Anumantha G. Kanthasamy

Publications

• Molecular Mechanisms Underlying Protective Effects of Quercetin Against Mitochondrial Dysfunction and Progressive Dopaminergic Neurodegeneration in Cell Culture and MitoPark Transgenic Mouse Models of Parkinson's Disease
  Journal of Neurochemistry. Apr, 2017  |   Pubmed ID: 28376279
• Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice
  Antioxidants & Redox Signaling. Apr, 2017  |   Pubmed ID: 28375739
• Role of Protein Kinase C in Metabolic Regulation of the Cardiac Na(+) Channel
  Heart Rhythm. Mar, 2017  |   Pubmed ID: 27989687
• P73 Gene in Dopaminergic Neurons is Highly Susceptible to Manganese Neurotoxicity
  Neurotoxicology. Mar, 2017  |   Pubmed ID: 27107493
• Role of Neurotoxicants and Traumatic Brain Injury in α-synuclein Protein Misfolding and Aggregation
  Brain Research Bulletin. Dec, 2016  |   Pubmed ID: 27993598
• Neuronal Protection Against Oxidative Insult by Polyanhydride Nanoparticle-based Mitochondria-targeted Antioxidant Therapy
  Nanomedicine : Nanotechnology, Biology, and Medicine. Oct, 2016  |   Pubmed ID: 27771430
• Prokineticin-2 Upregulation During Neuronal Injury Mediates a Compensatory Protective Response Against Dopaminergic Neuronal Degeneration
  Nature Communications. Oct, 2016  |   Pubmed ID: 27703142
• Differential Arousal Regulation by Prokineticin 2 Signaling in the Nocturnal Mouse and the Diurnal Monkey
  Molecular Brain. Aug, 2016  |   Pubmed ID: 27535380
• Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson's Disease
  Parkinson's Disease. 2016  |   Pubmed ID: 27298749
• Protein Kinase Cδ Upregulation in Microglia Drives Neuroinflammatory Responses and Dopaminergic Neurodegeneration in Experimental Models of Parkinson's Disease
  Neurobiology of Disease. Sep, 2016  |   Pubmed ID: 27151770
• Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease
  Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Jun, 2016  |   Pubmed ID: 26838361
• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition)
  Autophagy. Jan, 2016  |   Pubmed ID: 26799652
• Alterations in Mitochondrial Dynamics Induced by Tebufenpyrad and Pyridaben in a Dopaminergic Neuronal Cell Culture Model
  Neurotoxicology. Mar, 2016  |   Pubmed ID: 26141520
• EGCG Protects Against 6-OHDA-Induced Neurotoxicity in a Cell Culture Model
  Parkinson's Disease. 2015  |   Pubmed ID: 26770869
• Nano-enabled Delivery of Diverse Payloads Across Complex Biological Barriers
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2015  |   Pubmed ID: 26315817
• Molecular Cloning, Epigenetic Regulation, and Functional Characterization of Prkd1 Gene Promoter in Dopaminergic Cell Culture Models of Parkinson's Disease
  Journal of Neurochemistry. Oct, 2015  |   Pubmed ID: 26230914
• Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2015  |   Pubmed ID: 26157004
• Nanoneuromedicines for Degenerative, Inflammatory, and Infectious Nervous System Diseases
  Nanomedicine : Nanotechnology, Biology, and Medicine. Apr, 2015  |   Pubmed ID: 25645958
• α-Synuclein Protects Against Manganese Neurotoxic Insult During the Early Stages of Exposure in a Dopaminergic Cell Model of Parkinson's Disease
  Toxicological Sciences : an Official Journal of the Society of Toxicology. Feb, 2015  |   Pubmed ID: 25416158
• In Vitro Amplification of Scrapie and Chronic Wasting Disease PrP(res) Using Baculovirus-expressed Recombinant PrP As Substrate
  Prion. 2014  |   Pubmed ID: 25495764
• Histone Hyperacetylation Up-regulates Protein Kinase Cδ in Dopaminergic Neurons to Induce Cell Death: Relevance to Epigenetic Mechanisms of Neurodegeneration in Parkinson Disease
  The Journal of Biological Chemistry. Dec, 2014  |   Pubmed ID: 25342743
