Akira Sawa

Publications

• Environmental Stresso, Rs and Epigenetic Control of the Hypothalamic-Pituitary-Adrenal-Axis (HPA-axis)
  Neuroendocrinology. Nov, 2014  |   Pubmed ID: 25427939
• Role of Apoptosis Signal-regulating Kinase 1 (ASK1) As an Activator of the GAPDH-Siah1 Stress-Signaling Cascade
  The Journal of Biological Chemistry. Nov, 2014  |   Pubmed ID: 25391652
• Is Prophylactic Psychiatry Around the Corner? Combating Adolescent Oxidative Stress for Adult Psychosis and Schizophrenia
  Neuron. Sep, 2014  |   Pubmed ID: 25189204
• Neuropeptide Precursor VGF is Genetically Associated with Social Anhedonia and Underrepresented in the Brain of Major Mental Illness: Its Downregulation by DISC1
  Human Molecular Genetics. Nov, 2014  |   Pubmed ID: 24934694
• Human Stem Cells and Surrogate Tissues for Basic and Translational Study of Mental Disorders
  Biological Psychiatry. Jun, 2014  |   Pubmed ID: 24862565
• Inflammatory Molecular Signature Associated with Infectious Agents in Psychosis
  Schizophrenia Bulletin. Sep, 2014  |   Pubmed ID: 24743863
• Reasons for Not Seeking General Medical Care Among Individuals with Serious Mental Illness
  Psychiatric Services (Washington, D.C.). Jun, 2014  |   Pubmed ID: 24733659
• PAKs Inhibitors Ameliorate Schizophrenia-associated Dendritic Spine Deterioration in Vitro and in Vivo During Late Adolescence
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014  |   Pubmed ID: 24706880
• Oxidative Stress and Schizophrenia: Recent Breakthroughs from an Old Story
  Current Opinion in Psychiatry. May, 2014  |   Pubmed ID: 24613987
• Regional Brain Distribution of Translocator Protein Using [(11)C]DPA-713 PET in Individuals Infected with HIV
  Journal of Neurovirology. Jun, 2014  |   Pubmed ID: 24567030
• Promoting Careers in Academic Research to Psychiatry Residents
  Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry. Apr, 2014  |   Pubmed ID: 24497181
• Modeling Heterogeneous Patients with a Clinical Diagnosis of Schizophrenia with Induced Pluripotent Stem Cells
  Biological Psychiatry. Jun, 2014  |   Pubmed ID: 24331955
• Hippocampal Volume Reduction Correlates with Apathy in Traumatic Brain Injury, but Not Schizophrenia
  The Journal of Neuropsychiatry and Clinical Neurosciences. 2013  |   Pubmed ID: 24247856
• Olfactory Cells Via Nasal Biopsy Reflect the Developing Brain in Gene Expression Profiles: Utility and Limitation of the Surrogate Tissues in Research for Brain Disorders
  Neuroscience Research. Dec, 2013  |   Pubmed ID: 24120685
• Deficits in MicroRNA-mediated Cxcr4/Cxcl12 Signaling in Neurodevelopmental Deficits in a 22q11 Deletion Syndrome Mouse Model
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013  |   Pubmed ID: 24101523
• Reduced Anterior Cingulate Gray Matter Volume and Thickness in Subjects with Deficit Schizophrenia
  Schizophrenia Research. Nov, 2013  |   Pubmed ID: 24035178
• Regulation of N-Methyl-D-Aspartate Receptors by Disrupted-in-Schizophrenia-1
  Biological Psychiatry. Jul, 2013  |   Pubmed ID: 23906531
• Relationships Between Serum Leptin Level and Severity of Positive Symptoms in Schizophrenia
  Neuroscience Research. Sep-Oct, 2013  |   Pubmed ID: 23896201
• Cuprizone Short-term Exposure: Astrocytic IL-6 Activation and Behavioral Changes Relevant to Psychosis
  Neurobiology of Disease. Nov, 2013  |   Pubmed ID: 23867234
• Cognitive and Motivational Deficits Together with Prefrontal Oxidative Stress in a Mouse Model for Neuropsychiatric Illness
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013  |   Pubmed ID: 23840059
• Mouse Models of Gene-environment Interactions in Schizophrenia
  Neurobiology of Disease. Sep, 2013  |   Pubmed ID: 23748077
• MicroRNA-382 Expression is Elevated in the Olfactory Neuroepithelium of Schizophrenia Patients
  Neurobiology of Disease. Jul, 2013  |   Pubmed ID: 23542694
• Astroglial IFITM3 Mediates Neuronal Impairments Following Neonatal Immune Challenge in Mice
  Glia. May, 2013  |   Pubmed ID: 23382131
• Schizophrenia Research in 2013: Are We Making Progress?
