In JoVE (1)
Other Publications (1)
Articles by Anna Kucharski in JoVE
Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases Pedro Brugarolas1, Mohammed Bhuiyan2, Anna Kucharski2, Richard Freifelder2 1Department of Neurology, The University of Chicago, 2Department of Radiology, The University of Chicago We demonstrate the semi-automated radiochemical synthesis of [18F]3F4AP and quality control procedures.
Other articles by Anna Kucharski on PubMed
Bistacrine Derivatives As New Potent Antimalarials Bioorganic & Medicinal Chemistry. Aug, 2016 | Pubmed ID: 27316542 Linking two tacrine molecules results in a tremendous increase of activity against Plasmodia in comparison to the monomer. This finding prompted the synthesis of a library of monomeric and dimeric tacrine derivatives in order to derive structure-activity relationships. The most active compounds towards chloroquine sensitive Plasmodium strain 3D7 and chloroquine resistant strain Dd2 show IC50 values in the nanomolar range of concentration, low cytotoxicity and target the cysteine protease falcipain-2, which is essential for parasite growth.