Alexei Protopopov

Publications

• Co-clinical Assessment Identifies Patterns of BRAF Inhibitor Resistance in Melanoma
  The Journal of Clinical Investigation. Apr, 2015  |   Pubmed ID: 25705882
• Identification of a Novel Fusion Gene, IRF2BP2-RARA, in Acute Promyelocytic Leukemia
  Journal of the National Comprehensive Cancer Network : JNCCN. Jan, 2015  |   Pubmed ID: 25583766
• Telomere Dysfunction Suppresses Multiple Endocrine Neoplasia in Mice
  Genes & Cancer. Sep, 2014  |   Pubmed ID: 25352948
• Characterization of HPV and Host Genome Interactions in Primary Head and Neck Cancers
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014  |   Pubmed ID: 25313082
• Intratumor Heterogeneity in Localized Lung Adenocarcinomas Delineated by Multiregion Sequencing
  Science (New York, N.Y.). Oct, 2014  |   Pubmed ID: 25301631
• Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer
  Cell. Jul, 2014  |   Pubmed ID: 24954535
• Recurrent PTPRB and PLCG1 Mutations in Angiosarcoma
  Nature Genetics. Apr, 2014  |   Pubmed ID: 24633157
• Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and P53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer
  The Journal of Biological Chemistry. Feb, 2014  |   Pubmed ID: 24398677
• Role of Telomere Dysfunction in Cardiac Failure in Duchenne Muscular Dystrophy
  Nature Cell Biology. Aug, 2013  |   Pubmed ID: 23831727
• ZNF365 Promotes Stability of Fragile * Sites and Telomeres
  Cancer Discovery. Jun, 2013  |   Pubmed ID: 23776040
• Diverse Mechanisms of Somatic Structural Variations in Human Cancer Genomes
  Cell. May, 2013  |   Pubmed ID: 23663786
• TRIM13 (RFP2) Downregulation Decreases Tumour Cell Growth in Multiple Myeloma Through Inhibition of NF Kappa B Pathway and Proteasome Activity
  British Journal of Haematology. Jul, 2013  |   Pubmed ID: 23647456
• Quantitative Imaging of Haematopoietic Stem and Progenitor Cell Localization and Hypoxic Status in the Bone Marrow Microenvironment
  Nature Cell Biology. May, 2013  |   Pubmed ID: 23624405
• Spectrum of Somatic Mitochondrial Mutations in Five Cancers
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012  |   Pubmed ID: 22891333
• Melanoma Genome Sequencing Reveals Frequent PREX2 Mutations
  Nature. May, 2012  |   Pubmed ID: 22622578
• Telomerase Reactivation Following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases
  Cell. Mar, 2012  |   Pubmed ID: 22341455
• Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer
  Cell. Feb, 2012  |   Pubmed ID: 22341440
• DNA Breaks and Chromosome Pulverization from Errors in Mitosis
  Nature. Feb, 2012  |   Pubmed ID: 22258507
• Genes with a Spike Expression Are Clustered in Chromosome (sub)bands and Spike (sub)bands Have a Powerful Prognostic Value in Patients with Multiple Myeloma
  Haematologica. Apr, 2012  |   Pubmed ID: 22102711
• Altered Antisense-to-sense Transcript Ratios in Breast Cancer
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012  |   Pubmed ID: 21098291
• PTEN is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB-cytokine Network
  Cancer Discovery. Jul, 2011  |   Pubmed ID: 21984975
• The BCL11B Tumor Suppressor is Mutated Across the Major Molecular Subtypes of T-cell Acute Lymphoblastic Leukemia
  Blood. Oct, 2011  |   Pubmed ID: 21878675
• Telomere Dysfunction Induces Metabolic and Mitochondrial Compromise
  Nature. Feb, 2011  |   Pubmed ID: 21307849
• Telomerase Reactivation Reverses Tissue Degeneration in Aged Telomerase-deficient Mice
  Nature. Jan, 2011  |   Pubmed ID: 21113150
• Glioma Oncoprotein Bcl2L12 Inhibits the P53 Tumor Suppressor
  Genes & Development. Oct, 2010  |   Pubmed ID: 20837658
• Absence of Biallelic TCRgamma Deletion Predicts Early Treatment Failure in Pediatric T-cell Acute Lymphoblastic Leukemia
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Aug, 2010  |   Pubmed ID: 20644084
• Inactivation of LEF1 in T-cell Acute Lymphoblastic Leukemia
  Blood. Apr, 2010  |   Pubmed ID: 20124220
• FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis
  Cell Stem Cell. Nov, 2009  |   Pubmed ID: 19896444
• GOLPH3 调节 MTOR 信号和雷帕霉素敏感性的癌症。
  Nature. Jun, 2009  |   Pubmed ID: 19553991
• High Mutability of the Tumor Suppressor Genes RASSF1 and RBSP3 (CTDSPL) in Cancer
  PloS One. 2009  |   Pubmed ID: 19478941
• High Frequency of PTEN, PI3K, and AKT Abnormalities in T-cell Acute Lymphoblastic Leukemia
  Blood. Jul, 2009  |   Pubmed ID: 19458356
• Biologic Sequelae of I{kappa}B Kinase (IKK) Inhibition in Multiple Myeloma: Therapeutic Implications
  Blood. May, 2009  |   Pubmed ID: 19270264
• Genomic Alterations Link Rho Family of GTPases to the Highly Invasive Phenotype of Pancreas Cancer
