Alex Freeman

Publications

• Correction To: Machine Learning Classifiers Can Predict Gleason Pattern 4 Prostate Cancer with Greater Accuracy Than Experienced Radiologists
  European Radiology. Sep, 2019  |   Pubmed ID: 31506815
• Prediction of Significant Prostate Cancer in Biopsy-naïve Men: Validation of a Novel Risk Model Combining MRI and Clinical Parameters and Comparison to an ERSPC Risk Calculator and PI-RADS
  PloS One. 2019  |   Pubmed ID: 31450235
• A Multicentre Analysis of the Detection of Clinically Significant Prostate Cancer Following Transperineal Image-fusion Targeted and Nontargeted Systematic Prostate Biopsy in Men at Risk
  European Urology Oncology. Mar, 2019  |   Pubmed ID: 31411968
• Molecular and Histopathology Directed Therapy for Advanced Bladder Cancer
  Nature Reviews. Urology. Aug, 2019  |   Pubmed ID: 31289379
• NeuroSAFE Robot-assisted Laparoscopic Prostatectomy Versus Standard Robot-assisted Laparoscopic Prostatectomy for Men with Localised Prostate Cancer (NeuroSAFE PROOF): Protocol for a Randomised Controlled Feasibility Study
  BMJ Open. Jun, 2019  |   Pubmed ID: 31189680
• Machine Learning Classifiers Can Predict Gleason Pattern 4 Prostate Cancer with Greater Accuracy Than Experienced Radiologists
  European Radiology. Sep, 2019  |   Pubmed ID: 31187216
• Targeted Biopsy of the Prostate: Does This Result in Improvement in Detection of High-grade Cancer or the Occurrence of the Will Rogers Phenomenon?
  BJU International. May, 2019  |   Pubmed ID: 31081983
• Primary Squamous Cell Carcinoma of the Male Proximal Urethra: Outcomes from a Single Centre
  European Urology Focus. Mar, 2019  |   Pubmed ID: 30853605
• PEOPLE: PatiEnt PrOstate SamPLes for REsearch, a Tissue Collection Pathway Utilizing Magnetic Resonance Imaging Data to Target Tumor and Benign Tissue in Fresh Radical Prostatectomy Specimens
  The Prostate. May, 2019  |   Pubmed ID: 30807665
• VERDICT MRI Validation in Fresh and Fixed Prostate Specimens Using Patient-specific Moulds for Histological and MR Alignment
  NMR in Biomedicine. 05, 2019  |   Pubmed ID: 30779863
• Medium-term Oncological Outcomes in a Large Cohort of Men Treated with Either Focal or Hemi-ablation Using High-intensity Focused Ultrasonography for Primary Localized Prostate Cancer
  BJU International. Sep, 2019  |   Pubmed ID: 30753756
• Pathological Findings and Magnetic Resonance Imaging Concordance at Salvage Radical Prostatectomy for Local Recurrence Following Partial Ablation Using High Intensity Focused Ultrasound
  The Journal of Urology. 06, 2019  |   Pubmed ID: 30730409
• Training and Accreditation Standards for Pathologists Undertaking Clinical Trial Work
  The Journal of Pathology. Clinical Research. Apr, 2019  |   Pubmed ID: 30680942
• Dermatoscopic Findings of Penile Intraepithelial Neoplasia: Bowenoid Papulosis, Bowen Disease and Erythroplasia of Queyrat
  The Australasian Journal of Dermatology. Aug, 2019  |   Pubmed ID: 30585302
• The SmartTarget Biopsy Trial: A Prospective, Within-person Randomised, Blinded Trial Comparing the Accuracy of Visual-registration and Magnetic Resonance Imaging/Ultrasound Image-fusion Targeted Biopsies for Prostate Cancer Risk Stratification
  European Urology. 05, 2019  |   Pubmed ID: 30527787
• Multi-parametric MRI Zone-specific Diagnostic Model Performance Compared with Experienced Radiologists for Detection of Prostate Cancer
  European Radiology. Aug, 2019  |   Pubmed ID: 30456585
• Quality Assurance Guidance for Scoring and Reporting for Pathologists and Laboratories Undertaking Clinical Trial Work
  The Journal of Pathology. Clinical Research. Apr, 2019  |   Pubmed ID: 30407751
• VERDICT-AMICO: Ultrafast Fitting Algorithm for Non-invasive Prostate Microstructure Characterization
  NMR in Biomedicine. 01, 2019  |   Pubmed ID: 30378195
