Ana M. Sebastião Instituto de Farmacologia e Neurociências Faculdade de Medicina da Universidade de Lisboa Biography Publications Institution JoVE Articles Ana M. Sebastião has not added a biography. If you are Ana M. Sebastião and would like to personalize this page please email our Author Liaison for assistance. Publications Caffeine Has a Dual Influence on NMDA Receptor-mediated Glutamatergic Transmission at the Hippocampus Purinergic Signalling. 12, 2020 | Pubmed ID: 33025424 Impairment of Adenosinergic System in Rett Syndrome: Novel Therapeutic Target to Boost BDNF Signalling Neurobiology of Disease. 11, 2020 | Pubmed ID: 32798727 Brain-Sparing Sympathofacilitators Mitigate Obesity Without Adverse Cardiovascular Effects Cell Metabolism. May, 2020 | Pubmed ID: 32402266 Going the Extra (Synaptic) Mile: Excitotoxicity As the Road Toward Neurodegenerative Diseases Frontiers in Cellular Neuroscience. 2020 | Pubmed ID: 32390802 Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome Neuroscience. Jun, 2019 | Pubmed ID: 31229630 Memory Deficits Induced by Chronic Cannabinoid Exposure Are Prevented by Adenosine AR Receptor Antagonism Neuropharmacology. 09, 2019 | Pubmed ID: 31103616 Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology Molecules (Basel, Switzerland). Apr, 2019 | Pubmed ID: 30959794 TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins Frontiers in Molecular Neuroscience. 2019 | Pubmed ID: 30774582 On the Assembly of Microreactors with Parallel Enzymatic Pathways Advanced Biosystems. May, 2018 | Pubmed ID: 33103855 Depression Assessment in Clinical Trials and Pre-clinical Tests: A Critical Review Current Topics in Medicinal Chemistry. 2018 | Pubmed ID: 30430942 Anxiety Assessment in Pre-clinical Tests and in Clinical Trials: A Critical Review Current Topics in Medicinal Chemistry. 2018 | Pubmed ID: 30430939 Adenosine A Receptors Facilitate Synaptic NMDA Currents in CA1 Pyramidal Neurons British Journal of Pharmacology. 12, 2018 | Pubmed ID: 30220081 Ex Vivo Model of Epilepsy in Organotypic Slices-a New Tool for Drug Screening Journal of Neuroinflammation. Jul, 2018 | Pubmed ID: 29996878 Chronic, Intermittent Treatment with a Cannabinoid Receptor Agonist Impairs Recognition Memory and Brain Network Functional Connectivity Journal of Neurochemistry. 10, 2018 | Pubmed ID: 29989183 Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors Frontiers in Pharmacology. 2018 | Pubmed ID: 29713276 Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β Frontiers in Pharmacology. 2018 | Pubmed ID: 29695962 Platinum Nanoparticle-Based Microreactors As Support for Neuroblastoma Cells ACS Applied Materials & Interfaces. Mar, 2018 | Pubmed ID: 29083859 Erythropoietin Induces Homeostatic Plasticity at Hippocampal Synapses Cerebral Cortex (New York, N.Y. : 1991). 08, 2018 | Pubmed ID: 29053799 Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats Molecular Neurobiology. May, 2018 | Pubmed ID: 28534273 Neurogenesis in a Rat Model of Sporadic Alzheimer's Disease: Porto Biomedical Journal. Sep-Oct, 2017 | Pubmed ID: 32258683 Glycine Receptor Activation Impairs ATP-Induced Calcium Transients in Cultured Cortical Astrocytes Frontiers in Molecular Neuroscience. 2017 | Pubmed ID: 29386993 Dual Influence of Endocannabinoids on Long-Term Potentiation of Synaptic Transmission Frontiers in Pharmacology. 2017 | Pubmed ID: 29311928 VPAC and VPAC Receptor Activation on GABA Release from Hippocampal Nerve Terminals Involve Several Different Signalling Pathways British Journal of Pharmacology. Dec, 2017 | Pubmed ID: 28945273 Interaction Between Cannabinoid Type 1 and Type 2 Receptors in the Modulation of Subventricular Zone and Dentate Gyrus Neurogenesis Frontiers in Pharmacology. 2017 | Pubmed ID: 28848435 Chronic and Acute Adenosine A Receptor Blockade Prevents Long-term Episodic Memory Disruption Caused by Acute Cannabinoid CB Receptor Activation Neuropharmacology. 05, 2017 | Pubmed ID: 28235548 Enhanced LTP in Aged Rats: Detrimental or Compensatory? Neuropharmacology. 03, 2017 | Pubmed ID: 27889488 Hippocampal GABAergic Transmission: a New Target for Adenosine Control of Excitability Journal of Neurochemistry. 