Albert Jeltsch Institute of Biochemistry Stuttgart University Biography Publications Institution JoVE Articles Albert Jeltsch has not added a biography. If you are Albert Jeltsch and would like to personalize this page please email our Author Liaison for assistance. Publications Application of Histone Modification-specific Interaction Domains As an Alternative to Antibodies Genome Research. Nov, 2014 | Pubmed ID: 25301795 Cooperative DNA Binding and Protein/DNA Fiber Formation Increases the Activity of the Dnmt3a DNA Methyltransferase The Journal of Biological Chemistry. Oct, 2014 | Pubmed ID: 25147181 Role of Somatic Cancer Mutations in Human Protein Lysine Methyltransferases Biochimica Et Biophysica Acta. Aug, 2014 | Pubmed ID: 25123655 Regulation of DNA Methylation Patterns by CK2-mediated Phosphorylation of Dnmt3a Cell Reports. Aug, 2014 | Pubmed ID: 25066127 New Concepts in DNA Methylation Trends in Biochemical Sciences. Jul, 2014 | Pubmed ID: 24947342 Label-free Measurement of Histone Lysine Methyltransferases Activity by Matrix-assisted Laser Desorption/ionization Time-of-flight Mass Spectrometry Analytical Biochemistry. Jul, 2014 | Pubmed ID: 24747023 The Dnmt2 RNA Methyltransferase Homolog of Geobacter Sulfurreducens Specifically Methylates TRNA-Glu Nucleic Acids Research. 2014 | Pubmed ID: 24711368 Design, Synthesis and Biological Evaluation of 4-amino-N- (4-aminophenyl)benzamide Analogues of Quinoline-based SGI-1027 As Inhibitors of DNA Methylation ChemMedChem. Mar, 2014 | Pubmed ID: 24678024 Targeted Mutagenesis Results in an Activation of DNA Methyltransferase 1 and Confirms an Autoinhibitory Role of Its RFTS Domain Chembiochem : a European Journal of Chemical Biology. Mar, 2014 | Pubmed ID: 24532244 Targeted Methylation of the Epithelial Cell Adhesion Molecule (EpCAM) Promoter to Silence Its Expression in Ovarian Cancer Cells PloS One. 2014 | Pubmed ID: 24489952 Substrate Specificity Analysis and Novel Substrates of the Protein Lysine Methyltransferase NSD1 Chemistry & Biology. Feb, 2014 | Pubmed ID: 24412544 The UHRF1 Protein Stimulates the Activity and Specificity of the Maintenance DNA Methyltransferase DNMT1 by an Allosteric Mechanism The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24368767 Synthesis and Evaluation of Analogues of N-phthaloyl-l-tryptophan (RG108) As Inhibitors of DNA Methyltransferase 1 Journal of Medicinal Chemistry. Jan, 2014 | Pubmed ID: 24328113 The Tudor Domain of the PHD Finger Protein 1 is a Dual Reader of Lysine Trimethylation at Lysine 36 of Histone H3 and Lysine 27 of Histone Variant H3t Journal of Molecular Biology. Apr, 2014 | Pubmed ID: 23954330 Non-radioactive Protein Lysine Methyltransferase Microplate Assay Based on Reading Domains ChemMedChem. Mar, 2014 | Pubmed ID: 23671032 Genomic Imprinting--the Struggle of the Genders at the Molecular Level Angewandte Chemie (International Ed. in English). Dec, 2013 | Pubmed ID: 24346936 Target Recognition, RNA Methylation Activity and Transcriptional Regulation of the Dictyostelium Discoideum Dnmt2-homologue (DnmA) Nucleic Acids Research. Oct, 2013 | Pubmed ID: 23877245 Multimerization of the Dnmt3a DNA Methyltransferase and Its Functional Implications Progress in Molecular Biology and Translational Science. 