Arnold J. Levine Rutgers Cancer Institute of New Jersey Rutgers University Biography Publications Institution JoVE Articles Arnold J. Levine has not added a biography. If you are Arnold J. Levine and would like to personalize this page please email our Author Liaison for assistance. Publications A Cell-Penetrating Bispecific Antibody for Therapeutic Regulation of Intracellular Targets Molecular Cancer Therapeutics. Aug, 2012 | Pubmed ID: 22863609 Attenuation of the Retinoblastoma Pathway in Pancreatic Neuroendocrine Tumors Due to Increased Cdk4/Cdk6 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2012 | Pubmed ID: 22761470 Amplified Loci on Chromosomes 8 and 17 Predict Early Relapse in ER-Positive Breast Cancers PloS One. 2012 | Pubmed ID: 22719901 Allele-specific P53 Mutant Reactivation Cancer Cell. May, 2012 | Pubmed ID: 22624712 Chronic Restraint Stress Attenuates P53 Function and Promotes Tumorigenesis Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22509031 Viral Reassortment As an Information Exchange Between Viral Segments Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22331898 Mutant P53 Disrupts Mammary Tissue Architecture Via the Mevalonate Pathway Cell. Jan, 2012 | Pubmed ID: 22265415 The Evolution of the P53 Family of Genes Cell Cycle (Georgetown, Tex.). Jan, 2012 | Pubmed ID: 22214668 Molecular Classification of Prostate Cancer Using Curated Expression Signatures Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22123976 Parkin, a P53 Target Gene, Mediates the Role of P53 in Glucose Metabolism and the Warburg Effect Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21930938 Introduction: The Changing Directions of P53 Research Genes & Cancer. Apr, 2011 | Pubmed ID: 21785490 Monographs Editor Genes & Cancer. Apr, 2011 | Pubmed ID: 21779506 Topology Based Data Analysis Identifies a Subgroup of Breast Cancers with a Unique Mutational Profile and Excellent Survival Proceedings of the National Academy of Sciences of the United States of America. Apr, 2011 | Pubmed ID: 21482760 The P53 Family: Guardians of Maternal Reproduction Nature Reviews. Molecular Cell Biology. Apr, 2011 | Pubmed ID: 21427767 Regulation of Female Reproduction by P53 and Its Family Members FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2011 | Pubmed ID: 21402718 A Genetic Variant in a PP2A Regulatory Subunit Encoded by the PPP2R2B Gene Associates with Altered Breast Cancer Risk and Recurrence International Journal of Cancer. Journal International Du Cancer. May, 2011 | Pubmed ID: 20669227 Polymorphic Variants in TSC1 and TSC2 and Their Association with Breast Cancer Phenotypes Breast Cancer Research and Treatment. Feb, 2011 | Pubmed ID: 20658316 Inactivation of P53 in Breast Cancers Correlates with Stem Cell Transcriptional Signatures Proceedings of the National Academy of Sciences of the United States of America. Dec, 2010 | Pubmed ID: 21149740 The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes Science (New York, N.Y.). Dec, 2010 | Pubmed ID: 21127244 Association of Nuclear Localization of a Long Interspersed Nuclear Element-1 Protein in Breast Tumors with Poor Prognostic Outcomes Genes & Cancer. Feb, 2010 | Pubmed ID: 20948976 Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the P53 Pathway Genes & Cancer. May, 2010 | Pubmed ID: 20871795 Sequences from Ancestral Single-stranded DNA Viruses in Vertebrate Genomes: the Parvoviridae and Circoviridae Are More Than 40 to 50 Million Years Old Journal of Virology. Dec, 2010 | Pubmed ID: 20861255 A High-frequency Regulatory Polymorphism in the P53 Pathway Accelerates Tumor Development Cancer Cell. Sep, 2010 | Pubmed ID: 20832750 Unexpected Inheritance: Multiple Integrations of Ancient Bornavirus and Ebolavirus/marburgvirus Sequences in Vertebrate Genomes PLoS Pathogens. 2010 | Pubmed ID: 20686665 Negative Regulation of Tumor Suppressor P53 by MicroRNA MiR-504 Molecular Cell. Jun, 2010 | Pubmed ID: 20542001 P53 and NF-κB: Different Strategies for Responding to Stress Lead to a Functional Antagonism FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2010 | Pubmed ID: 20530750 The Origins and Evolution of the P53 Family of Genes Cold Spring Harbor Perspectives in Biology. Jun, 2010 | Pubmed ID: 20516129 Identifying MRNA Targets of MicroRNA Dysregulated in Cancer: with Application to Clear Cell Renal Cell Carcinoma BMC Systems Biology. 