Antonio Bedalov

Publications

• Screen for Reactivation of MeCP2 on the Inactive X Chromosome Identifies the BMP/TGF-β Superfamily As a Regulator of XIST Expression
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2017  |   Pubmed ID: 28143937
• SIR2 Suppresses Replication Gaps and Genome Instability by Balancing Replication Between Repetitive and Unique Sequences
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2017  |   Pubmed ID: 28049846
• A High-throughput Small Molecule Screen Identifies Synergism Between DNA Methylation and Aurora Kinase Pathways for X Reactivation
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2016  |   Pubmed ID: 28182563
• Wild-type Microglia Do Not Reverse Pathology in Mouse Models of Rett Syndrome
  Nature. May, 2015  |   Pubmed ID: 25993969
• The Androgen-regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis
  Cancer Discovery. Nov, 2014  |   Pubmed ID: 25122198
• Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues As Sirtuin Inhibitors
  Journal of Medicinal Chemistry. Apr, 2014  |   Pubmed ID: 24697269
• Enterocyte-specific Inactivation of SIRT1 Reduces Tumor Load in the APC(+/min) Mouse Model
  PloS One. 2013  |   Pubmed ID: 23799088
• A Natural Polymorphism in RDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan
  PLoS Genetics. 2013  |   Pubmed ID: 23505383
• Proteomic Classification of Acute Leukemias by Alignment-based Quantitation of LC-MS/MS Data Sets
  Journal of Proteome Research. Oct, 2012  |   Pubmed ID: 22900933
• SIRT1 is Dispensable for Function of Hematopoietic Stem Cells in Adult Mice
  Blood. Feb, 2012  |   Pubmed ID: 22219225
• Absence of Effects of Sir2 Overexpression on Lifespan in C. Elegans and Drosophila
  Nature. Sep, 2011  |   Pubmed ID: 21938067
• Genetic Variation Shapes Protein Networks Mainly Through Non-transcriptional Mechanisms
  PLoS Biology. Sep, 2011  |   Pubmed ID: 21909241
• Natural Polymorphism in BUL2 Links Cellular Amino Acid Availability with Chronological Aging and Telomere Maintenance in Yeast
  PLoS Genetics. Aug, 2011  |   Pubmed ID: 21901113
• Sirtuin Modulators
  Handbook of Experimental Pharmacology. 2011  |   Pubmed ID: 21879453
• Conditioning with Treosulfan and Fludarabine Followed by Allogeneic Hematopoietic Cell Transplantation for High-risk Hematologic Malignancies
  Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Mar, 2011  |   Pubmed ID: 20685259
• Identification of Inhibitors of Chromatin Modifying Enzymes Using the Yeast Phenotypic Screens
  Methods in Molecular Biology (Clifton, N.J.). 2009  |   Pubmed ID: 19521823
• Intracellular NAD Levels Regulate Tumor Necrosis Factor Protein Synthesis in a Sirtuin-dependent Manner
  Nature Medicine. Feb, 2009  |   Pubmed ID: 19151729
• Identification and Characterization of Small-molecule Inhibitors of Hepsin
  Molecular Cancer Therapeutics. Oct, 2008  |   Pubmed ID: 18852137
• Identification of Small Molecule Inhibitors of Pseudomonas Aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen
  PLoS Genetics. Feb, 2008  |   Pubmed ID: 18454192
• Hst3 is Regulated by Mec1-dependent Proteolysis and Controls the S Phase Checkpoint and Sister Chromatid Cohesion by Deacetylating Histone H3 at Lysine 56
  The Journal of Biological Chemistry. Dec, 2007  |   Pubmed ID: 17977840
• Genetic Basis of Proteome Variation in Yeast
  Nature Genetics. Nov, 2007  |   Pubmed ID: 17952072
• Hematopoietic Cell Transplantation in Patients with Myelodysplastic Syndrome or Acute Myeloid Leukemia Arising from Myelodysplastic Syndrome: Similar Outcomes in Patients with De Novo Disease and Disease Following Prior Therapy or Antecedent Hematologic Disorders
  Blood. Aug, 2007  |   Pubmed ID: 17488876
• Pharmacogenetics: Yeast Lead the Way
  Chemistry & Biology. Mar, 2006  |   Pubmed ID: 16638528
• Antitumor Activity of a Small-molecule Inhibitor of Human Silent Information Regulator 2 Enzymes
  Cancer Research. Apr, 2006  |   Pubmed ID: 16618762
• Telomere Length As a Quantitative Trait: Genome-wide Survey and Genetic Mapping of Telomere Length-control Genes in Yeast
  PLoS Genetics. Mar, 2006  |   Pubmed ID: 16552446
• Identification and Characterization of Sir2 Inhibitors Through Phenotypic Assays in Yeast
  Combinatorial Chemistry & High Throughput Screening. Nov, 2004  |   Pubmed ID: 15578928
• Neuroscience. NAD to the Rescue
  Science (New York, N.Y.). Aug, 2004  |   Pubmed ID: 15310883
• Yeast As a Model System for Anticancer Drug Discovery
  Nature Reviews. Cancer. 06, 2004  |   Pubmed ID: 15170450
• Inhibitors of Sir2: Evaluation of Splitomicin Analogues
  Journal of Medicinal Chemistry. May, 2004  |   Pubmed ID: 15115404
• Identification of Selective Inhibitors of NAD+-dependent Deacetylases Using Phenotypic Screens in Yeast
  The Journal of Biological Chemistry. Dec, 2003  |   Pubmed ID: 14534292
• NAD+-dependent Deacetylase Hst1p Controls Biosynthesis and Cellular NAD+ Levels in Saccharomyces Cerevisiae
  Molecular and Cellular Biology. Oct, 2003  |   Pubmed ID: 12972620
• Sir2 Flexes Its Muscle
  Developmental Cell. Aug, 2003  |   Pubmed ID: 12919668
• Identification of a Small Molecule Inhibitor of Sir2p
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2001  |   Pubmed ID: 11752457