Alexander Quaas Institute of Pathology University Hospital Cologne Biography Publications Institution JoVE Articles Alexander Quaas has not added a biography. If you are Alexander Quaas and would like to personalize this page please email our Author Liaison for assistance. Publications Hemangiosis Carcinomatosa As an Independent Risk Factor for Long-term Survival in Non-Small Cell Lung Cancer Patients Surgical Oncology. Jun, 2022 | Pubmed ID: 35738083 Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice International Journal of Molecular Sciences. May, 2022 | Pubmed ID: 35628414 Influence of Patient Sex on Outcomes After Pancreatic Surgery: Multicentre Study The British Journal of Surgery. May, 2022 | Pubmed ID: 35574811 Fructose-1,6-bisphosphatase 1 (FBP1) is an Independent Biomarker Associated with a Favorable Prognosis in Esophageal Adenocarcinoma Journal of Cancer Research and Clinical Oncology. Apr, 2022 | Pubmed ID: 35477823 COVID-19 Infection Induce MiR-371a-3p Upregulation Resulting in Influence on Male Fertility Biomedicines. Apr, 2022 | Pubmed ID: 35453608 Long-Term Outcome After Histopathological Complete Response with and Without Nodal Metastases Following Multimodal Treatment of Esophageal Cancer Annals of Surgical Oncology. Apr, 2022 | Pubmed ID: 35403919 Organ Manifestations of COVID-19: What Have We Learned So Far (not Only) from Autopsies? Virchows Archiv : an International Journal of Pathology. Apr, 2022 | Pubmed ID: 35364700 International Tumor Budding Consensus Conference Criteria Determine the Prognosis of Oesophageal Adenocarcinoma with Poor Response to Neoadjuvant Treatment Pathology, Research and Practice. Apr, 2022 | Pubmed ID: 35316631 Expression of Neighbor of Punc E11 (NOPE) in Early Stage Esophageal Adenocarcinoma is Associated with Reduced Survival Scientific Reports. 03, 2022 | Pubmed ID: 35246597 Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures As Correlates of Impaired Cancer Immunosurveillance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 04, 2022 | Pubmed ID: 35191474 Deep Learning Based on Hematoxylin-eosin Staining Outperforms Immunohistochemistry in Predicting Molecular Subtypes of Gastric Adenocarcinoma The Journal of Pathology. 06, 2022 | Pubmed ID: 35119111 Placental Growth Factor Promotes Tumour Desmoplasia and Treatment Resistance in Intrahepatic Cholangiocarcinoma Gut. 01, 2022 | Pubmed ID: 33431577 Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, Turkey Pathogens (Basel, Switzerland). Nov, 2021 | Pubmed ID: 34959488 IL-17B/RB Activation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Metabolism and Growth Cancers. Oct, 2021 | Pubmed ID: 34771503 A Novel Hybrid Stent with Endoscopic Vacuum Therapy for Treating Leaks of the Upper Gastrointestinal Tract Visceral Medicine. Oct, 2021 | Pubmed ID: 34722723 MAPK-pathway Inhibition Mediates Inflammatory Reprogramming and Sensitizes Tumors to Targeted Activation of Innate Immunity Sensor RIG-I Nature Communications. 09, 2021 | Pubmed ID: 34535668 Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma Cancers. Aug, 2021 | Pubmed ID: 34503107 Development and Validation of Deep Learning Classifiers to Detect Epstein-Barr Virus and Microsatellite Instability Status in Gastric Cancer: a Retrospective Multicentre Cohort Study The Lancet. Digital Health. 10, 2021 | Pubmed ID: 34417147 Occurrence of High Microsatellite-Instability/Mismatch Repair Deficiency in Nearly 2,000 Human Adenocarcinomas of the Gastrointestinal Tract, Pancreas, and Bile Ducts: A Study From a Large German Comprehensive Cancer Center Frontiers in Oncology. 2021 | Pubmed ID: 34367937 Quality Control Stress Test for Deep Learning-based Diagnostic Model in Digital Pathology Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. 12, 2021 | Pubmed ID: 34168282 First Description of Hematogenously Metastasized Sclerosing Epithelioid Fibrosarcoma Arising in the Uterine Cervix Gynecologic Oncology Reports. Aug, 2021 | Pubmed ID: 34159243 CD86 Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses Cancer Immunology Research. 