Alberto Lleó Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau Universitat Autònoma de Barcelona Biography Publications Institution JoVE Articles Alberto Lleó has not added a biography. If you are Alberto Lleó and would like to personalize this page please email our Author Liaison for assistance. Publications Intermediate and Expanded HTT Alleles and the Risk for α-Synucleinopathies Movement Disorders : Official Journal of the Movement Disorder Society. Jul, 2022 | Pubmed ID: 35852957 Establishing In-House Cutoffs of CSF Alzheimer's Disease Biomarkers for the AT(N) Stratification of the Alzheimer Center Barcelona Cohort International Journal of Molecular Sciences. Jun, 2022 | Pubmed ID: 35805894 Myelin Loss in C9orf72 Hexanucleotide Expansion Carriers Journal of Neuroscience Research. Jun, 2022 | Pubmed ID: 35766328 Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome JAMA Network Open. 05, 2022 | Pubmed ID: 35604690 Correction: Cerebrospinal Fluid Tau Levels Are Associated with Abnormal Neuronal Plasticity Markers in Alzheimer's Disease Molecular Neurodegeneration. May, 2022 | Pubmed ID: 35550177 Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration JAMA Network Open. 04, 2022 | Pubmed ID: 35486397 Importance of Cerebrospinal Fluid Storage Conditions for the Alzheimer's Disease Diagnostics on an Automated Platform Clinical Chemistry and Laboratory Medicine. Jun, 2022 | Pubmed ID: 35405043 Multimarker Synaptic Protein Cerebrospinal Fluid Panels Reflect TDP-43 Pathology and Cognitive Performance in a Pathological Cohort of Frontotemporal Lobar Degeneration Molecular Neurodegeneration. 04, 2022 | Pubmed ID: 35395770 New Insights into the Genetic Etiology of Alzheimer's Disease and Related Dementias Nature Genetics. 04, 2022 | Pubmed ID: 35379992 Cerebrospinal Fluid Tau Levels Are Associated with Abnormal Neuronal Plasticity Markers in Alzheimer's Disease Molecular Neurodegeneration. 03, 2022 | Pubmed ID: 35346299 Blood Amyloid and Tau Biomarkers As Predictors of Cerebrospinal Fluid Profiles Journal of Neural Transmission (Vienna, Austria : 1996). 02, 2022 | Pubmed ID: 35169889 The Aβ1-42/Aβ1-40 Ratio in CSF is More Strongly Associated to Tau Markers and Clinical Progression Than Aβ1-42 Alone Alzheimer's Research & Therapy. 02, 2022 | Pubmed ID: 35105351 Neuropathology of a Patient with Alzheimer Disease Treated with Low Doses of Verubecestat Neuropathology and Applied Neurobiology. 04, 2022 | Pubmed ID: 34825396 Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies Frontiers in Neurology. 2021 | Pubmed ID: 35115992 Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Chain for the Diagnostic and Prognostic Evaluation of Frontotemporal Dementia Translational Neurodegeneration. 12, 2021 | Pubmed ID: 34893073 Correction To: Cerebrospinal Fluid Levels of the Neurotrophic Factor Neuroleukin Are Increased in Early Alzheimer's Disease, but Not in Cerebral Amyloid Angiopathy Alzheimer's Research & Therapy. Nov, 2021 | Pubmed ID: 34784952 Cerebrospinal Fluid Levels of the Neurotrophic Factor Neuroleukin Are Increased in Early Alzheimer's Disease, but Not in Cerebral Amyloid Angiopathy Alzheimer's Research & Therapy. 09, 2021 | Pubmed ID: 34560885 CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals Proteomes. Aug, 2021 | Pubmed ID: 34449748 Metabolite Signature of Alzheimer's Disease in Adults with Down Syndrome Annals of Neurology. 09, 2021 | Pubmed ID: 34309066 Diagnostic and Prognostic Performance and Longitudinal Changes in Plasma Neurofilament Light Chain Concentrations in Adults with Down Syndrome: a Cohort Study The Lancet. Neurology. 