Adolfo Saiardi

Publications

• ITPK1 is an InsP/ADP Phosphotransferase That Controls Phosphate Signaling in Arabidopsis
  Molecular Plant. Jul, 2021  |   Pubmed ID: 34274522
• A Stable Immature Lattice Packages IP for HIV Capsid Maturation
  Science Advances. Mar, 2021  |   Pubmed ID: 33692109
• Cytoplasmic Cleavage of IMPA1 3' UTR is Necessary for Maintaining Axon Integrity
  Cell Reports. Feb, 2021  |   Pubmed ID: 33626357
• IP6K3 and IPMK Variations in LOAD and Longevity: Evidence for a Multifaceted Signaling Network at the Crossroad Between Neurodegeneration and Survival
  Mechanisms of Ageing and Development. 04, 2021  |   Pubmed ID: 33497757
• Inositol Phosphate Kinases in the Eukaryote Landscape
  Advances in Biological Regulation. 01, 2021  |   Pubmed ID: 33422459
• Phytocannabinoid-dependent MTORC1 Regulation is Dependent Upon Inositol Polyphosphate Multikinase Activity
  British Journal of Pharmacology. 03, 2021  |   Pubmed ID: 33347604
• MINPP1 Prevents Intracellular Accumulation of the Chelator Inositol Hexakisphosphate and is Mutated in Pontocerebellar Hypoplasia
  Nature Communications. 11, 2020  |   Pubmed ID: 33257696
• Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry
  Nature Communications. 11, 2020  |   Pubmed ID: 33247133
• IP-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery
  MBio. 10, 2020  |   Pubmed ID: 33082258
• Effects of the Putative Lithium Mimetic Ebselen on Pilocarpine-induced Neural Activity
  European Journal of Pharmacology. Sep, 2020  |   Pubmed ID: 32687920
• Interplay Between Primary Familial Brain Calcification-associated SLC20A2 and XPR1 Phosphate Transporters Requires Inositol Polyphosphates for Control of Cellular Phosphate Homeostasis
  The Journal of Biological Chemistry. 07, 2020  |   Pubmed ID: 32393577
• Inorganic Polyphosphate in Mammals: Where's Wally?
  Biochemical Society Transactions. 02, 2020  |   Pubmed ID: 32049314
• Development of a Yeast Model to Study the Contribution of Vacuolar Polyphosphate Metabolism to Lysine Polyphosphorylation
  The Journal of Biological Chemistry. 02, 2020  |   Pubmed ID: 31844018
• Dictyostelium Discoideum As a Model to Study Inositol Polyphosphates and Inorganic Polyphosphate
  Methods in Molecular Biology (Clifton, N.J.). 2020  |   Pubmed ID: 31773570
• Cellular IP Levels Limit HIV Production While Viruses That Cannot Efficiently Package IP Are Attenuated for Infection and Replication
  Cell Reports. 12, 2019  |   Pubmed ID: 31851928
• ITPK1 Mediates the Lipid-independent Synthesis of Inositol Phosphates Controlled by Metabolism
  Proceedings of the National Academy of Sciences of the United States of America. 12, 2019  |   Pubmed ID: 31754032
• ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity
  ACS Chemical Biology. 10, 2019  |   Pubmed ID: 31525024
• Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity of Present Novel Drug Targeting Opportunities
  Frontiers in Cellular and Infection Microbiology. 2019  |   Pubmed ID: 31380293
• Harnessing C-labeled -inositol to Interrogate Inositol Phosphate Messengers by NMR
  Chemical Science. May, 2019  |   Pubmed ID: 31191882
• The Inositol Hexakisphosphate Kinases IP6K1 and -2 Regulate Human Cellular Phosphate Homeostasis, Including XPR1-mediated Phosphate Export
  The Journal of Biological Chemistry. 07, 2019  |   Pubmed ID: 31186349
• Inositol Polyphosphate Multikinase (), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity
  Genes. 02, 2019  |   Pubmed ID: 30744060
• Crosstalk Between Ras and Inositol Phosphate Signaling Revealed by Lithium Action on Inositol Monophosphatase in Schizophyllum Commune