2013 | Pubmed ID: 23663978 Oxygen, Epigenetic Signaling, and the Evolution of Early Life Trends in Biochemical Sciences. Apr, 2013 | Pubmed ID: 23454078 Identification of Novel Inhibitors of DNA Methylation by Screening of a Chemical Library ACS Chemical Biology. Mar, 2013 | Pubmed ID: 23294304 Targeted Methylation and Gene Silencing of VEGF-A in Human Cells by Using a Designed Dnmt3a-Dnmt3L Single-chain Fusion Protein with Increased DNA Methylation Activity Journal of Molecular Biology. Feb, 2013 | Pubmed ID: 23220192 Pmt1, a Dnmt2 Homolog in Schizosaccharomyces Pombe, Mediates TRNA Methylation in Response to Nutrient Signaling Nucleic Acids Research. Dec, 2012 | Pubmed ID: 23074192 DNA Methyltransferase Inhibitors in Cancer: a Chemical and Therapeutic Patent Overview and Selected Clinical Studies Expert Opinion on Therapeutic Patents. Dec, 2012 | Pubmed ID: 23033952 Identification of ICAD-derived Peptides Capable of Inhibiting Caspase-activated DNase The FEBS Journal. Aug, 2012 | Pubmed ID: 22727028 Mechanistic Details of the DNA Recognition by the Dnmt1 DNA Methyltransferase FEBS Letters. Jun, 2012 | Pubmed ID: 22641038 DNA Interaction of the CcrM DNA Methyltransferase: a Mutational and Modeling Study Chembiochem : a European Journal of Chemical Biology. Jun, 2012 | Pubmed ID: 22639453 Specificity of Dnmt1 for Methylation of Hemimethylated CpG Sites Resides in Its Catalytic Domain Chemistry & Biology. May, 2012 | Pubmed ID: 22633409 Mapping the TRNA Binding Site on the Surface of Human DNMT2 Methyltransferase Biochemistry. Jun, 2012 | Pubmed ID: 22591353 The SET8 H4K20 Protein Lysine Methyltransferase Has a Long Recognition Sequence Covering Seven Amino Acid Residues Biochimie. Nov, 2012 | Pubmed ID: 22583696 A Fluorescence-based Supramolecular Tandem Assay for Monitoring Lysine Methyltransferase Activity in Homogeneous Solution Chemistry (Weinheim an Der Bergstrasse, Germany). Mar, 2012 | Pubmed ID: 22367964 Rapid Synthesis of New DNMT Inhibitors Derivatives of Procainamide Chembiochem : a European Journal of Chemical Biology. Jan, 2012 | Pubmed ID: 22170584 Using the Fluorescence Decay of 2-aminopurine to Investigate Conformational Change in the Recognition Sequence of the EcoRV DNA-(adenine-N6)-methyltransferase on Enzyme Binding Biophysical Chemistry. Jan, 2012 | Pubmed ID: 21962489 Function and Disruption of DNA Methyltransferase 3a Cooperative DNA Binding and Nucleoprotein Filament Formation Nucleic Acids Research. Jan, 2012 | Pubmed ID: 21926161 The Caulobacter Crescentus DNA-(adenine-N6)-methyltransferase CcrM Methylates DNA in a Distributive Manner Nucleic Acids Research. Feb, 2012 | Pubmed ID: 21926159 On the Evolutionary Origin of Eukaryotic DNA Methyltransferases and Dnmt2 PloS One. 2011 | Pubmed ID: 22140515 Epigenetics Europe Conference. Munich, Germany, 8-9 September 2011 Epigenomics. Dec, 2011 | Pubmed ID: 22126289 Burning off DNA Methylation: New Evidence for Oxygen-dependent DNA Demethylation Chembiochem : a European Journal of Chemical Biology. Nov, 2011 | Pubmed ID: 21998074 DNA Methyltransferase Assays Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21913079 Application of Celluspots Peptide Arrays for the Analysis of the Binding Specificity of Epigenetic Reading Domains to Modified Histone Tails BMC Biochemistry. 