08, 2021 | Pubmed ID: 34302785 Phosphorylated Tau181 in Plasma As a Potential Biomarker for Alzheimer's Disease in Adults with Down Syndrome Nature Communications. 07, 2021 | Pubmed ID: 34262030 Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome JAMA Neurology. 08, 2021 | Pubmed ID: 34228042 Use of Plasma Biomarkers for AT(N) Classification of Neurodegenerative Dementias Journal of Neurology, Neurosurgery, and Psychiatry. 11, 2021 | Pubmed ID: 34103344 Common Variants in Alzheimer's Disease and Risk Stratification by Polygenic Risk Scores Nature Communications. 06, 2021 | Pubmed ID: 34099642 AMYQ: An Index to Standardize Quantitative Amyloid Load Across PET Tracers Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 09, 2021 | Pubmed ID: 33797846 Diagnostic Utility of Measuring Cerebral Atrophy in the Behavioral Variant of Frontotemporal Dementia and Association With Clinical Deterioration JAMA Network Open. 03, 2021 | Pubmed ID: 33704477 Sex Differences in the Behavioral Variant of Frontotemporal Dementia: A New Window to Executive and Behavioral Reserve Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 08, 2021 | Pubmed ID: 33590953 Genome Sequencing Analysis Identifies New Loci Associated with Lewy Body Dementia and Provides Insights into Its Genetic Architecture Nature Genetics. 03, 2021 | Pubmed ID: 33589841 White Matter Hyperintensities Are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers Journal of Alzheimer's Disease : JAD. 2021 | Pubmed ID: 33252070 Nerve Growth Factor (NGF) Pathway Biomarkers in Down Syndrome Prior to and After the Onset of Clinical Alzheimer's Disease: A Paired CSF and Plasma Study Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 04, 2021 | Pubmed ID: 33226181 Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease Neurology. 02, 2021 | Pubmed ID: 33199433 Biphasic Cortical Macro- and Microstructural Changes in Autosomal Dominant Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 04, 2021 | Pubmed ID: 33196147 Heterozygous APOE Christchurch in Familial Alzheimer's Disease Without Mutations in Other Mendelian Genes Neuropathology and Applied Neurobiology. 06, 2021 | Pubmed ID: 33095930 Genetic Variation in APOE, GRN, and TP53 Are Phenotype Modifiers in Frontotemporal Dementia Neurobiology of Aging. 03, 2021 | Pubmed ID: 32972771 Pathophysiological Subtypes of Alzheimer's Disease Based on Cerebrospinal Fluid Proteomics Brain : a Journal of Neurology. 12, 2020 | Pubmed ID: 33439986 Serum Neurofilament Light Chain Predicts Long-term Prognosis in Guillain-Barré Syndrome Patients Journal of Neurology, Neurosurgery, and Psychiatry. Nov, 2020 | Pubmed ID: 33154183 Cerebrospinal Fluid A Beta 1-40 Peptides Increase in Alzheimer's Disease and Are Highly Correlated with Phospho-tau in Control Individuals Alzheimer's Research & Therapy. 10, 2020 | Pubmed ID: 33008460 , Age at Onset, and Ancestry Help Discriminate Behavioral from Language Variants in FTLD Cohorts Neurology. 12, 2020 | Pubmed ID: 32943482 Cortical Microstructure in the Amyotrophic Lateral Sclerosis-frontotemporal Dementia Continuum Neurology. 11, 2020 | Pubmed ID: 32913016 Evaluation of Biochemical and Hematological Parameters in Adults with Down Syndrome Scientific Reports. 08, 2020 | Pubmed ID: 32792619 Obesity Impacts Brain Metabolism and Structure Independently of Amyloid and Tau Pathology in Healthy Elderly Alzheimer's & Dementia (Amsterdam, Netherlands). 