Other Publications (1)
Articles by Artiom Gruzdev in JoVE
Trans-inner Cell Mass Injection of Embryonic Stem Cells Leads to Higher Chimerism Rates Gregory J. Scott1, Artiom Gruzdev1, Thomas B. Hagler1, Manas K. Ray1 1Knock Out Mouse Core, NIEHS/NIH Here we present a protocol to increase chimera production without the use of new equipment. A simple orientation change of the embryo for injection can increase the number of embryos produced, and potentially reduce the timeline to germline transmission.
Other articles by Artiom Gruzdev on PubMed
Regulation of T Helper Cell Subsets by Cyclooxygenases and Their Metabolites Prostaglandins & Other Lipid Mediators. Nov, 2012 | Pubmed ID: 23201570 Cyclooxygenases and their metabolites are important regulators of inflammatory responses and play critical roles in regulating the differentiation of T helper cell subsets in inflammatory diseases. In this review, we highlight new information on regulation of T helper cell subsets by cyclooxygenases and their metabolites. Prostanoids influence cytokine production by both antigen presenting cells and T cells to regulate the differentiation of naÃ¯ve CD4(+) T cells to Th1, Th2 and Th17 cell phenotypes. Cyclooxygenases and PGE(2) generally exacerbate Th2 and Th17 phenotypes, while suppressing Th1 differentiation. Thus, cycloxygenases may play a critical role in diseases that involve immune cell dysfunction. Targeting of cyclooxygenases and their eicosanoid products may represent a new approach for treatment of inflammatory diseases, tumors and autoimmune disorders.