Assaf Friedler

Publications

• The Disordered Region of Arabidopsis VIP1 Binds the Agrobacterium VirE2 Protein Outside Its DNA-binding Site
  Protein Engineering, Design & Selection : PEDS. Nov, 2014  |   Pubmed ID: 25212215
• A Role of Disordered Domains in Regulating Protein Oligomerization and Stability
  Chemical Communications (Cambridge, England). Sep, 2014  |   Pubmed ID: 25054624
• A Tandem in Situ Peptide Cyclization Through Trifluoroacetic Acid Cleavage
  Angewandte Chemie (International Ed. in English). Sep, 2014  |   Pubmed ID: 24827640
• Bacterial Magnetosome Biomineralization--a Novel Platform to Study Molecular Mechanisms of Human CDF-related Type-II Diabetes
  PloS One. 2014  |   Pubmed ID: 24819161
• Allosteric Modulation of Protein Oligomerization: an Emerging Approach to Drug Design
  Frontiers in Chemistry. 2014  |   Pubmed ID: 24790978
• Integrated Strategy Reveals the Protein Interface Between Cancer Targets Bcl-2 and NAF-1
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014  |   Pubmed ID: 24706857
• Cation Diffusion Facilitators Transport Initiation and Regulation is Mediated by Cation Induced Conformational Changes of the Cytoplasmic Domain
  PloS One. 2014  |   Pubmed ID: 24658343
• A Highly Efficient in Situ N-acetylation Approach for Solid Phase Synthesis
  Organic & Biomolecular Chemistry. Mar, 2014  |   Pubmed ID: 24526269
• The STIL Protein Contains Intrinsically Disordered Regions That Mediate Its Protein-protein Interactions
  Chemical Communications (Cambridge, England). May, 2014  |   Pubmed ID: 24022511
• Acetylation of Lysine 382 and Phosphorylation of Serine 392 in P53 Modulate the Interaction Between P53 and MDC1 in Vitro
  PloS One. 2013  |   Pubmed ID: 24194938
• Characterization of the Translocation-competent Complex Between the Helicobacter Pylori Oncogenic Protein CagA and the Accessory Protein CagF
  The Journal of Biological Chemistry. Nov, 2013  |   Pubmed ID: 24072713
• Mapping the Vif-A3G Interaction Using Peptide Arrays: a Basis for Anti-HIV Lead Peptides
  Bioorganic & Medicinal Chemistry. Jun, 2013  |   Pubmed ID: 23545135
• Regulation of ASPP2 Interaction with P53 Core Domain by an Intramolecular Autoinhibitory Mechanism
  PloS One. 2013  |   Pubmed ID: 23472201
• Monitoring the HIV-1 Integrase Enzymatic Activity Using Atomic Force Microscopy in a 2LTR System
  Chemical Communications (Cambridge, England). Apr, 2013  |   Pubmed ID: 23463374
• High Resolution Characterization of Myosin IIC Protein Tailpiece and Its Effect on Filament Assembly
  The Journal of Biological Chemistry. Apr, 2013  |   Pubmed ID: 23426373
• Revealing the Ligand Binding Site of NhaA Na+/H+ Antiporter and Its PH Dependence
  The Journal of Biological Chemistry. Nov, 2012  |   Pubmed ID: 22915592
• Peptides That Inhibit HIV-1 Integrase by Blocking Its Protein-protein Interactions
  The FEBS Journal. Aug, 2012  |   Pubmed ID: 22742518
• Specific Recognition of P53 Tetramers by Peptides Derived from P53 Interacting Proteins
  PloS One. 2012  |   Pubmed ID: 22693587
• A Comparative Study of Backbone Versus Side Chain Peptide Cyclization: Application for HIV-1 Integrase Inhibitors
  Bioorganic & Medicinal Chemistry. May, 2012  |   Pubmed ID: 22507205
