Aaron Ciechanover

Publications

• Intracellular Protein Degradation: From a Vague Idea Through the Lysosome and the Ubiquitin-Proteasome System and Onto Human Diseases and Drug Targeting
  Neuro-degenerative Diseases. Feb, 2012  |   Pubmed ID: 22327508
• HUWE1 Ubiquitinates MyoD and Targets It for Proteasomal Degradation
  Biochemical and Biophysical Research Communications. Feb, 2012  |   Pubmed ID: 22277673
• FAT10 is a Proteasomal Degradation Signal That is Itself Regulated by Ubiquitination
  Molecular Biology of the Cell. Jan, 2012  |   Pubmed ID: 22072791
• Intracellular Protein Degradation: From a Vague Idea Thru the Lysosome and the Ubiquitin-proteasome System and Onto Human Diseases and Drug Targeting
  Biochimica Et Biophysica Acta. Jan, 2012  |   Pubmed ID: 21435401
• Switches, Excitable Responses and Oscillations in the Ring1B/Bmi1 Ubiquitination System
  PLoS Computational Biology. Dec, 2011  |   Pubmed ID: 22194680
• Innate and Adaptive Immunity: the 2011 Nobel Prize in Physiology or Medicine
  American Journal of Respiratory and Critical Care Medicine. Dec, 2011  |   Pubmed ID: 22162893
• Response to Health in the Occupied Palestinian Territory
  Lancet. Oct, 2011  |   Pubmed ID: 22035555
• On the Wings of Imagination
  Nature. Oct, 2011  |   Pubmed ID: 21993824
• The Predator Becomes the Prey: Regulating the Ubiquitin System by Ubiquitylation and Degradation
  Nature Reviews. Molecular Cell Biology. Sep, 2011  |   Pubmed ID: 21860393
• Ubiquitination and Degradation of Proteins
  Methods in Molecular Biology (Clifton, N.J.). 2011  |   Pubmed ID: 21604134
• PRAJA1 is a Ubiquitin Ligase for the Polycomb Repressive Complex 2 Proteins
  Biochemical and Biophysical Research Communications. May, 2011  |   Pubmed ID: 21513699
• Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2
  The Journal of Biological Chemistry. Jun, 2011  |   Pubmed ID: 21493713
• Requirement of ATM-dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-strand Breaks
  Molecular Cell. Mar, 2011  |   Pubmed ID: 21362549
• Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination is Sufficient for Proteasomal Processing of the P105 NF-κB Precursor
  Advances in Experimental Medicine and Biology. 2011  |   Pubmed ID: 21153313
• Epstein-Barr Virus-encoded EBNA-5 Forms Trimolecular Protein Complexes with MDM2 and P53 and Inhibits the Transactivating Function of P53
  International Journal of Cancer. Journal International Du Cancer. Feb, 2011  |   Pubmed ID: 20473904
• Regulation of the Polycomb Protein RING1B Ubiquitination by USP7
  Biochemical and Biophysical Research Communications. Sep, 2010  |   Pubmed ID: 20800574
• Intracellular Protein Degradation: from a Vague Idea Through the Lysosome and the Ubiquitin-proteasome System and Onto Human Diseases and Drug Targeting
  Medicina. 2010  |   Pubmed ID: 20447892
• Regulation of the Polycomb Protein Ring1B by Self-ubiquitination or by E6-AP May Have Implications to the Pathogenesis of Angelman Syndrome
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010  |   Pubmed ID: 20351251
• The Ubiquitin System: Historical Perspective
  Proceedings of the American Thoracic Society. Feb, 2010  |   Pubmed ID: 20160143
• Degradation of Ubiquitin: the Fate of the Cellular Reaper
  Cell Cycle (Georgetown, Tex.). Feb, 2010  |   Pubmed ID: 20107325
• The 26 S Proteasome: from Basic Mechanisms to Drug Targeting
  The Journal of Biological Chemistry. Dec, 2009  |   Pubmed ID: 19812037
• ABIN-1 Negatively Regulates NF-kappaB by Inhibiting Processing of the P105 Precursor
  Biochemical and Biophysical Research Communications. Nov, 2009  |   Pubmed ID: 19695220
• Ubiquitin Degradation with Its Substrate, or As a Monomer in a Ubiquitination-independent Mode, Provides Clues to Proteasome Regulation
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2009  |   Pubmed ID: 19581590
• Interview with Aaron Ciechanover
  Biochemical and Biophysical Research Communications. Sep, 2009  |   Pubmed ID: 19549505
• Tracing the History of the Ubiquitin Proteolytic System: the Pioneering Article
  Biochemical and Biophysical Research Communications. Sep, 2009  |   Pubmed ID: 19539608
• Ubiquitination Participates in the Lysosomal Degradation of Na,K-ATPase in Steady-state Conditions
  American Journal of Respiratory Cell and Molecular Biology. Dec, 2009  |   Pubmed ID: 19286978
• Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination is Sufficient for Proteasomal Processing of the P105 NF-kappaB Precursor
  Molecular Cell. Feb, 2009  |   Pubmed ID: 19250910
• Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology
  Annual Review of Pharmacology and Toxicology. 2009  |   Pubmed ID: 18834306
• The N-terminal Domain of MyoD is Necessary and Sufficient for Its Nuclear Localization-dependent Degradation by the Ubiquitin System
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2008  |   Pubmed ID: 18836078
• Ubiquitin-proteasome-mediated Degradation of Keratin Intermediate Filaments in Mechanically Stimulated A549 Cells
  The Journal of Biological Chemistry. Sep, 2008  |   Pubmed ID: 18617517
• The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development
  Cancer Cell. Jul, 2008  |   Pubmed ID: 18598940
• In Vivo Interactions of MyoD, Id1, and E2A Proteins Determined by Acceptor Photobleaching Fluorescence Resonance Energy Transfer
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2008  |   Pubmed ID: 18198216
• Hypoxia-mediated Na-K-ATPase Degradation Requires Von Hippel Lindau Protein
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2008  |   Pubmed ID: 18073334
• Intracellular Protein Degradation from a Vague Idea Through the Lysosome and the Ubiquitin-proteasome System and on to Human Diseases and Drug Targeting: Nobel Lecture, December 8, 2004
  Annals of the New York Academy of Sciences. Nov, 2007  |   Pubmed ID: 18083918
• Ubiquitin is Degraded by the Ubiquitin System As a Monomer and As Part of Its Conjugated Target
  Biochemical and Biophysical Research Communications. Nov, 2007  |   Pubmed ID: 17870054
• Phosphorylation and Ubiquitination Are Necessary for Na,K-ATPase Endocytosis During Hypoxia
  Cellular Signalling. Sep, 2007  |   Pubmed ID: 17532187
• The Polycomb Protein Ring1B Generates Self Atypical Mixed Ubiquitin Chains Required for Its in Vitro Histone H2A Ligase Activity
  Molecular Cell. Dec, 2006  |   Pubmed ID: 17157253
• Intracellular Protein Degradation: from a Vague Idea Thru the Lysosome and the Ubiquitin-proteasome System and Onto Human Diseases and Drug Targeting
  Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2006  |   Pubmed ID: 17124032
• Narrative Review: Protein Degradation and Human Diseases: the Ubiquitin Connection
  Annals of Internal Medicine. Nov, 2006  |   Pubmed ID: 17088581
• Nobel Round-table Discussion #2: Conflicts of Interest, Scientific Misconduct, Fair Sharing, and Intellectual Property in an Interdisciplinary/inter-institutional Consortium
  Experimental Biology and Medicine (Maywood, N.J.). Jul, 2006  |   Pubmed ID: 16816129
• Nobel Round-table Discussion #1: the Future of Interdisciplinary Research and Training
  Experimental Biology and Medicine (Maywood, N.J.). Jul, 2006  |   Pubmed ID: 16816128
• Intracellular Protein Degradation: from a Vague Idea Thru the Lysosome and the Ubiquitin-proteasome System and Onto Human Diseases and Drug Targeting
  Experimental Biology and Medicine (Maywood, N.J.). Jul, 2006  |   Pubmed ID: 16816126
• Two Distinct Ubiquitin-dependent Mechanisms Are Involved in NF-kappaB P105 Proteolysis
  Biochemical and Biophysical Research Communications. Jun, 2006  |   Pubmed ID: 16678126
• Hypoxia-mediated Degradation of Na,K-ATPase Via Mitochondrial Reactive Oxygen Species and the Ubiquitin-conjugating System
  Circulation Research. May, 2006  |   Pubmed ID: 16614303
• The Ubiquitin Proteolytic System: from an Idea to the Patient Bed
  Proceedings of the American Thoracic Society. 2006  |   Pubmed ID: 16493148
• The Ubiquitin Proteolytic System: from a Vague Idea, Through Basic Mechanisms, and Onto Human Diseases and Drug Targeting
  Neurology. Jan, 2006  |   Pubmed ID: 16432150
• Intracellular Protein Degradation: from a Vague Idea, Through the Lysosome and the Ubiquitin-proteasome System, and Onto Human Diseases and Drug Targeting (Nobel Lecture)
  Angewandte Chemie (International Ed. in English). Sep, 2005  |   Pubmed ID: 16142822
• Early Work on the Ubiquitin Proteasome System, an Interview with Aaron Ciechanover. Interview by CDD
  Cell Death and Differentiation. Sep, 2005  |   Pubmed ID: 16094393
• The Ubiquitin-proteasome System--micro Target for Macro Intervention?
