications. Sep, 2009 | Pubmed ID: 19549505 Tracing the History of the Ubiquitin Proteolytic System: the Pioneering Article Biochemical and Biophysical Research Communications. Sep, 2009 | Pubmed ID: 19539608 Ubiquitination Participates in the Lysosomal Degradation of Na,K-ATPase in Steady-state Conditions American Journal of Respiratory Cell and Molecular Biology. Dec, 2009 | Pubmed ID: 19286978 Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination is Sufficient for Proteasomal Processing of the P105 NF-kappaB Precursor Molecular Cell. Feb, 2009 | Pubmed ID: 19250910 Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology Annual Review of Pharmacology and Toxicology. 2009 | Pubmed ID: 18834306 The N-terminal Domain of MyoD is Necessary and Sufficient for Its Nuclear Localization-dependent Degradation by the Ubiquitin System Proceedings of the National Academy of Sciences of the United States of America. Oct, 2008 | Pubmed ID: 18836078 Ubiquitin-proteasome-mediated Degradation of Keratin Intermediate Filaments in Mechanically Stimulated A549 Cells The Journal of Biological Chemistry. Sep, 2008 | Pubmed ID: 18617517 The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development Cancer Cell. Jul, 2008 | Pubmed ID: 18598940 In Vivo Interactions of MyoD, Id1, and E2A Proteins Determined by Acceptor Photobleaching Fluorescence Resonance Energy Transfer FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2008 | Pubmed ID: 18198216 Hypoxia-mediated Na-K-ATPase Degradation Requires Von Hippel Lindau Protein FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2008 | Pubmed ID: 18073334 Intracellular Protein Degradation from a Vague Idea Through the Lysosome and the Ubiquitin-proteasome System and on to Human Diseases and Drug Targeting: Nobel Lecture, December 8, 2004 Annals of the New York Academy of Sciences. Nov, 2007 | Pubmed ID: 18083918 Ubiquitin is Degraded by the Ubiquitin System As a Monomer and As Part of Its Conjugated Target Biochemical and Biophysical Research Communications. Nov, 2007 | Pubmed ID: 17870054 Phosphorylation and Ubiquitination Are Necessary for Na,K-ATPase Endocytosis During Hypoxia Cellular Signalling. Sep, 2007 | Pubmed ID: 17532187 The Polycomb Protein Ring1B Generates Self Atypical Mixed Ubiquitin Chains Required for Its in Vitro Histone H2A Ligase Activity Molecular Cell. Dec, 2006 | Pubmed ID: 17157253 Intracellular Protein Degradation: from a Vague Idea Thru the Lysosome and the Ubiquitin-proteasome System and Onto Human Diseases and Drug Targeting Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2006 | Pubmed ID: 17124032 Narrative Review: Protein Degradation and Human Diseases: the Ubiquitin Connection Annals of Internal Medicine. Nov, 2006 | Pubmed ID: 17088581 Nobel Round-table Discussion #2: Conflicts of Interest, Scientific Misconduct, Fair Sharing, and Intellectual Property in an Interdisciplinary/inter-institutional Consortium Experimental Biology and Medicine (Maywood, N.J.). Jul, 2006 | Pubmed ID: 16816129 Nobel Round-table Discussion #1: the Future of Interdisciplinary Research and Training Experimental Biology and Medicine (Maywood, N.J.). Jul, 2006 | Pubmed ID: 16816128 Intracellular Protein Degradation: from a Vague Idea Thru the Lysosome and the Ubiquitin-proteasome System and Onto Human Diseases and Drug Targeting Experimental Biology and Medicine (Maywood, N.J.). Jul, 2006 | Pubmed ID: 16816126 Two Distinct Ubiquitin-dependent Mechanisms Are Involved in NF-kappaB P105 Proteolysis Biochemical and Biophysical Research Communications. Jun, 2006 | Pubmed ID: 16678126 Hypoxia-mediated Degradation of Na,K-ATPase Via Mitochondrial Reactive Oxygen Species and the Ubiquitin-conjugating System Circulation Research. May, 2006 | Pubmed ID: 16614303 The Ubiquitin Proteolytic System: from an Idea to the Patient Bed Proceedings of the American Thoracic Society. 2006 | Pubmed ID: 16493148 The Ubiquitin Proteolytic System: from a Vague Idea, Through Basic Mechanisms, and Onto Human Diseases and Drug Targeting Neurology. Jan, 2006 | Pubmed ID: 16432150 Intracellular Protein Degradation: from a Vague Idea, Through the Lysosome and the Ubiquitin-proteasome System, and Onto Human Diseases and Drug Targeting (Nobel Lecture) Angewandte Chemie (International Ed. in English). Sep, 2005 | Pubmed ID: 16142822 Early Work on the Ubiquitin Proteasome System, an Interview with Aaron Ciechanover. Interview by CDD Cell Death and Differentiation. Sep, 2005 | Pubmed ID: 16094393 The Ubiquitin-proteasome System--micro Target for Macro Intervention? International Journal of Cardiovascular Interventions. 