• Molecular Basis of the Interaction Between Proapoptotic Truncated BID (tBID) Protein and Mitochondrial Carrier Homologue 2 (MTCH2) Protein: Key Players in Mitochondrial Death Pathway
  The Journal of Biological Chemistry. Apr, 2012  |   Pubmed ID: 22416135
• Peptides Mimicking the Unique ARTS-XIAP Binding Site Promote Apoptotic Cell Death in Cultured Cancer Cells
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2012  |   Pubmed ID: 22392914
• A Structural Model of the HIV-1 Rev-integrase Complex: the Molecular Basis of Integrase Regulation by Rev
  Biochemical and Biophysical Research Communications. Dec, 2011  |   Pubmed ID: 22093836
• Exposición De Señal Hidrofóbico Bipartita Desencadena Nuclear Control De Calidad De Ndc10 En La Envoltura Nuclear Retículo Endoplásmico
  Molecular Biology of the Cell. Dec, 2011  |   Pubmed ID: 21998200
• Mechanism of the Interaction Between the Intrinsically Disordered C-terminus of the Pro-apoptotic ARTS Protein and the Bir3 Domain of XIAP
  PloS One. 2011  |   Pubmed ID: 21949740
• Chemical Synthesis and Expression of the HIV-1 Rev Protein
  Chembiochem : a European Journal of Chemical Biology. May, 2011  |   Pubmed ID: 21488138
• The Effect of Tachykinin Neuropeptides on Amyloid β Aggregation
  Biochemical and Biophysical Research Communications. Apr, 2011  |   Pubmed ID: 21352807
• Crowding Alone Cannot Account for Cosolute Effect on Amyloid Aggregation
  PloS One. 2011  |   Pubmed ID: 21249221
• Studying Protein-protein Interactions Using Peptide Arrays
  Chemical Society Reviews. May, 2011  |   Pubmed ID: 21243154
• Peptides That Bind the HIV-1 Integrase and Modulate Its Enzymatic Activity--kinetic Studies and Mode of Action
  The FEBS Journal. Jan, 2011  |   Pubmed ID: 21156026
• Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded
  Journal of Molecular Biology. Jan, 2011  |   Pubmed ID: 21087614
• From Peptides to Proteins: Lessons from My Years at the Centre for Protein Engineering
  Protein Engineering, Design & Selection : PEDS. Jan, 2011  |   Pubmed ID: 21062759
• The ASPP Interaction Network: Electrostatic Differentiation Between Pro- and Anti-apoptotic Proteins
  Journal of Molecular Recognition : JMR. Mar-Apr, 2011  |   Pubmed ID: 20623514
• Using Peptides to Study Protein-protein Interactions
  Future Medicinal Chemistry. Jun, 2010  |   Pubmed ID: 21426115
• Nucleocytoplasmic Shuttling of HIV-1 Integrase is Controlled by the Viral Rev Protein
  Nucleus (Austin, Tex.). Mar-Apr, 2010  |   Pubmed ID: 21326951
• Transportin 3 and Importin α Are Required for Effective Nuclear Import of HIV-1 Integrase in Virus-infected Cells
  Nucleus (Austin, Tex.). Sep-Oct, 2010  |   Pubmed ID: 21326825
• Cyclic Peptide Inhibitors of HIV-1 Integrase Derived from the LEDGF/p75 Protein
  Bioorganic & Medicinal Chemistry. Dec, 2010  |   Pubmed ID: 20974536
• A Family of Cell-adhering Peptides Homologous to Fibrinogen C-termini
  Biochemical and Biophysical Research Communications. Oct, 2010  |   Pubmed ID: 20833137
• Specific Eradication of HIV-1 from Infected Cultured Cells
  AIDS Research and Therapy. 2010  |   Pubmed ID: 20723214
• Peptides Derived from the HIV-1 Integrase Promote HIV-1 Infection and Multi-integration of Viral CDNA in LEDGF/p75-knockdown Cells
  Virology Journal. 2010  |   Pubmed ID: 20678206
• The C Terminus of P53 Binds the N-terminal Domain of MDM2
  Nature Structural & Molecular Biology. Aug, 2010  |   Pubmed ID: 20639885
