Abdulbaki Agbas is a Professor of Biosciences in the Department of Basic Sciences, Kansas City University of Medicine and Biosciences (KCU) in Kansas City, Missouri. He received his undergraduate degree in chemistry and a Master of Science degree in clinical biochemistry from Ataturk University of Erzurum-Turkey, and a Ph.D. in biochemistry from the University of Szeged-Hungary.
Dr. Agbas had received extensive training in international laboratories in the field of biochemistry, neurobiology, and cell biology. He was awarded a UNESCO-International Training Fellowship program in modern biology in the Biological Research Center of Hungarian Academy of Sciences. During his fellowship program, how worked on opioid receptor characterizations in the human placenta under the mentorship of Dr. Anna Borsodi. He then continued on the physiology of human placental opioid receptors during his tenure at the University of Missouri-Kansas City, Kansas City, Missouri-USA. Dr. Agbas stayed in Kansas City area, worked in area universities, and broadened his training and expertise in the field of cell biology and neurobiology. Dr. Agbas was a contributing scientist in an NIH-Program Project on “reactive oxygen species (ROS) and aging” led by Dr. Elias K. Michaelis for more than a decade.
Since 2010, Dr. Agbas established his own laboratory and research team to work on developing blood-based biomarkers for Alzheimer’s disease and amyotrophic lateral sclerosis (ALS). He has passion on mitochondria biology and developed an interest how mitochondria respiration profile can be used as an “organelle based biomarker” in disease states. He is a founding member of the “Heartland Center for Mitochondria Medicine”. Dr. Agbas also teaches various biochemistry subjects for medical and graduate students at KCU.
1. Platelet proteolytic machinery assessment in Alzheimer’s Disease
Muriu RG et al, bioRxiv 2019, doi: https://doi.org/10.101760116
2. Mitochondrial Electron Transfer Cascade Enzyme Activity Assessment in Cultured Neurons and Select Brain Regions
Agbas A, et al. Curr Protoc Toxicol 2019. PMID 30951613 Free PMC article.
3. Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial
Statland JM, et al. Muscle Nerve 2019 - Clinical Trial. Among authors: Agbas A. PMID 30192007 Free PMC article.
4. Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1G93A Rodent Spinal Cord Tissue
Kim JM, et al. Neurochem Res 2019. Among authors: Agbas A, Agbas E. PMID 29299811 Free PMC article.
5. Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease
Wilhite R, et al. Future Sci OA 2017. Among authors: Agbas A. PMID 29134122 Free PMC article
6. Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression
Michaelis EK, et al. Neurochem Int 2011. PMID 21397652 Free PMC article.
7. Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate
Wang X, et al. BMC Genomics 2010. PMID 20529287 Free PMC article.
8. Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability
Bao X, et al. J Neurosci 2009. PMID 19890003 Free PMC article.
9. The Role of Methionine Oxidation/Reduction in the Regulation of Immune Response
Agbas A and Moskovitz J. Curr Signal Transduct Ther 2009. PMID 19823697 Free PMC article.
10. A rat brain bicistronic gene with an internal ribosome entry site codes for a phencyclidine-binding protein with cytotoxic activity
Hui D, et al. J Biol Chem 2009. PMID 19028684 Free PMC article.
11. Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo
Agbas A, et al. Biochem J 2007. PMID 17324120 Free PMC article.
Decreased activity and increased aggregation of brain calcineurin during aging
Agbas A, et al. Brain Res 2005. PMID 16150427
12. Selective dendrite-targeting of mRNAs of NR1 splice variants without exon 5: identification of a cis-acting sequence and isolation of sequence-binding proteins
Pal R, et al. Brain Res 2003. PMID 14642443
13. Structure and function of an early divergent form of laminin in hydra: a structurally conserved ECM component that is essential for epithelial morphogenesis
Zhang X, et al. Dev Genes Evol 2002. PMID 12012231
14. Superoxide modification and inactivation of a neuronal receptor-like complex
Agbas A, et al. Free Radic Biol Med 2002. PMID 11958952
15. MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse
De Lisle RC, et al. Gastroenterology 1997. Among authors: Agbas A. PMID 9247472
Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry
Agbas A, et al. Peptides 1995. PMID 7479294
16. Cloning and biological function of laminin in Hydra vulgaris
Sarras MP, et al. Dev Biol 1994. Among authors: Agbas A. PMID 8026633
17. Evidence for cell surface extracellular matrix binding proteins in Hydra vulgaris
Ağbaş A and Sarras MP. Cell Adhes Commun 1994. Among authors: Agbas A. PMID 7982034
18. Effects of methadone use during pregnancy on human placental opioid receptors
Ahmed MS, et al. Membr Biochem 1993. Among authors: Agbas A. PMID 8395641
19. Properties and functions of human placental opioid system
Ahmed MS, et al. Life Sci 1992 - Review. Among authors: Agbas A. PMID 1309934
20. Illicit drug use during pregnancy: effects of opiates and cocaine on human placenta
Ahmed MS, et al. NIDA Res Monogr 1990. Among authors: Agbas A. PMID 1876008
21. Opioids regulate the release of human chorionic gonadotropin hormone from trophoblast tissue
Cemerikic B, et al. Life Sci 1991. Among authors: Agbas A. PMID 1652048
22. Characterization of human placental opioid receptors by 3H-ethylketocyclazocine and 3H-naloxone binding
Agbas A, et al. Neuropeptides 1988. PMID 290737
23. Congenital erythropoietic porphyria
Kürkçüoğlu M, et al. Turk J Pediatr 1985. Among authors: Agbas A. PMID 3984055