2020 | Pubmed ID: 32743041 Motor Cortex Transcriptome Reveals Microglial Key Events in Amyotrophic Lateral Sclerosis Neurology(R) Neuroimmunology & Neuroinflammation. 09, 2020 | Pubmed ID: 32669313 Clinical and Biomarker Changes of Alzheimer's Disease in Adults with Down Syndrome: a Cross-sectional Study Lancet (London, England). 06, 2020 | Pubmed ID: 32593336 Disease-Specific Changes in Reelin Protein and MRNA in Neurodegenerative Diseases Cells. 05, 2020 | Pubmed ID: 32438605 Cortical Microstructural Correlates of Astrocytosis in Autosomal-dominant Alzheimer Disease Neurology. 05, 2020 | Pubmed ID: 32291295 Downregulation of MiR-335-5P in Amyotrophic Lateral Sclerosis Can Contribute to Neuronal Mitochondrial Dysfunction and Apoptosis Scientific Reports. 03, 2020 | Pubmed ID: 32152380 Correction To: A Nonsynonymous Mutation in PLCG2 Reduces the Risk of Alzheimer's Disease, Dementia with Lewy Bodies and Frontotemporal Dementia, and Increases the Likelihood of Longevity Acta Neuropathologica. 05, 2020 | Pubmed ID: 31955222 Role for ATXN1, ATXN2, and HTT Intermediate Repeats in Frontotemporal Dementia and Alzheimer's Disease Neurobiology of Aging. 03, 2020 | Pubmed ID: 31810584 Atrophy of Basal Forebrain Initiates with Tau Pathology in Individuals at Risk for Alzheimer's Disease Cerebral Cortex (New York, N.Y. : 1991). 04, 2020 | Pubmed ID: 31799623 Detection of Amyloid Beta Peptides in Body Fluids for the Diagnosis of Alzheimer's Disease: Where Do We Stand? Critical Reviews in Clinical Laboratory Sciences. 03, 2020 | Pubmed ID: 31661652 APP-derived Peptides Reflect Neurodegeneration in Frontotemporal Dementia Annals of Clinical and Translational Neurology. 12, 2019 | Pubmed ID: 31789459 The Sant Pau Initiative on Neurodegeneration (SPIN) Cohort: A Data Set for Biomarker Discovery and Validation in Neurodegenerative Disorders Alzheimer's & Dementia (New York, N. Y.). 2019 | Pubmed ID: 31650016 Trisomy 21 Activates the Kynurenine Pathway Via Increased Dosage of Interferon Receptors Nature Communications. 10, 2019 | Pubmed ID: 31628327 Author Correction: GBA and APOE ε4 Associate with Sporadic Dementia with Lewy Bodies in European Genome Wide Association Study Scientific Reports. Oct, 2019 | Pubmed ID: 31619746 Agreement of Amyloid PET and CSF Biomarkers for Alzheimer's Disease on Lumipulse Annals of Clinical and Translational Neurology. 09, 2019 | Pubmed ID: 31464088 The Gene Cluster is a Key Modulator of Soluble TREM2 and Alzheimer's Disease Risk Science Translational Medicine. 08, 2019 | Pubmed ID: 31413141 A Nonsynonymous Mutation in PLCG2 Reduces the Risk of Alzheimer's Disease, Dementia with Lewy Bodies and Frontotemporal Dementia, and Increases the Likelihood of Longevity Acta Neuropathologica. 08, 2019 | Pubmed ID: 31131421 Altered MicroRNAs Related to Synaptic Function As Potential Plasma Biomarkers for Alzheimer's Disease Alzheimer's Research & Therapy. 05, 2019 | Pubmed ID: 31092279 GBA and APOE ε4 Associate with Sporadic Dementia with Lewy Bodies in European Genome Wide Association Study Scientific Reports. 05, 2019 | Pubmed ID: 31065058 Heritability and Genetic Variance of Dementia with Lewy Bodies Neurobiology of Disease. 07, 2019 | Pubmed ID: 30953760 Clinical and Video-polysomnographic Analysis of Rapid Eye Movement Sleep Behavior Disorder and Other Sleep Disturbances in Dementia with Lewy Bodies Sleep. 07, 2019 | Pubmed ID: 30946468 Nanoscale Structure of Amyloid-β Plaques in Alzheimer's Disease Scientific Reports. 