Articles by Antoinette T. Nguyen in JoVE
Neurodevelopmental Reflex Testing in Neonatal Rat Pups Antoinette T. Nguyen1, Edward A. Armstrong1, Jerome Y. Yager1 1Department of Pediatrics, University of Alberta Behavioral testing is the gold standard for determining outcomes following brain injury, and can identify the presence of developmental disabilities in infants and children. Neurodevelopmental reflexes are an early indicator of these abnormalities. A host of easily accomplished developmental reflex tests in the neonatal rodent were developed and described here.
Other articles by Antoinette T. Nguyen on PubMed
An Assay for Social Interaction in Drosophila Fragile X Mutants Fly. Jul-Sep, 2010 | Pubmed ID: 20519966 We developed a novel assay to examine social interactions in Drosophila and, as a first attempt, apply it here at examining the behavior of Drosophila Fragile X Mental Retardation gene (dfmr1) mutants. Fragile X syndrome is the most common cause of single gene intellectual disability (ID) and is frequently associated with autism. Our results suggest that dfmr1 mutants are less active than wild-type flies and interact with each other less often. In addition, mutants for one allele of dfmr1, dfmr1(B55), are more likely to come in close contact with a wild-type fly than another dfmr1(B55) mutant. Our results raise the possibility of defective social expression with preserved receptive abilities. We further suggest that the assay may be applied in a general strategy of examining endophenoypes of complex human neurological disorders in Drosophila, and specifically in order to understand the genetic basis of social interaction defects linked with ID.
Consumption of Broccoli Sprouts During Late Gestation and Lactation Confers Protection Against Developmental Delay Induced by Maternal Inflammation Behavioural Brain Research. Jul, 2016 | Pubmed ID: 27038765 The presence of a fetal inflammatory response is linked to cerebral palsy. Unfortunately no preventive therapies are available. In this study, we determined whether dietary supplementation with broccoli sprouts (BrSp), a phase-II enzyme inducer, would be effective in preventing the behavioural and pathologic manifestations in a rodent model of inflammation during late pregnancy.
Using a Patient Navigator to Improve Postpartum Care in an Urban Women's Health Clinic Obstetrics and Gynecology. Apr, 2017 | Pubmed ID: 28383374 To estimate whether postpartum visit attendance was improved in women exposed to a postpartum patient navigation program compared with those who received care immediately before the program's initiation and to assess whether other postpartum health behaviors improved during the intervention period.