Akira Sawa Department of Psychiatry Johns Hopkins University Biography Publications Institution JoVE Articles Akira Sawa has not added a biography. If you are Akira Sawa and would like to personalize this page please email our Author Liaison for assistance. Publications Environmental Stresso, Rs and Epigenetic Control of the Hypothalamic-Pituitary-Adrenal-Axis (HPA-axis) Neuroendocrinology. Nov, 2014 | Pubmed ID: 25427939 Role of Apoptosis Signal-regulating Kinase 1 (ASK1) As an Activator of the GAPDH-Siah1 Stress-Signaling Cascade The Journal of Biological Chemistry. Nov, 2014 | Pubmed ID: 25391652 Is Prophylactic Psychiatry Around the Corner? Combating Adolescent Oxidative Stress for Adult Psychosis and Schizophrenia Neuron. Sep, 2014 | Pubmed ID: 25189204 Neuropeptide Precursor VGF is Genetically Associated with Social Anhedonia and Underrepresented in the Brain of Major Mental Illness: Its Downregulation by DISC1 Human Molecular Genetics. Nov, 2014 | Pubmed ID: 24934694 Human Stem Cells and Surrogate Tissues for Basic and Translational Study of Mental Disorders Biological Psychiatry. Jun, 2014 | Pubmed ID: 24862565 Inflammatory Molecular Signature Associated with Infectious Agents in Psychosis Schizophrenia Bulletin. Sep, 2014 | Pubmed ID: 24743863 Reasons for Not Seeking General Medical Care Among Individuals with Serious Mental Illness Psychiatric Services (Washington, D.C.). Jun, 2014 | Pubmed ID: 24733659 PAKs Inhibitors Ameliorate Schizophrenia-associated Dendritic Spine Deterioration in Vitro and in Vivo During Late Adolescence Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24706880 Oxidative Stress and Schizophrenia: Recent Breakthroughs from an Old Story Current Opinion in Psychiatry. May, 2014 | Pubmed ID: 24613987 Regional Brain Distribution of Translocator Protein Using [(11)C]DPA-713 PET in Individuals Infected with HIV Journal of Neurovirology. Jun, 2014 | Pubmed ID: 24567030 Promoting Careers in Academic Research to Psychiatry Residents Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry. Apr, 2014 | Pubmed ID: 24497181 Modeling Heterogeneous Patients with a Clinical Diagnosis of Schizophrenia with Induced Pluripotent Stem Cells Biological Psychiatry. Jun, 2014 | Pubmed ID: 24331955 Hippocampal Volume Reduction Correlates with Apathy in Traumatic Brain Injury, but Not Schizophrenia The Journal of Neuropsychiatry and Clinical Neurosciences. 2013 | Pubmed ID: 24247856 Olfactory Cells Via Nasal Biopsy Reflect the Developing Brain in Gene Expression Profiles: Utility and Limitation of the Surrogate Tissues in Research for Brain Disorders Neuroscience Research. Dec, 2013 | Pubmed ID: 24120685 Deficits in MicroRNA-mediated Cxcr4/Cxcl12 Signaling in Neurodevelopmental Deficits in a 22q11 Deletion Syndrome Mouse Model Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013 | Pubmed ID: 24101523 Reduced Anterior Cingulate Gray Matter Volume and Thickness in Subjects with Deficit Schizophrenia Schizophrenia Research. Nov, 2013 | Pubmed ID: 24035178 Regulation of N-Methyl-D-Aspartate Receptors by Disrupted-in-Schizophrenia-1 Biological Psychiatry. Jul, 2013 | Pubmed ID: 23906531 Relationships Between Serum Leptin Level and Severity of Positive Symptoms in Schizophrenia Neuroscience Research. Sep-Oct, 2013 | Pubmed ID: 23896201 Cuprizone Short-term Exposure: Astrocytic IL-6 Activation and Behavioral Changes Relevant to Psychosis Neurobiology of Disease. Nov, 2013 | Pubmed ID: 23867234 Cognitive and Motivational Deficits Together with Prefrontal Oxidative Stress in a Mouse Model for Neuropsychiatric Illness Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23840059 Mouse Models of Gene-environment Interactions in Schizophrenia Neurobiology of Disease. Sep, 2013 | Pubmed ID: 23748077 MicroRNA-382 Expression is Elevated in the Olfactory Neuroepithelium of Schizophrenia Patients Neurobiology of Disease. Jul, 2013 | Pubmed ID: 23542694 Astroglial