2010 | Pubmed ID: 20420713 Fine-scale Detection of Population-specific Linkage Disequilibrium Using Haplotype Entropy in the Human Genome BMC Genetics. 2010 | Pubmed ID: 20416085 The Regulation of Energy Metabolism and the IGF-1/mTOR Pathways by the P53 Protein Trends in Cell Biology. Jul, 2010 | Pubmed ID: 20399660 Higher Order Boolean Networks As Models of Cell State Dynamics Journal of Theoretical Biology. Jun, 2010 | Pubmed ID: 20303985 Germline Mutations and Polymorphisms in the Origins of Cancers in Women Journal of Oncology. 2010 | Pubmed ID: 20111735 Differential Levels of Transcription of P53-regulated Genes by the Arginine/proline Polymorphism: P53 with Arginine at Codon 72 Favors Apoptosis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2010 | Pubmed ID: 20019240 Chemosensitivity Profiles Identify Polymorphisms in the P53 Network Genes 14-3-3tau and CD44 That Affect Sarcoma Incidence and Survival Cancer Research. Jan, 2010 | Pubmed ID: 19996285 The Regulation of Human Reproduction by P53 and Its Pathway Cell Cycle (Georgetown, Tex.). Nov, 2009 | Pubmed ID: 19884797 One Billion Years of P53/p63/p73 Evolution Proceedings of the National Academy of Sciences of the United States of America. Oct, 2009 | Pubmed ID: 19826090 Stem Cell Biology Meets P53 Nature Biotechnology. Oct, 2009 | Pubmed ID: 19816447 The First 30 Years of P53: Growing Ever More Complex Nature Reviews. Cancer. Oct, 2009 | Pubmed ID: 19776744 Recent Natural Selection Identifies a Genetic Variant in a Regulatory Subunit of Protein Phosphatase 2A That Associates with Altered Cancer Risk and Survival Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2009 | Pubmed ID: 19773383 A Polymorphic Variant in Human MDM4 Associates with Accelerated Age of Onset of Estrogen Receptor Negative Breast Cancer Carcinogenesis. Nov, 2009 | Pubmed ID: 19762336 Patterns of Oligonucleotide Sequences in Viral and Host Cell RNA Identify Mediators of the Host Innate Immune System PloS One. 2009 | Pubmed ID: 19536338 Altered Tumor Formation and Evolutionary Selection of Genetic Variants in the Human MDM4 Oncogene Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19497887 Single-nucleotide Polymorphisms in the P53 Pathway Regulate Fertility in Humans Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19470478 The Regulation of the Endosomal Compartment by P53 the Tumor Suppressor Gene The FEBS Journal. Apr, 2009 | Pubmed ID: 19302216 The Common Mechanisms of Transformation by the Small DNA Tumor Viruses: The Inactivation of Tumor Suppressor Gene Products: P53 Virology. Feb, 2009 | Pubmed ID: 19081592 Non-random Reassortment in Human Influenza A Viruses Influenza and Other Respiratory Viruses. Jan, 2008 | Pubmed ID: 19453489 The Genetics of the P53 Pathway, Apoptosis and Cancer Therapy Nature Reviews. Drug Discovery. Dec, 2008 | Pubmed ID: 19043449 P53 Mutations in Lymphomas: Position Matters Blood. Oct, 2008 | Pubmed ID: 18840714 Why Do We Not Yet Have a Human Immunodeficiency Virus Vaccine? Journal of Virology. Dec, 2008 | Pubmed ID: 18829744 A Recoding Method to Improve the Humoral Immune Response to an HIV DNA Vaccine PloS One. 2008 | Pubmed ID: 18791646 Anomalies in the Influenza Virus Genome Database: New Biology or Laboratory Errors? Journal of Virology. Sep, 2008 | Pubmed ID: 18579605 Patterns of Evolution and Host Gene Mimicry in Influenza and Other RNA Viruses PLoS Pathogens. Jun, 2008 | Pubmed ID: 18535658 P53: a New Player in Reproduction Cell Cycle (Georgetown, Tex.). Apr, 2008 | Pubmed ID: 18414047 The Tumor Suppressor P53: Cancer and Aging Cell Cycle (Georgetown, Tex.). Apr, 2008 | Pubmed ID: 18414039 The Computational Detection of Functional Nucleotide Sequence Motifs in the Coding Regions of Organisms Experimental Biology and Medicine (Maywood, N.J.). Jun, 2008 | Pubmed ID: 18408149 An Information-theoretic Analysis of Genetics, Gender and Age in Cancer Patients PloS One. 2008 | Pubmed ID: 18398474 Suppression of Immediate-early Viral Gene Expression by Herpesvirus-coded MicroRNAs: Implications for Latency Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18378902 Highly Conserved Regions of Influenza a Virus Polymerase Gene Segments Are Critical for Efficient Viral RNA Packaging Journal of Virology. Mar, 2008 | Pubmed ID: 18094182 P53 Regulates Maternal Reproduction Through LIF Nature. Nov, 2007 | Pubmed ID: 18046411 High Expression of Lymphocyte-associated Genes in Node-negative HER2+ Breast Cancers Correlates with Lower Recurrence Rates Cancer Research. Nov, 2007 | Pubmed ID: 18006808 Probing Potential Binding Modes of the P53 Tetramer to DNA Based on the Symmetries Encoded in P53 Response Elements Nucleic Acids Research. 