• Oxidation of Helix-3 Methionines Precedes the Formation of PK Resistant PrP
  PLoS Pathogens. 2010  |   Pubmed ID: 20625387
• Stimulation of the HIV-1 Integrase Enzymatic Activity and CDNA Integration by a Peptide Derived from the Integrase Protein
  Biopolymers. Aug, 2010  |   Pubmed ID: 20517955
• Peptide-modified "smart" Hydrogels and Genetically Engineered Stem Cells for Skeletal Tissue Engineering
  Biomacromolecules. Jun, 2010  |   Pubmed ID: 20462241
• Structural Disorder in the HIV-1 Vif Protein and Interaction-dependent Gain of Structure
  Protein and Peptide Letters. Aug, 2010  |   Pubmed ID: 20450485
• Mechanism of Action of the HIV-1 Integrase Inhibitory Peptide LEDGF 361-370
  Biochemical and Biophysical Research Communications. Apr, 2010  |   Pubmed ID: 20171172
• Over-expression of the HIV-1 Rev Promotes Death of Nondividing Eukaryotic Cells
  Virus Genes. Jun, 2010  |   Pubmed ID: 20151187
• A Novel Role for the Viral Rev Protein in Promoting Resistance to Superinfection by Human Immunodeficiency Virus Type 1
  The Journal of General Virology. Jun, 2010  |   Pubmed ID: 20147519
• The Positively Charged Region of the Myosin IIC Non-helical Tailpiece Promotes Filament Assembly
  The Journal of Biological Chemistry. Mar, 2010  |   Pubmed ID: 19959848
• Integration of HIV-1 DNA is Regulated by Interplay Between Viral Rev and Cellular LEDGF/p75 Proteins
  Molecular Medicine (Cambridge, Mass.). Jan-Feb, 2010  |   Pubmed ID: 19855849
• Novel Regulation of HIV-1 Replication and Pathogenicity: Rev Inhibition of Integration
  Protein Engineering, Design & Selection : PEDS. Dec, 2009  |   Pubmed ID: 19875511
• Peptide Inhibitors of HIV-1 Integrase: from Mechanistic Studies to Improved Lead Compounds
  Bioorganic & Medicinal Chemistry. Nov, 2009  |   Pubmed ID: 19850483
• A Model for the Interaction Between NF-kappa-B and ASPP2 Suggests an I-kappa-B-like Binding Mechanism
  Proteins. Nov, 2009  |   Pubmed ID: 19507243
• The C-terminal Domain of the HIV-1 Vif Protein is Natively Unfolded in Its Unbound State
  Protein Engineering, Design & Selection : PEDS. May, 2009  |   Pubmed ID: 19218568
• Peptides Derived from HIV-1 Integrase That Bind Rev Stimulate Viral Genome Integration
  PloS One. 2009  |   Pubmed ID: 19127291
• Design and Synthesis of Backbone Cyclic Phosphorylated Peptides: The IkappaB Model
  Biopolymers. Feb, 2009  |   Pubmed ID: 19025995
• Molecular Basis of the Interaction Between the Antiapoptotic Bcl-2 Family Proteins and the Proapoptotic Protein ASPP2
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008  |   Pubmed ID: 18719108
• The Structure and Interactions of the Proline-rich Domain of ASPP2
  The Journal of Biological Chemistry. Jul, 2008  |   Pubmed ID: 18448430
• Synthesis of a Novel Macrocyclic Library: Discovery of an IGF-1R Inhibitor
  Journal of Combinatorial Chemistry. Mar-Apr, 2008  |   Pubmed ID: 18271560
• Peptides Derived from HIV-1 Rev Inhibit HIV-1 Integrase in a Shiftide Mechanism
  Biopolymers. 2008  |   Pubmed ID: 18219678
• Correlation Between Shiftide Activity and HIV-1 Integrase Inhibition by a Peptide Selected from a Combinatorial Library
  Journal of Molecular Biology. Feb, 2008  |   Pubmed ID: 18201721
• Using Peptides to Study the Interaction Between the P53 Tetramerization Domain and HIV-1 Tat