• Prostate Imaging Compared to Transperineal Ultrasound-guided Biopsy for Significant Prostate Cancer Risk Evaluation (PICTURE): a Prospective Cohort Validating Study Assessing Prostate HistoScanning
  Prostate Cancer and Prostatic Diseases. 05, 2019  |   Pubmed ID: 30279583
• Management of Radiologically Indeterminate Magnetic Resonance Imaging Signals in Men at Risk of Prostate Cancer
  European Urology Focus. 01, 2019  |   Pubmed ID: 28753883
• Prostate Cancer Diagnostic Pathway: Is a One-stop Cognitive MRI Targeted Biopsy Service a Realistic Goal in Everyday Practice? A Pilot Cohort in a Tertiary Referral Centre in the UK
  BMJ Open. 10, 2018  |   Pubmed ID: 30361408
• Urine-derived Lymphocytes As a Non-invasive Measure of the Bladder Tumor Immune Microenvironment
  The Journal of Experimental Medicine. 11, 2018  |   Pubmed ID: 30257862
• Immunohistochemical Biomarker Validation in Highly Selective Needle Biopsy Microarrays Derived from MpMRI-characterized Prostates
  The Prostate. 12, 2018  |   Pubmed ID: 30073682
• Multiparametric MRI to Improve Detection of Prostate Cancer Compared with Transrectal Ultrasound-guided Prostate Biopsy Alone: the PROMIS Study
  Health Technology Assessment (Winchester, England). 07, 2018  |   Pubmed ID: 30040065
• Accuracy of Transperineal Targeted Prostate Biopsies, Visual Estimation and Image Fusion in Men Needing Repeat Biopsy in the PICTURE Trial
  The Journal of Urology. 12, 2018  |   Pubmed ID: 30017964
• Patient Reported Outcome Measures for Transperineal Template Prostate Mapping Biopsies in the PICTURE Study
  The Journal of Urology. 12, 2018  |   Pubmed ID: 29940251
• MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis
  The New England Journal of Medicine. May, 2018  |   Pubmed ID: 29552975
• Phenotypic Appearances of Prostate Utilizing PET-MRI and PET-CT with 68Ga-PSMA, Radiolabelled Choline and 68Ga-DOTATATE
  Nuclear Medicine Communications. Mar, 2018  |   Pubmed ID: 29384832
• Characterizing Indeterminate (Likert-score 3/5) Peripheral Zone Prostate Lesions with PSA Density, PI-RADS Scoring and Qualitative Descriptors on Multiparametric MRI
  The British Journal of Radiology. Feb, 2018  |   Pubmed ID: 29189042
• The CADMUS Trial - Multi-parametric Ultrasound Targeted Biopsies Compared to Multi-parametric MRI Targeted Biopsies in the Diagnosis of Clinically Significant Prostate Cancer
  Contemporary Clinical Trials. 03, 2018  |   Pubmed ID: 29108869
• Predictive Factors for Local Recurrence After Glansectomy and Neoglans Reconstruction for Penile Squamous Cell Carcinoma
  Urologic Oncology. 04, 2018  |   Pubmed ID: 28882673
• Glansectomy and Split-thickness Skin Graft for Penile Cancer
  European Urology. 02, 2018  |   Pubmed ID: 27746062
• A Multicentre Randomised Controlled Trial Assessing Whether MRI-targeted Biopsy is Non-inferior to Standard Transrectal Ultrasound Guided Biopsy for the Diagnosis of Clinically Significant Prostate Cancer in Men Without Prior Biopsy: a Study Protocol
  BMJ Open. Oct, 2017  |   Pubmed ID: 29025845
• Apparatus for Histological Validation of and Magnetic Resonance Imaging of the Human Prostate
  Frontiers in Oncology. 2017  |   Pubmed ID: 28393049
• Spectrum of Metastatic and Nonmetastatic Skeletal Findings with Dual-phase 18F-FECH PET/CT in Patients with Biochemical Relapse of Prostate Cancer
  Nuclear Medicine Communications. May, 2017  |   Pubmed ID: 28379896
• The PICTURE Study: Diagnostic Accuracy of Multiparametric MRI in Men Requiring a Repeat Prostate Biopsy
  British Journal of Cancer. Apr, 2017  |   Pubmed ID: 28350785
• Port-Site Metastases After Robotic Radical Cystectomy: A Systematic Review and Management Options
  Clinical Genitourinary Cancer. 08, 2017  |   Pubmed ID: 28209455
• UroMark-a Urinary Biomarker Assay for the Detection of Bladder Cancer
