Alexander L Klibanov

Publications

• Ultrasound Molecular Imaging of Cancer: Design and Formulation Strategies of Targeted Contrast Agents
  Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer. 2020  |   Pubmed ID: 32594391
• Targeted Ultrasound Contrast Imaging of Tumor Vasculature With Positively Charged Microbubbles
  Investigative Radiology. Jun, 2020  |   Pubmed ID: 32569011
• Augmentation of Brain Tumor Interstitial Flow Via Focused Ultrasound Promotes Brain-penetrating Nanoparticle Dispersion and Transfection
  Science Advances. May, 2020  |   Pubmed ID: 32494662
• Closed-loop Feedback Control of Microbubble Diameter from a Flow-focusing Microfluidic Device
  Biomicrofluidics. May, 2020  |   Pubmed ID: 32454925
• Sonoselective Transfection of Cerebral Vasculature Without Blood-brain Barrier Disruption
  Proceedings of the National Academy of Sciences of the United States of America. 03, 2020  |   Pubmed ID: 32123081
• Liposomal Delivery of PPARα/γ Dual Agonist Tesaglitazar in a Model of Obesity Enriches Macrophage Targeting and Limits Liver and Kidney Drug Effects
  Theranostics. 2020  |   Pubmed ID: 31903139
• Pulsed Ultrasound Attenuates the Hyperglycemic Exacerbation of Myocardial Ischemia-reperfusion Injury
  The Journal of Thoracic and Cardiovascular Surgery. Nov, 2019  |   Pubmed ID: 31839230
• Importance of Thorough Tissue and Cellular Level Characterization of Targeted Drugs in the Evaluation of Pharmacodynamic Effects
  PloS One. 2019  |   Pubmed ID: 31725756
• Monitoring Oxygenation Levels Deep in the Tumor Core: Noninvasive Imaging of Hypoxia, Now in Real-Time 3D
  Cancer Research. Sep, 2019  |   Pubmed ID: 31519775
• Validation of Normalized Singular Spectrum Area As a Classifier for Molecularly Targeted Microbubble Adherence
  Ultrasound in Medicine & Biology. 09, 2019  |   Pubmed ID: 31227262
• Correction: A Flow Focusing Microfluidic Device with an Integrated Coulter Particle Counter for Production, Counting and Size Characterization of Monodisperse Microbubbles
  Lab on a Chip. 05, 2019  |   Pubmed ID: 31026008
• Moving Toward Noninvasive, Focused Ultrasound Therapeutic Delivery of Drugs in the Brain: Prolonged Opening of Blood-Brain Barrier May Not Be Needed
  Radiology. May, 2019  |   Pubmed ID: 30917292
• Efficacy of Sonothrombolysis Using Microbubbles Produced by a Catheter-Based Microfluidic Device in a Rat Model of Ischemic Stroke
  Annals of Biomedical Engineering. Apr, 2019  |   Pubmed ID: 30689066
• Formation of Microbubbles for Targeted Ultrasound Contrast Imaging: Practical Translation Considerations
  Langmuir : the ACS Journal of Surfaces and Colloids. 08, 2019  |   Pubmed ID: 30509068
• Ultrasound Molecular Imaging for Differentiation of Benign and Malignant Tumors in Patients
  Quantitative Imaging in Medicine and Surgery. Dec, 2018  |   Pubmed ID: 30701161
• Changes in Cell Fate Determine the Regenerative and Functional Capacity of the Developing Kidney Before and After Release of Obstruction
  Clinical Science (London, England : 1979). 12, 2018  |   Pubmed ID: 30442812
• A Flow Focusing Microfluidic Device with an Integrated Coulter Particle Counter for Production, Counting and Size Characterization of Monodisperse Microbubbles
  Lab on a Chip. 08, 2018  |   Pubmed ID: 30070301
• Plectin-targeted Liposomes Enhance the Therapeutic Efficacy of a PARP Inhibitor in the Treatment of Ovarian Cancer
  Theranostics. 2018  |   Pubmed ID: 29774075
• Klf4 Has an Unexpected Protective Role in Perivascular Cells Within the Microvasculature
  American Journal of Physiology. Heart and Circulatory Physiology. 08, 2018  |   Pubmed ID: 29631369
• Targeting of Microbubbles: Contrast Agents for Ultrasound Molecular Imaging
  Journal of Drug Targeting. Jun - Jul, 2018  |   Pubmed ID: 29258335