  Advances in Biological Regulation. 05, 2019  |   Pubmed ID: 30639095
• Hydrophilic Interaction Liquid Chromatography-tandem Mass Spectrometry for the Quantitative Analysis of Mammalian-derived Inositol Poly/pyrophosphates
  Journal of Chromatography. A. Oct, 2018  |   Pubmed ID: 30220429
• Lithium and Fluoxetine Regulate the Rate of Phosphoinositide Synthesis in Neurons: a New View of Their Mechanisms of Action in Bipolar Disorder
  Translational Psychiatry. 08, 2018  |   Pubmed ID: 30171184
• Rab4A Organizes Endosomal Domains for Sorting Cargo to Lysosome-related Organelles
  Journal of Cell Science. 09, 2018  |   Pubmed ID: 30154210
• Inositol Phosphates Purification Using Titanium Dioxide Beads
  Bio-protocol. Aug, 2018  |   Pubmed ID: 30148188
• Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome
  ACS Chemical Biology. 08, 2018  |   Pubmed ID: 29924597
• IP6 is an HIV Pocket Factor That Prevents Capsid Collapse and Promotes DNA Synthesis
  ELife. 05, 2018  |   Pubmed ID: 29848441
• Asp1 Bifunctional Activity Modulates Spindle Function Via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces Pombe
  Molecular and Cellular Biology. 05, 2018  |   Pubmed ID: 29440310
• Microbial Inositol Polyphosphate Metabolic Pathway As Drug Development Target
  Advances in Biological Regulation. 01, 2018  |   Pubmed ID: 28964726
• IP3-4 Kinase Arg1 Regulates Cell Wall Homeostasis and Surface Architecture to Promote Clearance of Cryptococcus Neoformans Infection in a Mouse Model
  Virulence. Oct, 2017  |   Pubmed ID: 28976803
• The Inositol Pyrophosphate Synthesis Pathway in Trypanosoma Brucei is Linked to Polyphosphate Synthesis in Acidocalcisomes
  Molecular Microbiology. Oct, 2017  |   Pubmed ID: 28792096
• Has Inositol Played Any Role in the Origin of Life?
  Life (Basel, Switzerland). Jun, 2017  |   Pubmed ID: 28587245
• Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling
  Topics in Current Chemistry (Cham). Feb, 2017  |   Pubmed ID: 28101851
• Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective
  Trends in Biochemical Sciences. 03, 2017  |   Pubmed ID: 27876550
• Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery
  Journal of Fungi (Basel, Switzerland). Sep, 2016  |   Pubmed ID: 29376941
• Protein Pyrophosphorylation: Moving Forward
  The Biochemical Journal. 11, 2016  |   Pubmed ID: 27789744
• Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels
  PloS One. 2016  |   Pubmed ID: 27788189
• Identification of a Major IP5 Kinase in Cryptococcus Neoformans Confirms That PP-IP5/IP7, Not IP6, is Essential for Virulence
  Scientific Reports. Apr, 2016  |   Pubmed ID: 27033523
• Phosphate, Inositol and Polyphosphates
  Biochemical Society Transactions. Feb, 2016  |   Pubmed ID: 26862212
• The New World of Inorganic Polyphosphates
  Biochemical Society Transactions. Feb, 2016  |   Pubmed ID: 26862182
• Developmental Accumulation of Inorganic Polyphosphate Affects Germination and Energetic Metabolism in Dictyostelium Discoideum
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2016  |   Pubmed ID: 26755590
• Why Always Lysine? The Ongoing Tale of One of the Most Modified Amino Acids
  Advances in Biological Regulation. Jan, 2016  |   Pubmed ID: 26482291
• There is No 'Conundrum' of InsP6
  Open Biology. Nov, 2015  |   Pubmed ID: 26581573
• Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity
  MBio. Jun, 2015  |   Pubmed ID: 26037119
• Prometabolites of 5-Diphospho-myo-inositol Pentakisphosphate
  Angewandte Chemie (International Ed. in English). Aug, 2015  |   Pubmed ID: 26014370
• VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis
  The Plant Cell. Apr, 2015  |   Pubmed ID: 25901085
• A Novel Method for the Purification of Inositol Phosphates from Biological Samples Reveals That No Phytate is Present in Human Plasma or Urine
  Open Biology. Mar, 2015  |   Pubmed ID: 25808508
• Protein Polyphosphorylation of Lysine Residues by Inorganic Polyphosphate
  Molecular Cell. Apr, 2015  |   Pubmed ID: 25773596
• Raman Spectroscopy Detection of Phytic Acid in Plant Seeds Reveals the Absence of Inorganic Polyphosphate
  Molecular Plant. May, 2015  |   Pubmed ID: 25620771
• Inositol Phosphates Induce DAPI Fluorescence Shift
  The Biochemical Journal. Jun, 2014  |   Pubmed ID: 24670057
• Functions of Inorganic Polyphosphates in Eukaryotic Cells: a Coat of Many Colours
  Biochemical Society Transactions. Feb, 2014  |   Pubmed ID: 24450634
• Analysis of Dictyostelium Discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis
  PloS One. 2014  |   Pubmed ID: 24416420
• Inositol Pyrophosphates Regulate JMJD2C-dependent Histone Demethylation
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013  |   Pubmed ID: 24191012
• Modulation of Inositol Polyphosphate Levels Regulates Neuronal Differentiation
  Molecular Biology of the Cell. Sep, 2013  |   Pubmed ID: 23864704
• Inositol Pyrophosphates: Between Signalling and Metabolism
  The Biochemical Journal. Jun, 2013  |   Pubmed ID: 23725456
• Arginine Transcriptional Response Does Not Require Inositol Phosphate Synthesis
  The Journal of Biological Chemistry. Nov, 2012  |   Pubmed ID: 22992733
• How Inositol Pyrophosphates Control Cellular Phosphate Homeostasis?
  Advances in Biological Regulation. May, 2012  |   Pubmed ID: 22781748
• Cell Signalling by Inositol Pyrophosphates
  Sub-cellular Biochemistry. 2012  |   Pubmed ID: 22374099
• Influence of Inositol Pyrophosphates on Cellular Energy Dynamics
  Science (New York, N.Y.). Nov, 2011  |   Pubmed ID: 22076377
• Identification of an Evolutionarily Conserved Family of Inorganic Polyphosphate Endopolyphosphatases
  The Journal of Biological Chemistry. Sep, 2011  |   Pubmed ID: 21775424
• Inositol Hexakisphosphate Kinases Induce Cell Death in Huntington Disease
  The Journal of Biological Chemistry. Jul, 2011  |   Pubmed ID: 21652713
• IP6K Gene Identification in Plant Genomes by Tag Searching
  BMC Proceedings. 2011  |   Pubmed ID: 21554757
• Inositol Polyphosphate Multikinase is a Physiologic PI3-kinase That Activates Akt/PKB
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011  |   Pubmed ID: 21220345
• The Signaling Role of Inositol Hexakisphosphate Kinases (IP6Ks)
  Advances in Enzyme Regulation. 2011  |   Pubmed ID: 21035498
• Inositol Hexakisphosphate Kinases Promote Autophagy
  The International Journal of Biochemistry & Cell Biology. Dec, 2010  |   Pubmed ID: 20883817
• Synthesis of InsP7 by the Inositol Hexakisphosphate Kinase 1 (IP6K1)
  Methods in Molecular Biology (Clifton, N.J.). 2010  |   Pubmed ID: 20645182
• An NGF-responsive Element Targets Myo-inositol Monophosphatase-1 MRNA to Sympathetic Neuron Axons
  Nature Neuroscience. Mar, 2010  |   Pubmed ID: 20118926
• Inositol Pyrophosphate Mediated Pyrophosphorylation of AP3B1 Regulates HIV-1 Gag Release
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009  |   Pubmed ID: 19934039
• Inositol Pyrophosphates Modulate Hydrogen Peroxide Signalling
  The Biochemical Journal. Oct, 2009  |   Pubmed ID: 19614566
• Inositol Pyrophosphates and Their Unique Metabolic Complexity: Analysis by Gel Electrophoresis
  PloS One. 2009  |   Pubmed ID: 19440344
• Are Inositol Pyrophosphates Signalling Molecules?
