Anthony A High Center for Proteomics and Metabolomics St Jude Children's Research Hospital Biography Publications Institution JoVE Articles Anthony A High I am the Director of the Center for Proteomics and Metabolomics at St. Jude Children’s Research Hospital in Memphis, Tennessee. I hold a Ph.D. degree in Chemistry from the University of Virginia and received my postdoctoral training in mass spectrometry at the Louis Pasteur University in Strasbourg, France. I have been conducting research at St. Jude Children’s Research Hospital for more than 17 years. In each of these positions, I have provided specialized expertise to other investigators on problems related to protein chemistry and proteomics. I have also pursued my own research in the development of mass spectrometry techniques to aid in protein quantitation. I have published over 50 research articles and papers in peer-reviewed scientific journals. I have been serving as a reviewer for more than 8 different scientific journals. I am a member of several scientific societies, including the Association of Biomolecular Resource Facilities (ABRF) and the American Society of Mass Spectrometry (ASMS). Publications Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry Journal of Proteome Research. 01, 2021 | Pubmed ID: 33175545 Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression Neuron. 03, 2020 | Pubmed ID: 31926610 Deep Multiomics Profiling of Brain Tumors Identifies Signaling Networks Downstream of Cancer Driver Genes Nature Communications. 08, 2019 | Pubmed ID: 31420543 Deep Undepleted Human Serum Proteome Profiling Toward Biomarker Discovery for Alzheimer's Disease Clinical Proteomics. Month, 2019 | Pubmed ID: 31019427 Identification of Toll-like Receptor Signaling Inhibitors Based on Selective Activation of Hierarchically Acting Signaling Proteins Science Signaling. 08, 2018 | Pubmed ID: 30108181 Extensive Peptide Fractionation and Y1 Ion-Based Interference Detection Method for Enabling Accurate Quantification by Isobaric Labeling and Mass Spectrometry Analytical Chemistry. Mar, 2017 | Pubmed ID: 28194965 Deep Profiling of Proteome and Phosphoproteome by Isobaric Labeling, Extensive Liquid Chromatography, and Mass Spectrometry Methods in Enzymology. Month, 2017 | Pubmed ID: 28109439 Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination Journal of Molecular Biology. Mar, 2016 | Pubmed ID: 26475525 Quantitative Protein Analysis by Mass Spectrometry Methods in Molecular Biology (Clifton, N.J.). Month, 2015 | Pubmed ID: 25859956 Integrated Approaches for Analyzing U1-70K Cleavage in Alzheimer's Disease Journal of Proteome Research. Nov, 2014 | Pubmed ID: 24902715 Quantitative Proteomic Analysis of the Influenza A Virus Nonstructural Proteins NS1 and NS2 During Natural Cell Infection Identifies PACT As an NS1 Target Protein and Antiviral Host Factor Journal of Virology. Aug, 2014 | Pubmed ID: 24899174 Identification and Characterization of Phosphorylation Sites Within the Pregnane X Receptor Protein Biochemical Pharmacology. Jan, 2014 | Pubmed ID: 24184507 Hematopoietic Progenitor Cell Lines with Myeloid and Lymphoid Potential Nature Methods. Aug, 2013 | Pubmed ID: 23749299 HECT-E3 Ligase ETC-1 Regulates Securin and Cyclin B1 Cytoplasmic Abundance to Promote Timely Anaphase During Meiosis in C. Elegans Development (Cambridge, England). May, 2013 | Pubmed ID: 23578927 A20-binding Inhibitor of NF-κB (ABIN1) Controls Toll-like Receptor-mediated CCAAT/enhancer-binding Protein β Activation and Protects from Inflammatory Disease Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22011580 The E3 Ubiquitin Ligase Mind Bomb-2 (MIB2) Protein Controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB Activation The Journal of Biological Chemistry. Oct, 2011 | Pubmed ID: 21896478 Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery Journal of Proteome Research. Feb, 2010 | Pubmed ID: 20020773 Sgt1 Dimerization is Negatively Regulated by Protein Kinase CK2-mediated Phosphorylation at Ser361 The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19398558 Large-scale Analysis of Thermostable, Mammalian Proteins Provides Insights into the Intrinsically Disordered Proteome Journal of Proteome Research. Jan, 2009 | Pubmed ID: 19067583 JUMPn: Eine optimierte Anwendung für Protein-Co-Expressions-Clustering und Netzwerkanalyse in der Proteomik David Vanderwall1, Poudel Suresh1,2, Yingxue Fu2, Ji-Hoon Cho2, Timothy I. Shaw2,3, Ashutosh Mishra2, Anthony A. High2, Junmin Peng1,2, Yuxin Li1,2 1Departments of Structural Biology and Developmental Neurobiology, St. Jude Children’s Research Hospital, 2Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, 3Department of Computational Biology, St. Jude Children’s Research Hospital JoVE 62796 Biochemistry Tiefen Proteom Profilierung durch isobare Kennzeichnung, umfangreiche Flüssigchromatographie-Massenspektrometrie und softwaregestützte Quantifizierung Anthony A. High1, Haiyan Tan1, Vishwajeeth R. Pagala1, Mingming Niu2,3, Ji-Hoon Cho1, Xusheng Wang1, Bing Bai2, Junmin Peng1,2 1St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 2Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, 3Heilongjiang University of Chinese Medicine JoVE 56474 Biochemistry
JUMPn: Eine optimierte Anwendung für Protein-Co-Expressions-Clustering und Netzwerkanalyse in der Proteomik David Vanderwall1, Poudel Suresh1,2, Yingxue Fu2, Ji-Hoon Cho2, Timothy I. Shaw2,3, Ashutosh Mishra2, Anthony A. High2, Junmin Peng1,2, Yuxin Li1,2 1Departments of Structural Biology and Developmental Neurobiology, St. Jude Children’s Research Hospital, 2Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, 3Department of Computational Biology, St. Jude Children’s Research Hospital JoVE 62796 Biochemistry
Tiefen Proteom Profilierung durch isobare Kennzeichnung, umfangreiche Flüssigchromatographie-Massenspektrometrie und softwaregestützte Quantifizierung Anthony A. High1, Haiyan Tan1, Vishwajeeth R. Pagala1, Mingming Niu2,3, Ji-Hoon Cho1, Xusheng Wang1, Bing Bai2, Junmin Peng1,2 1St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 2Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, 3Heilongjiang University of Chinese Medicine JoVE 56474 Biochemistry
