Ari M. Melnick

Publications

• The H3K27me3 Demethylase UTX is a Gender-specific Tumor Suppressor in T-cell Acute Lymphoblastic Leukemia
  Blood. Jan, 2015  |   Pubmed ID: 25320243
• Deep Sequencing Reveals Clonal Evolution Patterns and Mutation Events Associated with Relapse in B-cell Lymphomas
  Genome Biology. 2014  |   Pubmed ID: 25123191
• Histone Deacetylase Inhibitor Treatment Induces 'BRCAness' and Synergistic Lethality with PARP Inhibitor and Cisplatin Against Human Triple Negative Breast Cancer Cells
  Oncotarget. Jul, 2014  |   Pubmed ID: 25026298
• Hematopoietic Stem Cell Origin of BRAFV600E Mutations in Hairy Cell Leukemia
  Science Translational Medicine. May, 2014  |   Pubmed ID: 24871132
• Mechanistic Rationale for Targeting the Unfolded Protein Response in Pre-B Acute Lymphoblastic Leukemia
  Proceedings of the National Academy of Sciences of the United States of America. May, 2014  |   Pubmed ID: 24821775
• Differentiation Therapy for IDH1/2 Mutant Malignancies
  Cell Research. Aug, 2013  |   Pubmed ID: 23732524
• New Effector Functions and Regulatory Mechanisms of BCL6 in Normal and Malignant Lymphocytes
  Current Opinion in Immunology. Jun, 2013  |   Pubmed ID: 23725655
• EZH2 is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
  Cancer Cell. May, 2013  |   Pubmed ID: 23680150
• BCL6 Breaks Occur at Different AID Sequence Motifs in Ig-BCL6 and Non-Ig-BCL6 Rearrangements
  Blood. May, 2013  |   Pubmed ID: 23476051
• Notch Activation Inhibits AML Growth and Survival: a Potential Therapeutic Approach
  The Journal of Experimental Medicine. Feb, 2013  |   Pubmed ID: 23359069
• Epigenetic Repression of MiR-31 Disrupts Androgen Receptor Homeostasis and Contributes to Prostate Cancer Progression
  Cancer Research. Feb, 2013  |   Pubmed ID: 23233736
• Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms
  Cancer Research. Feb, 2013  |   Pubmed ID: 23066032
• Negative Regulation of Osteoclast Precursor Differentiation by CD11b and β2 Integrin-B-cell Lymphoma 6 Signaling
  Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jan, 2013  |   Pubmed ID: 22893614
• Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-acute Lymphoblastic Leukemia
  Cancer Discovery. Nov, 2012  |   Pubmed ID: 23107779
• Genome-wide Detection of Genes Targeted by Non-Ig Somatic Hypermutation in Lymphoma
  PloS One. 2012  |   Pubmed ID: 22808135
• Oncogene-mediated Alterations in Chromatin Conformation
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2012  |   Pubmed ID: 22615383
• The Bcl6-SMRT/NCoR Cistrome Represses Inflammation to Attenuate Atherosclerosis
  Cell Metabolism. Apr, 2012  |   Pubmed ID: 22465074
• SYK Inhibition and Response Prediction in Diffuse Large B-cell Lymphoma
  Blood. Dec, 2011  |   Pubmed ID: 22025527
• BCL6-mediated Repression of P53 is Critical for Leukemia Stem Cell Survival in Chronic Myeloid Leukemia
  The Journal of Experimental Medicine. Oct, 2011  |   Pubmed ID: 21911423
• Epigenetics in AML
  Best Practice & Research. Clinical Haematology. Dec, 2010  |   Pubmed ID: 21130408
• EZH2-mediated Epigenetic Silencing in Germinal Center B Cells Contributes to Proliferation and Lymphomagenesis
  Blood. Dec, 2010  |   Pubmed ID: 20736451
• BCL6 is Critical for the Development of a Diverse Primary B Cell Repertoire
  The Journal of Experimental Medicine. Jun, 2010  |   Pubmed ID: 20498019
• Derepression in the Desert: the Third Workshop on Clinical Translation of Epigenetics in Cancer Therapeutics
  Cancer Research. Jul, 2008  |   Pubmed ID: 18593891
• The Theoretical Basis of Transcriptional Therapy of Cancer: Can It Be Put into Practice?
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2005  |   Pubmed ID: 15867201
• The Flt3 Internal Tandem Duplication Mutant Inhibits the Function of Transcriptional Repressors by Blocking Interactions with SMRT
  Blood. Jun, 2004  |   Pubmed ID: 14982881