09, 2021 | Pubmed ID: 34155067 Cancer-specific Immune Evasion and Substantial Heterogeneity Within Cancer Types Provide Evidence for Personalized Immunotherapy NPJ Precision Oncology. Jun, 2021 | Pubmed ID: 34135436 Maternal Exercise Mediates Hepatic Metabolic Programming Via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers Cells. 05, 2021 | Pubmed ID: 34069390 Sex-specific Prognostic Effect of CD66b-positive Tumor-infiltrating Neutrophils (TANs) in Gastric and Esophageal Adenocarcinoma Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 11, 2021 | Pubmed ID: 34009535 Optimized PD-L1 Scoring of Gastric Cancer Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 09, 2021 | Pubmed ID: 33954872 Trophoblast Cell Surface Antigen 2 (Trop-2) Protein is Highly Expressed in Salivary Gland Carcinomas and Represents a Potential Therapeutic Target Head and Neck Pathology. Dec, 2021 | Pubmed ID: 33886073 Protein-loss of SWI/SNF-complex Core Subunits Influences Prognosis Dependent on Histological Subtypes of Intra- and Extrahepatic Cholangiocarcinoma Oncology Letters. May, 2021 | Pubmed ID: 33747206 Tumor Infiltrating Lymphocyte Clusters Are Associated with Response to Immune Checkpoint Inhibition in BRAF V600 Mutated Malignant Melanomas Scientific Reports. 01, 2021 | Pubmed ID: 33469107 Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 02, 2021 | Pubmed ID: 33262137 Microwave Ablation Enhances Tumor-specific Immune Response in Patients with Hepatocellular Carcinoma Cancer Immunology, Immunotherapy : CII. Apr, 2021 | Pubmed ID: 33006650 Tumor Budding Assessed According to the Criteria of the International Tumor Budding Consensus Conference Determines Prognosis in Resected Esophageal Adenocarcinoma Virchows Archiv : an International Journal of Pathology. Mar, 2021 | Pubmed ID: 32761393 LAG-3, TIM-3 and VISTA Expression on Tumor-Infiltrating Lymphocytes in Oropharyngeal Squamous Cell Carcinoma-Potential Biomarkers for Targeted Therapy Concepts International Journal of Molecular Sciences. Dec, 2020 | Pubmed ID: 33396515 Deep Learning for Sensitive Detection of Helicobacter Pylori in Gastric Biopsies BMC Gastroenterology. Dec, 2020 | Pubmed ID: 33308189 GATA Binding Protein 6 (GATA6) is Co-amplified with PIK3CA in Patients with Esophageal Adenocarcinoma and is Linked to Neoadjuvant Therapy Journal of Cancer Research and Clinical Oncology. Dec, 2020 | Pubmed ID: 33300112 Regorafenib Combined with PD1 Blockade Increases CD8 T-cell Infiltration by Inducing CXCL10 Expression in Hepatocellular Carcinoma Journal for Immunotherapy of Cancer. 11, 2020 | Pubmed ID: 33234602 Interferon-Induced Protein With Multiple Tetratricopeptide Repeats 3 Is Associated With Response to Chemotherapy and Recurrence but Not With Survival Pancreas. Nov/Dec, 2020 | Pubmed ID: 33122518 ATP Synthase Modulation Leads to an Increase of Spare Respiratory Capacity in HPV Associated Cancers Scientific Reports. 10, 2020 | Pubmed ID: 33060693 Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma Journal of Immunology Research. 2020 | Pubmed ID: 33029538 Maternal Exercise Conveys Protection Against NAFLD in the Offspring Via Hepatic Metabolic Programming Scientific Reports. 09, 2020 | Pubmed ID: 32963289 Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 11, 2020 | Pubmed ID: 32817080 PD-L1 Expression and a High Tumor Infiltrate of CD8+ Lymphocytes Predict Outcome in Patients with Oropharyngeal Squamous Cells Carcinoma International Journal of Molecular Sciences. Jul, 2020 | Pubmed ID: 32718057 Y Chromosome Loss is a Frequent Event in Barrett's Adenocarcinoma and Associated with Poor Outcome Cancers. Jun, 2020 | Pubmed ID: 32629877 Amplification of KRAS and Its Heterogeneity in Non-Asian Gastric Adenocarcinomas BMC Cancer. Jun, 2020 | Pubmed ID: 32571252 Cell Type-specific Transcriptomics of Esophageal Adenocarcinoma As a Scalable Alternative for Single Cell Transcriptomics Molecular Oncology. 