  International Journal of Cardiovascular Interventions. 2005  |   Pubmed ID: 16019609
• E12 and E47 Modulate Cellular Localization and Proteasome-mediated Degradation of MyoD and Id1
  Oncogene. Sep, 2005  |   Pubmed ID: 16007194
• N-terminal Ubiquitination
  Methods in Molecular Biology (Clifton, N.J.). 2005  |   Pubmed ID: 15917637
• Ubiquitin-proteasome-mediated Degradation, Intracellular Localization, and Protein Synthesis of MyoD and Id1 During Muscle Differentiation
  The Journal of Biological Chemistry. Jul, 2005  |   Pubmed ID: 15888449
• Regulation of the Proapoptotic ARTS Protein by Ubiquitin-mediated Degradation
  The Journal of Biological Chemistry. Jul, 2005  |   Pubmed ID: 15837787
• Proteolysis: from the Lysosome to Ubiquitin and the Proteasome
  Nature Reviews. Molecular Cell Biology. Jan, 2005  |   Pubmed ID: 15688069
• The Ubiquitin System: Pathogenesis of Human Diseases and Drug Targeting
  Biochimica Et Biophysica Acta. Nov, 2004  |   Pubmed ID: 15571805
• The Tumor Suppressor Protein P16(INK4a) and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the Ubiquitin System. Direct Evidence for Ubiquitination at the N-terminal Residue
  The Journal of Biological Chemistry. Oct, 2004  |   Pubmed ID: 15254040
• The Ubiquitin System: from Basic Mechanisms to the Patient Bed
  IUBMB Life. Apr, 2004  |   Pubmed ID: 15230346
• Ubiquitin-Proteasome-mediated Degradation of Id1 is Modulated by MyoD
  The Journal of Biological Chemistry. Jul, 2004  |   Pubmed ID: 15163661
• Caspase Activation Inhibits Proteasome Function During Apoptosis
  Molecular Cell. Apr, 2004  |   Pubmed ID: 15068805
• Ubiquitin As a Central Cellular Regulator
  Cell. Jan, 2004  |   Pubmed ID: 15055578
• N-terminal Ubiquitination: More Protein Substrates Join In
  Trends in Cell Biology. Mar, 2004  |   Pubmed ID: 15055197
• Degradation of the Id2 Developmental Regulator: Targeting Via N-terminal Ubiquitination
  Biochemical and Biophysical Research Communications. Feb, 2004  |   Pubmed ID: 14733935
• The Ubiquitin-proteasome System in Cardiovascular Diseases-a Hypothesis Extended
  Cardiovascular Research. Jan, 2004  |   Pubmed ID: 14732197
• Mechanism of Processing of the NF-kappa B2 P100 Precursor: Identification of the Specific Polyubiquitin Chain-anchoring Lysine Residue and Analysis of the Role of NEDD8-modification on the SCF(beta-TrCP) Ubiquitin Ligase
  Oncogene. Apr, 2004  |   Pubmed ID: 14676825
• Dual Effects of IkappaB Kinase Beta-mediated Phosphorylation on P105 Fate: SCF(beta-TrCP)-dependent Degradation and SCF(beta-TrCP)-independent Processing
  Molecular and Cellular Biology. Jan, 2004  |   Pubmed ID: 14673179
• The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg
  Neuron. Oct, 2003  |   Pubmed ID: 14556719
• HdmX Stimulates Hdm2-mediated Ubiquitination and Degradation of P53
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2003  |   Pubmed ID: 14507994
• Oxidative Stress-related Increase in Ubiquitination in Early Coronary Atherogenesis
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2003  |   Pubmed ID: 12958191
• Inverse Relationship Between Skp2 Ubiquitin Ligase and the Cyclin Dependent Kinase Inhibitor P27Kip1 in Prostate Cancer
  The Journal of Urology. Jul, 2003  |   Pubmed ID: 12796697
• A Novel Mammalian Endoplasmic Reticulum Ubiquitin Ligase Homologous to the Yeast Hrd1
  Biochemical and Biophysical Research Communications. Mar, 2003  |   Pubmed ID: 12646171
• Determinants of Nuclear and Cytoplasmic Ubiquitin-mediated Degradation of MyoD
  The Journal of Biological Chemistry. Jan, 2003  |   Pubmed ID: 12397066
• Increased Ubiquitin Immunoreactivity in Unstable Atherosclerotic Plaques Associated with Acute Coronary Syndromes
  Journal of the American College of Cardiology. Dec, 2002  |   Pubmed ID: 12475450
• Regulation of Drosophila IAP1 Degradation and Apoptosis by Reaper and UbcD1
  Nature Cell Biology. Jun, 2002  |   Pubmed ID: 12021769
• The NEDD8 Pathway is Essential for SCF(beta -TrCP)-mediated Ubiquitination and Processing of the NF-kappa B Precursor P105
  The Journal of Biological Chemistry. Jun, 2002  |   Pubmed ID: 11953428
• The Ubiquitin-proteasome Proteolytic Pathway: Destruction for the Sake of Construction
  Physiological Reviews. Apr, 2002  |   Pubmed ID: 11917093
• Ubiquitin-mediated Degradation of Cellular Proteins in Health and Disease
  Hepatology (Baltimore, Md.). Jan, 2002  |   Pubmed ID: 11786953