Atsushi Enomoto Department of Pathology Nagoya University Graduate School of Medicine Biography Publications Institution JoVE Articles Atsushi Enomoto has not added a biography. If you are Atsushi Enomoto and would like to personalize this page please email our Author Liaison for assistance. Publications Newly Established Patient-derived Organoid Model of Intracranial Meningioma Neuro-oncology. Jul, 2021 | Pubmed ID: 34214169 The BMP Antagonist Gremlin 1 Contributes to the Development of Cortical Excitatory Neurons, Motor Balance and Fear Responses Development (Cambridge, England). 07, 2021 | Pubmed ID: 34184027 Size and Surface Modification of Silica Nanoparticles Affect the Severity of Lung Toxicity by Modulating Endosomal ROS Generation in Macrophages Particle and Fibre Toxicology. 06, 2021 | Pubmed ID: 34134732 The CD44/COL17A1 Pathway Promotes the Formation of Multilayered, Transformed Epithelia Current Biology : CB. Jul, 2021 | Pubmed ID: 34087104 Fibroblasts Positive for Meflin Have Anti-fibrotic Property in Pulmonary Fibrosis The European Respiratory Journal. May, 2021 | Pubmed ID: 34049947 A New Primate Model of Hypophyseal Dysfunction Scientific Reports. May, 2021 | Pubmed ID: 34031474 The Sodium-glucose Cotransporter-2 Inhibitor Tofogliflozin Prevents the Progression of Nonalcoholic Steatohepatitis-associated Liver Tumors in a Novel Murine Model Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Aug, 2021 | Pubmed ID: 34029949 CD4 T Cells Are Essential for the Development of Destructive Thyroiditis Induced by Anti-PD-1 Antibody in Thyroglobulin-immunized Mice Science Translational Medicine. 05, 2021 | Pubmed ID: 33980577 Meflin Defines Mesenchymal Stem Cells And/or Their Early Progenitors with Multilineage Differentiation Capacity Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jul, 2021 | Pubmed ID: 33960573 Oncolytic Activity of Naturally Attenuated Herpes-simplex Virus HF10 Against an Immunocompetent Model of Oral Carcinoma Molecular Therapy Oncolytics. Mar, 2021 | Pubmed ID: 33665360 The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis Gastroenterology. 03, 2021 | Pubmed ID: 33197448 Vascular PDGFR-alpha Protects Against BBB Dysfunction After Stroke in Mice Angiogenesis. 02, 2021 | Pubmed ID: 32918673 CD109 Regulates in Vivo Tumor Invasion in Lung Adenocarcinoma Through TGF-β Signaling Cancer Science. Dec, 2020 | Pubmed ID: 33007133 The Daple-CK1ε Complex Regulates Dvl2 Phosphorylation and Canonical Wnt Signaling Biochemical and Biophysical Research Communications. 11, 2020 | Pubmed ID: 32888647 Complex Roles of the Actin-binding Protein Girdin/GIV in DNA Damage-induced Apoptosis of Cancer Cells Cancer Science. Nov, 2020 | Pubmed ID: 32875699 Connective Tissue Growth Factor Produced by Cancer‑associated Fibroblasts Correlates with Poor Prognosis in Epithelioid Malignant Pleural Mesothelioma Oncology Reports. Sep, 2020 | Pubmed ID: 32705221 Cancer-associated Fibroblasts That Restrain Cancer Progression: Hypotheses and Perspectives Cancer Science. Apr, 2020 | Pubmed ID: 32060987 Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis Cancer Research. 10, 2019 | Pubmed ID: 31439548 TDP-43 Regulates Early-phase Insulin Secretion Via CaV1.2-mediated Exocytosis in Islets The Journal of Clinical Investigation. 07, 2019 | Pubmed ID: 31355778 Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction Circulation Research. 08, 2019 | Pubmed ID: 31221024 CD109: a Multifunctional GPI-anchored Protein with Key Roles in Tumor Progression and Physiological Homeostasis Pathology International. May, 2019 | Pubmed ID: 31219232 Dephosphorylation of Girdin by PP2A Inhibits Breast Cancer Metastasis Biochemical and Biophysical Research Communications. 05, 2019 | Pubmed ID: 30935690 Cancer-associated Fibroblasts in Gastrointestinal Cancer Nature Reviews. Gastroenterology & Hepatology. 