06, 2020 | Pubmed ID: 32255255 Immune Profile and Immunosurveillance in Treatment-naive and Neoadjuvantly Treated Esophageal Adenocarcinoma Cancer Immunology, Immunotherapy : CII. Apr, 2020 | Pubmed ID: 31960110 Diagnostic Challenges and Treatment Options for Cutaneous T Cell Pseudolymphoma: A Case Study with Rituximab Treatment The American Journal of Case Reports. Jan, 2020 | Pubmed ID: 31919337 PIK3CA and KRAS Amplification In Esophageal Adenocarcinoma and Their Impact on the Inflammatory Tumor Microenvironment and Prognosis Translational Oncology. Feb, 2020 | Pubmed ID: 31865178 First Report on Two Cases of Pleomorphic Dermal Sarcoma Successfully Treated with Immune Checkpoint Inhibitors Oncoimmunology. 2019 | Pubmed ID: 31741767 Upregulation of MiR-17-92 Cluster is Associated with Progression and Lymph Node Metastasis in Oesophageal Adenocarcinoma Scientific Reports. 08, 2019 | Pubmed ID: 31431687 Immune-phenotyping of Pleomorphic Dermal Sarcomas Suggests This Entity As a Potential Candidate for Immunotherapy Cancer Immunology, Immunotherapy : CII. Jun, 2019 | Pubmed ID: 30963193 Successful Use of TNFα Blockade in a Severe Case of Idiopathic Non-granulomatous Ulcerative Jejunoileitis Associated with Thrombotic Thrombocytopenic Purpura BMJ Open Gastroenterology. 2019 | Pubmed ID: 30899536 P53 Overexpression is a Prognosticator of Poor Outcome in Esophageal Cancer Oncology Letters. Apr, 2019 | Pubmed ID: 30881503 Tumor-associated B Cells and Humoral Immune Response in Head and Neck Squamous Cell Carcinoma Oncoimmunology. 2019 | Pubmed ID: 30723574 Alterations in ERBB2 and BRCA and Microsatellite Instability As New Personalized Treatment Options in Small Bowel Carcinoma BMC Gastroenterology. Feb, 2019 | Pubmed ID: 30717682 HER2/neu (ERBB2) Expression and Gene Amplification Correlates with Better Survival in Esophageal Adenocarcinoma BMC Cancer. Jan, 2019 | Pubmed ID: 30621632 Genomic Characterization of TP53-Wild-Type Esophageal Carcinoma Translational Oncology. Jan, 2019 | Pubmed ID: 30317074 Somatic Alterations in Circulating Cell-free DNA of Oesophageal Carcinoma Patients During Primary Staging Are Indicative for Post-surgical Tumour Recurrence Scientific Reports. 10, 2018 | Pubmed ID: 30297788 Immunohistochemical Expression of Melanocytic and Myofibroblastic Markers and Their Molecular Correlation in Atypical Fibroxanthomas and Pleomorphic Dermal Sarcomas Journal of Cutaneous Pathology. Dec, 2018 | Pubmed ID: 30155964 Therapy Susceptible Germline-related BRCA 1-mutation in a Case of Metastasized Mixed Adeno-neuroendocrine Carcinoma (MANEC) of the Small Bowel BMC Gastroenterology. May, 2018 | Pubmed ID: 29855275 Gene Amplification is a Rare Event in Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma Oncotarget. Apr, 2018 | Pubmed ID: 29765529 Low SOX2 Expression Marks a Distinct Subset of Adenoid Cystic Carcinoma of the Head and Neck and is Associated with an Advanced Tumor Stage PloS One. 2018 | Pubmed ID: 29596469 Copy Number Variations in Atypical Fibroxanthomas and Pleomorphic Dermal Sarcomas Oncotarget. Dec, 2017 | Pubmed ID: 29312620 New Concepts of Personalized Therapy in Salivary Gland Carcinomas Oral Oncology. 05, 2017 | Pubmed ID: 28325631 MDM2 and CDK4 Amplifications Are Rare Events in Salivary Duct Carcinomas Oncotarget. Nov, 2016 | Pubmed ID: 27662657 Oncogene and Therapeutic Target Analyses in Atypical Fibroxanthomas and Pleomorphic Dermal Sarcomas Oncotarget. Apr, 2016 | Pubmed ID: 26943575 Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion Ningbo Fan*1, Lisa Raatz*1, Seung-Hun Chon1, Alexander Quaas2, Christiane Bruns1, Yue Zhao1 1Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 2Institute of Pathology, University Hospital Cologne JoVE 63281 Cancer Research
Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion Ningbo Fan*1, Lisa Raatz*1, Seung-Hun Chon1, Alexander Quaas2, Christiane Bruns1, Yue Zhao1 1Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 2Institute of Pathology, University Hospital Cologne JoVE 63281 Cancer Research