2007 | Pubmed ID: 17986463 Reconstructing Signal Transduction Pathways: Challenges and Opportunities Annals of the New York Academy of Sciences. Dec, 2007 | Pubmed ID: 17934060 Declining P53 Function in the Aging Process: a Possible Mechanism for the Increased Tumor Incidence in Older Populations Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17921246 Sequence Analysis of P53 Response-elements Suggests Multiple Binding Modes of the P53 Tetramer to DNA Targets Nucleic Acids Research. 2007 | Pubmed ID: 17439973 The Regulation of AMPK Beta1, TSC2, and PTEN Expression by P53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways Cancer Research. Apr, 2007 | Pubmed ID: 17409411 A Single Nucleotide Polymorphism in the MDM2 Gene Disrupts the Oscillation of P53 and MDM2 Levels in Cells Cancer Research. Mar, 2007 | Pubmed ID: 17363597 Haplotype Structure and Selection of the MDM2 Oncogene in Humans Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17360557 Comparison of Avian and Human Influenza A Viruses Reveals a Mutational Bias on the Viral Genomes Journal of Virology. Dec, 2006 | Pubmed ID: 16987977 MDM2 SNP309 Accelerates Colorectal Tumour Formation in Women Journal of Medical Genetics. Dec, 2006 | Pubmed ID: 16825430 MDM2 SNP309 Accelerates Tumor Formation in a Gender-specific and Hormone-dependent Manner Cancer Research. May, 2006 | Pubmed ID: 16707433 The Regulation of Exosome Secretion: a Novel Function of the P53 Protein Cancer Research. May, 2006 | Pubmed ID: 16651434 Comparison of the Human and Worm P53 Structures Suggests a Way for Enhancing Stability Biochemistry. Mar, 2006 | Pubmed ID: 16548519 Beyond PTEN Mutations: the PI3K Pathway As an Integrator of Multiple Inputs During Tumorigenesis Nature Reviews. Cancer. Mar, 2006 | Pubmed ID: 16453012 Coordination and Communication Between the P53 and IGF-1-AKT-TOR Signal Transduction Pathways Genes & Development. Feb, 2006 | Pubmed ID: 16452501 A Robust Meta-classification Strategy for Cancer Detection from MS Data Proteomics. Jan, 2006 | Pubmed ID: 16342141 A Robust Meta-classification Strategy for Cancer Diagnosis from Gene Expression Data Proceedings / IEEE Computational Systems Bioinformatics Conference, CSB. IEEE Computational Systems Bioinformatics Conference. 2005 | Pubmed ID: 16447989 Robust Diagnosis of Non-Hodgkin Lymphoma Phenotypes Validated on Gene Expression Data from Different Laboratories Genome Informatics. International Conference on Genome Informatics. 2005 | Pubmed ID: 16362926 A Relative-entropy Algorithm for Genomic Fingerprinting Captures Host-phage Similarities Journal of Bacteriology. Dec, 2005 | Pubmed ID: 16321941 Detection of Functional Single-nucleotide Polymorphisms That Affect Apoptosis Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005 | Pubmed ID: 16260726 The Contribution of the Trp/Met/Phe Residues to Physical Interactions of P53 with Cellular Proteins Physical Biology. Jun, 2005 | Pubmed ID: 16204849 A Plausible Model for the Digital Response of P53 to DNA Damage Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005 | Pubmed ID: 16186499 The Coordinate Regulation of the P53 and MTOR Pathways in Cells Proceedings of the National Academy of Sciences of the United States of America. Jun, 2005 | Pubmed ID: 15928081 A Chromatin-associated and Transcriptionally Inactive P53-Mdm2 Complex Occurs in Mdm2 SNP309 Homozygous Cells The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15908423 The P53 Pathway: Positive and Negative Feedback Loops Oncogene. Apr, 2005 | Pubmed ID: 15838523 Comparison of the Protein-protein Interfaces in the P53-DNA Crystal