Ann M. Leen Center for Cell and Gene Therapy Baylor College of Medicine Biography Publications Institution JoVE Articles Ann M. Leen has not added a biography. If you are Ann M. Leen and would like to personalize this page please email our Author Liaison for assistance. Publications Oncolytic Immunotherapy of Advanced Solid Tumors with a CD40L Expressing Replicating Adenovirus: Assessment of Safety and Immunological Responses in Patients Cancer Research. Feb, 2012 | Pubmed ID: 22323527 Generation of Polyclonal CMV-specific T Cells for the Adoptive Immunotherapy of Glioblastoma Journal of Immunotherapy (Hagerstown, Md. : 1997). Feb, 2012 | Pubmed ID: 22306904 Production of Good Manufacturing Practice-grade Cytotoxic T Lymphocytes Specific for Epstein-Barr Virus, Cytomegalovirus and Adenovirus to Prevent or Treat Viral Infections Post-allogeneic Hematopoietic Stem Cell Transplant Cytotherapy. Jan, 2012 | Pubmed ID: 22172091 Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2011 | Pubmed ID: 21915103 Improving T-cell Therapy for Relapsed EBV-negative Hodgkin Lymphoma by Targeting Upregulated MAGE-A4 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2011 | Pubmed ID: 21908573 Engineered T Cells for Pancreatic Cancer Treatment HPB : the Official Journal of the International Hepato Pancreato Biliary Association. Sep, 2011 | Pubmed ID: 21843265 PiggyBac-mediated Cancer Immunotherapy Using EBV-specific Cytotoxic T-cells Expressing HER2-specific Chimeric Antigen Receptor Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2011 | Pubmed ID: 21772253 Good Manufacturing Practice-grade Cytotoxic T Lymphocytes Specific for Latent Membrane Proteins (LMP)-1 and LMP2 for Patients with Epstein-Barr Virus-associated Lymphoma Cytotherapy. May, 2011 | Pubmed ID: 21361747 High-avidity Cytotoxic T Lymphocytes Specific for a New PRAME-derived Peptide Can Target Leukemic and Leukemic-precursor Cells Blood. Mar, 2011 | Pubmed ID: 21278353 T-cell Therapy: the Next Generation Expert Review of Hematology. Apr, 2010 | Pubmed ID: 21083454 How I Treat Adenovirus in Hematopoietic Stem Cell Transplant Recipients Blood. Dec, 2010 | Pubmed ID: 20837781 Allogeneic Virus-specific T Cells with HLA Alloreactivity Do Not Produce GVHD in Human Subjects Blood. Nov, 2010 | Pubmed ID: 20709906 Accelerated Production of Antigen-specific T Cells for Preclinical and Clinical Applications Using Gas-permeable Rapid Expansion Cultureware (G-Rex) Journal of Immunotherapy (Hagerstown, Md. : 1997). Apr, 2010 | Pubmed ID: 20445351 Adverse Events Following Infusion of T Cells for Adoptive Immunotherapy: a 10-year Experience Cytotherapy. Oct, 2010 | Pubmed ID: 20429793 Antigen-specific Cytotoxic T Lymphocytes Can Target Chemoresistant Side-population Tumor Cells in Hodgkin Lymphoma Leukemia & Lymphoma. May, 2010 | Pubmed ID: 20367572 Challenges of T Cell Therapies for Virus-associated Diseases After Hematopoietic Stem Cell Transplantation Expert Opinion on Biological Therapy. Mar, 2010 | Pubmed ID: 20132056 Derivation of Human T Lymphocytes from Cord Blood and Peripheral Blood with Antiviral and Antileukemic Specificity from a Single Culture As Protection Against Infection and Relapse After Stem Cell Transplantation Blood. Apr, 2010 | Pubmed ID: 20110422 Cytotoxic T Lymphocyte Therapy with Donor T Cells Prevents and Treats Adenovirus and Epstein-Barr Virus Infections After Haploidentical and Matched Unrelated Stem Cell Transplantation Blood. Nov, 2009 | Pubmed ID: 19700662 Nucleofection of DCs to Generate