IFITM3 Mediates Neuronal Impairments Following Neonatal Immune Challenge in Mice Glia. May, 2013 | Pubmed ID: 23382131 Schizophrenia Research in 2013: Are We Making Progress? Neurobiology of Disease. May, 2013 | Pubmed ID: 23380149 Synapse-specific Contributions in the Cortical Pathology of Schizophrenia Neurobiology of Disease. May, 2013 | Pubmed ID: 23336981 Adolescent Stress-induced Epigenetic Control of Dopaminergic Neurons Via Glucocorticoids Science (New York, N.Y.). Jan, 2013 | Pubmed ID: 23329051 Subcortical Dopaminergic Deficits in a DISC1 Mutant Model: a Study in Direct Reference to Human Molecular Brain Imaging Human Molecular Genetics. Apr, 2013 | Pubmed ID: 23314019 DISC1: a Key Lead in Studying Cortical Development and Associated Brain Disorders The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Oct, 2013 | Pubmed ID: 23300216 DISC1 As a Therapeutic Target for Mental Illnesses Expert Opinion on Therapeutic Targets. Dec, 2012 | Pubmed ID: 23130881 Diabetes is Associated with Lower Global Cognitive Function in Schizophrenia Schizophrenia Research. Dec, 2012 | Pubmed ID: 23031192 PKA and PDE4D3 Anchoring to AKAP9 Provides Distinct Regulation of CAMP Signals at the Centrosome The Journal of Cell Biology. Aug, 2012 | Pubmed ID: 22908311 Pharmacokinetics of Oral D-serine in D-amino Acid Oxidase Knockout Mice Drug Metabolism and Disposition: the Biological Fate of Chemicals. Nov, 2012 | Pubmed ID: 22837388 Proteomic, Genomic and Translational Approaches Identify CRMP1 for a Role in Schizophrenia and Its Underlying Traits Human Molecular Genetics. Aug, 2012 | Pubmed ID: 22798627 KCTD13 is a Major Driver of Mirrored Neuroanatomical Phenotypes of the 16p11.2 Copy Number Variant Nature. May, 2012 | Pubmed ID: 22596160 Glucocorticoid-induced Loss of DNA Methylation in Non-neuronal Cells and Potential Involvement of DNMT1 in Epigenetic Regulation of Fkbp5 Biochemical and Biophysical Research Communications. Apr, 2012 | Pubmed ID: 22445894 Better Understanding of Mechanisms of Schizophrenia and Bipolar Disorder: from Human Gene Expression Profiles to Mouse Models Neurobiology of Disease. Jan, 2012 | Pubmed ID: 21914480 Protein S-nitrosylation: Role for Nitric Oxide Signaling in Neuronal Death Biochimica Et Biophysica Acta. Jun, 2012 | Pubmed ID: 21803124 Mouse Strain Differences in Phencyclidine-induced Behavioural Changes The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). Jul, 2012 | Pubmed ID: 21733237 In Utero Electroporation As a Tool for Genetic Manipulation in Vivo to Study Psychiatric Disorders: from Genes to Circuits and Behaviors The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Apr, 2012 | Pubmed ID: 21551077 Anti-/Propsychotic Drug Signaling Via Heteromeric GPCRs--a Balancing Act? Cell. Nov, 2011 | Pubmed ID: 22118451 Linking Neurodevelopmental and Synaptic Theories of Mental Illness Through DISC1 Nature Reviews. Neuroscience. Dec, 2011 | Pubmed ID: 22095064 Following the Genes: a Framework for Animal Modeling of Psychiatric Disorders BMC Biology. 2011 | Pubmed ID: 22078115 Advancing Drug Discovery for Schizophrenia Annals of the New York Academy of Sciences. Oct, 2011 | Pubmed ID: 22032400 DISC1 at 10: Connecting Psychiatric Genetics and Neuroscience Trends in Molecular Medicine. Dec, 2011 | Pubmed ID: 22015021 Human Nasal Olfactory Epithelium As a Dynamic Marker for CNS Therapy Development Experimental Neurology. Dec, 2011 | Pubmed ID: 21945230 The Insula-claustrum Region and Delusions in Schizophrenia Schizophrenia Research. Dec, 2011 | Pubmed ID: 21875780 Effects of Antipsychotics on the Behavioral Deficits in Human Dominant-negative DISC1 Transgenic Mice with Neonatal PolyI:C Treatment Behavioural Brain Research. Nov, 2011 | Pubmed ID: 21835207 Altered MHC Class I Expression in Dorsolateral Prefrontal Cortex of Nonsmoker Patients with Schizophrenia Neuroscience Research. Nov, 2011 | Pubmed ID: 21801761 DISC1 Regulates Synaptic