2011 | Pubmed ID: 21884582 C5-DNA Methyltransferase Inhibitors: from Screening to Effects on Zebrafish Embryo Development Chembiochem : a European Journal of Chemical Biology. Jun, 2011 | Pubmed ID: 21633996 Histone Tails Regulate DNA Methylation by Allosterically Activating De Novo Methyltransferase Cell Research. Aug, 2011 | Pubmed ID: 21606950 Oligomerization and Binding of the Dnmt3a DNA Methyltransferase to Parallel DNA Molecules: Heterochromatic Localization and Role of Dnmt3L The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21566127 The Inhibition of the Mammalian DNA Methyltransferase 3a (Dnmt3a) by Dietary Black Tea and Coffee Polyphenols BMC Biochemistry. 2011 | Pubmed ID: 21510884 Auto-methylation of the Mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at Its Active Site Cysteine Residue The FEBS Journal. Jun, 2011 | Pubmed ID: 21481189 The ATRX-ADD Domain Binds to H3 Tail Peptides and Reads the Combined Methylation State of K4 and K9 Human Molecular Genetics. Jun, 2011 | Pubmed ID: 21421568 Approaches to Enzyme and Substrate Design of the Murine Dnmt3a DNA Methyltransferase Chembiochem : a European Journal of Chemical Biology. Jul, 2011 | Pubmed ID: 21400651 Specificity Analysis-based Identification of New Methylation Targets of the SET7/9 Protein Lysine Methyltransferase Chemistry & Biology. Jan, 2011 | Pubmed ID: 21276944 Structure and Function of Mammalian DNA Methyltransferases Chembiochem : a European Journal of Chemical Biology. Jan, 2011 | Pubmed ID: 21243710 Molecular Epigenetics: Connecting Human Biology and Disease with Little Marks Chembiochem : a European Journal of Chemical Biology. Jan, 2011 | Pubmed ID: 21243707 Detailed Specificity Analysis of Antibodies Binding to Modified Histone Tails with Peptide Arrays Epigenetics : Official Journal of the DNA Methylation Society. Feb, 2011 | Pubmed ID: 20962581 The Application of Next Generation Sequencing in DNA Methylation Analysis Genes. 2010 | Pubmed ID: 24710012 Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine PloS One. 2010 | Pubmed ID: 20808780 Silencing of Gene Expression by Targeted DNA Methylation: Concepts and Approaches Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20680833 The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20547484 Molecular Biology. Phylogeny of Methylomes Science (New York, N.Y.). May, 2010 | Pubmed ID: 20466912 BISMA--fast and Accurate Bisulfite Sequencing Data Analysis of Individual Clones from Unique and Repetitive Sequences BMC Bioinformatics. 2010 | Pubmed ID: 20459626 Chromatin Methylation Activity of Dnmt3a and Dnmt3a/3L is Guided by Interaction of the ADD Domain with the Histone H3 Tail Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20223770 Changing the DNA Recognition Specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by Directed Evolution Journal of Molecular Biology. Jan, 2010 | Pubmed ID: 19766657 Non-imprinted Allele-specific DNA Methylation on Human Autosomes Genome Biology. 2009 | Pubmed ID: 19958531 New Clustering Module in BDPC Bisulfite Sequencing Data Presentation and Compilation Web Application for DNA Methylation Analyses BioTechniques. Sep, 2009 | Pubmed ID: 19852764 A Continuous Protein Methyltransferase (G9a) Assay for Enzyme Activity Measurement and Inhibitor Screening Journal of Biomolecular Screening. Oct, 2009 | Pubmed ID: 19734436 Transition from EcoDam to T4Dam DNA Recognition Mechanism Without Loss of Activity and Specificity Chembiochem : a European Journal of Chemical