  Neurobiology of Disease. May, 2013  |   Pubmed ID: 23380149
• Synapse-specific Contributions in the Cortical Pathology of Schizophrenia
  Neurobiology of Disease. May, 2013  |   Pubmed ID: 23336981
• Adolescent Stress-induced Epigenetic Control of Dopaminergic Neurons Via Glucocorticoids
  Science (New York, N.Y.). Jan, 2013  |   Pubmed ID: 23329051
• Subcortical Dopaminergic Deficits in a DISC1 Mutant Model: a Study in Direct Reference to Human Molecular Brain Imaging
  Human Molecular Genetics. Apr, 2013  |   Pubmed ID: 23314019
• DISC1: a Key Lead in Studying Cortical Development and Associated Brain Disorders
  The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Oct, 2013  |   Pubmed ID: 23300216
• DISC1 As a Therapeutic Target for Mental Illnesses
  Expert Opinion on Therapeutic Targets. Dec, 2012  |   Pubmed ID: 23130881
• Diabetes is Associated with Lower Global Cognitive Function in Schizophrenia
  Schizophrenia Research. Dec, 2012  |   Pubmed ID: 23031192
• PKA and PDE4D3 Anchoring to AKAP9 Provides Distinct Regulation of CAMP Signals at the Centrosome
  The Journal of Cell Biology. Aug, 2012  |   Pubmed ID: 22908311
• Pharmacokinetics of Oral D-serine in D-amino Acid Oxidase Knockout Mice
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Nov, 2012  |   Pubmed ID: 22837388
• 蛋白质组学、 基因组和平移的办法确定 CRMP1 精神分裂症和及其基本特征的作用。
  Human Molecular Genetics. Aug, 2012  |   Pubmed ID: 22798627
• KCTD13 is a Major Driver of Mirrored Neuroanatomical Phenotypes of the 16p11.2 Copy Number Variant
  Nature. May, 2012  |   Pubmed ID: 22596160
• DNA 甲基化非神经细胞和 DNMT1 潜在参与 Fkbp5 表观遗传调控糖皮质激素所致的损失。
  Biochemical and Biophysical Research Communications. Apr, 2012  |   Pubmed ID: 22445894
• Better Understanding of Mechanisms of Schizophrenia and Bipolar Disorder: from Human Gene Expression Profiles to Mouse Models
  Neurobiology of Disease. Jan, 2012  |   Pubmed ID: 21914480
• Protein S-nitrosylation: Role for Nitric Oxide Signaling in Neuronal Death
  Biochimica Et Biophysica Acta. Jun, 2012  |   Pubmed ID: 21803124
• Mouse Strain Differences in Phencyclidine-induced Behavioural Changes
  The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). Jul, 2012  |   Pubmed ID: 21733237
• In Utero Electroporation As a Tool for Genetic Manipulation in Vivo to Study Psychiatric Disorders: from Genes to Circuits and Behaviors
  The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Apr, 2012  |   Pubmed ID: 21551077
• Anti-/Propsychotic Drug Signaling Via Heteromeric GPCRs--a Balancing Act?