• A Novel Mitochondrially-targeted Apocynin Derivative Prevents Hyposmia and Loss of Motor Function in the Leucine-rich Repeat Kinase 2 (LRRK2(R1441G)) Transgenic Mouse Model of Parkinson's Disease
  Neuroscience Letters. Nov, 2014  |   Pubmed ID: 25263790
• Protein Kinase D1 (PKD1) Phosphorylation Promotes Dopaminergic Neuronal Survival During 6-OHDA-induced Oxidative Stress
  PloS One. 2014  |   Pubmed ID: 24806360
• Role of Proteolytic Activation of Protein Kinase Cδ in the Pathogenesis of Prion Disease
  Prion. Jan-Feb, 2014  |   Pubmed ID: 24576946
• Vanadium Exposure Induces Olfactory Dysfunction in an Animal Model of Metal Neurotoxicity
  Neurotoxicology. Jul, 2014  |   Pubmed ID: 24362016
• Mitochondria-targeted Antioxidants for Treatment of Parkinson's Disease: Preclinical and Clinical Outcomes
  Biochimica Et Biophysica Acta. Aug, 2014  |   Pubmed ID: 24060637
• The Peptidyl-prolyl Isomerase Pin1 Up-regulation and Proapoptotic Function in Dopaminergic Neurons: Relevance to the Pathogenesis of Parkinson Disease
  The Journal of Biological Chemistry. Jul, 2013  |   Pubmed ID: 23754278
• Diapocynin Prevents Early Parkinson's Disease Symptoms in the Leucine-rich Repeat Kinase 2 (LRRK2R¹⁴⁴¹G) Transgenic Mouse
  Neuroscience Letters. Aug, 2013  |   Pubmed ID: 23721786
• Anti-inflammatory and Neuroprotective Effects of an Orally Active Apocynin Derivative in Pre-clinical Models of Parkinson's Disease
  Journal of Neuroinflammation. Oct, 2012  |   Pubmed ID: 23092448
• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy
  Autophagy. Apr, 2012  |   Pubmed ID: 22966490
• Alterations in Bioenergetic Function Induced by Parkinson's Disease Mimetic Compounds: Lack of Correlation with Superoxide Generation
  Journal of Neurochemistry. Sep, 2012  |   Pubmed ID: 22708893
• Proteolytic Activation of Proapoptotic Kinase Protein Kinase Cδ by Tumor Necrosis Factor α Death Receptor Signaling in Dopaminergic Neurons During Neuroinflammation
  Journal of Neuroinflammation. Apr, 2012  |   Pubmed ID: 22540228
• Role of Oxidative Stress in Methamphetamine-induced Dopaminergic Toxicity Mediated by Protein Kinase Cδ
  Behavioural Brain Research. Jun, 2012  |   Pubmed ID: 22512859
• Neuroprotective Effect of Resveratrol Against Methamphetamine-induced Dopaminergic Apoptotic Cell Death in a Cell Culture Model of Neurotoxicity
  Current Neuropharmacology. Mar, 2011  |   Pubmed ID: 21886561
• Infectious Prion Protein Alters Manganese Transport and Neurotoxicity in a Cell Culture Model of Prion Disease
  Neurotoxicology. Oct, 2011  |   Pubmed ID: 21871919
• Manganese Nanoparticle Activates Mitochondrial Dependent Apoptotic Signaling and Autophagy in Dopaminergic Neuronal Cells
  Toxicology and Applied Pharmacology. Nov, 2011  |   Pubmed ID: 21856324
• Measurement of Proteasomal Dysfunction in Cell Models of Dopaminergic Degeneration
  Methods in Molecular Biology (Clifton, N.J.). 2011  |   Pubmed ID: 21815074
• Environmental Neurotoxic Pesticide Dieldrin Activates a Non Receptor Tyrosine Kinase to Promote PKCδ-mediated Dopaminergic Apoptosis in a Dopaminergic Neuronal Cell Model
  Neurotoxicology. Oct, 2011  |   Pubmed ID: 21801747
• Protein Kinase D1 (PKD1) Activation Mediates a Compensatory Protective Response During Early Stages of Oxidative Stress-induced Neuronal Degeneration
  Molecular Neurodegeneration. Jun, 2011  |   Pubmed ID: 21696630
• PKCδ Inhibition Enhances Tyrosine Hydroxylase Phosphorylation in Mice After Methamphetamine Treatment
  Neurochemistry International. Aug, 2011  |   Pubmed ID: 21672585
• Transcriptional Regulation of Pro-apoptotic Protein Kinase Cdelta: Implications for Oxidative Stress-induced Neuronal Cell Death