Biology. Oct, 2009 | Pubmed ID: 19725089 On the Divalent Metal Ion Dependence of DNA Cleavage by Restriction Endonucleases of the EcoRI Family Journal of Molecular Biology. Oct, 2009 | Pubmed ID: 19682999 The Ankyrin Repeat Domain of Huntingtin Interacting Protein 14 Contains a Surface Aromatic Cage, a Potential Site for Methyl-lysine Binding Proteins. Aug, 2009 | Pubmed ID: 19434754 DNA Methylation Analysis of Chromosome 21 Gene Promoters at Single Base Pair and Single Allele Resolution PLoS Genetics. Mar, 2009 | Pubmed ID: 19325872 Impact of 7,8-dihydro-8-oxoguanine on Methylation of the CpG Site by Dnmt3a Biochemistry. Feb, 2009 | Pubmed ID: 19161295 DNA Methylation Analysis by Bisulfite Conversion, Cloning, and Sequencing of Individual Clones Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 18987815 Specificity of Protein Lysine Methyltransferases and Methods for Detection of Lysine Methylation of Non-histone Proteins Molecular BioSystems. Dec, 2008 | Pubmed ID: 19396382 Formation of Nucleoprotein Filaments by Mammalian DNA Methyltransferase Dnmt3a in Complex with Regulator Dnmt3L Nucleic Acids Research. Dec, 2008 | Pubmed ID: 18945701 Reading and Writing DNA Methylation Nature Structural & Molecular Biology. Oct, 2008 | Pubmed ID: 18836494 Putting the Pieces Together: Histone H2B Ubiquitylation Directly Stimulates Histone H3K79 Methylation Chembiochem : a European Journal of Chemical Biology. Sep, 2008 | Pubmed ID: 18712750 Human DNMT2 Methylates TRNA(Asp) Molecules Using a DNA Methyltransferase-like Catalytic Mechanism RNA (New York, N.Y.). Aug, 2008 | Pubmed ID: 18567810 Protein Lysine Methyltransferase G9a Acts on Non-histone Targets Nature Chemical Biology. Jun, 2008 | Pubmed ID: 18438403 Persistent Downregulation of the Pancarcinoma-associated Epithelial Cell Adhesion Molecule Via Active Intranuclear Methylation International Journal of Cancer. Journal International Du Cancer. Jul, 2008 | Pubmed ID: 18398839 Cyclical DNA Methylation of a Transcriptionally Active Promoter Nature. Mar, 2008 | Pubmed ID: 18322525 Bisulfite Sequencing Data Presentation and Compilation (BDPC) Web Server--a Useful Tool for DNA Methylation Analysis Nucleic Acids Research. Mar, 2008 | Pubmed ID: 18296484 Detection and Quantitation of the Activity of DNA Methyltransferases Using a Biotin/avidin Microplate Assay Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18287657 Analysis of the Substrate Specificity of the Dim-5 Histone Lysine Methyltransferase Using Peptide Arrays Chemistry & Biology. Jan, 2008 | Pubmed ID: 18215768 Mapping of Protein-protein Interaction Sites by the 'absence of Interference' Approach Journal of Molecular Biology. Feb, 2008 | Pubmed ID: 18191145 Continuous Enzymatic Assay for Histone Lysine Methyltransferases BioTechniques. Nov, 2007 | Pubmed ID: 18072589 The M.EcoRV DNA-(adenine N6)-methyltransferase Uses DNA Bending for Recognition of an Expanded EcoDam Recognition Site The Journal of Biological Chemistry. Dec, 2007 | Pubmed ID: 17977824 Phosphorylation of Serine-515 Activates the Mammalian Maintenance Methyltransferase Dnmt1 Epigenetics : Official Journal of the DNA Methylation Society. Sep, 2007 | Pubmed ID: 17965600 Structure of Dnmt3a Bound to Dnmt3L Suggests a Model for De Novo DNA Methylation Nature. Sep, 2007 | Pubmed ID: 17713477 Deoxyribonucleic Acid Methyl Transferases 