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008  |   Pubmed ID: 19050074
• Oncogenesis of T-ALL and Nonmalignant Consequences of Overexpressing Intracellular NOTCH1
  The Journal of Experimental Medicine. Nov, 2008  |   Pubmed ID: 18981238
• Bcl2L12-mediated Inhibition of Effector Caspase-3 and Caspase-7 Via Distinct Mechanisms in Glioblastoma
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008  |   Pubmed ID: 18669646
• Feedback Circuit Among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
  Cancer Cell. Apr, 2008  |   Pubmed ID: 18394558
• Full Complexity Genomic Hybridization on 60-mer Oligonucleotide Microarrays for Array Comparative Genomic Hybridization (aCGH)
  Methods in Molecular Biology (Clifton, N.J.). 2008  |   Pubmed ID: 18370097
• Telomere Dysfunction Promotes Genome Instability and Metastatic Potential in a K-ras P53 Mouse Model of Lung Cancer
  Carcinogenesis. Apr, 2008  |   Pubmed ID: 18283039
• Common and Distinct Genomic Events in Sporadic Colorectal Cancer and Diverse Cancer Types
  Cancer Research. Nov, 2007  |   Pubmed ID: 18006816
• A Comparison of DNA Copy Number Profiling Platforms
  Cancer Research. Nov, 2007  |   Pubmed ID: 17968032
• Chromosomally Unstable Mouse Tumours Have Genomic Alterations Similar to Diverse Human Cancers
  Nature. Jun, 2007  |   Pubmed ID: 17515920
• The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis
  Cancer Cell. Apr, 2007  |   Pubmed ID: 17418411
• Epidermal Growth Factor Receptor Variant III Mutations in Lung Tumorigenesis and Sensitivity to Tyrosine Kinase Inhibitors
  Proceedings of the National Academy of Sciences of the United States of America. May, 2006  |   Pubmed ID: 16672372
• High-resolution Genomic Profiles Define Distinct Clinico-pathogenetic Subgroups of Multiple Myeloma Patients
  Cancer Cell. Apr, 2006  |   Pubmed ID: 16616336
• Block of T Cell Development in P53-deficient Mice Accelerates Development of Lymphomas with Characteristic RAG-dependent Cytogenetic Alterations
  Cancer Cell. Feb, 2006  |   Pubmed ID: 16473278
• Epigenetic Transdifferentiation of Normal Melanocytes by a Metastatic Melanoma Microenvironment
  Cancer Research. Nov, 2005  |   Pubmed ID: 16288000
• HUNC-93B1, a Novel Gene Mainly Expressed in the Heart, is Related to Left Ventricular Diastolic Function, Heart Failure Morbidity and Mortality in Elderly Men
  European Journal of Heart Failure. Oct, 2005  |   Pubmed ID: 16111919
• Telomerase Inhibition by SiRNA Causes Senescence and Apoptosis in Barrett's Adenocarcinoma Cells: Mechanism and Therapeutic Potential
  Molecular Cancer. 2005  |   Pubmed ID: 16022731
• High-resolution Genomic Profiles of Human Lung Cancer
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005  |   Pubmed ID: 15983384
• High-resolution Global Profiling of Genomic Alterations with Long Oligonucleotide Microarray
  Cancer Research. Jul, 2004  |   Pubmed ID: 15256441
• MSin3-associated Protein, MSds3, is Essential for Pericentric Heterochromatin Formation and Chromosome Segregation in Mammalian Cells
  Genes & Development. Oct, 2003  |   Pubmed ID: 14522945
• Restriction Site Tagged (RST) Microarrays: a Novel Technique to Study the Species Composition of Complex Microbial Systems
  Nucleic Acids Research. Aug, 2003  |   Pubmed ID: 12907747
• Deletion Mapping Using Quantitative Real-time PCR Identifies Two Distinct 3p21.3 Regions Affected in Most Cervical Carcinomas
  Oncogene. May, 2003  |   Pubmed ID: 12771950
• An Integrated Physical and Gene Map of the 3.5-Mb Chromosome 3p21.3 (AP20) Region Implicated in Major Human Epithelial Malignancies
  Cancer Research. Jan, 2003  |   Pubmed ID: 12543795
• NotI Subtraction and NotI-specific Microarrays to Detect Copy Number and Methylation Changes in Whole Genomes
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002  |   Pubmed ID: 12149436
• NotI Flanking Sequences: a Tool for Gene Discovery and Verification of the Human Genome
  Nucleic Acids Research. Jul, 2002  |   Pubmed ID: 12136098
• Human Cell Lines Engineered for Tetracycline-regulated Expression of Tumor Suppressor Candidate Genes from a Frequently Affected Chromosomal Region, 3p21
  The Journal of Gene Medicine. Jul-Aug, 2002  |   Pubmed ID: 12124982
• The RASSF1A Tumor Suppressor Gene is Inactivated in Prostate Tumors and Suppresses Growth of Prostate Carcinoma Cells
  Cancer Research. Jun, 2002  |   Pubmed ID: 12067994
• HUNC93B1: a Novel Human Gene Representing a New Gene Family and Encoding an Unc-93-like Protein
  Gene. Jan, 2002  |   Pubmed ID: 11867227
• A New Approach to Genome Mapping and Sequencing: Slalom Libraries
  Nucleic Acids Research. Jan, 2002  |   Pubmed ID: 11788732