Anna Szlachcic Department of Protein Engineering, Faculty of Biotechnology University of Wroclaw Biography Publications Institution JoVE Articles Anna Szlachcic has not added a biography. If you are Anna Szlachcic and would like to personalize this page please email our Author Liaison for assistance. Publications FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1 Cancers. Oct, 2020 | Pubmed ID: 33076489 Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity Cells. 08, 2019 | Pubmed ID: 31443196 Identification of a Peptide Antagonist of the FGF1-FGFR1 Signaling Axis by Phage Display Selection FEBS Open Bio. 05, 2019 | Pubmed ID: 30968602 Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity International Journal of Molecular Sciences. Aug, 2018 | Pubmed ID: 30134556 FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect Towards Cancer Cells Overproducing FGF Receptor 1 International Journal of Molecular Sciences. Jul, 2018 | Pubmed ID: 30029518 High-Yield Site-Specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E Via Cysteine Flanked by Basic Residues Bioconjugate Chemistry. 07, 2017 | Pubmed ID: 28598150 Site-specific Conjugation of Fibroblast Growth Factor 2 (FGF2) Based on Incorporation of Alkyne-reactive Unnatural Amino Acid Bioorganic & Medicinal Chemistry. 07, 2017 | Pubmed ID: 28522266 Design and Characteristics of Cytotoxic Fibroblast Growth Factor 1 Conjugate for Fibroblast Growth Factor Receptor-targeted Cancer Therapy Drug Design, Development and Therapy. 2016 | Pubmed ID: 27563235 FGF1-gold Nanoparticle Conjugates Targeting FGFR Efficiently Decrease Cell Viability Upon NIR Irradiation International Journal of Nanomedicine. 2012 | Pubmed ID: 23226697 Tailoring Small Proteins Towards Biomedical Applications Current Pharmaceutical Biotechnology. Nov, 2011 | Pubmed ID: 21902634 Longer Action Means Better Drug: Tuning Up Protein Therapeutics Biotechnology Advances. Jul-Aug, 2011 | Pubmed ID: 21443940 Two Pentadehydropeptides with Different Configurations of the DeltaPhe Residues Acta Crystallographica. Section C, Crystal Structure Communications. Mar, 2010 | Pubmed ID: 20203407 The Structural Basis of Tail-anchored Membrane Protein Recognition by Get3 Nature. Sep, 2009 | Pubmed ID: 19675567 Increased Protein Stability of FGF1 Can Compensate for Its Reduced Affinity for Heparin The Journal of Biological Chemistry. Sep, 2009 | Pubmed ID: 19574212 Structure of a Highly Stable Mutant of Human Fibroblast Growth Factor 1 Acta Crystallographica. Section D, Biological Crystallography. Jan, 2009 | Pubmed ID: 19153468 Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation Mateusz Adam Krzyscik1,2, Aleksandra Sokolowska-Wedzina1, Karolina Jendryczko1, Marta Pozniak1, Daria Nawrocka1, Natalia Porebska1, Malgorzata Zakrzewska1, Jacek Otlewski1, Anna Szlachcic1, Lukasz Opalinski1 1Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, 2Department of Protein Biotechnology, Faculty of Biotechnology, University of Wroclaw JoVE 61918 Biochemistry
Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation Mateusz Adam Krzyscik1,2, Aleksandra Sokolowska-Wedzina1, Karolina Jendryczko1, Marta Pozniak1, Daria Nawrocka1, Natalia Porebska1, Malgorzata Zakrzewska1, Jacek Otlewski1, Anna Szlachcic1, Lukasz Opalinski1 1Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, 2Department of Protein Biotechnology, Faculty of Biotechnology, University of Wroclaw JoVE 61918 Biochemistry