In JoVE (1)
Other Publications (1)
Articles by Anna Frumkin in JoVE
Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism Ido Karady1, Anna Frumkin1, Shiran Dror1, Netta Shemesh1, Nadav Shai1, Anat Ben-Zvi1 1Department of Life Sciences, National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev To study the relationship between protein homeostasis, stress and aging, we monitored changes in protein folding by following protein dysfunction, protein localization in the cell and protein stability at the organismal, cellular and protein levels, using the genetically tractable metazoan Caenorhabditis elegans as a model system.
Other articles by Anna Frumkin on PubMed
Regulation of Cellular Protein Quality Control Networks in a Multicellular Organism The FEBS Journal. Feb, 2012 | Pubmed ID: 22177281 The long-term health of all metazoan cells is linked to protein quality control, which is achieved by proteostasis, a complex network of molecular interactions that determines the health of the proteome under physiological or stress conditions. Studying the regulation of cellular proteostasis in the context of the whole organism has unraveled multiple layers of cell-nonautonomous regulation, including neuronal regulation, cell-to-cell stress signals and endocrine signaling that affect growth, development and aging. Here, we discuss emerging concepts in cell-nonautonomous regulation of protein quality control networks. The identification of organismal modulators of cellular proteostasis may present novel, yet general targets for misfolding disease intervention.