Alessandro Prigione Department of General Pediatrics Heinrich Heine University Biography Publications Institution JoVE Articles Alessandro Prigione Alessandro Prigione is a tenured Associate Professor of Pediatric Metabolic Medicine at the Department of General Pediatrics, Neonatology and Pediatric Cardiology at Heinrich Heine University (HHU) in Düsseldorf Germany.The interest of the Prigione group is to develop induced pluripotent stem cells (iPSC)-based approaches for disease modeling and drug discovery of rare incurable neurological and neurodevelopmental disorders affecting mitochondrial metabolism. A specific focus is on Leigh syndrome, which is the most severe mitochondrial disease affecting children. His laboratory employs human neurons and brain organoids from patients with Leigh syndrome to dissect the neuronal-specific disease mechanisms to possibly identify novel disease targets and interventions. Publications Mitochondria in Neurogenesis: Implications for Mitochondrial Diseases Stem Cells (Dayton, Ohio). Jun, 2021 | Pubmed ID: 34089537 Bioenergetic Profiling of Human Pluripotent Stem Cells Methods in Molecular Biology (Clifton, N.J.). Month, 2021 | Pubmed ID: 34080164 Generation of Human IPSC-derived Neural Progenitor Cells (NPCs) As Drug Discovery Model for Neurological and Mitochondrial Disorders Bio-protocol. Mar, 2021 | Pubmed ID: 33796613 Defective Metabolic Programming Impairs Early Neuronal Morphogenesis in Neural Cultures and an Organoid Model of Leigh Syndrome Nature Communications. 03, 2021 | Pubmed ID: 33771987 Assessment of Ethanol-Induced Toxicity on IPSC-Derived Human Neurons Using a Novel High-Throughput Mitochondrial Neuronal Health (MNH) Assay Frontiers in Cell and Developmental Biology. Month, 2020 | Pubmed ID: 33224955 Therapeutic Approaches to Treat Mitochondrial Diseases: "One-Size-Fits-All" and "Precision Medicine" Strategies Pharmaceutics. Nov, 2020 | Pubmed ID: 33187380 Biocompatibility of α-AlO Ceramic Substrates with Human Neural Precursor Cells Journal of Functional Biomaterials. Sep, 2020 | Pubmed ID: 32947990 PDGFA-associated Protein 1 Protects Mature B Lymphocytes from Stress-induced Cell Death and Promotes Antibody Gene Diversification The Journal of Experimental Medicine. 10, 2020 | Pubmed ID: 32609329 Tackling Mitochondrial Diversity in Brain Function: from Animal Models to Human Brain Organoids The International Journal of Biochemistry & Cell Biology. 06, 2020 | Pubmed ID: 32339638 Nuclear Inclusions of Pathogenic Ataxin-1 Induce Oxidative Stress and Perturb the Protein Synthesis Machinery Redox Biology. 05, 2020 | Pubmed ID: 32145456 Human Mesenchymal Factors Induce Rat Hippocampal- and Human Neural Stem Cell Dependent Oligodendrogenesis Glia. 01, 2018 | Pubmed ID: 28940767 Human IPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological MtDNA Disorders Cell Stem Cell. 05, 2017 | Pubmed ID: 28132834 Erratum: Induced Pluripotent Stem Cell-derived Neuronal Cells from a Sporadic Alzheimer's Disease Donor As a Model for Investigating AD-associated Gene Regulatory Networks BMC Genomics. Jun, 2015 | Pubmed ID: 26048372 Induced Pluripotent Stem Cell-derived Neuronal Cells from a Sporadic Alzheimer's Disease Donor As a Model for Investigating AD-associated Gene Regulatory Networks BMC Genomics. Feb, 2015 | Pubmed ID: 25765079 A Mitochondrial Strategy for Safeguarding the Reprogrammed Genome Cell Regeneration (London, England). Month, 2014 | Pubmed ID: 25408884 Transcriptome Based Identification of Mouse Cumulus Cell Markers That Predict the Developmental Competence of Their Enclosed Antral Oocytes BMC Genomics. Month, 2013 | Pubmed ID: 23758669 Mitokondriyal Hastalık Modellemesi için İnsan Beyni Organoidlerinin Üretimi Stephanie Le1, Laura Petersilie2, Gizem Inak1,4, Carmen Menacho-Pando1, Karl W. Kafitz2, Agnieszka Rybak-Wolf3, Nikolaus Rajewsky3, Christine R. Rose2, Alessandro Prigione1,5 1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, 2Institute of Neurobiology, Heinrich Heine University, 3Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrueck Center for Molecular Medicine (MDC), 4Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, 5Max Delbrueck Center for Molecular Medicine (MDC) JoVE 62756 Neuroscience
Mitokondriyal Hastalık Modellemesi için İnsan Beyni Organoidlerinin Üretimi Stephanie Le1, Laura Petersilie2, Gizem Inak1,4, Carmen Menacho-Pando1, Karl W. Kafitz2, Agnieszka Rybak-Wolf3, Nikolaus Rajewsky3, Christine R. Rose2, Alessandro Prigione1,5 1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, 2Institute of Neurobiology, Heinrich Heine University, 3Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrueck Center for Molecular Medicine (MDC), 4Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, 5Max Delbrueck Center for Molecular Medicine (MDC) JoVE 62756 Neuroscience