Adam D. Bachstetter

Publications

• Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury During Chronic Phase
  Journal of Cellular Immunology. 2022  |   Pubmed ID: 35611116
• Adaptive Immune Cells Shape Obesity-associated Type 2 Diabetes Mellitus and Less Prominent Comorbidities
  Nature Reviews. Endocrinology. 01, 2022  |   Pubmed ID: 34703027
• Dysregulation of Systemic Immunity in Aging and Dementia
  Frontiers in Cellular Neuroscience. 2021  |   Pubmed ID: 34239415
• Inflammatory Regulation of CNS Barriers After Traumatic Brain Injury: A Tale Directed by Interleukin-1
  Frontiers in Immunology. 2021  |   Pubmed ID: 34093593
• Space-occupying Brain Lesions, Trauma-related Tau Astrogliopathy, and ARTAG: a Report of Two Cases and a Literature Review
  Acta Neuropathologica Communications. 03, 2021  |   Pubmed ID: 33757579
• Dystrophic Microglia Are Associated with Neurodegenerative Disease and Not Healthy Aging in the Human Brain
  Neurobiology of Aging. 03, 2021  |   Pubmed ID: 33422891
• Pre-Clinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases
  Journal of Neurotrauma. 05, 2021  |   Pubmed ID: 33297844
• Optimization and Validation of a Modified Radial-arm Water Maze Protocol Using a Murine Model of Mild Closed Head Traumatic Brain Injury
  PloS One. 2020  |   Pubmed ID: 32810143
• An Active Avoidance Behavioral Paradigm for Use in a Mild Closed Head Model of Traumatic Brain Injury in Mice
  Journal of Neuroscience Methods. 09, 2020  |   Pubmed ID: 32592717
• Effects of Advanced Age Upon Astrocyte-specific Responses to Acute Traumatic Brain Injury in Mice
  Journal of Neuroinflammation. Apr, 2020  |   Pubmed ID: 32290848
• The Effects of Mild Closed Head Injuries on Tauopathy and Cognitive Deficits in Rodents: Primary Results in Wild Type and RTg4510 Mice, and a Systematic Review
  Experimental Neurology. 04, 2020  |   Pubmed ID: 31930992
• Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene
  Journal of Neuropathology and Experimental Neurology. 01, 2020  |   Pubmed ID: 31748784
• Genetic Knockout of Myosin Light Chain Kinase (MLCK210) Prevents Cerebral Microhemorrhages and Attenuates Neuroinflammation in a Mouse Model of Vascular Cognitive Impairment and Dementia
  GeroScience. 10, 2019  |   Pubmed ID: 31104189
• Effects of the Dual Orexin Receptor Antagonist DORA-22 on Sleep in 5XFAD Mice
  Alzheimer's & Dementia (New York, N. Y.). 2019  |   Pubmed ID: 30859123
• A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats
  Journal of Neurotrauma. 06, 2019  |   Pubmed ID: 30661454
• Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model
  Neuroscience. 02, 2019  |   Pubmed ID: 30529693
• Simulation of P2X-mediated Calcium Signalling in Microglia
  The Journal of Physiology. 02, 2019  |   Pubmed ID: 30462840
• Depression Following a Traumatic Brain Injury: Uncovering Cytokine Dysregulation As a Pathogenic Mechanism
  Neural Regeneration Research. Oct, 2018  |   Pubmed ID: 30136679
• A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism
  Journal of Neurotrauma. 10, 2018  |   Pubmed ID: 29808778
• Novel TNF Receptor-1 Inhibitors Identified As Potential Therapeutic Candidates for Traumatic Brain Injury
  Journal of Neuroinflammation. May, 2018  |   Pubmed ID: 29789012
• Overlapping but Distinct TDP-43 and Tau Pathologic Patterns in Aged Hippocampi
  Brain Pathology (Zurich, Switzerland). 03, 2018  |   Pubmed ID: 28281308
• Retention of Normal Glia Function by an Isoform-selective Protein Kinase Inhibitor Drug Candidate That Modulates Cytokine Production and Cognitive Outcomes
  Journal of Neuroinflammation. 04, 2017  |   Pubmed ID: 28381303
• Rod-shaped Microglia Morphology is Associated with Aging in 2 Human Autopsy Series
  Neurobiology of Aging. 04, 2017  |   Pubmed ID: 28131016
• Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats After Diffuse Brain Injury
  Journal of Neurotrauma. Jan, 2017  |   Pubmed ID: 27142118
• Risk Factors and Global Cognitive Status Related to Brain Arteriolosclerosis in Elderly Individuals
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 01, 2017  |   Pubmed ID: 26738751