12, 2016 | Pubmed ID: 27778347 Adenosine A2A Receptors in Neuronal Outgrowth: a Target for Nerve Regeneration? Neural Regeneration Research. May, 2016 | Pubmed ID: 27335540 BDNF Modulates Glycine Uptake in Hippocampal Synaptosomes by Decreasing Membrane Insertion of Glycine Transporter 2 Neurochemistry International. 10, 2016 | Pubmed ID: 27296115 BDNF-induced Presynaptic Facilitation of GABAergic Transmission in the Hippocampus of Young Adults is Dependent of TrkB and Adenosine A2A Receptors Purinergic Signalling. 06, 2016 | Pubmed ID: 26897393 Purine Nucleosides in Neuroregeneration and Neuroprotection Neuropharmacology. 05, 2016 | Pubmed ID: 26577017 Axonal Elongation and Dendritic Branching is Enhanced by Adenosine A2A Receptors Activation in Cerebral Cortical Neurons Brain Structure & Function. 06, 2016 | Pubmed ID: 26068054 Adenosine A1 Receptor Suppresses Tonic GABAA Receptor Currents in Hippocampal Pyramidal Cells and in a Defined Subpopulation of Interneurons Cerebral Cortex (New York, N.Y. : 1991). Mar, 2016 | Pubmed ID: 25452570 Neural Commitment of Human Pluripotent Stem Cells Under Defined Conditions Recapitulates Neural Development and Generates Patient-specific Neural Cells Biotechnology Journal. Oct, 2015 | Pubmed ID: 26123315 The Giant Miniature Endplate Potentials Frequency is Increased in Aged Rats Neuroscience Letters. Jan, 2015 | Pubmed ID: 25449868 Neuromodulation and Metamodulation by Adenosine: Impact and Subtleties Upon Synaptic Plasticity Regulation Brain Research. Sep, 2015 | Pubmed ID: 25446444 MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins Molecular Neurobiology. 2015 | Pubmed ID: 24973144 Modeling the Functional Network of Primary Intercellular Ca2+ Wave Propagation in Astrocytes and Its Application to Study Drug Effects Journal of Theoretical Biology. Sep, 2014 | Pubmed ID: 24813072 Neuroprotection Afforded by Adenosine A2A Receptor Blockade is Modulated by Corticotrophin-releasing Factor (CRF) in Glutamate Injured Cortical Neurons Journal of Neurochemistry. Dec, 2012 | Pubmed ID: 23057965 Extracellular Alpha-synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-receptor Activation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2012 | Pubmed ID: 22915117 Brain-derived Neurotrophic Factor (BDNF) Enhances GABA Transport by Modulating the Trafficking of GABA Transporter-1 (GAT-1) from the Plasma Membrane of Rat Cortical Astrocytes The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21969376 Nitric Oxide Mediates Interactions Between GABAA Receptors and Adenosine A1 Receptors in the Rat Hippocampus European Journal of Pharmacology. Aug, 2006 | Pubmed ID: 16831416 Triggering of BDNF Facilitatory Action on Neuromuscular Transmission by Adenosine A2A Receptors Neuroscience Letters. Aug, 2006 | Pubmed ID: 16790314 A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures Cláudia A. Valente1,2, Francisco J. Meda*1,2, Mafalda Carvalho*1,2, Ana M. Sebastião1,2 1Instituto de Farmacologia e Neurociências, Faculdade de Medicina da Universidade de Lisboa, 2Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa JoVE 61330 Neuroscience Isolation and Expansion of Neurospheres from Postnatal (P1−3) Mouse Neurogenic Niches Rita Soares1,2,3, Filipa F. Ribeiro1,2, Diogo M. Lourenço1,2, Rui S. Rodrigues1,2, João B. Moreira1,2, Ana M. Sebastião1,2, Vanessa A. Morais1,3, Sara Xapelli1,2 1Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 2Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 3Instituto de Biologia Molecular, Faculdade de Medicina, Universidade de Lisboa JoVE 60822 Neuroscience
A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures Cláudia A. Valente1,2, Francisco J. Meda*1,2, Mafalda Carvalho*1,2, Ana M. Sebastião1,2 1Instituto de Farmacologia e Neurociências, Faculdade de Medicina da Universidade de Lisboa, 2Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa JoVE 61330 Neuroscience
Isolation and Expansion of Neurospheres from Postnatal (P1−3) Mouse Neurogenic Niches Rita Soares1,2,3, Filipa F. Ribeiro1,2, Diogo M. Lourenço1,2, Rui S. Rodrigues1,2, João B. Moreira1,2, Ana M. Sebastião1,2, Vanessa A. Morais1,3, Sara Xapelli1,2 1Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 2Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 3Instituto de Biologia Molecular, Faculdade de Medicina, Universidade de Lisboa JoVE 60822 Neuroscience