  Cell. Nov, 2011  |   Pubmed ID: 22118451
• Linking Neurodevelopmental and Synaptic Theories of Mental Illness Through DISC1
  Nature Reviews. Neuroscience. Dec, 2011  |   Pubmed ID: 22095064
• Following the Genes: a Framework for Animal Modeling of Psychiatric Disorders
  BMC Biology. 2011  |   Pubmed ID: 22078115
• 推进精神分裂症药物的发现。
  Annals of the New York Academy of Sciences. Oct, 2011  |   Pubmed ID: 22032400
• DISC1 at 10: Connecting Psychiatric Genetics and Neuroscience
  Trends in Molecular Medicine. Dec, 2011  |   Pubmed ID: 22015021
• 人类鼻腔嗅粘膜作为治疗中枢神经系统发育的动态标记。
  Experimental Neurology. Dec, 2011  |   Pubmed ID: 21945230
• The Insula-claustrum Region and Delusions in Schizophrenia
  Schizophrenia Research. Dec, 2011  |   Pubmed ID: 21875780
• Effects of Antipsychotics on the Behavioral Deficits in Human Dominant-negative DISC1 Transgenic Mice with Neonatal PolyI:C Treatment
  Behavioural Brain Research. Nov, 2011  |   Pubmed ID: 21835207
• Altered MHC Class I Expression in Dorsolateral Prefrontal Cortex of Nonsmoker Patients with Schizophrenia
  Neuroscience Research. Nov, 2011  |   Pubmed ID: 21801761
• DISC1 Regulates Synaptic Vesicle Transport Via a Lithium-sensitive Pathway
  Neuroscience Research. Sep, 2011  |   Pubmed ID: 21664390
• Readdressing Synaptic Pruning Theory for Schizophrenia: Combination of Brain Imaging and Cell Biology
  Communicative & Integrative Biology. Mar, 2011  |   Pubmed ID: 21655443
• 肌醇 Hexakisphosphate 激酶诱导细胞死亡在亨廷顿病。
  The Journal of Biological Chemistry. Jul, 2011  |   Pubmed ID: 21652713
• Glutathione is a Physiologic Reservoir of Neuronal Glutamate
  Biochemical and Biophysical Research Communications. Jun, 2011  |   Pubmed ID: 21539809
• Working Memory Deficits in Neuronal Nitric Oxide Synthase Knockout Mice: Potential Impairments in Prefrontal Cortex Mediated Cognitive Function
  Biochemical and Biophysical Research Communications. May, 2011  |   Pubmed ID: 21539806
• DISC1-dependent Switch from Progenitor Proliferation to Migration in the Developing Cortex
  Nature. May, 2011  |   Pubmed ID: 21471969
• Impaired NMDA Receptor Transmission Alters Striatal Synapses and DISC1 Protein in an Age-dependent Manner
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2011  |   Pubmed ID: 21436042
• A Novel Balanced Chromosomal Translocation Found in Subjects with Schizophrenia and Schizotypal Personality Disorder: Altered L-serine Level Associated with Disruption of PSAT1 Gene Expression
  Neuroscience Research. Feb, 2011  |   Pubmed ID: 20955740
• Nitric Oxide Signaling and Nitrosative Stress in Neurons: Role for S-nitrosylation
  Antioxidants & Redox Signaling. Apr, 2011  |   Pubmed ID: 20812870
• The Diverse Functions of GAPDH: Views from Different Subcellular Compartments
  Cellular Signalling. Feb, 2011  |   Pubmed ID: 20727968
• 产前相互作用的 DISC1 突变和免疫激活产生成人精神病理学。
  Biological Psychiatry. Dec, 2010  |   Pubmed ID: 21130225
• 中断-中-精神分裂症 1 与淀粉样前体蛋白的生化和功能相互作用调节神经元迁移哺乳动物大脑皮层发育过程。
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2010  |   Pubmed ID: 20685985
• Assessing the Role of Endooligopeptidase Activity of Ndel1 (nuclear-distribution Gene E Homolog Like-1) in Neurite Outgrowth
  Molecular and Cellular Neurosciences. Aug, 2010  |   Pubmed ID: 20462516
• Gray-matter Abnormalities in Deficit Schizophrenia
  Schizophrenia Research. Jul, 2010  |   Pubmed ID: 20452187
• Disturbed Synaptic Connectivity in Schizophrenia: Convergence of Genetic Risk Factors During Neurodevelopment
  Brain Research Bulletin. Sep, 2010  |   Pubmed ID: 20433911
• 中断-中-精神分裂症-1 的表达被受网站测试版淀粉样前体蛋白裂解酶-1-质控梯级。
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010  |   Pubmed ID: 20212127
• Knockdown of DISC1 by in Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits
  Neuron. Feb, 2010  |   Pubmed ID: 20188653