3a and 3b Associate with the Nuclear Orphan Receptor COUP-TFI During Gene Activation Molecular Endocrinology (Baltimore, Md.). Sep, 2007 | Pubmed ID: 17579209 Two Alternative Conformations of S-adenosyl-L-homocysteine Bound to Escherichia Coli DNA Adenine Methyltransferase and the Implication of Conformational Changes in Regulating the Catalytic Cycle The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17545164 Application of DNA Methyltransferases in Targeted DNA Methylation Applied Microbiology and Biotechnology. Jul, 2007 | Pubmed ID: 17431611 Reversible Inactivation of the CG Specific SssI DNA (cytosine-C5)-methyltransferase with a Photocleavable Protecting Group Chembiochem : a European Journal of Chemical Biology. Jan, 2007 | Pubmed ID: 17195251 Chimeric DNA Methyltransferases Target DNA Methylation to Specific DNA Sequences and Repress Expression of Target Genes Nucleic Acids Research. 2007 | Pubmed ID: 17151075 On the Enzymatic Properties of Dnmt1: Specificity, Processivity, Mechanism of Linear Diffusion and Allosteric Regulation of the Enzyme Epigenetics : Official Journal of the DNA Methylation Society. Apr-Jun, 2006 | Pubmed ID: 17965604 German Human Methylome Project Started Cancer Research. Jul, 2006 | Pubmed ID: 16849590 Two Substrates Are Better Than One: Dual Specificities for Dnmt2 Methyltransferases Trends in Biochemical Sciences. Jun, 2006 | Pubmed ID: 16679017 Mutations in DNA Methyltransferase DNMT3B in ICF Syndrome Affect Its Regulation by DNMT3L Human Molecular Genetics. May, 2006 | Pubmed ID: 16543361 Structure and Substrate Recognition of the Escherichia Coli DNA Adenine Methyltransferase Journal of Molecular Biology. Apr, 2006 | Pubmed ID: 16524590 Accuracy of DNA Methylation Pattern Preservation by the Dnmt1 Methyltransferase Nucleic Acids Research. 2006 | Pubmed ID: 16500889 Mutational Analysis of the Catalytic Domain of the Murine Dnmt3a DNA-(cytosine C5)-methyltransferase Journal of Molecular Biology. Mar, 2006 | Pubmed ID: 16472822 Developing a Programmed Restriction Endonuclease for Highly Specific DNA Cleavage Nucleic Acids Research. 2005 | Pubmed ID: 16356926 De Novo Methylation of Nucleosomal DNA by the Mammalian Dnmt1 and Dnmt3A DNA Methyltransferases Biochemistry. Jul, 2005 | Pubmed ID: 16026162 Avidin Plate Assay System for Enzymatic Characterization of a Histone Lysine Methyltransferase Analytical Biochemistry. Jul, 2005 | Pubmed ID: 15935324 Transition from Nonspecific to Specific DNA Interactions Along the Substrate-recognition Pathway of Dam Methyltransferase Cell. May, 2005 | Pubmed ID: 15882618 Profound Flanking Sequence Preference of Dnmt3a and Dnmt3b Mammalian DNA Methyltransferases Shape the Human Epigenome Journal of Molecular Biology. May, 2005 | Pubmed ID: 15854647 Mechanism of Stimulation of Catalytic Activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15671018 Mechanism of Inhibition of DNA Methyltransferases by Cytidine Analogs in Cancer Therapy Cancer Biology & Therapy. Nov, 2004 | Pubmed ID: 15539938 Anomalous Mobility of Polymerase Chain Reaction Products After Bisulfite Treatment of DNA Analytical Biochemistry. Oct, 2004 | Pubmed ID: 15351297 The Dnmt1 DNA-(cytosine-C5)-methyltransferase Methylates DNA Processively with High Preference for Hemimethylated Target Sites The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15339928 