  The Journal of Biological Chemistry. Jun, 2011  |   Pubmed ID: 21467032
• Phytic Acid Protects Against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model
  Parkinson's Disease. Feb, 2011  |   Pubmed ID: 21331377
• α-Synuclein Negatively Regulates Protein Kinase Cδ Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing P300 Histone Acetyltransferase Activity
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011  |   Pubmed ID: 21307242
• A Simple Magnetic Separation Method for High-yield Isolation of Pure Primary Microglia
  Journal of Neuroscience Methods. Jan, 2011  |   Pubmed ID: 21074565
• Manganese Upregulates Cellular Prion Protein and Contributes to Altered Stabilization and Proteolysis: Relevance to Role of Metals in Pathogenesis of Prion Disease
  Toxicological Sciences : an Official Journal of the Society of Toxicology. Jun, 2010  |   Pubmed ID: 20176619
• Curcumin Enhances Paraquat-induced Apoptosis of N27 Mesencephalic Cells Via the Generation of Reactive Oxygen Species
  Neurotoxicology. Nov, 2009  |   Pubmed ID: 19660496
• Vanadium Induces Dopaminergic Neurotoxicity Via Protein Kinase Cdelta Dependent Oxidative Signaling Mechanisms: Relevance to Etiopathogenesis of Parkinson's Disease
  Toxicology and Applied Pharmacology. Oct, 2009  |   Pubmed ID: 19646462
• Mitochondrial Accumulation of Polyubiquitinated Proteins and Differential Regulation of Apoptosis by Polyubiquitination Sites Lys-48 and -63
  Journal of Cellular and Molecular Medicine. Aug, 2009  |   Pubmed ID: 19432818
• Environmental Neurotoxin Dieldrin Induces Apoptosis Via Caspase-3-dependent Proteolytic Activation of Protein Kinase C Delta (PKCdelta): Implications for Neurodegeneration in Parkinson's Disease
  Molecular Brain. 2008  |   Pubmed ID: 18945348
• Opposing Roles of Prion Protein in Oxidative Stress- and ER Stress-induced Apoptotic Signaling
  Free Radical Biology & Medicine. Dec, 2008  |   Pubmed ID: 18835352
• Proteasome Inhibitor-induced Apoptosis is Mediated by Positive Feedback Amplification of PKCdelta Proteolytic Activation and Mitochondrial Translocation
  Journal of Cellular and Molecular Medicine. Dec, 2008  |   Pubmed ID: 18298651
• Neuroprotective Effect of the Natural Iron Chelator, Phytic Acid in a Cell Culture Model of Parkinson's Disease
  Toxicology. Mar, 2008  |   Pubmed ID: 18255213
• Pharmacological Inhibition of Neuronal NADPH Oxidase Protects Against 1-methyl-4-phenylpyridinium (MPP+)-induced Oxidative Stress and Apoptosis in Mesencephalic Dopaminergic Neuronal Cells
  Neurotoxicology. Sep, 2007  |   Pubmed ID: 17904225
• Neuroprotective Effect of Protein Kinase C Delta Inhibitor Rottlerin in Cell Culture and Animal Models of Parkinson's Disease
  The Journal of Pharmacology and Experimental Therapeutics. Sep, 2007  |   Pubmed ID: 17565007
• Environmental Neurotoxic Chemicals-induced Ubiquitin Proteasome System Dysfunction in the Pathogenesis and Progression of Parkinson's Disease
  Pharmacology & Therapeutics. Jun, 2007  |   Pubmed ID: 17521740
• Normal Cellular Prion Protein Protects Against Manganese-induced Oxidative Stress and Apoptotic Cell Death
  Toxicological Sciences : an Official Journal of the Society of Toxicology. Aug, 2007  |   Pubmed ID: 17483122
• Microarray Analysis of Oxidative Stress Regulated Genes in Mesencephalic Dopaminergic Neuronal Cells: Relevance to Oxidative Damage in Parkinson's Disease
  Neurochemistry International. May, 2007  |   Pubmed ID: 17397968
• A Novel Peptide Inhibitor Targeted to Caspase-3 Cleavage Site of a Proapoptotic Kinase Protein Kinase C Delta (PKCdelta) Protects Against Dopaminergic Neuronal Degeneration in Parkinson's Disease Models