  Biopolymers. 2008  |   Pubmed ID: 18189286
• The DNA Damage Response Mediator MDC1 Directly Interacts with the Anaphase-promoting Complex/cyclosome
  The Journal of Biological Chemistry. Nov, 2007  |   Pubmed ID: 17827148
• Expression and Characterization of a Novel Reverse Transcriptase of the LTR Retrotransposon Tf1
  Virology. Sep, 2007  |   Pubmed ID: 17524442
• Inhibiting HIV-1 Integrase by Shifting Its Oligomerization Equilibrium
  Proceedings of the National Academy of Sciences of the United States of America. May, 2007  |   Pubmed ID: 17488811
• Interaction Between HIV-1 Rev and Integrase Proteins: a Basis for the Development of Anti-HIV Peptides
  The Journal of Biological Chemistry. May, 2007  |   Pubmed ID: 17403681
• Butyrylcholinesterase Attenuates Amyloid Fibril Formation in Vitro
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006  |   Pubmed ID: 16731619
• Modulation of Binding of DNA to the C-terminal Domain of P53 by Acetylation
  Structure (London, England : 1993). Apr, 2005  |   Pubmed ID: 15837201
• Binding of Rad51 and Other Peptide Sequences to a Promiscuous, Highly Electrostatic Binding Site in P53
  The Journal of Biological Chemistry. Mar, 2005  |   Pubmed ID: 15611070
• Comparison of BRCT Domains of BRCA1 and 53BP1: a Biophysical Analysis
  Protein Science : a Publication of the Protein Society. Mar, 2004  |   Pubmed ID: 14978302
• Binding of P53-derived Ligands to MDM2 Induces a Variety of Long Range Conformational Changes
  Journal of Molecular Biology. Feb, 2004  |   Pubmed ID: 14741215
• Structural Distortion of P53 by the Mutation R249S and Its Rescue by a Designed Peptide: Implications for "mutant Conformation"
  Journal of Molecular Biology. Feb, 2004  |   Pubmed ID: 14741214
• Rescue of Mutants of the Tumor Suppressor P53 in Cancer Cells by a Designed Peptide
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003  |   Pubmed ID: 14595027
• Cooperative Organization in a Macromolecular Complex
  Nature Structural Biology. Sep, 2003  |   Pubmed ID: 12897769
• Kinetic Instability of P53 Core Domain Mutants: Implications for Rescue by Small Molecules
  The Journal of Biological Chemistry. Jun, 2003  |   Pubmed ID: 12700230
• Molecular Mechanism of the Interaction Between MDM2 and P53
  Journal of Molecular Biology. Oct, 2002  |   Pubmed ID: 12381304
• The Structure of an FF Domain from Human HYPA/FBP11
  Journal of Molecular Biology. Oct, 2002  |   Pubmed ID: 12381297
• Human Immunodeficiency Virus Type 1 Vif Binds the Viral Protease by Interaction with Its N-terminal Region
  The Journal of General Virology. Sep, 2002  |   Pubmed ID: 12185277
• Two Sequence Motifs from HIF-1alpha Bind to the DNA-binding Site of P53
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002  |   Pubmed ID: 12124396
• HIV-1 Vif-derived Peptide Inhibits Drug-resistant HIV Proteases
  Biochemical and Biophysical Research Communications. Apr, 2002  |   Pubmed ID: 11944889
• Inhibition of Nuclear Import by Backbone Cyclic Peptidomimetics Derived from the HIV-1 MA NLS Sequence
  Biochimica Et Biophysica Acta. Feb, 2002  |   Pubmed ID: 11904219
• A Peptide That Binds and Stabilizes P53 Core Domain: Chaperone Strategy for Rescue of Oncogenic Mutants
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2002  |   Pubmed ID: 11782540