Ann M. Leen Center for Cell and Gene Therapy Baylor College of Medicine Biography Publications Institution JoVE Articles Ann M. Leen has not added a biography. If you are Ann M. Leen and would like to personalize this page please email our Author Liaison for assistance. Publications Oncolytic Immunotherapy of Advanced Solid Tumors with a CD40L Expressing Replicating Adenovirus: Assessment of Safety and Immunological Responses in Patients Cancer Research. Feb, 2012 | Pubmed ID: 22323527 Generation of Polyclonal CMV-specific T Cells for the Adoptive Immunotherapy of Glioblastoma Journal of Immunotherapy (Hagerstown, Md. : 1997). Feb, 2012 | Pubmed ID: 22306904 Production of Good Manufacturing Practice-grade Cytotoxic T Lymphocytes Specific for Epstein-Barr Virus, Cytomegalovirus and Adenovirus to Prevent or Treat Viral Infections Post-allogeneic Hematopoietic Stem Cell Transplant Cytotherapy. Jan, 2012 | Pubmed ID: 22172091 Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2011 | Pubmed ID: 21915103 Improving T-cell Therapy for Relapsed EBV-negative Hodgkin Lymphoma by Targeting Upregulated MAGE-A4 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2011 | Pubmed ID: 21908573 Engineered T Cells for Pancreatic Cancer Treatment HPB : the Official Journal of the International Hepato Pancreato Biliary Association. Sep, 2011 | Pubmed ID: 21843265 PiggyBac-mediated Cancer Immunotherapy Using EBV-specific Cytotoxic T-cells Expressing HER2-specific Chimeric Antigen Receptor Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2011 | Pubmed ID: 21772253 Good Manufacturing Practice-grade Cytotoxic T Lymphocytes Specific for Latent Membrane Proteins (LMP)-1 and LMP2 for Patients with Epstein-Barr Virus-associated Lymphoma Cytotherapy. May, 2011 | Pubmed ID: 21361747 High-avidity Cytotoxic T Lymphocytes Specific for a New PRAME-derived Peptide Can Target Leukemic and Leukemic-precursor Cells Blood. Mar, 2011 | Pubmed ID: 21278353 T-cell Therapy: the Next Generation Expert Review of Hematology. Apr, 2010 | Pubmed ID: 21083454 How I Treat Adenovirus in Hematopoietic Stem Cell Transplant Recipients Blood. Dec, 2010 | Pubmed ID: 20837781 Allogeneic Virus-specific T Cells with HLA Alloreactivity Do Not Produce GVHD in Human Subjects Blood. Nov, 2010 | Pubmed ID: 20709906 Accelerated Production of Antigen-specific T Cells for Preclinical and Clinical Applications Using Gas-permeable Rapid Expansion Cultureware (G-Rex) Journal of Immunotherapy (Hagerstown, Md. : 1997). Apr, 2010 | Pubmed ID: 20445351 Adverse Events Following Infusion of T Cells for Adoptive Immunotherapy: a 10-year Experience Cytotherapy. Oct, 2010 | Pubmed ID: 20429793 Antigen-specific Cytotoxic T Lymphocytes Can Target Chemoresistant Side-population Tumor Cells in Hodgkin Lymphoma Leukemia & Lymphoma. May, 2010 | Pubmed ID: 20367572 Challenges of T Cell Therapies for Virus-associated Diseases After Hematopoietic Stem Cell Transplantation Expert Opinion on Biological Therapy. Mar, 2010 | Pubmed ID: 20132056 Derivation of Human T Lymphocytes from Cord Blood and Peripheral Blood with Antiviral and Antileukemic Specificity from a Single Culture As Protection Against Infection and Relapse After Stem Cell Transplantation Blood. Apr, 2010 | Pubmed ID: 20110422 Cytotoxic T Lymphocyte Therapy with Donor T Cells Prevents and Treats Adenovirus and Epstein-Barr Virus Infections After Haploidentical and Matched Unrelated Stem Cell Transplantation Blood. Nov, 2009 | Pubmed ID: 19700662 Nucleofection of DCs to Generate