Multivirus-specific T Cells for Prevention or Treatment of Viral Infections in the Immunocompromised Host Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2009 | Pubmed ID: 19584818 Genetic Modification of T Cells with IL-21 Enhances Antigen Presentation and Generation of Central Memory Tumor-specific Cytotoxic T-lymphocytes Journal of Immunotherapy (Hagerstown, Md. : 1997). Sep, 2009 | Pubmed ID: 19561536 Functionally Active Virus-specific T Cells That Target CMV, Adenovirus, and EBV Can Be Expanded from Naive T-cell Populations in Cord Blood and Will Target a Range of Viral Epitopes Blood. Aug, 2009 | Pubmed ID: 19443656 Genetic Manipulation of Tumor-specific Cytotoxic T Lymphocytes to Restore Responsiveness to IL-7 Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2009 | Pubmed ID: 19259067 Cytotoxic T Lymphocytes As Immune-therapy in Haematological Practice British Journal of Haematology. Oct, 2008 | Pubmed ID: 18691164 Exploiting Cytokine Secretion to Rapidly Produce Multivirus-specific T Cells for Adoptive Immunotherapy Journal of Immunotherapy (Hagerstown, Md. : 1997). Sep, 2008 | Pubmed ID: 18600178 Using Dendritic Cell Maturation and IL-12 Producing Capacity As Markers of Function: a Cautionary Tale Journal of Immunotherapy (Hagerstown, Md. : 1997). May, 2008 | Pubmed ID: 18391760 Identification of Hexon-specific CD4 and CD8 T-cell Epitopes for Vaccine and Immunotherapy Journal of Virology. Jan, 2008 | Pubmed ID: 17942545 Complete Responses of Relapsed Lymphoma Following Genetic Modification of Tumor-antigen Presenting Cells and T-lymphocyte Transfer Blood. Oct, 2007 | Pubmed ID: 17609424 Autologous Designer Antigen-presenting Cells by Gene Modification of T Lymphocyte Blasts with IL-7 and IL-12 Journal of Immunotherapy (Hagerstown, Md. : 1997). Jul-Aug, 2007 | Pubmed ID: 17589291 Improving T Cell Therapy for Cancer Annual Review of Immunology. 2007 | Pubmed ID: 17129181 Monoculture-derived T Lymphocytes Specific for Multiple Viruses Expand and Produce Clinically Relevant Effects in Immunocompromised Individuals Nature Medicine. Oct, 2006 | Pubmed ID: 16998485 Adenoviral Infections in Hematopoietic Stem Cell Transplantation Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Mar, 2006 | Pubmed ID: 16503493 Characterization of Latent Membrane Protein 2 Specificity in CTL Lines from Patients with EBV-positive Nasopharyngeal Carcinoma and Lymphoma Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148164 Adenovirus As an Emerging Pathogen in Immunocompromised Patients British Journal of Haematology. Jan, 2005 | Pubmed ID: 15638847 Conserved CTL Epitopes on the Adenovirus Hexon Protein Expand Subgroup Cross-reactive and Subgroup-specific CD8+ T Cells Blood. Oct, 2004 | Pubmed ID: 15265797 Fiber-modified Adenoviruses Generate Subgroup Cross-reactive, Adenovirus-specific Cytotoxic T Lymphocytes for Therapeutic Applications Blood. Feb, 2004 | Pubmed ID: 14525768 Geração de células T específicas Multivirus para Prevenir / tratar infecções virais após transplante de células-tronco hematopoéticas alogênico Ulrike Gerdemann1, Juan F. Vera1, Cliona M. Rooney1, Ann M. Leen1 1Center for Cell and Gene Therapy, Baylor College of Medicine JoVE 2736 Immunology and Infection
Geração de células T específicas Multivirus para Prevenir / tratar infecções virais após transplante de células-tronco hematopoéticas alogênico Ulrike Gerdemann1, Juan F. Vera1, Cliona M. Rooney1, Ann M. Leen1 1Center for Cell and Gene Therapy, Baylor College of Medicine JoVE 2736 Immunology and Infection