  Clinical Epigenetics. 2017  |   Pubmed ID: 28163793
• Diagnostic Accuracy of Multi-parametric MRI and TRUS Biopsy in Prostate Cancer (PROMIS): a Paired Validating Confirmatory Study
  Lancet (London, England). 02, 2017  |   Pubmed ID: 28110982
• The Effect of Dutasteride on Magnetic Resonance Imaging Defined Prostate Cancer: MAPPED-A Randomized, Placebo Controlled, Double-Blind Clinical Trial
  The Journal of Urology. 04, 2017  |   Pubmed ID: 27871928
• Nanoknife Electroporation Ablation Trial: A Prospective Development Study Investigating Focal Irreversible Electroporation for Localized Prostate Cancer
  The Journal of Urology. 03, 2017  |   Pubmed ID: 27697580
• Prostate-specific Antigen Vs. Magnetic Resonance Imaging Parameters for Assessing Oncological Outcomes After High Intensity-focused Ultrasound Focal Therapy for Localized Prostate Cancer
  Urologic Oncology. 01, 2017  |   Pubmed ID: 27663393
• F-FECH PET/CT to Assess Clinically Significant Disease in Prostate Cancer: Correlation With Maximum and Total Cancer Core Length Obtained Via MRI-Guided Template Mapping Biopsies
  AJR. American Journal of Roentgenology. Dec, 2016  |   Pubmed ID: 27611962
• Does True Gleason Pattern 3 Merit Its Cancer Descriptor?
  Nature Reviews. Urology. 09, 2016  |   Pubmed ID: 27530265
• CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma
  Cancer Research. 08, 2016  |   Pubmed ID: 27325650
• What Burden of Prostate Cancer Can Radiologists Rule Out on Multiparametric Magnetic Resonance Imaging? A Sensitivity Analysis Based on Varying the Target Condition in Template Prostate Mapping Biopsies
  Urology. Sep, 2015  |   Pubmed ID: 26253041
• Visually Directed Vs. Software-based Targeted Biopsy Compared to Transperineal Template Mapping Biopsy in the Detection of Clinically Significant Prostate Cancer
  Urologic Oncology. Oct, 2015  |   Pubmed ID: 26195330
• Focal Ablation Targeted to the Index Lesion in Multifocal Localised Prostate Cancer: a Prospective Development Study
  European Urology. Dec, 2015  |   Pubmed ID: 25682339
• Zone-specific Logistic Regression Models Improve Classification of Prostate Cancer on Multi-parametric MRI
  European Radiology. Sep, 2015  |   Pubmed ID: 25680730
• An Unusual Swelling in the Male Perineum
  BMJ Case Reports. Jan, 2015  |   Pubmed ID: 25612751
• Epigenetics Markers of Metastasis and HPV-induced Tumorigenesis in Penile Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2015  |   Pubmed ID: 25538261
• Identifying the Index Lesion with Template Prostate Mapping Biopsies
  The Journal of Urology. Apr, 2015  |   Pubmed ID: 25463987
• Microstructural Characterization of Normal and Malignant Human Prostate Tissue with Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours Magnetic Resonance Imaging
  Investigative Radiology. Apr, 2015  |   Pubmed ID: 25426656
• Logistic Regression Model for Diagnosis of Transition Zone Prostate Cancer on Multi-parametric MRI
  European Radiology. Feb, 2015  |   Pubmed ID: 25226842
• Loss of Expression of the Tumour Suppressor Gene AIMP3 Predicts Survival Following Radiotherapy in Muscle-invasive Bladder Cancer
  International Journal of Cancer. Journal International Du Cancer. Feb, 2015  |   Pubmed ID: 24917520
• A Prospective Development Study Investigating Focal Irreversible Electroporation in Men with Localised Prostate Cancer: Nanoknife Electroporation Ablation Trial (NEAT)
  Contemporary Clinical Trials. Sep, 2014  |   Pubmed ID: 25072507
• Gonadotrophin-independent Precocious Puberty Associated with Later Diagnosis of Testicular Embryonal Carcinoma
  Hormone Research in Paediatrics. 2014  |   Pubmed ID: 25012595
• Can Multiparametric Magnetic Resonance Imaging Predict Upgrading of Transrectal Ultrasound Biopsy Results at More Definitive Histology?