• Neuroanatomic and Cognitive Abnormalities Related to Herpes Simplex Virus Type 1 in Schizophrenia
  Schizophrenia Research. May, 2010  |   Pubmed ID: 20153952
• 中断-中-精神分裂症 1 (DISC1) 规定了通过 Rac1 的谷氨酸突触的刺。
  Nature Neuroscience. Mar, 2010  |   Pubmed ID: 20139976
• A Novel Role for Glyceraldehyde-3-phosphate Dehydrogenase and Monoamine Oxidase B Cascade in Ethanol-induced Cellular Damage
  Biological Psychiatry. May, 2010  |   Pubmed ID: 20022592
• Review of Pathological Hallmarks of Schizophrenia: Comparison of Genetic Models with Patients and Nongenetic Models
  Schizophrenia Bulletin. Mar, 2010  |   Pubmed ID: 19903746
• Negative Symptoms of Schizophrenia Correlate with Impairment on the University of Pennsylvania Smell Identification Test
  Neuroscience Research. Jan, 2010  |   Pubmed ID: 19819272
• Combined Effect of Neonatal Immune Activation and Mutant DISC1 on Phenotypic Changes in Adulthood
  Behavioural Brain Research. Jan, 2010  |   Pubmed ID: 19716847
• Genetic Animal Models for Schizophrenia: Advantages and Limitations of Genetic Manipulation in Drosophila, Zebrafish, Rodents, and Primates
  Progress in Brain Research. 2009  |   Pubmed ID: 20302812
• Preface. This Volume Focuses on How Genetic Models for Schizophrenia, That Is, Manipulation in Genetic Susceptibility Factors for the Disease, Have Potential in Opening a New Window of Better Understanding of Etiology-relevant Mechanisms
  Progress in Brain Research. 2009  |   Pubmed ID: 19932335
• Glyceraldehyde-3-phosphate Dehydrogenase Aggregate Formation Participates in Oxidative Stress-induced Cell Death
  The Journal of Biological Chemistry. Dec, 2009  |   Pubmed ID: 19837666
• 了解 DISC1 在精神疾病及正常发育过程的作用。
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009  |   Pubmed ID: 19828788
• A Novel Role for HGas7b in Microtubular Maintenance: Possible Implication in Tau-associated Pathology in Alzheimer Disease
  The Journal of Biological Chemistry. Nov, 2009  |   Pubmed ID: 19801671
• Neurodevelopmental Mechanisms of Schizophrenia: Understanding Disturbed Postnatal Brain Maturation Through Neuregulin-1-ErbB4 and DISC1
  Trends in Neurosciences. Sep, 2009  |   Pubmed ID: 19712980
• Cortical Development and Glutamatergic Dysregulation in Schizophrenia
  Biological Psychiatry. Sep, 2009  |   Pubmed ID: 19712774
• Using Bioinformatic Tools
  The American Journal of Psychiatry. Aug, 2009  |   Pubmed ID: 19651749
• GOSPEL: a Neuroprotective Protein That Binds to GAPDH Upon S-nitrosylation
  Neuron. Jul, 2009  |   Pubmed ID: 19607794
• Animal Models of Gene-environment Interactions in Schizophrenia
  Behavioural Brain Research. Dec, 2009  |   Pubmed ID: 19379776
• Schizophrenia and Epilepsy: is There a Shared Susceptibility?
  Neuroscience Research. Apr, 2009  |   Pubmed ID: 19367784
• Peripheral Olfactory System for Clinical and Basic Psychiatry: a Promising Entry Point to the Mystery of Brain Mechanism and Biomarker Identification in Schizophrenia
  The American Journal of Psychiatry. Feb, 2009  |   Pubmed ID: 19188289
• Proteomic and Histochemical Analysis of Proteins Involved in the Dying-back-type of Axonal Degeneration in the Gracile Axonal Dystrophy (gad) Mouse
  Neurochemistry International. May-Jun, 2009  |   Pubmed ID: 19154771
• Recruitment of PCM1 to the Centrosome by the Cooperative Action of DISC1 and BBS4: a Candidate for Psychiatric Illnesses
  Archives of General Psychiatry. Sep, 2008  |   Pubmed ID: 18762586
• Nitric Oxide-induced Nuclear GAPDH Activates P300/CBP and Mediates Apoptosis
  Nature Cell Biology. Jul, 2008  |   Pubmed ID: 18552833
• Elucidating the Relationship Between DISC1, NDEL1 and NDE1 and the Risk for Schizophrenia: Evidence of Epistasis and Competitive Binding
  Human Molecular Genetics. Aug, 2008  |   Pubmed ID: 18469341