Alain Baulard Inserm U1019 - CNRS UMR 8024, Institut Pasteur de Lille Université de Lille Biography Publications Institution JoVE Articles Alain Baulard has not added a biography. If you are Alain Baulard and would like to personalize this page please email our Author Liaison for assistance. Publications Structural and Docking Studies of Potent Ethionamide Boosters Acta Crystallographica. Section C, Crystal Structure Communications. Nov, 2013 | Pubmed ID: 24192167 Mechanism of Competence Activation by the ComRS Signalling System in Streptococci Molecular Microbiology. Mar, 2013 | Pubmed ID: 23323845 Discovery of Novel N-phenylphenoxyacetamide Derivatives As EthR Inhibitors and Ethionamide Boosters by Combining High-throughput Screening and Synthesis Journal of Medicinal Chemistry. Jul, 2012 | Pubmed ID: 22738293 Tuberculosis: the Drug Development Pipeline at a Glance European Journal of Medicinal Chemistry. May, 2012 | Pubmed ID: 22421275 Structural Activation of the Transcriptional Repressor EthR from Mycobacterium Tuberculosis by Single Amino Acid Change Mimicking Natural and Synthetic Ligands Nucleic Acids Research. Apr, 2012 | Pubmed ID: 22156370 Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-oxadiazole EthR Inhibitors Journal of Medicinal Chemistry. Jan, 2012 | Pubmed ID: 22098589 MALDI Imaging Techniques Dedicated to Drug-distribution Studies Bioanalysis. Jun, 2011 | Pubmed ID: 21679033 Ethionamide Boosters: Synthesis, Biological Activity, and Structure-activity Relationships of a Series of 1,2,4-oxadiazole EthR Inhibitors Journal of Medicinal Chemistry. Apr, 2011 | Pubmed ID: 21417236 Exploring Drug Target Flexibility Using in Situ Click Chemistry: Application to a Mycobacterial Transcriptional Regulator ACS Chemical Biology. Nov, 2010 | Pubmed ID: 20704273 Synthetic EthR Inhibitors Boost Antituberculous Activity of Ethionamide Nature Medicine. May, 2009 | Pubmed ID: 19412174 Molecular Mapping of Lipoarabinomannans on Mycobacteria Langmuir : the ACS Journal of Surfaces and Colloids. Apr, 2009 | Pubmed ID: 19278203 Molecular Genetics of Para-aminosalicylic Acid Resistance in Clinical Isolates and Spontaneous Mutants of Mycobacterium Tuberculosis Antimicrobial Agents and Chemotherapy. May, 2009 | Pubmed ID: 19237648 Organization of the Mycobacterial Cell Wall: a Nanoscale View Pflügers Archiv : European Journal of Physiology. Apr, 2008 | Pubmed ID: 18043940 Direct Measurement of Hydrophobic Forces on Cell Surfaces Using AFM Langmuir : the ACS Journal of Surfaces and Colloids. Nov, 2007 | Pubmed ID: 17941657 Antibody Response in Pulmonary Tuberculosis Against Recombinant 27kDa (MPT51, Rv3803c) Protein of Mycobacterium Tuberculosis Scandinavian Journal of Infectious Diseases. 2007 | Pubmed ID: 17852894 Chemical Force Microscopy of Single Live Cells Nano Letters. Oct, 2007 | Pubmed ID: 17850167 Ethambutol-induced Alterations in Mycobacterium Bovis BCG Imaged by Atomic Force Microscopy FEMS Microbiology Letters. Nov, 2006 | Pubmed ID: 17064372 Selective Intracellular Accumulation of the Major Metabolite Issued from the Activation of the Prodrug Ethionamide in Mycobacteria The Journal of Antimicrobial Chemotherapy. Oct, 2006 | Pubmed ID: 16895935 Insights into Mechanisms of Induction and Ligands Recognition in the Transcriptional Repressor EthR from Mycobacterium Tuberculosis Tuberculosis (Edinburgh, Scotland). Mar, 2006 | Pubmed ID: 16243584 Monitoring of the Ethionamide Pro-drug Activation in Mycobacteria by (1)H High Resolution Magic Angle Spinning NMR Biochemical and Biophysical Research Communications. Jun, 2005 | Pubmed ID: 15850780 [Doping in the Peloton of Antituberculosis Drugs] Médecine Sciences : M/S. Apr, 2005 | Pubmed ID: 15811295 Structure of EthR in a Ligand Bound Conformation Reveals Therapeutic Perspectives Against Tuberculosis Molecular Cell. Oct, 2004 | Pubmed ID: 15494316 Cloning, Expression, and Purification of the 27 KDa (MPT51, Rv3803c) Protein of Mycobacterium Tuberculosis Protein Expression and Purification. Jul, 2004 | Pubmed ID: 15177284 Identification of a Novel Class of Omega,E,E-farnesyl Diphosphate Synthase from Mycobacterium Tuberculosis Journal of Lipid Research. Jun, 2004 | Pubmed ID: 15060088 EthR, a Repressor of the TetR/CamR Family Implicated in Ethionamide Resistance in Mycobacteria, Octamerizes Cooperatively on Its Operator Molecular Microbiology. Jan, 2004 | Pubmed ID: 14651620 Unique Mechanism of Action of the Thiourea Drug Isoxyl on Mycobacterium Tuberculosis The Journal of Biological Chemistry. Dec, 2003 | Pubmed ID: 14559907 Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12654922 In Vivo Interaction Between the Polyprenol Phosphate Mannose Synthase Ppm1 and the Integral Membrane Protein Ppm2 from Mycobacterium Smegmatis Revealed by a Bacterial Two-hybrid System The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12427759 Characterization of a Putative Alpha-mannosyltransferase Involved in Phosphatidylinositol Trimannoside Biosynthesis in Mycobacterium Tuberculosis The Biochemical Journal. May, 2002 | Pubmed ID: 11964144 Ppm1, a Novel Polyprenol Monophosphomannose Synthase from Mycobacterium Tuberculosis The Biochemical Journal. Jul, 2002 | Pubmed ID: 11931640 A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening Christophe. J Queval*1, Ok-Ryul Song*1, Vincent Delorme*1, Raffaella Iantomasi1, Romain Veyron-Churlet1, Nathalie Deboosère1, Valérie Landry1, Alain Baulard1, Priscille Brodin1 1Inserm U1019 - CNRS UMR 8024, Institut Pasteur de Lille, Université de Lille JoVE 51114 Immunology and Infection
A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening Christophe. J Queval*1, Ok-Ryul Song*1, Vincent Delorme*1, Raffaella Iantomasi1, Romain Veyron-Churlet1, Nathalie Deboosère1, Valérie Landry1, Alain Baulard1, Priscille Brodin1 1Inserm U1019 - CNRS UMR 8024, Institut Pasteur de Lille, Université de Lille JoVE 51114 Immunology and Infection