Stopped-flow and Mutational Analysis of Base Flipping by the Escherichia Coli Dam DNA-(adenine-N6)-methyltransferase Journal of Molecular Biology. Aug, 2004 | Pubmed ID: 15276835 Chromatin Targeting of De Novo DNA Methyltransferases by the PWWP Domain The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 14998998 Maintenance of Species Identity and Controlling Speciation of Bacteria: a New Function for Restriction/modification Systems? Gene. Oct, 2003 | Pubmed ID: 14604787 Structural and Biochemical Characterization of a New Mg(2+) Binding Site Near Tyr94 in the Restriction Endonuclease PvuII Journal of Molecular Biology. Aug, 2003 | Pubmed ID: 12888347 The Human Dnmt2 Has Residual DNA-(cytosine-C5) Methyltransferase Activity The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12794065 Catalytic Mechanism of DNA-(cytosine-C5)-methyltransferases Revisited: Covalent Intermediate Formation is Not Essential for Methyl Group Transfer by the Murine Dnmt3a Enzyme Journal of Molecular Biology. Jun, 2003 | Pubmed ID: 12787669 Methylation Sensitivity of Restriction Enzymes Interacting with GATC Sites BioTechniques. May, 2003 | Pubmed ID: 12765016 A Nomenclature for Restriction Enzymes, DNA Methyltransferases, Homing Endonucleases and Their Genes Nucleic Acids Research. Apr, 2003 | Pubmed ID: 12654995 Detection and Analysis of Enzymatic DNA Methylation of Oligonucleotide Substrates by Matrix-assisted Laser Desorption Ionization Time-of-flight Mass Spectrometry Analytical Biochemistry. Feb, 2003 | Pubmed ID: 12576072 High-throughput Purification of PolyHis-tagged Recombinant Fusion Proteins Methods in Molecular Biology (Clifton, N.J.). 2003 | Pubmed ID: 12491887 Probing the DNA Interface of the EcoRV DNA-(adenine-N6)-methyltransferase by Site-directed Mutagenesis, Fluorescence Spectroscopy, and UV Cross-linking Biochemistry. Dec, 2002 | Pubmed ID: 12450373 Dnmt3a and Dnmt1 Functionally Cooperate During De Novo Methylation of DNA European Journal of Biochemistry / FEBS. Oct, 2002 | Pubmed ID: 12383256 Specificity of DNA Triple Helix Formation Analyzed by a FRET Assay BMC Biochemistry. 2002 | Pubmed ID: 12323077 The Escherichia Coli Dam DNA Methyltransferase Modifies DNA in a Highly Processive Reaction Journal of Molecular Biology. Jun, 2002 | Pubmed ID: 12079349 A Fluorimetric Assay for On-line Detection of DNA Cleavage by Restriction Endonucleases Journal of Biotechnology. Jun, 2002 | Pubmed ID: 12039534 Beyond Watson and Crick: DNA Methylation and Molecular Enzymology of DNA Methyltransferases Chembiochem : a European Journal of Chemical Biology. Apr, 2002 | Pubmed ID: 11933228 Molecular Enzymology of the Catalytic Domains of the Dnmt3a and Dnmt3b DNA Methyltransferases The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11919202 Site-directed Mutagenesis by Polymerase Chain Reaction Methods in Molecular Biology (Clifton, N.J.). 2002 | Pubmed ID: 11768980 Specificity Analysis of Protein Lysine Methyltransferases Using SPOT Peptide Arrays Srikanth Kudithipudi1, Denis Kusevic1, Sara Weirich1, Albert Jeltsch1 1Institute of Biochemistry, Stuttgart University JoVE 52203 Biology
Specificity Analysis of Protein Lysine Methyltransferases Using SPOT Peptide Arrays Srikanth Kudithipudi1, Denis Kusevic1, Sara Weirich1, Albert Jeltsch1 1Institute of Biochemistry, Stuttgart University JoVE 52203 Biology