03, 2019 | Pubmed ID: 30914681 Cortical Microstructure in the Behavioural Variant of Frontotemporal Dementia: Looking Beyond Atrophy Brain : a Journal of Neurology. 04, 2019 | Pubmed ID: 30906945 Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid Molecular & Cellular Proteomics : MCP. 03, 2019 | Pubmed ID: 30606734 Decreased Circulating ErbB4 Ectodomain Fragments As a Read-out of Impaired Signaling Function in Amyotrophic Lateral Sclerosis Neurobiology of Disease. 04, 2019 | Pubmed ID: 30594809 HTT Gene Intermediate Alleles in Neurodegeneration: Evidence for Association with Alzheimer's Disease Neurobiology of Aging. 04, 2019 | Pubmed ID: 30583877 Impact of CSF Storage Volume on the Analysis of Alzheimer's Disease Biomarkers on an Automated Platform Clinica Chimica Acta; International Journal of Clinical Chemistry. Mar, 2019 | Pubmed ID: 30579960 A Comprehensive Screening of Copy Number Variability in Dementia with Lewy Bodies Neurobiology of Aging. 03, 2019 | Pubmed ID: 30448004 Elevated YKL-40 and Low SAPPβ:YKL-40 Ratio in Antemortem Cerebrospinal Fluid of Patients with Pathologically Confirmed FTLD Journal of Neurology, Neurosurgery, and Psychiatry. 02, 2019 | Pubmed ID: 30297518 Cerebrospinal Fluid Mitochondrial DNA Levels in Patients with Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). 10, 2019 | Pubmed ID: 29985092 Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [F]-Flutemetamol PET Scan Result Frontiers in Aging Neuroscience. 2018 | Pubmed ID: 30618716 Prevalence of Sleep Disorders in Adults With Down Syndrome: A Comparative Study of Self-Reported, Actigraphic, and Polysomnographic Findings Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine. 10, 2018 | Pubmed ID: 30353801 CSF SAPPβ, YKL-40, and NfL Along the ALS-FTD Spectrum Neurology. 10, 2018 | Pubmed ID: 30291183 A C6orf10/LOC101929163 Locus is Associated with Age of Onset in C9orf72 Carriers Brain : a Journal of Neurology. 10, 2018 | Pubmed ID: 30252044 Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer's Disease Frontiers in Neuroscience. 2018 | Pubmed ID: 30245615 Challenges Associated with Biomarker-based Classification Systems for Alzheimer's Disease Alzheimer's & Dementia (Amsterdam, Netherlands). 2018 | Pubmed ID: 30175226 Distinct Clinical Features and Outcomes in Motor Neuron Disease Associated with Behavioural Variant Frontotemporal Dementia Dementia and Geriatric Cognitive Disorders. 2018 | Pubmed ID: 29886477 No Supportive Evidence for TIA1 Gene Mutations in a European Cohort of ALS-FTD Spectrum Patients Neurobiology of Aging. 09, 2018 | Pubmed ID: 29886022 Monoaminergic Impairment in Down Syndrome with Alzheimer's Disease Compared to Early-onset Alzheimer's Disease Alzheimer's & Dementia (Amsterdam, Netherlands). 2018 | Pubmed ID: 29780859 Rare Nonsynonymous Variants in SORT1 Are Associated with Increased Risk for Frontotemporal Dementia Neurobiology of Aging. 06, 2018 | Pubmed ID: 29555433 A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes JAMA Neurology. 06, 2018 | Pubmed ID: 29554190 White Paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming Barriers in Biomarker Development and Clinical Translation Alzheimer's Research & Therapy. 03, 2018 | Pubmed ID: 29544527 Cerebral Changes and Disrupted Gray Matter Cortical Networks in Asymptomatic Older Adults at Risk for Alzheimer's Disease Neurobiology of Aging. 04, 2018 | Pubmed ID: 29331877 Investigating the Genetic Architecture of Dementia with Lewy Bodies: a Two-stage Genome-wide Association Study The Lancet. Neurology. Jan, 2018 | Pubmed ID: 29263008 Alzheimer's Disease: An Ignored Condition Medicina Clinica. 