• In Vitro Sonothrombolysis Enhancement by Transiently Stable Microbubbles Produced by a Flow-Focusing Microfluidic Device
  Annals of Biomedical Engineering. Feb, 2018  |   Pubmed ID: 29192346
• Muscle-derived Extracellular Superoxide Dismutase Inhibits Endothelial Activation and Protects Against Multiple Organ Dysfunction Syndrome in Mice
  Free Radical Biology & Medicine. 12, 2017  |   Pubmed ID: 28982599
• Evaluation of Pharmacokinetic and Pharmacodynamic Profiles of Liposomes for the Cell Type-specific Delivery of Small Molecule Drugs
  Nanomedicine : Nanotechnology, Biology, and Medicine. Nov, 2017  |   Pubmed ID: 28754465
• Focal Areas of Increased Lipid Concentration on the Coating of Microbubbles During Short Tone-burst Ultrasound Insonification
  PloS One. 2017  |   Pubmed ID: 28686673
• Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model
  Nano Letters. 06, 2017  |   Pubmed ID: 28511006
• Ultrasound Molecular Imaging of Inflammation in Mouse Abdominal Aorta
  Investigative Radiology. 09, 2017  |   Pubmed ID: 28430714
• Renal Collectrin Protects Against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II
  Journal of the American Society of Nephrology : JASN. Jun, 2017  |   Pubmed ID: 28062568
• The Use of Acoustic Radiation Force Decorrelation-Weighted Pulse Inversion for Enhanced Ultrasound Contrast Imaging
  Investigative Radiology. 02, 2017  |   Pubmed ID: 27495188
• Macrophages Redirect Phagocytosis by Non-professional Phagocytes and Influence Inflammation
  Nature. 11, 2016  |   Pubmed ID: 27820945
• Ultra-Low-Dose Ultrasound Molecular Imaging for the Detection of Angiogenesis in a Mouse Murine Tumor Model: How Little Can We See?
  Investigative Radiology. 12, 2016  |   Pubmed ID: 27654582
• Non-Invasive, Focal Disconnection of Brain Circuitry Using Magnetic Resonance-Guided Low-Intensity Focused Ultrasound to Deliver a Neurotoxin
  Ultrasound in Medicine & Biology. 09, 2016  |   Pubmed ID: 27260243
• Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2016  |   Pubmed ID: 26961944
• Targeted Gene Transfer to the Brain Via the Delivery of Brain-penetrating DNA Nanoparticles with Focused Ultrasound
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2016  |   Pubmed ID: 26732553
• Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic Imaging
  Bioconjugate Chemistry. Feb, 2016  |   Pubmed ID: 26603129
• Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles
  Advances in Experimental Medicine and Biology. 2016  |   Pubmed ID: 26486340
• Size Exclusion HPLC Detection of Small-Size Impurities As a Complementary Means for Quality Analysis of Extracellular Vesicles
  Journal of Circulating Biomarkers. Jan-Dec, 2015  |   Pubmed ID: 28936242
• Regulation of L-selectin-dependent Hydrodynamic Shear Thresholding by Leukocyte Deformability and Shear Dependent Bond Number
  Biorheology. 2015  |   Pubmed ID: 26600268
• Ultrasound in Radiology: From Anatomic, Functional, Molecular Imaging to Drug Delivery and Image-Guided Therapy
  Investigative Radiology. Sep, 2015  |   Pubmed ID: 26200224
• Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results
  Investigative Radiology. Nov, 2015  |   Pubmed ID: 26135018
• Development of Target-specific Liposomes for Delivering Small Molecule Drugs After Reperfused Myocardial Infarction
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2015  |   Pubmed ID: 26122651
• Therapy of Prostate Cancer Using a Novel Cancer Terminator Virus and a Small Molecule BH-3 Mimetic
  Oncotarget. May, 2015  |   Pubmed ID: 25926554
• Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli
  Immunity. Apr, 2015  |   Pubmed ID: 25902482
• Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles
  Annals of Biomedical Engineering. Nov, 2015  |   Pubmed ID: 25893508
• Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles
  Small (Weinheim an Der Bergstrasse, Germany). Jul, 2015  |   Pubmed ID: 25703465
• In Vivo Imaging of Microfluidic-produced Microbubbles
  Biomedical Microdevices. Feb, 2015  |   Pubmed ID: 25663444
• Ultrasound-based Measurement of Molecular Marker Concentration in Large Blood Vessels: a Feasibility Study
  Ultrasound in Medicine & Biology. Jan, 2015  |   Pubmed ID: 25308943
• The Local Effects of Ovarian Diathermy in an Ovine Model of Polycystic Ovary Syndrome
  PloS One. 2014  |   Pubmed ID: 25343339
• Localized in Vivo Model Drug Delivery with Intravascular Ultrasound and Microbubbles
  Ultrasound in Medicine & Biology. Oct, 2014  |   Pubmed ID: 25130449
• Non-invasive Delivery of Stealth, Brain-penetrating Nanoparticles Across the Blood-brain Barrier Using MRI-guided Focused Ultrasound
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2014  |   Pubmed ID: 24979210
• Imaging Flow Cytometry Elucidates Limitations of Microparticle Analysis by Conventional Flow Cytometry
  Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Sep, 2014  |   Pubmed ID: 24903900
• Nucleic Acid Delivery with Microbubbles and Ultrasound
  Advanced Drug Delivery Reviews. Jun, 2014  |   Pubmed ID: 24486388
• Binding Dynamics of Targeted Microbubbles in Response to Modulated Acoustic Radiation Force
  Physics in Medicine and Biology. Jan, 2014  |   Pubmed ID: 24374866
• Synthesis and Characterization of Transiently Stable Albumin-coated Microbubbles Via a Flow-focusing Microfluidic Device
  Ultrasound in Medicine & Biology. Feb, 2014  |   Pubmed ID: 24342914
• Shear Forces from Flow Are Responsible for a Distinct Statistical Signature of Adherent Microbubbles in Large Vessels
  Molecular Imaging. Sep, 2013  |   Pubmed ID: 23981785
• Ultrasound Contrast Materials in Cardiovascular Medicine: from Perfusion Assessment to Molecular Imaging
  Journal of Cardiovascular Translational Research. Oct, 2013  |   Pubmed ID: 23913363
• Ultrasound Prevents Renal Ischemia-reperfusion Injury by Stimulating the Splenic Cholinergic Anti-inflammatory Pathway
  Journal of the American Society of Nephrology : JASN. Sep, 2013  |   Pubmed ID: 23907510
• Phosphatidylserine Receptor BAI1 and Apoptotic Cells As New Promoters of Myoblast Fusion
  Nature. May, 2013  |   Pubmed ID: 23615608
• Ultrasound-based Molecular Imaging and Specific Gene Delivery to Mesenteric Vasculature by Endothelial Adhesion Molecule Targeted Microbubbles in a Mouse Model of Crohn's Disease
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2013  |   Pubmed ID: 23142578
• Ultrasound-mediated Vascular Gene Transfection by Cavitation of Endothelial-targeted Cationic Microbubbles
  JACC. Cardiovascular Imaging. Dec, 2012  |   Pubmed ID: 23236976
• Intravascular Ultrasound Catheter to Enhance Microbubble-based Drug Delivery Via Acoustic Radiation Force
  IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Oct, 2012  |   Pubmed ID: 23143566
• Microbubbles As Ultrasound Contrast Agents for Molecular Imaging: Preparation and Application
  AJR. American Journal of Roentgenology. Aug, 2012  |   Pubmed ID: 22826389
• Markedly Enhanced Skeletal Muscle Transfection Achieved by the Ultrasound-targeted Delivery of Non-viral Gene Nanocarriers with Microbubbles
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2012  |   Pubmed ID: 22800583
• Monocyte And/or Macrophage Infiltration of Heart After Myocardial Infarction: MR Imaging by Using T1-shortening Liposomes
  Radiology. Aug, 2012  |   Pubmed ID: 22723500
• Nanobody-coupled Microbubbles As Novel Molecular Tracer
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2012  |   Pubmed ID: 22197777
• Inhibitor of Differentiation-3 Mediates High Fat Diet-induced Visceral Fat Expansion
  Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2012  |   Pubmed ID: 22075252