  Urologic Oncology. Aug, 2014  |   Pubmed ID: 24981993
• Changes in Mast Cell Number and Stem Cell Factor Expression in Human Skin After Radiotherapy for Breast Cancer
  Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. May, 2014  |   Pubmed ID: 24746564
• The PICTURE Study -- Prostate Imaging (multi-parametric MRI and Prostate HistoScanning™) Compared to Transperineal Ultrasound Guided Biopsy for Significant Prostate Cancer Risk Evaluation
  Contemporary Clinical Trials. Jan, 2014  |   Pubmed ID: 24291455
• Prostate Cancer Tumour Features on Template Prostate-mapping Biopsies: Implications for Focal Therapy
  European Urology. Jul, 2014  |   Pubmed ID: 24207133
• Performance of Multiparametric MRI in Men at Risk of Prostate Cancer Before the First Biopsy: a Paired Validating Cohort Study Using Template Prostate Mapping Biopsies As the Reference Standard
  Prostate Cancer and Prostatic Diseases. Mar, 2014  |   Pubmed ID: 24126797
• The Accuracy of Multiparametric MRI in Men with Negative Biopsy and Elevated PSA Level--can It Rule out Clinically Significant Prostate Cancer?
  Urologic Oncology. Jan, 2014  |   Pubmed ID: 24055430
• Prostate Cancer Risk Inflation As a Consequence of Image-targeted Biopsy of the Prostate: a Computer Simulation Study
  European Urology. Mar, 2014  |   Pubmed ID: 23312572
• Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-expression in Human Prostate Cancer Tissue
  PloS One. 2013  |   Pubmed ID: 24386364
• Prognostic Gleason Grade Grouping: Data Based on the Modified Gleason Scoring System
  BJU International. May, 2013  |   Pubmed ID: 23578229
• Evaluation of Retained Testes in Adolescent Girls and Women with Complete Androgen Insensitivity Syndrome
  Radiology. Jul, 2013  |   Pubmed ID: 23533290
• Genital Lichen Sclerosus/balanitis Xerotica Obliterans in Men with Penile Carcinoma: a Critical Analysis
  BJU International. May, 2013  |   Pubmed ID: 23356463
• Transperineal Magnetic Resonance Image Targeted Prostate Biopsy Versus Transperineal Template Prostate Biopsy in the Detection of Clinically Significant Prostate Cancer
  The Journal of Urology. Mar, 2013  |   Pubmed ID: 23063807
• Do Low-grade and Low-volume Prostate Cancers Bear the Hallmarks of Malignancy?
  The Lancet. Oncology. Nov, 2012  |   Pubmed ID: 23117005
• CD49f is an Efficient Marker of Monolayer- and Spheroid Colony-forming Cells of the Benign and Malignant Human Prostate
  PloS One. 2012  |   Pubmed ID: 23071686
• Focal Salvage Therapy for Localized Prostate Cancer Recurrence After External Beam Radiotherapy: a Pilot Study
  Cancer. Sep, 2012  |   Pubmed ID: 22907704
• Focal Therapy for Localised Unifocal and Multifocal Prostate Cancer: a Prospective Development Study
  The Lancet. Oncology. Jun, 2012  |   Pubmed ID: 22512844
• A Biopsy Simulation Study to Assess the Accuracy of Several Transrectal Ultrasonography (TRUS)-biopsy Strategies Compared with Template Prostate Mapping Biopsies in Patients Who Have Undergone Radical Prostatectomy
  BJU International. Sep, 2012  |   Pubmed ID: 22394583
• Whole-gland Salvage High-intensity Focused Ultrasound Therapy for Localized Prostate Cancer Recurrence After External Beam Radiation Therapy
  Cancer. Jun, 2012  |   Pubmed ID: 22071795
• Epithelioid Hemangioma of the Penis: Case Report and Review of Literature
  Journal of Medical Case Reports. Jun, 2011  |   Pubmed ID: 21718503
• Multi-parametric Magnetic Resonance Imaging to Rule-in and Rule-out Clinically Important Prostate Cancer in Men at Risk: a Cohort Study
  Urologia Internationalis. 2011  |   Pubmed ID: 21701136
• Characterizing Clinically Significant Prostate Cancer Using Template Prostate Mapping Biopsy
  The Journal of Urology. Aug, 2011  |   Pubmed ID: 21679984
• PCR-based Tissue Identification: the UCLH Experience
  Journal of Clinical Pathology. Oct, 2011  |   Pubmed ID: 21617171
• A Novel Role for Wnt/Ca2+ Signaling in Actin Cytoskeleton Remodeling and Cell Motility in Prostate Cancer
  PloS One. May, 2010  |   Pubmed ID: 20454608
• The Use of High-resolution Magnetic Resonance Imaging in the Management of Patients Presenting with Priapism
  BJU International. Dec, 2010  |   Pubmed ID: 20438564
• DNA Replication Licensing Factors and Aneuploidy Are Linked to Tumor Cell Cycle State and Clinical Outcome in Penile Carcinoma
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2009  |   Pubmed ID: 19920109
• Case Study: the Surgical Management of Angiokeratoma Resulting from Radiotherapy for Penile Cancer
  TheScientificWorldJournal. May, 2009  |   Pubmed ID: 19468654
• Is It Time to Consider a Role for MRI Before Prostate Biopsy?