Structures: Towards Elucidation of the Biological Interface Proceedings of the National Academy of Sciences of the United States of America. Mar, 2005 | Pubmed ID: 15738397 MDM2 is a Central Node in the P53 Pathway: 12 Years and Counting Current Cancer Drug Targets. Feb, 2005 | Pubmed ID: 15720184 In the Quest for Stable Rescuing Mutants of P53: Computational Mutagenesis of Flexible Loop L1 Biochemistry. Feb, 2005 | Pubmed ID: 15683227 A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the P53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans Cell. Nov, 2004 | Pubmed ID: 15550242 Epigenetic and Genetic Loss of Hic1 Function Accentuates the Role of P53 in Tumorigenesis Cancer Cell. Oct, 2004 | Pubmed ID: 15488761 Tissue-specific Codon Usage and the Expression of Human Genes Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15314228 Actvation of NF-kappaB by the API2/MALT1 Fusions Inhibits P53 Dependant but Not FAS Induced Apoptosis: a Directional Link Between NF-kappaB and P53 Cell Cycle (Georgetown, Tex.). Aug, 2004 | Pubmed ID: 15280657 Activation of NF-kappaB and Inhibition of P53-mediated Apoptosis by API2/mucosa-associated Lymphoid Tissue 1 Fusions Promote Oncogenesis Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15184680 P53 is a Tumor Suppressor Gene Cell. Jan, 2004 | Pubmed ID: 15055586 Dynamics of the P53-Mdm2 Feedback Loop in Individual Cells Nature Genetics. Feb, 2004 | Pubmed ID: 14730303 Beclin 1, an Autophagy Gene Essential for Early Embryonic Development, is a Haploinsufficient Tumor Suppressor Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14657337 The Presence of P53 Mutations in Human Osteosarcomas Correlates with High Levels of Genomic Instability Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 12972634 CIAP1 and the Serine Protease HTRA2 Are Involved in a Novel P53-dependent Apoptosis Pathway in Mammals Genes & Development. Feb, 2003 | Pubmed ID: 12569127 Overexpression of WISP-1 Down-regulated Motility and Invasion of Lung Cancer Cells Through Inhibition of Rac Activation The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12529380 Stochastic Gene Expression in a Single Cell Science (New York, N.Y.). Aug, 2002 | Pubmed ID: 12183631 Novel Gain of Function Activity of P53 Mutants: Activation of the DUTPase Gene Expression Leading to Resistance to 5-fluorouracil Oncogene. Jul, 2002 | Pubmed ID: 12096336 P53 Regulates Cell Survival by Inhibiting PIK3CA in Squamous Cell Carcinomas Genes & Development. Apr, 2002 | Pubmed ID: 11959846 WISP-1 Attenuates P53-mediated Apoptosis in Response to DNA Damage Through Activation of the Akt Kinase Genes & Development. Jan, 2002 | Pubmed ID: 11782444 High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately Wenjin Chen2,3, Chung Wong1,3, Evan Vosburgh1,3, Arnold J. Levine3,4, David J. Foran2,3, Eugenia Y. Xu1,3 1Raymond and Beverly Sackler Foundation, New Jersey, 2Histopathology and Imaging Shared Resource, Rutgers University, 3Rutgers Cancer Institute of New Jersey, Rutgers University, 4School of Natural Sciences, Institute for Advanced Study, New Jersey JoVE 51639 Biology Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy Chung Wong1, Evan Vosburgh1,2, Arnold J. Levine2,3, Lei Cong2, Eugenia Y. Xu1,2 1Raymond and Beverly Sackler Foundation, 2The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, 3School of Natural Sciences, Institute for Advanced Study, Princeton, New Jersey JoVE 4218 Medicine
High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately Wenjin Chen2,3, Chung Wong1,3, Evan Vosburgh1,3, Arnold J. Levine3,4, David J. Foran2,3, Eugenia Y. Xu1,3 1Raymond and Beverly Sackler Foundation, New Jersey, 2Histopathology and Imaging Shared Resource, Rutgers University, 3Rutgers Cancer Institute of New Jersey, Rutgers University, 4School of Natural Sciences, Institute for Advanced Study, New Jersey JoVE 51639 Biology
Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy Chung Wong1, Evan Vosburgh1,2, Arnold J. Levine2,3, Lei Cong2, Eugenia Y. Xu1,2 1Raymond and Beverly Sackler Foundation, 2The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, 3School of Natural Sciences, Institute for Advanced Study, Princeton, New Jersey JoVE 4218 Medicine
