Alan N. Schechter Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Biography Publications Institution JoVE Articles Alan N. Schechter has not added a biography. If you are Alan N. Schechter and would like to personalize this page please email our Author Liaison for assistance. Publications Control of Rat Muscle Nitrate Levels After Perturbation of Steady State Dietary Nitrate Intake Nitric Oxide : Biology and Chemistry. 05, 2021 | Pubmed ID: 33713800 Potential Roles of Nitrate and Nitrite in Nitric Oxide Metabolism in the Eye Scientific Reports. 08, 2020 | Pubmed ID: 32759980 Nitrate Uptake and Metabolism in Human Skeletal Muscle Cell Cultures Nitric Oxide : Biology and Chemistry. 01, 2020 | Pubmed ID: 31604144 Human Skeletal Muscle Nitrate Store: Influence of Dietary Nitrate Supplementation and Exercise The Journal of Physiology. 12, 2019 | Pubmed ID: 31350908 Inhaled Nebulized Nitrite and Nitrate Therapy in a Canine Model of Hypoxia-induced Pulmonary Hypertension Nitric Oxide : Biology and Chemistry. 10, 2019 | Pubmed ID: 31299340 Compensatory Mechanisms in Myoglobin Deficient Mice Preserve NO Homeostasis Nitric Oxide : Biology and Chemistry. 09, 2019 | Pubmed ID: 31173908 Airlie House Legend American Journal of Hematology. 12, 2018 | Pubmed ID: 30242871 Decreased Nitrite Reductase Activity of Deoxyhemoglobin Correlates with Platelet Activation in Hemoglobin E/ß-thalassemia Subjects PloS One. 2018 | Pubmed ID: 30235277 Phosphorylated Vasodilator-stimulated Phosphoprotein (P-VASPSer239) in Platelets is Increased by Nitrite and Partially Deoxygenated Erythrocytes PloS One. 2018 | Pubmed ID: 29505609 Effect of Dietary Nitrate Levels on Nitrate Fluxes in Rat Skeletal Muscle and Liver Nitric Oxide : Biology and Chemistry. 05, 2018 | Pubmed ID: 29378248 Central Sensitization Associated with Low Fetal Hemoglobin Levels in Adults with Sickle Cell Anemia Scandinavian Journal of Pain. 10, 2017 | Pubmed ID: 28969994 Skeletal and Myocardial Microvascular Blood Flow in Hydroxycarbamide-treated Patients with Sickle Cell Disease British Journal of Haematology. 11, 2017 | Pubmed ID: 28880374 Acid Test for Nitrite Pharmacology Hypertension (Dallas, Tex. : 1979). Jan, 2017 | Pubmed ID: 27802420 Angiogenic Factors Are Increased in Circulating Granulocytes and CD34(+) Cells of Myeloproliferative Neoplasms Molecular Carcinogenesis. Jun, 2016 | Pubmed ID: 27341002 Tempol Improves Xanthine Oxidoreductase-mediated Vascular Responses to Nitrite in Experimental Renovascular Hypertension Redox Biology. Aug, 2016 | Pubmed ID: 27078869 Nitrate As a Source of Nitrite and Nitric Oxide During Exercise Hyperemia in Rat Skeletal Muscle Nitric Oxide : Biology and Chemistry. May, 2016 | Pubmed ID: 27000467 Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the MTOR Signaling Pathway PloS One. 2015 | Pubmed ID: 26275051 Construction of Effective Disposable Biosensors for Point of Care Testing of Nitrite Talanta. Sep, 2015 | Pubmed ID: 26003719 Nitrate Reduction to Nitrite, Nitric Oxide and Ammonia by Gut Bacteria Under Physiological Conditions PloS One. 2015 | Pubmed ID: 25803049 A Flow Cytometric Analysis of the Inhibition of Platelet Reactivity Due to Nitrite Reduction by Deoxygenated Erythrocytes PloS One. 2014 | Pubmed ID: 24642865 Increased Reticulocytosis During Infancy is Associated with Increased Hospitalizations in Sickle Cell Anemia Patients During the First