05, 2019 | Pubmed ID: 30778141 A Rare Pseudo Tumour in the Extraembryonic Coelom in First Trimester of Pregnancy: Ultrasound and Pathology Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology. May, 2019 | Pubmed ID: 30406702 Chemerin Promotes Angiogenesis In vivo Physiological Reports. Dec, 2018 | Pubmed ID: 30588761 Girdin/GIV Regulates Collective Cancer Cell Migration by Controlling Cell Adhesion and Cytoskeletal Organization Cancer Science. Nov, 2018 | Pubmed ID: 30194792 Trefoil Factor 1 Inhibits Epithelial-mesenchymal Transition of Pancreatic Intraepithelial Neoplasm The Journal of Clinical Investigation. 08, 2018 | Pubmed ID: 29809170 CD109 Deficiency Induces Osteopenia with an Osteoporosis-like Phenotype in Vivo Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jul, 2018 | Pubmed ID: 29767469 Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure Scientific Reports. 05, 2018 | Pubmed ID: 29739947 Negative Regulation of Amino Acid Signaling by MAPK-regulated 4F2hc/Girdin Complex PLoS Biology. Mar, 2018 | Pubmed ID: 29538402 Regulation of Keratin 5/14 Intermediate Filaments by CDK1, Aurora-B, and Rho-kinase Biochemical and Biophysical Research Communications. 04, 2018 | Pubmed ID: 29518391 Development of a Method to Preliminarily Embed Tissue Samples Using Low Melting Temperature Fish Gelatin Before Sectioning: A Technical Note Pathology International. Feb, 2018 | Pubmed ID: 29465759 Critical Role of Rabphilin-3A in the Pathophysiology of Experimental Lymphocytic Neurohypophysitis The Journal of Pathology. Jan, 2018 | Pubmed ID: 29377134 Cullin-associated NEDD8-dissociated Protein 1, a Novel Interactor of Rabphilin-3A, Deubiquitylates Rabphilin-3A and Regulates Arginine Vasopressin Secretion in PC12 Cells Endocrine Journal. Mar, 2018 | Pubmed ID: 29367474 ASC Amino Acid Transporter 2, Defined by Enzyme-mediated Activation of Radical Sources, Enhances Malignancy of GD2-positive Small-cell Lung Cancer Cancer Science. Jan, 2018 | Pubmed ID: 29151270 Significance of Perivascular Tumour Cells Defined by CD109 Expression in Progression of Glioma The Journal of Pathology. Dec, 2017 | Pubmed ID: 28888050 Significance of Low MTORC1 Activity in Defining the Characteristics of Brain Tumor Stem Cells Neuro-oncology. 05, 2017 | Pubmed ID: 28453744 Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 06, 2017 | Pubmed ID: 28375676 A Case of Sialolithiasis in a Minor Salivary Gland of the Buccal Mucosa Journal of Clinical and Diagnostic Research : JCDR. Nov, 2016 | Pubmed ID: 28050512 Well-differentiated Neuroendocrine Tumor of the Breast with Extensive Lymphatic and Vascular Infiltration Pathology International. Dec, 2016 | Pubmed ID: 27862661 Suppression of Skin Tumorigenesis in CD109-deficient Mice Oncotarget. Dec, 2016 | Pubmed ID: 27756876 High-fat Diet Feeding Promotes Stemness and Precancerous Changes in Murine Gastric Mucosa Mediated by Leptin Receptor Signaling Pathway Archives of Biochemistry and Biophysics. Nov, 2016 | Pubmed ID: 27693038 Desmin Phosphorylation by Cdk1 is Required for Efficient Separation of Desmin Intermediate Filaments in Mitosis and Detected in Murine Embryonic/newborn Muscle and Human Rhabdomyosarcoma Tissues Biochemical and Biophysical Research Communications. 09, 2016 | Pubmed ID: 27565725 Clinicopathological and Immunohistochemical Characteristics of Verruciform Xanthoma of the Lower Gingiva: A Case Report Journal of Clinical and Diagnostic Research : JCDR. Jun, 2016 | Pubmed ID: 27504422 Ectodermal Dysplasia: Management of Knife-Edged Irregular Ridge and Its Rehabilitation with Hybrid Implant Prosthesis Journal of Clinical and Diagnostic Research : JCDR. May, 2016 | Pubmed ID: 27437373 Identification of Meflin As a Potential Marker for Mesenchymal Stromal Cells Scientific Reports. Feb, 2016 | Pubmed ID: 26924503 Collective Invasion of Cancer: Perspectives from Pathology and Development Pathology International. Apr, 2016 | Pubmed ID: 26897041 Role for Daple in Non-canonical Wnt Signaling During Gastric Cancer Invasion and Metastasis Cancer Science. Feb, 2016 | Pubmed ID: 26577606 Akt-Girdin As Oncotarget Oncoscience. 