• Focused Ultrasound-mediated Drug Delivery from Microbubbles Reduces Drug Dose Necessary for Therapeutic Effect on Neointima Formation--brief Report
  Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2011  |   Pubmed ID: 21960561
• Phagocytic Activity of Neuronal Progenitors Regulates Adult Neurogenesis
  Nature Cell Biology. Jul, 2011  |   Pubmed ID: 21804544
• Localized Ultrasound Enhances Delivery of Rapamycin from Microbubbles to Prevent Smooth Muscle Proliferation
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2011  |   Pubmed ID: 21549778
• Real-time Technique for Improving Molecular Imaging and Guiding Drug Delivery in Large Blood Vessels: in Vitro and Ex Vivo Results
  Molecular Imaging. Aug, 2011  |   Pubmed ID: 21521555
• Inhibition of Glioma Growth by Microbubble Activation in a Subcutaneous Model Using Low Duty Cycle Ultrasound Without Significant Heating
  Journal of Neurosurgery. Jun, 2011  |   Pubmed ID: 21214331
• An Ultrasound Contrast Agent Targeted to P-selectin Detects Activated Platelets at Supra-arterial Shear Flow Conditions
  Investigative Radiology. Oct, 2010  |   Pubmed ID: 20808239
• Analysis of in Vitro Transfection by Sonoporation Using Cationic and Neutral Microbubbles
  Ultrasound in Medicine & Biology. Nov, 2010  |   Pubmed ID: 20800945
• Targeted Gene Transfection from Microbubbles into Vascular Smooth Muscle Cells Using Focused, Ultrasound-mediated Delivery
  Ultrasound in Medicine & Biology. Sep, 2010  |   Pubmed ID: 20800174
• Ultrasound-triggered Release of Materials Entrapped in Microbubble-liposome Constructs: a Tool for Targeted Drug Delivery
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2010  |   Pubmed ID: 20691227
• Molecular Imaging of Atherosclerotic Plaques Targeted to Oxidized LDL Receptor LOX-1 by SPECT/CT and Magnetic Resonance
  Circulation. Cardiovascular Imaging. Jul, 2010  |   Pubmed ID: 20442371
• Focused in Vivo Delivery of Plasmid DNA to the Porcine Vascular Wall Via Intravascular Ultrasound Destruction of Microbubbles
  Journal of Vascular Research. 2010  |   Pubmed ID: 19923850
• Dual Frequency Method for Simultaneous Translation and Real-time Imaging of Ultrasound Contrast Agents Within Large Blood Vessels
  Ultrasound in Medicine & Biology. Dec, 2009  |   Pubmed ID: 19828229
• Muscle Contraction, but Not Insulin, Increases Microvascular Blood Volume in the Presence of Free Fatty Acid-induced Insulin Resistance
  Diabetes. Nov, 2009  |   Pubmed ID: 19675134
• Action at a Distance: Lengthening Adhesion Bonds with Poly(ethylene Glycol) Spacers Enhances Mechanically Stressed Affinity for Improved Vascular Targeting of Microparticles
  Langmuir : the ACS Journal of Surfaces and Colloids. Sep, 2009  |   Pubmed ID: 19621909
• Preparation of Targeted Microbubbles: Ultrasound Contrast Agents for Molecular Imaging
  Medical & Biological Engineering & Computing. Aug, 2009  |   Pubmed ID: 19517153
• Targeted Delivery of Nanoparticles Bearing Fibroblast Growth Factor-2 by Ultrasonic Microbubble Destruction for Therapeutic Arteriogenesis
  Small (Weinheim an Der Bergstrasse, Germany). Oct, 2008  |   Pubmed ID: 18720443
• Microbubbles in Ultrasound-triggered Drug and Gene Delivery
  Advanced Drug Delivery Reviews. Jun, 2008  |   Pubmed ID: 18486268
• Acoustic Attenuation by Contrast Agent Microbubbles in Superficial Tissue Markedly Diminishes Petechiae Bioeffects in Deep Tissue
  Investigative Radiology. May, 2008  |   Pubmed ID: 18424953
• Ultrasonic Microbubble Destruction Stimulates Therapeutic Arteriogenesis Via the CD18-dependent Recruitment of Bone Marrow-derived Cells
  Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2008  |   Pubmed ID: 18403725
• Ultrasound Molecular Imaging with Targeted Microbubble Contrast Agents
  Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology. Nov-Dec, 2007  |   Pubmed ID: 18022115
