Andrew V. Samuelson Department of Biomedical Genetics University of Rochester Medical Center Biography Publications Institution JoVE Articles Andrew V. Samuelson I am committed to understanding the underlying molecular and genetic basis of aging, and have been active in the aging field for over fifteen years. My research uses a combination of genetic, molecular, biochemical, and functional genomic approaches in C. elegans to study aging. My graduate training was in the laboratory of Dr. Scott Lowe at CSHL and my research focused on understanding how oncogene signaling induced proapoptotic signaling by the p53 tumor suppressor gene. My post-doctoral research was in the laboratory of Dr. Gary Ruvkun at the Massachusetts General Hospital. From a comprehensive genome-wide RNAi screen in C. elegans, I identified 103 “progeric gene inactivations” (PGP) that were essential for decreased ILS to extend longevity and produced signs of premature aging by several independent criteria. Since starting my laboratory, we have increasingly focused on studying transcriptional regulators of aging, vital for maintaining protein homeostasis. We include the use of C. elegans neuronal models of Alzhiemers’ Disease (AD) and related tauopathies, as age-associated decline of proteostasis is a causative factor in the manifestation of many protein-folding diseases. Publications The Homeodomain-interacting Protein Kinase HPK-1 Preserves Protein Homeostasis and Longevity Through Master Regulatory Control of the HSF-1 Chaperone Network and TORC1-restricted Autophagy in Caenorhabditis Elegans PLoS Genetics. Oct, 2017 | Pubmed ID: 29036198 Autolysosome Biogenesis and Developmental Senescence Are Regulated by Both Spns1 and V-ATPase Autophagy. Feb, 2017 | Pubmed ID: 27875093 The Role of the Antioxidant and Longevity-promoting Nrf2 Pathway in Metabolic Regulation Current Opinion in Clinical Nutrition and Metabolic Care. Jan, 2011 | Pubmed ID: 21102319 Kwantificering van weefselspecifieke proteostatische achteruitgang van Caenorhabditis elegans Maria I. Lazaro-Pena1, Adam B. Cornwell1, Andrew V. Samuelson1 1Department of Biomedical Genetics, University of Rochester Medical Center JoVE 61100 Biology De Replica Set, methode: Een High-throughput benadering van kwantitatief maatregel Caenorhabditis elegans levensduur Adam B. Cornwell1, Jesse R. Llop1, Peter Salzman2,3, Juilee Thakar4, Andrew V. Samuelson1 1Department of Biomedical Genetics, University of Rochester Medical Center, 2Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 3Non-Clinical Statistics, Bristol-Myers Squibb, 4Department of Microbiology and Immunology, University of Rochester Medical Center JoVE 57819 Genetics
Kwantificering van weefselspecifieke proteostatische achteruitgang van Caenorhabditis elegans Maria I. Lazaro-Pena1, Adam B. Cornwell1, Andrew V. Samuelson1 1Department of Biomedical Genetics, University of Rochester Medical Center JoVE 61100 Biology
De Replica Set, methode: Een High-throughput benadering van kwantitatief maatregel Caenorhabditis elegans levensduur Adam B. Cornwell1, Jesse R. Llop1, Peter Salzman2,3, Juilee Thakar4, Andrew V. Samuelson1 1Department of Biomedical Genetics, University of Rochester Medical Center, 2Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 3Non-Clinical Statistics, Bristol-Myers Squibb, 4Department of Microbiology and Immunology, University of Rochester Medical Center JoVE 57819 Genetics