06, 2018 | Pubmed ID: 29196039 Cortical Microstructural Changes Along the Alzheimer's Disease Continuum Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 03, 2018 | Pubmed ID: 29080407 Cerebrospinal Fluid and Blood Biomarkers for Neurodegenerative Dementias: An Update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 06, 2018 | Pubmed ID: 29076399 Analysis of Known Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Genes Reveals a Substantial Genetic Burden in Patients Manifesting Both Diseases Not Carrying the Expansion Mutation Journal of Neurology, Neurosurgery, and Psychiatry. 02, 2018 | Pubmed ID: 28889094 Weight Loss in the Healthy Elderly Might Be a Non-cognitive Sign of Preclinical Alzheimer's Disease Oncotarget. Dec, 2017 | Pubmed ID: 29285207 Synaptic Phosphorylated α-synuclein in Dementia with Lewy Bodies Brain : a Journal of Neurology. Dec, 2017 | Pubmed ID: 29177427 The Pitfalls of Biomarker-based Classification Schemes Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 09, 2017 | Pubmed ID: 28704640 Consensus Guidelines for Lumbar Puncture in Patients with Neurological Diseases Alzheimer's & Dementia (Amsterdam, Netherlands). 2017 | Pubmed ID: 28603768 YKL-40 (Chitinase 3-like I) is Expressed in a Subset of Astrocytes in Alzheimer's Disease and Other Tauopathies Journal of Neuroinflammation. 06, 2017 | Pubmed ID: 28599675 CSF SAPPβ, YKL-40, and Neurofilament Light in Frontotemporal Lobar Degeneration Neurology. Jul, 2017 | Pubmed ID: 28592456 Diagnostic and Prognostic Value Of the Combination of Two Measures Of Verbal Memory in Mild Cognitive Impairment Due to Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28527215 Cerebral Amyloid Angiopathy in Down Syndrome and Sporadic and Autosomal-dominant Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Nov, 2017 | Pubmed ID: 28463681 Deleterious ABCA7 Mutations and Transcript Rescue Mechanisms in Early Onset Alzheimer's Disease Acta Neuropathologica. Sep, 2017 | Pubmed ID: 28447221 Regional Overlap of Pathologies in Lewy Body Disorders Journal of Neuropathology and Experimental Neurology. 03, 2017 | Pubmed ID: 28395086 MicroRNA Profile in Patients with Alzheimer's Disease: Analysis of MiR-9-5p and MiR-598 in Raw and Exosome Enriched Cerebrospinal Fluid Samples Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28269782 Cerebrospinal Fluid Mitochondrial DNA in the Alzheimer's Disease Continuum Neurobiology of Aging. 05, 2017 | Pubmed ID: 28089353 A Common Variant in the MC1R Gene (p.V92M) is Associated with Alzheimer's Disease Risk Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28059796 TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis Human Mutation. 03, 2017 | Pubmed ID: 28008748 Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Subjects with Down Syndrome Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 27858714 CSF MicroRNA Profiling in Alzheimer's Disease: a Screening and Validation Study Molecular Neurobiology. 11, 2017 | Pubmed ID: 27738874 Exome Sequencing in a Consanguineous Family Clinically Diagnosed with Early-onset Alzheimer's Disease Identifies a Homozygous CTSF Mutation Neurobiology of Aging. 