Multivirus-specific T Cells for Prevention or Treatment of Viral Infections in the Immunocompromised Host Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2009 | Pubmed ID: 19584818 Genetic Modification of T Cells with IL-21 Enhances Antigen Presentation and Generation of Central Memory Tumor-specific Cytotoxic T-lymphocytes Journal of Immunotherapy (Hagerstown, Md. : 1997). Sep, 2009 | Pubmed ID: 19561536 Functionally Active Virus-specific T Cells That Target CMV, Adenovirus, and EBV Can Be Expanded from Naive T-cell Populations in Cord Blood and Will Target a Range of Viral Epitopes Blood. Aug, 2009 | Pubmed ID: 19443656 Genetic Manipulation of Tumor-specific Cytotoxic T Lymphocytes to Restore Responsiveness to IL-7 Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2009 | Pubmed ID: 19259067 Cytotoxic T Lymphocytes As Immune-therapy in Haematological Practice British Journal of Haematology. Oct, 2008 | Pubmed ID: 18691164 Exploiting Cytokine Secretion to Rapidly Produce Multivirus-specific T Cells for Adoptive Immunotherapy Journal of Immunotherapy (Hagerstown, Md. : 1997). Sep, 2008 | Pubmed ID: 18600178 Using Dendritic Cell Maturation and IL-12 Producing Capacity As Markers of Function: a Cautionary Tale Journal of Immunotherapy (Hagerstown, Md. : 1997). May, 2008 | Pubmed ID: 18391760 Identification of Hexon-specific CD4 and CD8 T-cell Epitopes for Vaccine and Immunotherapy Journal of Virology. Jan, 2008 | Pubmed ID: 17942545 Complete Responses of Relapsed Lymphoma Following Genetic Modification of Tumor-antigen Presenting Cells and T-lymphocyte Transfer Blood. Oct, 2007 | Pubmed ID: 17609424 Autologous Designer Antigen-presenting Cells by Gene Modification of T Lymphocyte Blasts with IL-7 and IL-12 Journal of Immunotherapy (Hagerstown, Md. : 1997). Jul-Aug, 2007 | Pubmed ID: 17589291 Improving T Cell Therapy for Cancer Annual Review of Immunology. 2007 | Pubmed ID: 17129181 Monoculture-derived T Lymphocytes Specific for Multiple Viruses Expand and Produce Clinically Relevant Effects in Immunocompromised Individuals Nature Medicine. Oct, 2006 | Pubmed ID: 16998485 Adenoviral Infections in Hematopoietic Stem Cell Transplantation Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Mar, 2006 | Pubmed ID: 16503493 Characterization of Latent Membrane Protein 2 Specificity in CTL Lines from Patients with EBV-positive Nasopharyngeal Carcinoma and Lymphoma Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148164 Adenovirus As an Emerging Pathogen in Immunocompromised Patients British Journal of Haematology. Jan, 2005 | Pubmed ID: 15638847 Conserved CTL Epitopes on the Adenovirus Hexon Protein Expand Subgroup Cross-reactive and Subgroup-specific CD8+ T Cells Blood. Oct, 2004 | Pubmed ID: 15265797 Fiber-modified Adenoviruses Generate Subgroup Cross-reactive, Adenovirus-specific Cytotoxic T Lymphocytes for Therapeutic Applications Blood. Feb, 2004 | Pubmed ID: 14525768 Multivirus-spesifik T hücrelerinin üretilmesi Allojenik Hematopoetik Kök Hücre Nakli sonra Viral Enfeksiyonlar önleme / tedavi etmek için Ulrike Gerdemann1, Juan F. Vera1, Cliona M. Rooney1, Ann M. Leen1 1Center for Cell and Gene Therapy, Baylor College of Medicine JoVE 2736 Immunology and Infection
Multivirus-spesifik T hücrelerinin üretilmesi Allojenik Hematopoetik Kök Hücre Nakli sonra Viral Enfeksiyonlar önleme / tedavi etmek için Ulrike Gerdemann1, Juan F. Vera1, Cliona M. Rooney1, Ann M. Leen1 1Center for Cell and Gene Therapy, Baylor College of Medicine JoVE 2736 Immunology and Infection