Three Years of Life PloS One. 2013 | Pubmed ID: 23951011 In Vivo Reduction of Cell-free Methemoglobin to Oxyhemoglobin Results in Vasoconstriction in Canines Transfusion. Dec, 2013 | Pubmed ID: 23488474 Globin Gene Expression in Correlation with G Protein-related Genes During Erythroid Differentiation BMC Genomics. Feb, 2013 | Pubmed ID: 23425329 Effect of Blood Nitrite and Nitrate Levels on Murine Platelet Function PloS One. 2013 | Pubmed ID: 23383344 Comments on 'vascular Effects of Dietary Nitrate (as Found in Green Leafy Vegetables and Beetroot) Via the Nitrate-nitrite-nitric Oxide Pathway' British Journal of Clinical Pharmacology. Jun, 2013 | Pubmed ID: 23163510 Effect of Storage on Levels of Nitric Oxide Metabolites in Platelet Preparations Transfusion. Mar, 2013 | Pubmed ID: 22804724 Effect of Storage Levels of Nitric Oxide Derivatives in Blood Components F1000Research. 2012 | Pubmed ID: 24358838 Angeli's Salt Counteracts the Vasoactive Effects of Elevated Plasma Hemoglobin Free Radical Biology & Medicine. Dec, 2012 | Pubmed ID: 23099417 JAK-STAT and AKT Pathway-coupled Genes in Erythroid Progenitor Cells Through Ontogeny Journal of Translational Medicine. Jun, 2012 | Pubmed ID: 22676255 Inorganic Nitrate: a Major Player in the Cardiovascular Health Benefits of Vegetables? Nutrition Reviews. Jun, 2012 | Pubmed ID: 22646129 Platelet Inhibition by Nitrite is Dependent on Erythrocytes and Deoxygenation PloS One. 2012 | Pubmed ID: 22276188 Dietary Nitrite and Nitrate: a Review of Potential Mechanisms of Cardiovascular Benefits European Journal of Nutrition. Aug, 2011 | Pubmed ID: 21626413 Acute Erythropoietin Cardioprotection is Mediated by Endothelial Response Basic Research in Cardiology. May, 2011 | Pubmed ID: 21347618 Erythropoietin and Hypoxia Increase Erythropoietin Receptor and Nitric Oxide Levels in Lung Microvascular Endothelial Cells Cytokine. May, 2011 | Pubmed ID: 21324713 Measurement of Nitrite in Blood Samples Using the Ferricyanide-based Hemoglobin Oxidation Assay Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21161628 Translational Medicine--doing It Backwards Journal of Translational Medicine. Feb, 2010 | Pubmed ID: 20132543 Stimulated Stromal Cells Induce Gamma-globin Gene Expression in Erythroid Cells Via Nitric Oxide Production Experimental Hematology. Oct, 2009 | Pubmed ID: 19576950 Evidence-based Medicine Again Perspectives in Biology and Medicine. 2009 | Pubmed ID: 19395816 The Reaction of Cell-free Oxyhemoglobin with Nitrite Under Physiologically Relevant Conditions: Implications for Nitrite-based Therapies Nitric Oxide : Biology and Chemistry. Mar, 2009 | Pubmed ID: 19010434 Hemoglobin Research and the Origins of Molecular Medicine Blood. Nov, 2008 | Pubmed ID: 18988877 Oxidation of Iron-nitrosyl-hemoglobin by Dehydroascorbic Acid Releases Nitric Oxide to Form Nitrite in Human Erythrocytes Biochemistry. Mar, 2008 | Pubmed ID: 18225862 The Reaction Between Nitrite and Oxyhemoglobin: a Mechanistic Study The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18203719 Hydroxyurea Nitrosylates and Activates Soluble Guanylyl Cyclase in Human Erythroid Cells Blood. Feb, 2008 | Pubmed ID: 17993617 Nitric Oxide from Nitrite Reduction by Hemoglobin in the Plasma and Erythrocytes Nitric Oxide : Biology and Chemistry. Feb, 2008 | Pubmed ID: 17964300 Nitrite Infusion in Humans and Nonhuman Primates: Endocrine