10, 2016 | Pubmed ID: 27524508 Non-Fibrillar Oligomeric Amyloid-β Within Synapses Journal of Alzheimer's Disease : JAD. 05, 2016 | Pubmed ID: 27258414 Progranulin Protein Levels in Cerebrospinal Fluid in Primary Neurodegenerative Dementias Journal of Alzheimer's Disease : JAD. 2016 | Pubmed ID: 26682689 Assessing the Role of TUBA4A Gene in Frontotemporal Degeneration Neurobiology of Aging. Feb, 2016 | Pubmed ID: 26675813 Cerebrospinal Fluid Anti-Amyloid-β Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation Journal of Alzheimer's Disease : JAD. 2016 | Pubmed ID: 26639966 Missense Mutations in TENM4, a Regulator of Axon Guidance and Central Myelination, Cause Essential Tremor Human Molecular Genetics. Oct, 2015 | Pubmed ID: 26188006 Amyloid Precursor Protein Metabolism and Inflammation Markers in Preclinical Alzheimer Disease Neurology. Aug, 2015 | Pubmed ID: 26180139 Analysis of the CHCHD10 Gene in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis from Spain Brain : a Journal of Neurology. Dec, 2015 | Pubmed ID: 26152333 Prevalence of Amyloid PET Positivity in Dementia Syndromes: a Meta-analysis JAMA. May, 2015 | Pubmed ID: 25988463 Relationship Between Cortical Thickness and Cerebrospinal Fluid YKL-40 in Predementia Stages of Alzheimer's Disease Neurobiology of Aging. Jun, 2015 | Pubmed ID: 25865441 Genetic Variability in SQSTM1 and Risk of Early-onset Alzheimer Dementia: a European Early-onset Dementia Consortium Study Neurobiology of Aging. May, 2015 | Pubmed ID: 25796131 Cerebral Amyloid Angiopathy-related Atraumatic Convexal Subarachnoid Hemorrhage: an ARIA Before the Tsunami Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2015 | Pubmed ID: 25735919 Mendelian Genes for Parkinson's Disease Contribute to the Sporadic Forms of the Disease Human Molecular Genetics. Apr, 2015 | Pubmed ID: 25504046 Early Cerebellar Hypometabolism in Patients With Frontotemporal Dementia Carrying the C9orf72 Expansion Alzheimer Disease and Associated Disorders. Oct-Dec, 2015 | Pubmed ID: 25203513 Investigation of the Role of Rare TREM2 Variants in Frontotemporal Dementia Subtypes Neurobiology of Aging. Nov, 2014 | Pubmed ID: 25042114 TREM2 Mutations Implicated in Neurodegeneration Impair Cell Surface Transport and Phagocytosis Science Translational Medicine. Jul, 2014 | Pubmed ID: 24990881 Frontotemporal Dementia and Its Subtypes: a Genome-wide Association Study The Lancet. Neurology. Jul, 2014 | Pubmed ID: 24943344 Gene-wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease PloS One. 2014 | Pubmed ID: 24922517 Rare Mutations in SQSTM1 Modify Susceptibility to Frontotemporal Lobar Degeneration Acta Neuropathologica. Sep, 2014 | Pubmed ID: 24899140 Relationship Between β-Secretase, Inflammation and Core Cerebrospinal Fluid Biomarkers for Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24820015 Posttranslational Nitro-glycative Modifications of Albumin in Alzheimer's Disease: Implications in Cytotoxicity and Amyloid-β Peptide Aggregation Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24503620 Plasma Phosphorylated TDP-43 Levels Are Elevated in Patients with Frontotemporal Dementia Carrying a C9orf72 Repeat Expansion or a GRN Mutation Journal of Neurology, Neurosurgery, and Psychiatry. Jun, 2014 | Pubmed ID: 24309270 Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: a Multicenter Study in Spain Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24254700 Autosomal-dominant Alzheimer's Disease Mutations at the Same Codon of Amyloid Precursor Protein Differentially Alter Aβ Production Journal of Neurochemistry. Jan, 2014 | Pubmed ID: 24117942 Characterization of the Repeat Expansion Size in C9orf72 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Human Molecular Genetics. Feb, 