  Journal of Cellular Physiology. Jul, 2009  |   Pubmed ID: 19326391
• Inositol Hexakisphosphate Kinase Products Contain Diphosphate and Triphosphate Groups
  Chemistry & Biology. Mar, 2008  |   Pubmed ID: 18355727
• The Mood Stabilizer Valproate Inhibits Both Inositol- and Diacylglycerol-signaling Pathways in Caenorhabditis Elegans
  Molecular Biology of the Cell. May, 2008  |   Pubmed ID: 18287529
• Human ITPK1: a Reversible Inositol Phosphate Kinase/phosphatase That Links Receptor-dependent Phospholipase C to Ca2+-activated Chloride Channels
  Science Signaling. 2008  |   Pubmed ID: 18272466
• Polyunsaturated Fatty Acids Influence Synaptojanin Localization to Regulate Synaptic Vesicle Recycling
  Molecular Biology of the Cell. Mar, 2008  |   Pubmed ID: 18094048
• Inositol Polyphosphate Multikinase: Metabolic Architect of Nuclear Inositides
  Frontiers in Bioscience : a Journal and Virtual Library. 2008  |   Pubmed ID: 17981594
• Requirement of Inositol Pyrophosphates for Full Exocytotic Capacity in Pancreatic Beta Cells
  Science (New York, N.Y.). Nov, 2007  |   Pubmed ID: 18033884
• Protein Pyrophosphorylation by Inositol Pyrophosphates is a Posttranslational Event
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007  |   Pubmed ID: 17873058
• Inositol Pyrophosphates Get the Vip1 Treatment
  Cell. May, 2007  |   Pubmed ID: 17512396
• Extraction and Analysis of Soluble Inositol Polyphosphates from Yeast
  Nature Protocols. 2006  |   Pubmed ID: 17406485
• Inhibition of the Phosphatidylinositol 3-kinase/Akt Pathway by Inositol Pentakisphosphate Results in Antiangiogenic and Antitumor Effects
  Cancer Research. Sep, 2005  |   Pubmed ID: 16166311
• Inositol Polyphosphate Multikinase is a Nuclear PI3-kinase with Transcriptional Regulatory Activity
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005  |   Pubmed ID: 16123124
• Inositol Pyrophosphates Regulate Cell Death and Telomere Length Through Phosphoinositide 3-kinase-related Protein Kinases
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005  |   Pubmed ID: 15665079
• Inositol Hexakisphosphate Kinase-2, a Physiologic Mediator of Cell Death
  The Journal of Biological Chemistry. Jan, 2005  |   Pubmed ID: 15533939
• Phosphorylation of Proteins by Inositol Pyrophosphates
  Science (New York, N.Y.). Dec, 2004  |   Pubmed ID: 15604408
• Simultaneous Absence of Dopamine D1 and D2 Receptor-mediated Signaling is Lethal in Mice
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004  |   Pubmed ID: 15272078
• Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium Via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions
  Cell. Sep, 2003  |   Pubmed ID: 13678580
• Inositol Pyrophosphates Regulate Endocytic Trafficking
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002  |   Pubmed ID: 12391334
• Role of Dopamine D2-like Receptors in Cocaine Self-administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2002  |   Pubmed ID: 11923462
• Inositol Pyrophosphates Are Required for DNA Hyperrecombination in Protein Kinase C1 Mutant Yeast
  Biochemistry. Feb, 2002  |   Pubmed ID: 11851397