Amanke Oranu

Division of Gastroenterology

Perelman School of Medicine, University of Pennsylvania

Amanke Oranu

Amanke Oranu is an assistant professor at State University of New York upstate and an attending physician at Binghamton Hospital and Wilson general hospital, in New York. He completed his medical education in University of Nigeria 2003 after which he moved to the united states where he was the best graduating internal medicine resident from Meharry Medical College in Nashville Tennessee in 2010.

Dr. Oranu did his post-doctoral fellowship under the guardianship of Dr. Ukomadu at Brigham and Women’s Hospital and Harvard Medical school, in Boston Massachusetts from 2010 to 2014 where he focused on liver regeneration and liver cancer. His lab initially showed that phosphorylation of Ubiquitin-like, containing PHD and RING finger domains 1 (UHRF1) is key to liver development and regeneration. He was a recipient of the minority supplementary award from the National Institute of Diabetes and Digestive and Kidney in 2011. His distinction award poster at the Digestive Disease Week using cellular models. He showed that in the presence of UHRF1 mutation, the cellular regulated mechanisms like phosphorylation are impaired which affects the stability of the UHRF1 protein, subcellular localization of UHRF1, and its interaction with other proteins.

Dr. Oranu completed is Gastroenterology research fellowship at the Perelman School of Medicine, the Hospital of University of Pennsylvania, in 2017 under the stewardship of Dr. Rotonya Carr. His focus was on the effects of alcohol on VL 17A cell lines and mice models. This led to better understanding and characterization of various ceramides, ceramide synthase and perfecting lipid droplet isolation.


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