2014 | Pubmed ID: 24057670 Confluence of α-synuclein, Tau, and β-amyloid Pathologies in Dementia with Lewy Bodies Journal of Neuropathology and Experimental Neurology. Dec, 2013 | Pubmed ID: 24226269 Meta-analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer's Disease Nature Genetics. Oct, 2013 | Pubmed ID: 24162737 Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis PloS One. 2013 | Pubmed ID: 24069280 Distinct Patterns of APP Processing in the CNS in Autosomal-dominant and Sporadic Alzheimer Disease Acta Neuropathologica. Feb, 2013 | Pubmed ID: 23224319 MAPT H1 Haplotype is Associated with Enhanced α-synuclein Deposition in Dementia with Lewy Bodies Neurobiology of Aging. Mar, 2013 | Pubmed ID: 22819391 A Common BACE1 Polymorphism is a Risk Factor for Sporadic Creutzfeldt-Jakob Disease PloS One. 2012 | Pubmed ID: 22952813 Expansion Mutation in C9ORF72 Does Not Influence Plasma Progranulin Levels in Frontotemporal Dementia Neurobiology of Aging. Aug, 2012 | Pubmed ID: 22502998 Glucocerebrosidase Mutations Confer a Greater Risk of Dementia During Parkinson's Disease Course Movement Disorders : Official Journal of the Movement Disorder Society. Mar, 2012 | Pubmed ID: 22173904 Genetic Cross-interaction Between APOE and PRNP in Sporadic Alzheimer's and Creutzfeldt-Jakob Diseases PloS One. 2011 | Pubmed ID: 21799773 Dementia Risk in Parkinson Disease: Disentangling the Role of MAPT Haplotypes Archives of Neurology. Mar, 2011 | Pubmed ID: 21403021 Beta-Amyloid Disrupts Activity-dependent Gene Transcription Required for Memory Through the CREB Coactivator CRTC1 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2010 | Pubmed ID: 20631169 Clinical, Neuropathologic, and Biochemical Profile of the Amyloid Precursor Protein I716F Mutation Journal of Neuropathology and Experimental Neurology. Jan, 2010 | Pubmed ID: 20010303 Mild Cholesterol Depletion Reduces Amyloid-beta Production by Impairing APP Trafficking to the Cell Surface Journal of Neurochemistry. Jul, 2009 | Pubmed ID: 19457132 Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma Natalia Valle-Tamayo1,2, Rocío Pérez-González2,3, Gemma Chiva-Blanch4,5, Olivia Belbin1,2, Sara Serrano-Requena1,2, Sònia Sirisi1,2, Alba Cervantes González1,2, Oriol Giró4,5, Érika Sánchez-Aced1,2, Oriol Dols-Icardo1,2, Daniel Alcolea1,2, María Carmona-Iragui1,2, Amanda Jimenez4,5, Alberto Lleó1,2, Juan Fortea1,2, M. Florencia Iulita1,2 1Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, 2Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), 3Movement Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, 4Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, 5Spanish Biomedical Research Network in Physiopathology of Obesity and Nutrition (CIBEROBN) JoVE 64107 Neuroscience
Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma Natalia Valle-Tamayo1,2, Rocío Pérez-González2,3, Gemma Chiva-Blanch4,5, Olivia Belbin1,2, Sara Serrano-Requena1,2, Sònia Sirisi1,2, Alba Cervantes González1,2, Oriol Giró4,5, Érika Sánchez-Aced1,2, Oriol Dols-Icardo1,2, Daniel Alcolea1,2, María Carmona-Iragui1,2, Amanda Jimenez4,5, Alberto Lleó1,2, Juan Fortea1,2, M. Florencia Iulita1,2 1Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, 2Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), 3Movement Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, 4Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, 5Spanish Biomedical Research Network in Physiopathology of Obesity and Nutrition (CIBEROBN) JoVE 64107 Neuroscience