Articles by Andreas Schütze in JoVE
Experimentella metoder för undersökning av formminne Baserat Elastocaloric kylprocesser och Model Validation Marvin Schmidt1,2, Johannes Ullrich2, André Wieczorek3, Jan Frenzel3, Gunther Eggeler3, Andreas Schütze1, Stefan Seelecke2 1Lab for Measurement Technology, Saarland University, 2Intelligent Material Systems Lab, Saarland University, 3Lab for Material Science, Ruhr Universität Bochum
Other articles by Andreas Schütze on PubMed
HIF-1alpha is a Prognostic Marker in Oral Squamous Cell Carcinomas The International Journal of Biological Markers. Apr-Jun, 2010 | Pubmed ID: 20544685 The critical molecular regulator of hypoxia is the hypoxia-inducible factor 1 alpha (HIF-1alpha). The prognostic impact of this regulator protein in oral squamous cell carcinomas (OSCC) has not been comprehensively investigated. The aim of this study was to analyze the expression of HIF-1alpha in 82 patients with OSCC and to correlate it with their disease-specific survival. Immunohistochemical staining for HIF-1alpha was performed on 82 OSCC specimens using a standard immunoperoxidase technique. The expression of HIF-1alpha was correlated with poor disease-specific survival for OSCC patients. Patients with negatively or weakly HIF-1alpha-expressing tumors had a survival rate of 80%, whereas the survival decreased to only 33.6% in case of moderate or strong expression. In multivariate Cox regression analysis, we found a 3.5-fold increased risk of tumor-related death when HIF-1alpha was strongly expressed (p=0.016) compared to negative or weak expression of HIF-1alpha. We suggest HIF-1alpha is an independent prognostic marker in OSCC. Immunohistochemical detection of HIF-1alpha appears to be useful in the diagnosis of OSCC and to provide prognostic information in addition to TNM stage and histological grade.
Coexpression of Hypoxia-inducible Factor-1α and Glucose Transporter-1 is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients Histopathology. Jun, 2011 | Pubmed ID: 21438910 To study whether coexpression of the two hypoxia-related proteins hypoxia-inducible factor (HIF)-1α and glucose transporter (GLUT)-1 has prognostic relevance in oral squamous cell carcinomas (OSCCs).