Effects, Pharmacokinetics, and Tolerance Formation Circulation. Oct, 2007 | Pubmed ID: 17893272 Randomization in Clinical Trials of Titrated Therapies: Unintended Consequences of Using Fixed Treatment Protocols Critical Care Medicine. Jun, 2007 | Pubmed ID: 17440420 Hemolysis in Sickle Cell Mice Causes Pulmonary Hypertension Due to Global Impairment in Nitric Oxide Bioavailability Blood. Apr, 2007 | Pubmed ID: 17158223 The Measurement of Blood and Plasma Nitrite by Chemiluminescence: Pitfalls and Solutions Free Radical Biology & Medicine. Aug, 2006 | Pubmed ID: 16863986 Fetal Hemoglobin Silencing in Humans Blood. Sep, 2006 | Pubmed ID: 16735596 Hypoxia, Red Blood Cells, and Nitrite Regulate NO-dependent Hypoxic Vasodilation Blood. Jan, 2006 | Pubmed ID: 16195332 The Emerging Biology of the Nitrite Anion Nature Chemical Biology. Nov, 2005 | Pubmed ID: 16408064 Erythrocytes Are the Major Intravascular Storage Sites of Nitrite in Human Blood Blood. Jul, 2005 | Pubmed ID: 15774613 Why is Revitalizing Clinical Research So Important, Yet So Difficult? Perspectives in Biology and Medicine. 2004 | Pubmed ID: 15467172 Inhaled Nebulized Nitrite is a Hypoxia-sensitive NO-dependent Selective Pulmonary Vasodilator Nature Medicine. Oct, 2004 | Pubmed ID: 15361865 Linderstrom-Lang-Schellman's Model for Protein Stabilization Revisited Current Protein & Peptide Science. Aug, 2004 | Pubmed ID: 15320734 Increasing Hemoglobin Oxygen Saturation Levels in Sickle Trait Donor Whole Blood Prevents Hemoglobin S Polymerization and Allows Effective White Blood Cell Reduction by Filtration Transfusion. Sep, 2004 | Pubmed ID: 15318851 Erythropoietin and Hypoxia Stimulate Erythropoietin Receptor and Nitric Oxide Production by Endothelial Cells Blood. Oct, 2004 | Pubmed ID: 15205261 Pulmonary Hypertension As a Risk Factor for Death in Patients with Sickle Cell Disease The New England Journal of Medicine. Feb, 2004 | Pubmed ID: 14985486 Nitrite Reduction to Nitric Oxide by Deoxyhemoglobin Vasodilates the Human Circulation Nature Medicine. Dec, 2003 | Pubmed ID: 14595407 Identification and Characterization of Mechanistically Distinct Inducers of Gamma-globin Transcription Biochemical Pharmacology. Nov, 2003 | Pubmed ID: 14563486 Nitric Oxide's Reactions with Hemoglobin: a View Through the SNO-storm Nature Medicine. May, 2003 | Pubmed ID: 12724752 Hemoglobin and the Paracrine and Endocrine Functions of Nitric Oxide The New England Journal of Medicine. Apr, 2003 | Pubmed ID: 12686706 Red Blood Cell Magnetophoresis Biophysical Journal. Apr, 2003 | Pubmed ID: 12668472 Divergent Nitric Oxide Bioavailability in Men and Women with Sickle Cell Disease Circulation. Jan, 2003 | Pubmed ID: 12538427 Hydroxyurea Induces Fetal Hemoglobin by the Nitric Oxide-dependent Activation of Soluble Guanylyl Cyclase The Journal of Clinical Investigation. Jan, 2003 | Pubmed ID: 12531879 Cell-free Hemoglobin Limits Nitric Oxide Bioavailability in Sickle-cell Disease Nature Medicine. Dec, 2002 | Pubmed ID: 12426562 Sickle Hb Polymerization in RBC Components from Donors with Sickle Cell Trait Prevents Effective WBC Reduction by Filtration Transfusion. Nov, 2002 | Pubmed ID: 12421220 S-Nitrosohemoglobin is Unstable in the Reductive Erythrocyte Environment and Lacks O2/NO-linked Allosteric Function The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12023289 Prematurity in Gene Therapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2002 | Pubmed ID: 11863409 Quantitative Analysis of Globin Gene Induction in Single Human Erythroleukemic Cells Nucleic Acids Research. Dec, 2000 | Pubmed ID: 11121491 Role of Circulating Nitrite and S-nitrosohemoglobin in the Regulation of Regional Blood Flow in Humans Proceedings of the National Academy of Sciences of the United States of America. Oct, 2000 | Pubmed ID: 11027349 Relative Role of Heme Nitrosylation and Beta-cysteine 93 Nitrosation in the Transport and Metabolism of Nitric Oxide by Hemoglobin in the Human Circulation Proceedings of the National Academy of Sciences of the United States of America. Aug, 2000 | Pubmed ID: 10954746 Inhaled Nitric Oxide Augments Nitric Oxide Transport on Sickle Cell Hemoglobin Without Affecting Oxygen Affinity The Journal of Clinical Investigation. Oct, 1999 | Pubmed ID: 10510334 The Active Site of Staphylococcal Nuclease: Paramagnetic Relaxation of Bound Nucleotide Inhibitor Nuclei by Lanthanide Ions Proceedings of the National Academy of Sciences of the United States of America. Jul, 1974 | Pubmed ID: 4528015 An Immunologic Approach to the Conformational Equilibria of Polypeptides Proceedings of the National Academy of Sciences of the United States of America. Dec, 1972 | Pubmed ID: 4118873 Folding of Staphylococcal Nuclease: Magnetic Resonance and Fluorescence Studies of Individual Residues Proceedings of the National Academy of Sciences of the United States of America. Sep, 1971 | Pubmed ID: 4332245 Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements Ji Won Park*1, Samantha M. Thomas*1, Lee J. Wylie2, Andrew M. Jones2, Anni Vanhatalo2, Alan N. Schechter1, Barbora Piknova1 1Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 2Sport and Health Sciences, College of Life and Environmental Sciences, St Luke’s Campus, University of Exeter JoVE 62427 Biology Platelet-based Detection of Nitric Oxide in Blood by Measuring VASP Phosphorylation Sirada Srihirun1,2, Alan N. Schechter2, Barbora Piknova2 1Department of Pharmacology, Faculty of Dentistry, Mahidol University, 2Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health JoVE 58647 Medicine Measuring Nitrite and Nitrate, Metabolites in the Nitric Oxide Pathway, in Biological Materials using the Chemiluminescence Method Barbora Piknova1, Ji Won Park1, Katelyn S. Cassel1, Cameron N. Gilliard1, Alan N. Schechter1 1Molecular Medicine Branch, NIDDK, NIH JoVE 54879 Biology
Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements Ji Won Park*1, Samantha M. Thomas*1, Lee J. Wylie2, Andrew M. Jones2, Anni Vanhatalo2, Alan N. Schechter1, Barbora Piknova1 1Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 2Sport and Health Sciences, College of Life and Environmental Sciences, St Luke’s Campus, University of Exeter JoVE 62427 Biology
Platelet-based Detection of Nitric Oxide in Blood by Measuring VASP Phosphorylation Sirada Srihirun1,2, Alan N. Schechter2, Barbora Piknova2 1Department of Pharmacology, Faculty of Dentistry, Mahidol University, 2Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health JoVE 58647 Medicine
Measuring Nitrite and Nitrate, Metabolites in the Nitric Oxide Pathway, in Biological Materials using the Chemiluminescence Method Barbora Piknova1, Ji Won Park1, Katelyn S. Cassel1, Cameron N. Gilliard1, Alan N. Schechter1 1Molecular Medicine Branch, NIDDK, NIH JoVE 54879 Biology