2005 | Pubmed ID: 16019609 E12 and E47 Modulate Cellular Localization and Proteasome-mediated Degradation of MyoD and Id1 Oncogene. Sep, 2005 | Pubmed ID: 16007194 N-terminal Ubiquitination Methods in Molecular Biology (Clifton, N.J.). 2005 | Pubmed ID: 15917637 Ubiquitin-proteasome-mediated Degradation, Intracellular Localization, and Protein Synthesis of MyoD and Id1 During Muscle Differentiation The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15888449 Regulation of the Proapoptotic ARTS Protein by Ubiquitin-mediated Degradation The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15837787 Proteolysis: from the Lysosome to Ubiquitin and the Proteasome Nature Reviews. Molecular Cell Biology. Jan, 2005 | Pubmed ID: 15688069 The Ubiquitin System: Pathogenesis of Human Diseases and Drug Targeting Biochimica Et Biophysica Acta. Nov, 2004 | Pubmed ID: 15571805 The Tumor Suppressor Protein P16(INK4a) and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the Ubiquitin System. Direct Evidence for Ubiquitination at the N-terminal Residue The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15254040 The Ubiquitin System: from Basic Mechanisms to the Patient Bed IUBMB Life. Apr, 2004 | Pubmed ID: 15230346 Ubiquitin-Proteasome-mediated Degradation of Id1 is Modulated by MyoD The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15163661 Caspase Activation Inhibits Proteasome Function During Apoptosis Molecular Cell. Apr, 2004 | Pubmed ID: 15068805 Ubiquitin As a Central Cellular Regulator Cell. Jan, 2004 | Pubmed ID: 15055578 N-terminal Ubiquitination: More Protein Substrates Join In Trends in Cell Biology. Mar, 2004 | Pubmed ID: 15055197 Degradation of the Id2 Developmental Regulator: Targeting Via N-terminal Ubiquitination Biochemical and Biophysical Research Communications. Feb, 2004 | Pubmed ID: 14733935 The Ubiquitin-proteasome System in Cardiovascular Diseases-a Hypothesis Extended Cardiovascular Research. Jan, 2004 | Pubmed ID: 14732197 Mechanism of Processing of the NF-kappa B2 P100 Precursor: Identification of the Specific Polyubiquitin Chain-anchoring Lysine Residue and Analysis of the Role of NEDD8-modification on the SCF(beta-TrCP) Ubiquitin Ligase Oncogene. Apr, 2004 | Pubmed ID: 14676825 Dual Effects of IkappaB Kinase Beta-mediated Phosphorylation on P105 Fate: SCF(beta-TrCP)-dependent Degradation and SCF(beta-TrCP)-independent Processing Molecular and Cellular Biology. Jan, 2004 | Pubmed ID: 14673179 The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg Neuron. Oct, 2003 | Pubmed ID: 14556719 HdmX Stimulates Hdm2-mediated Ubiquitination and Degradation of P53 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2003 | Pubmed ID: 14507994 Oxidative Stress-related Increase in Ubiquitination in Early Coronary Atherogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2003 | Pubmed ID: 12958191 Inverse Relationship Between Skp2 Ubiquitin Ligase and the Cyclin Dependent Kinase Inhibitor P27Kip1 in Prostate Cancer The Journal of Urology. Jul, 2003 | Pubmed ID: 12796697 A Novel Mammalian Endoplasmic Reticulum Ubiquitin Ligase Homologous to the Yeast Hrd1 Biochemical and Biophysical Research Communications. Mar, 2003 | Pubmed ID: 12646171 Determinants of Nuclear and Cytoplasmic Ubiquitin-mediated Degradation of MyoD The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12397066 Increased Ubiquitin Immunoreactivity in Unstable Atherosclerotic Plaques Associated with Acute Coronary Syndromes Journal of the American College of Cardiology. Dec, 2002 | Pubmed ID: 12475450 Regulation of Drosophila IAP1 Degradation and Apoptosis by Reaper and UbcD1 Nature Cell Biology. Jun, 2002 | Pubmed ID: 12021769 The NEDD8 Pathway is Essential for SCF(beta -TrCP)-mediated Ubiquitination and Processing of the NF-kappa B Precursor P105 The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11953428 The Ubiquitin-proteasome Proteolytic Pathway: Destruction for the Sake of Construction Physiological Reviews. Apr, 2002 | Pubmed ID: 11917093 Ubiquitin-mediated Degradation of Cellular Proteins in Health and Disease Hepatology (Baltimore, Md.). Jan, 2002 | Pubmed ID: 11786953 The 2009 Lindau Nobel Laureate Meeting: Aaron Ciechanover, Chemistry 2004 Aaron Ciechanover JoVE 1559 Editorial
The 2009 Lindau Nobel Laureate Meeting: Aaron Ciechanover, Chemistry 2004 Aaron Ciechanover JoVE 1559 Editorial