Vesicle Transport Via a Lithium-sensitive Pathway Neuroscience Research. Sep, 2011 | Pubmed ID: 21664390 Readdressing Synaptic Pruning Theory for Schizophrenia: Combination of Brain Imaging and Cell Biology Communicative & Integrative Biology. Mar, 2011 | Pubmed ID: 21655443 Inositol Hexakisphosphate Kinases Induce Cell Death in Huntington Disease The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21652713 Glutathione is a Physiologic Reservoir of Neuronal Glutamate Biochemical and Biophysical Research Communications. Jun, 2011 | Pubmed ID: 21539809 Working Memory Deficits in Neuronal Nitric Oxide Synthase Knockout Mice: Potential Impairments in Prefrontal Cortex Mediated Cognitive Function Biochemical and Biophysical Research Communications. May, 2011 | Pubmed ID: 21539806 DISC1-dependent Switch from Progenitor Proliferation to Migration in the Developing Cortex Nature. May, 2011 | Pubmed ID: 21471969 Impaired NMDA Receptor Transmission Alters Striatal Synapses and DISC1 Protein in an Age-dependent Manner Proceedings of the National Academy of Sciences of the United States of America. Apr, 2011 | Pubmed ID: 21436042 A Novel Balanced Chromosomal Translocation Found in Subjects with Schizophrenia and Schizotypal Personality Disorder: Altered L-serine Level Associated with Disruption of PSAT1 Gene Expression Neuroscience Research. Feb, 2011 | Pubmed ID: 20955740 Nitric Oxide Signaling and Nitrosative Stress in Neurons: Role for S-nitrosylation Antioxidants & Redox Signaling. Apr, 2011 | Pubmed ID: 20812870 The Diverse Functions of GAPDH: Views from Different Subcellular Compartments Cellular Signalling. Feb, 2011 | Pubmed ID: 20727968 Prenatal Interaction of Mutant DISC1 and Immune Activation Produces Adult Psychopathology Biological Psychiatry. Dec, 2010 | Pubmed ID: 21130225 Biochemical and Functional Interaction of Disrupted-in-schizophrenia 1 and Amyloid Precursor Protein Regulates Neuronal Migration During Mammalian Cortical Development The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2010 | Pubmed ID: 20685985 Assessing the Role of Endooligopeptidase Activity of Ndel1 (nuclear-distribution Gene E Homolog Like-1) in Neurite Outgrowth Molecular and Cellular Neurosciences. Aug, 2010 | Pubmed ID: 20462516 Gray-matter Abnormalities in Deficit Schizophrenia Schizophrenia Research. Jul, 2010 | Pubmed ID: 20452187 Disturbed Synaptic Connectivity in Schizophrenia: Convergence of Genetic Risk Factors During Neurodevelopment Brain Research Bulletin. Sep, 2010 | Pubmed ID: 20433911 Disrupted-in-Schizophrenia-1 Expression is Regulated by Beta-site Amyloid Precursor Protein Cleaving Enzyme-1-neuregulin Cascade Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20212127 Knockdown of DISC1 by in Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits Neuron. Feb, 2010 | Pubmed ID: 20188653 Neuroanatomic and Cognitive Abnormalities Related to Herpes Simplex Virus Type 1 in Schizophrenia Schizophrenia Research. May, 2010 | Pubmed ID: 20153952 Disrupted-in-Schizophrenia 1 (DISC1) Regulates Spines of the Glutamate Synapse Via Rac1 Nature Neuroscience. Mar, 2010 | Pubmed ID: 20139976 A Novel Role for Glyceraldehyde-3-phosphate Dehydrogenase and Monoamine Oxidase B Cascade in Ethanol-induced Cellular Damage Biological Psychiatry. May, 2010 | Pubmed ID: 20022592 Review of Pathological Hallmarks of Schizophrenia: Comparison of Genetic Models with Patients and Nongenetic Models Schizophrenia Bulletin. Mar, 2010 | Pubmed ID: 19903746 Negative Symptoms of Schizophrenia Correlate with Impairment on the University of Pennsylvania Smell Identification Test Neuroscience Research. Jan, 2010 | Pubmed ID: 19819272 Combined Effect of Neonatal Immune Activation and Mutant DISC1 on Phenotypic Changes in Adulthood Behavioural Brain Research. Jan, 2010 | Pubmed ID: 19716847 Genetic Animal Models for Schizophrenia: Advantages and Limitations of Genetic Manipulation in Drosophila, Zebrafish, Rodents, and Primates Progress in Brain Research. 