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Articles by Anca Georgescu in JoVE
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La fragilidad en las personas infectadas por el VIH de medición. La identificación de los pacientes frágiles es el primer paso para la mejora y la Inversión de la fragilidad
Hilary C. Rees1, Voichita Ianas1, Patricia McCracken1, Shannon Smith1, Anca Georgescu1, Tirdad Zangeneh1, Jane Mohler2, Stephen A. Klotz1
1Division of Infectious Diseases, University of Arizona, 2Arizona Center on Aging, University of Arizona
Other articles by Anca Georgescu on PubMed
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The DNA Sequence and Biology of Human Chromosome 19
Nature.
Apr, 2004 |
Pubmed ID: 15057824 Chromosome 19 has the highest gene density of all human chromosomes, more than double the genome-wide average. The large clustered gene families, corresponding high G + C content, CpG islands and density of repetitive DNA indicate a chromosome rich in biological and evolutionary significance. Here we describe 55.8 million base pairs of highly accurate finished sequence representing 99.9% of the euchromatin portion of the chromosome. Manual curation of gene loci reveals 1,461 protein-coding genes and 321 pseudogenes. Among these are genes directly implicated in mendelian disorders, including familial hypercholesterolaemia and insulin-resistant diabetes. Nearly one-quarter of these genes belong to tandemly arranged families, encompassing more than 25% of the chromosome. Comparative analyses show a fascinating picture of conservation and divergence, revealing large blocks of gene orthology with rodents, scattered regions with more recent gene family expansions and deletions, and segments of coding and non-coding conservation with the distant fish species Takifugu.
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Resolution of Whipple Disease-Induced Pulmonary Hypertension Following Antibiotic Therapy
American Journal of Therapeutics.
Jan, 2013 |
Pubmed ID: 23344104 Whipple disease is a disorder caused by Tropheryma whipplei, a ubiquitous Gram-positive bacillus. In addition to gastrointestinal manifestations, many other systems may be involved in Whipple disease. Pulmonary hypertension (PH) is a rare manifestation of Whipple disease, and its clinical course is not well established. We report a case of a 45-year-old woman who presented with typical gastrointestinal manifestations of Whipple disease, which was diagnosed by duodenal biopsy. She was also noted to have elevated pulmonary arterial pressures on transthoracic echocardiography. There was no evidence of left-sided valvular disease, hypertrophy, or dyskinesis, and there was no evidence of endocarditis. The patient was started on intravenous ceftriaxone for 6 weeks and then transitioned to oral trimethoprim-sulfamethoxazole for a year. The patient demonstrated clinical improvement, endoscopic and histologic improvement, and also resolution of PH. This is the third reported case of PH that is convincingly secondary to Whipple disease that resolved after appropriate antibiotic therapy.
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