• BAI1 is an Engulfment Receptor for Apoptotic Cells Upstream of the ELMO/Dock180/Rac Module
  Nature. Nov, 2007  |   Pubmed ID: 17960134
• Enhanced Targeting of Ultrasound Contrast Agents Using Acoustic Radiation Force
  Ultrasound in Medicine & Biology. Jul, 2007  |   Pubmed ID: 17445966
• Microparticle Adhesive Dynamics and Rolling Mediated by Selectin-specific Antibodies Under Flow
  Biotechnology and Bioengineering. Feb, 2007  |   Pubmed ID: 16917925
• Targeted Ultrasound Contrast Agent for Molecular Imaging of Inflammation in High-shear Flow
  Contrast Media & Molecular Imaging. Nov-Dec, 2006  |   Pubmed ID: 17191766
• Effect of Microbubble Ligation to Cells on Ultrasound Signal Enhancement: Implications for Targeted Imaging
  Investigative Radiology. Oct, 2006  |   Pubmed ID: 16971795
• Deformable Gas-filled Microbubbles Targeted to P-selectin
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2006  |   Pubmed ID: 16887229
• 3D Perfusion Mapping in Post-infarct Mice Using Myocardial Contrast Echocardiography
  Ultrasound in Medicine & Biology. Jun, 2006  |   Pubmed ID: 16785003
• Microbubble Contrast Agents: Targeted Ultrasound Imaging and Ultrasound-assisted Drug-delivery Applications
  Investigative Radiology. Mar, 2006  |   Pubmed ID: 16481920
• Targeting Mucosal Addressin Cellular Adhesion Molecule (MAdCAM)-1 to Noninvasively Image Experimental Crohn's Disease
  Gastroenterology. Jan, 2006  |   Pubmed ID: 16401463
• Ultrasound-microbubble-induced Neovascularization in Mouse Skeletal Muscle
  Ultrasound in Medicine & Biology. Oct, 2005  |   Pubmed ID: 16223645
• Assessment of Endogenous and Therapeutic Arteriogenesis by Contrast Ultrasound Molecular Imaging of Integrin Expression
  Circulation. Jun, 2005  |   Pubmed ID: 15956135
• Simultaneous Integrin Alphavbeta3 and Glycoprotein IIb/IIIa Inhibition Causes Reduction in Infarct Size in a Model of Acute Coronary Thrombosis and Primary Angioplasty
  Cardiovascular Research. Jun, 2005  |   Pubmed ID: 15914120
• Acoustic Radiation Force Enhances Targeted Delivery of Ultrasound Contrast Microbubbles: in Vitro Verification
  IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Mar, 2005  |   Pubmed ID: 15857050
• Ligand-carrying Gas-filled Microbubbles: Ultrasound Contrast Agents for Targeted Molecular Imaging
  Bioconjugate Chemistry. Jan-Feb, 2005  |   Pubmed ID: 15656569
• Molecular Imaging with Targeted Ultrasound Contrast Microbubbles
  Ernst Schering Research Foundation Workshop. 2005  |   Pubmed ID: 15524217
• Microvascular Recruitment is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake in Vivo
  Diabetes. Jun, 2004  |   Pubmed ID: 15161743
• Binding and Detachment Dynamics of Microbubbles Targeted to P-selectin Under Controlled Shear Flow
  Journal of Controlled Release : Official Journal of the Controlled Release Society. May, 2004  |   Pubmed ID: 15120903
• Detection of Individual Microbubbles of Ultrasound Contrast Agents: Imaging of Free-floating and Targeted Bubbles
  Investigative Radiology. Mar, 2004  |   Pubmed ID: 15076011
• Targeted Tissue Transfection with Ultrasound Destruction of Plasmid-bearing Cationic Microbubbles
  Ultrasound in Medicine & Biology. Dec, 2003  |   Pubmed ID: 14698343
• Imaging Tumor Angiogenesis with Contrast Ultrasound and Microbubbles Targeted to Alpha(v)beta3
  Circulation. Jul, 2003  |   Pubmed ID: 12835208
• Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to Alpha(v)-integrins
  Circulation. Jan, 2003  |   Pubmed ID: 12551871
• Detection of Individual Microbubbles of an Ultrasound Contrast Agent: Fundamental and Pulse Inversion Imaging
  Academic Radiology. Aug, 2002  |   Pubmed ID: 12188248
• Noninvasive Imaging of Myocardial Reperfusion Injury Using Leukocyte-targeted Contrast Echocardiography
  Circulation. Apr, 2002  |   Pubmed ID: 11956115