• Targeting Innate Immunity for Neurodegenerative Disorders of the Central Nervous System
  Journal of Neurochemistry. Sep, 2016  |   Pubmed ID: 27248001
• Diffuse Traumatic Brain Injury Induces Prolonged Immune Dysregulation and Potentiates Hyperalgesia Following a Peripheral Immune Challenge
  Molecular Pain. 2016  |   Pubmed ID: 27178244
• MW151 Inhibited IL-1β Levels After Traumatic Brain Injury with No Effect on Microglia Physiological Responses
  PloS One. 2016  |   Pubmed ID: 26871438
• Time-dependent Effects of CX3CR1 in a Mouse Model of Mild Traumatic Brain Injury
  Journal of Neuroinflammation. Sep, 2015  |   Pubmed ID: 26329692
• Disease-related Microglia Heterogeneity in the Hippocampus of Alzheimer's Disease, Dementia with Lewy Bodies, and Hippocampal Sclerosis of Aging
  Acta Neuropathologica Communications. May, 2015  |   Pubmed ID: 26001591
• Closed Head Injury in an Age-related Alzheimer Mouse Model Leads to an Altered Neuroinflammatory Response and Persistent Cognitive Impairment
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2015  |   Pubmed ID: 25904805
• Attenuation of Traumatic Brain Injury-induced Cognitive Impairment in Mice by Targeting Increased Cytokine Levels with a Small Molecule Experimental Therapeutic
  Journal of Neuroinflammation. Apr, 2015  |   Pubmed ID: 25886256
• Inhibition of Neuronal P38α, but Not P38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults
  Journal of Molecular Neuroscience : MN. Feb, 2015  |   Pubmed ID: 25012593
• The P38alpha Mitogen-activated Protein Kinase Limits the CNS Proinflammatory Cytokine Response to Systemic Lipopolysaccharide, Potentially Through an IL-10 Dependent Mechanism
  Journal of Neuroinflammation. Oct, 2014  |   Pubmed ID: 25297465
• Generation and Behavior Characterization of CaMKIIβ Knockout Mice
  PloS One. 2014  |   Pubmed ID: 25127391
• Using Mice to Model Alzheimer's Dementia: an Overview of the Clinical Disease and the Preclinical Behavioral Changes in 10 Mouse Models
  Frontiers in Genetics. 2014  |   Pubmed ID: 24795750
• Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious P38α MAPK Inhibitors
  Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Sep, 2014  |   Pubmed ID: 24789302
• Diffuse Brain Injury Induces Acute Post-traumatic Sleep
  PloS One. 2014  |   Pubmed ID: 24416145
• Clinically Relevant Intronic Splicing Enhancer Mutation in Myelin Proteolipid Protein Leads to Progressive Microglia and Astrocyte Activation in White and Gray Matter Regions of the Brain
  Journal of Neuroinflammation. Dec, 2013  |   Pubmed ID: 24314267
• Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction
  PloS One. 2013  |   Pubmed ID: 23840427
• Comprehensive Behavioral Characterization of an APP/PS-1 Double Knock-in Mouse Model of Alzheimer's Disease
  Alzheimer's Research & Therapy. 2013  |   Pubmed ID: 23705774
• The P38α MAPK Regulates Microglial Responsiveness to Diffuse Traumatic Brain Injury
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2013  |   Pubmed ID: 23554495
• Deficiency in P38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons Against Inflammatory Insult in in Vitro and in Vivo Mouse Models
  PloS One. 2013  |   Pubmed ID: 23457629
• Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2012  |   Pubmed ID: 23152597
• Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-dependent Progression of Alzheimer's Disease-related Pathology
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2012  |   Pubmed ID: 22836255
• Microglial P38α MAPK is Critical for LPS-induced Neuron Degeneration, Through a Mechanism Involving TNFα
  Molecular Neurodegeneration. Dec, 2011  |   Pubmed ID: 22185458
• Microglial P38α MAPK is a Key Regulator of Proinflammatory Cytokine Up-regulation Induced by Toll-like Receptor (TLR) Ligands or Beta-amyloid (Aβ)
  Journal of Neuroinflammation. Jul, 2011  |   Pubmed ID: 21733175
• CX3CL1 Reduces Neurotoxicity and Microglial Activation in a Rat Model of Parkinson's Disease
  Journal of Neuroinflammation. Jan, 2011  |   Pubmed ID: 21266082
• The P38 MAP Kinase Family As Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS
  Aging and Disease. Dec, 2010  |   Pubmed ID: 22720195