2009 | Pubmed ID: 20302812 Preface. This Volume Focuses on How Genetic Models for Schizophrenia, That Is, Manipulation in Genetic Susceptibility Factors for the Disease, Have Potential in Opening a New Window of Better Understanding of Etiology-relevant Mechanisms Progress in Brain Research. 2009 | Pubmed ID: 19932335 Glyceraldehyde-3-phosphate Dehydrogenase Aggregate Formation Participates in Oxidative Stress-induced Cell Death The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19837666 Understanding the Role of DISC1 in Psychiatric Disease and During Normal Development The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19828788 A Novel Role for HGas7b in Microtubular Maintenance: Possible Implication in Tau-associated Pathology in Alzheimer Disease The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19801671 Neurodevelopmental Mechanisms of Schizophrenia: Understanding Disturbed Postnatal Brain Maturation Through Neuregulin-1-ErbB4 and DISC1 Trends in Neurosciences. Sep, 2009 | Pubmed ID: 19712980 Cortical Development and Glutamatergic Dysregulation in Schizophrenia Biological Psychiatry. Sep, 2009 | Pubmed ID: 19712774 Using Bioinformatic Tools The American Journal of Psychiatry. Aug, 2009 | Pubmed ID: 19651749 GOSPEL: a Neuroprotective Protein That Binds to GAPDH Upon S-nitrosylation Neuron. Jul, 2009 | Pubmed ID: 19607794 Animal Models of Gene-environment Interactions in Schizophrenia Behavioural Brain Research. Dec, 2009 | Pubmed ID: 19379776 Schizophrenia and Epilepsy: is There a Shared Susceptibility? Neuroscience Research. Apr, 2009 | Pubmed ID: 19367784 Peripheral Olfactory System for Clinical and Basic Psychiatry: a Promising Entry Point to the Mystery of Brain Mechanism and Biomarker Identification in Schizophrenia The American Journal of Psychiatry. Feb, 2009 | Pubmed ID: 19188289 Proteomic and Histochemical Analysis of Proteins Involved in the Dying-back-type of Axonal Degeneration in the Gracile Axonal Dystrophy (gad) Mouse Neurochemistry International. May-Jun, 2009 | Pubmed ID: 19154771 Recruitment of PCM1 to the Centrosome by the Cooperative Action of DISC1 and BBS4: a Candidate for Psychiatric Illnesses Archives of General Psychiatry. Sep, 2008 | Pubmed ID: 18762586 Nitric Oxide-induced Nuclear GAPDH Activates P300/CBP and Mediates Apoptosis Nature Cell Biology. Jul, 2008 | Pubmed ID: 18552833 Elucidating the Relationship Between DISC1, NDEL1 and NDE1 and the Risk for Schizophrenia: Evidence of Epistasis and Competitive Binding Human Molecular Genetics. Aug, 2008 | Pubmed ID: 18469341 الخلايا العصبية الشمية التي يتم الحصول عليها من خلال الأنف خزعة جنبا إلى جنب مع الليزر والتقاط تسليخ مجهري: نهج المحتملين لدراسة الاستجابة للعلاج في اضطرابات العقلية Soumya Narayan1, Charlee McLean2, Akira Sawa1, Sandra Y. Lin3, Narayan Rai2, MariaMananita S. Hipolito2, Nicola Cascella4, John J.I. Nurnberger, Jr.5, Koko Ishizuka1, Evaristus A. Nwulia2 1Department of Psychiatry, Johns Hopkins University, 2Department of Psychiatry and Behavioral Sciences, Howard University, 3Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, 4Department of Psychiatry, Sheppard Pratt Hospital, 5Department of Psychiatry, Indiana University JoVE 51853 Neuroscience
الخلايا العصبية الشمية التي يتم الحصول عليها من خلال الأنف خزعة جنبا إلى جنب مع الليزر والتقاط تسليخ مجهري: نهج المحتملين لدراسة الاستجابة للعلاج في اضطرابات العقلية Soumya Narayan1, Charlee McLean2, Akira Sawa1, Sandra Y. Lin3, Narayan Rai2, MariaMananita S. Hipolito2, Nicola Cascella4, John J.I. Nurnberger, Jr.5, Koko Ishizuka1, Evaristus A. Nwulia2 1Department of Psychiatry, Johns Hopkins University, 2Department of Psychiatry and Behavioral Sciences, Howard University, 3Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, 4Department of Psychiatry, Sheppard Pratt Hospital, 5Department of Psychiatry, Indiana University JoVE 51853 Neuroscience
