Articles by Ashlee R. Venancio in JoVE
一种确定环境富集对小鼠结肠肿瘤模型结肠菌群生物多样性影响的方法 Andrew K. Fuller1,2, Benjamin D. Bice1,2, Ashlee R. Venancio1,2, Olivia M. Crowley1,2, Ambur M. Staab1,2, Stephanie J. Georges1,2, Julio R. Hidalgo1,2, Annika V. Warncke1,2, Melinda L. Angus-Hill1,2 1Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, University of Utah, 2Huntsman Cancer Institute, University of Utah 环境富集 (EE) 是一种动物住房环境, 用于揭示生活方式、压力和疾病之间联系的机制。该协议描述了一个使用结肠肿瘤发生的小鼠模型和 EE 的过程, 专门定义可能影响动物死亡率的微生物群落生物多样性的变化。
Other articles by Ashlee R. Venancio on PubMed
Environmental Enrichment Induces Pericyte and IgA-Dependent Wound Repair and Lifespan Extension in a Colon Tumor Model Cell Reports. | Pubmed ID: 28445727 Environmental enrichment (EE) replicates mind-body therapy by providing complex housing to laboratory animals to improve their activity levels, behavior, and social interactions. Using a Tcf4Apc-mediated model of colon tumorigenesis, we found that EE vastly improved the survival of tumor-bearing animals, with differential effect on tumor load in male compared to female animals. Analysis of Tcf4Apcmales showed drastically reduced expression of circulating inflammatory cytokines and induced nuclear hormone receptor (NHR) signaling, both of which are common in the wound repair process. Interestingly, EE provoked tumor wound repair resolution through revascularization, plasma cell recruitment and IgA secretion, replacement of glandular tumor structures with pericytes in a process reminiscent of scarring, and normalization of microbiota. These EE-dependent changes likely underlie the profound improvement in survival of colon-tumor-bearing Tcf4Apcmales. Our studies highlight the exciting promise of EE in the design of future therapeutic strategies for colon cancer patients.