  Nature Reviews. Clinical Oncology. Apr, 2009  |   Pubmed ID: 19333226
• Perineural and Lymphovascular Invasion on Prostatic Biopsy: Pathological Assessment and Significance
  Surgical Oncology. Sep, 2009  |   Pubmed ID: 19299122
• Utility of Tissue Microarrays for Profiling Prognostic Biomarkers in Clinically Localized Prostate Cancer: the Expression of BCL-2, E-cadherin, Ki-67 and P53 As Predictors of Biochemical Failure After Radical Prostatectomy with Nested Control for Clinical and Pathological Risk Factors
  Asian Journal of Andrology. Jan, 2009  |   Pubmed ID: 19050681
• Paraganglioma of the Spermatic Cord: Case Report and Review of the Literature
  TheScientificWorldJournal. Dec, 2008  |   Pubmed ID: 19112537
• The Feasibility and Safety of High-intensity Focused Ultrasound As Salvage Therapy for Recurrent Prostate Cancer Following External Beam Radiotherapy
  BJU International. Sep, 2008  |   Pubmed ID: 18564135
• Investigating the Effects of High-dose Phenylephrine in the Management of Prolonged Ischaemic Priapism
  The Journal of Sexual Medicine. Sep, 2008  |   Pubmed ID: 18466270
• MR Imaging of Prostate After Treatment with High-intensity Focused Ultrasound
  Radiology. Mar, 2008  |   Pubmed ID: 18223121
• Paraneoplastic Cushing's Syndrome in Prostate Cancer: a Difficult Management Problem
  BJU International. Feb, 2008  |   Pubmed ID: 18070179
• Allelic Imbalance at 13q14.2 Approximately Q14.3 in Localized Prostate Cancer is Associated with Early Biochemical Relapse
  Cancer Genetics and Cytogenetics. Dec, 2007  |   Pubmed ID: 18036398
• Plexin-B1 Mutations in Prostate Cancer
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2007  |   Pubmed ID: 18024597
• A Review of the Efficacy of Surgical Treatment for and Pathological Changes in Patients with Chronic Scrotal Pain
  BJU International. May, 2007  |   Pubmed ID: 17244279
• What Surgical Resection Margins Are Required to Achieve Oncological Control in Men with Primary Penile Cancer?
  BJU International. Nov, 2005  |   Pubmed ID: 16225525
• Radical Prostatectomy: Pathology Findings in 1001 Cases Compared with Other Major Series and over Time
  BJU International. Jan, 2005  |   Pubmed ID: 15638892
• Comparison of the Zones of the Human Prostate with the Seminal Vesicle: Morphology, Immunohistochemistry, and Cell Kinetics
  The Prostate. Feb, 2005  |   Pubmed ID: 15389778
• Differential Expression of CD44 During Human Prostate Epithelial Cell Differentiation
  The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Aug, 2004  |   Pubmed ID: 15258184
• Clinical Features of Patients Who Present with Metastatic Prostate Carcinoma and Serum Prostate-specific Antigen (PSA) Levels < 10 Ng/mL: the "PSA Negative" Patients
  Cancer. Dec, 2003  |   Pubmed ID: 14635070