  Free Radical Biology & Medicine. Nov, 2006  |   Pubmed ID: 17045926
• Proteasome Inhibitor MG-132 Induces Dopaminergic Degeneration in Cell Culture and Animal Models
  Neurotoxicology. Sep, 2006  |   Pubmed ID: 16870259
• Interaction of Metals with Prion Protein: Possible Role of Divalent Cations in the Pathogenesis of Prion Diseases
  Neurotoxicology. Sep, 2006  |   Pubmed ID: 16860868
• Dieldrin-induced Neurotoxicity: Relevance to Parkinson's Disease Pathogenesis
  Neurotoxicology. Aug, 2005  |   Pubmed ID: 16112328
• Dieldrin Induces Ubiquitin-proteasome Dysfunction in Alpha-synuclein Overexpressing Dopaminergic Neuronal Cells and Enhances Susceptibility to Apoptotic Cell Death
  The Journal of Pharmacology and Experimental Therapeutics. Oct, 2005  |   Pubmed ID: 15987830
• Wild-type Alpha-synuclein Interacts with Pro-apoptotic Proteins PKCdelta and BAD to Protect Dopaminergic Neuronal Cells Against MPP+-induced Apoptotic Cell Death
  Brain Research. Molecular Brain Research. Sep, 2005  |   Pubmed ID: 15978696
• Tyrosine Phosphorylation Regulates the Proteolytic Activation of Protein Kinase Cdelta in Dopaminergic Neuronal Cells
  The Journal of Biological Chemistry. Aug, 2005  |   Pubmed ID: 15961393
• Blood Lipid and Oxidative Stress Responses to Soy Protein with Isoflavones and Phytic Acid in Postmenopausal Women
  The American Journal of Clinical Nutrition. Mar, 2005  |   Pubmed ID: 15755827
• Protein Kinase Cdelta is a Key Downstream Mediator of Manganese-induced Apoptosis in Dopaminergic Neuronal Cells
  The Journal of Pharmacology and Experimental Therapeutics. Apr, 2005  |   Pubmed ID: 15608081
• Activation of Protein Kinase C Delta by Proteolytic Cleavage Contributes to Manganese-induced Apoptosis in Dopaminergic Cells: Protective Role of Bcl-2
  Biochemical Pharmacology. Jan, 2005  |   Pubmed ID: 15588722
• Dieldrin Promotes Proteolytic Cleavage of Poly(ADP-ribose) Polymerase and Apoptosis in Dopaminergic Cells: Protective Effect of Mitochondrial Anti-apoptotic Protein Bcl-2
  Neurotoxicology. Jun, 2004  |   Pubmed ID: 15183012
• Suppression of Caspase-3-dependent Proteolytic Activation of Protein Kinase C Delta by Small Interfering RNA Prevents MPP+-induced Dopaminergic Degeneration
  Molecular and Cellular Neurosciences. Mar, 2004  |   Pubmed ID: 15033169
• Role of Proteolytic Activation of Protein Kinase Cdelta in Oxidative Stress-induced Apoptosis
  Antioxidants & Redox Signaling. Oct, 2003  |   Pubmed ID: 14580317
• Caspase-3 Dependent Proteolytic Activation of Protein Kinase C Delta Mediates and Regulates 1-methyl-4-phenylpyridinium (MPP+)-induced Apoptotic Cell Death in Dopaminergic Cells: Relevance to Oxidative Stress in Dopaminergic Degeneration
  The European Journal of Neuroscience. Sep, 2003  |   Pubmed ID: 14511319
• 5-hydroxytryptamine 1A Receptor Activation Protects Against N-methyl-D-aspartate-induced Apoptotic Cell Death in Striatal and Mesencephalic Cultures
  The Journal of Pharmacology and Experimental Therapeutics. Mar, 2003  |   Pubmed ID: 12604665
• Oxidative Stress and Mitochondrial-mediated Apoptosis in Dopaminergic Cells Exposed to Methylcyclopentadienyl Manganese Tricarbonyl
  The Journal of Pharmacology and Experimental Therapeutics. Jul, 2002  |   Pubmed ID: 12065696
• Caspase-3-dependent Proteolytic Cleavage of Protein Kinase Cdelta is Essential for Oxidative Stress-mediated Dopaminergic Cell Death After Exposure to Methylcyclopentadienyl Manganese Tricarbonyl
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2002  |   Pubmed ID: 11880503
• Antimyoclonic and Neuroprotective Effects of Lamotrigine in an Animal Model of Cardiac Arrest
  Restorative Neurology and Neuroscience. 1999  |   Pubmed ID: 12671243