2015 | Pubmed ID: 26682257 Akt-dependent Girdin Phosphorylation Regulates Repair Processes After Acute Myocardial Infarction Journal of Molecular and Cellular Cardiology. Nov, 2015 | Pubmed ID: 26393439 Potential Involvement of Kinesin-1 in the Regulation of Subcellular Localization of Girdin Biochemical and Biophysical Research Communications. Aug, 2015 | Pubmed ID: 26072378 Rabphilin-3A As a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis The Journal of Clinical Endocrinology and Metabolism. Jul, 2015 | Pubmed ID: 25919460 Girdin/GIV Regulates Transendothelial Permeability by Controlling VE-cadherin Trafficking Through the Small GTPase, R-Ras Biochemical and Biophysical Research Communications. May, 2015 | Pubmed ID: 25869066 Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25847236 New Endoplasmic Reticulum Stress Regulator, Gipie, Regulates the Survival of Vascular Smooth Muscle Cells and the Neointima Formation After Vascular Injury Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2015 | Pubmed ID: 25792451 Akt-Girdin Signaling in Cancer-associated Fibroblasts Contributes to Tumor Progression Cancer Research. Mar, 2015 | Pubmed ID: 25732845 Girdin is Phosphorylated on Tyrosine 1798 when Associated with Structures Required for Migration Biochemical and Biophysical Research Communications. Mar, 2015 | Pubmed ID: 25707853 Identification of the Novel Autoantigen Candidate Rab GDP Dissociation Inhibitor Alpha in Isolated Adrenocorticotropin Deficiency Endocrine Journal. 2015 | Pubmed ID: 25346144 Girdin Phosphorylation is Crucial for Synaptic Plasticity and Memory: a Potential Role in the Interaction of BDNF/TrkB/Akt Signaling with NMDA Receptor The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2014 | Pubmed ID: 25378165 Regulation of Cargo-selective Endocytosis by Dynamin 2 GTPase-activating Protein Girdin The EMBO Journal. Sep, 2014 | Pubmed ID: 25061227 Indoxyl Sulfate-induced Activation of (pro)renin Receptor is Involved in Expression of TGF-β1 and α-smooth Muscle Actin in Proximal Tubular Cells Endocrinology. May, 2014 | Pubmed ID: 24601883 Suppression of REV7 Enhances Cisplatin Sensitivity in Ovarian Clear Cell Carcinoma Cells Cancer Science. May, 2014 | Pubmed ID: 24597627 Role of Girdin in Intimal Hyperplasia in Vein Grafts and Efficacy of Atelocollagen-mediated Application of Small Interfering RNA for Vein Graft Failure Journal of Vascular Surgery. Aug, 2014 | Pubmed ID: 23948670 Degeneration of Retinal on Bipolar Cells Induced by Serum Including Autoantibody Against TRPM1 in Mouse Model of Paraneoplastic Retinopathy PloS One. 2013 | Pubmed ID: 24282602 Indoxyl Sulfate Promotes Cardiac Fibrosis with Enhanced Oxidative Stress in Hypertensive Rats Life Sciences. Jul, 2013 | Pubmed ID: 23702423 The REV7 Subunit of DNA Polymerase ζ is Essential for Primordial Germ Cell Maintenance in the Mouse The Journal of Biological Chemistry. Apr, 2013 | Pubmed ID: 23463509 Metamorphosis of Mesothelial Cells with Active Horizontal Motility in Tissue Culture Scientific Reports. 2013 | Pubmed ID: 23359855 Girdin and Its Phosphorylation Dynamically Regulate Neonatal Vascular Development and Pathological Neovascularization in the Retina The American Journal of Pathology. Feb, 2013 | Pubmed ID: 23195430 Expression of RET Finger Protein Predicts Chemoresistance in Epithelial Ovarian Cancer Cancer Medicine. Oct, 2012 | Pubmed ID: 23342271 Similar Phenotypes of Girdin Germ-line and Conditional Knockout Mice Indicate a Crucial Role for Girdin in the Nestin Lineage Biochemical and Biophysical Research Communications. Oct, 2012 | Pubmed ID: 22974978 Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109 The American Journal of Pathology. Oct, 2012 | Pubmed ID: 22846721 The Dishevelled-associating Protein Daple Controls the Non-canonical Wnt/Rac Pathway and Cell Motility Nature Communications. May, 2012 | Pubmed ID: 22643886 Involvement of Girdin in the Determination of Cell Polarity During Cell Migration PloS One. 2012 | Pubmed ID: 22574214 Indoxyl Sulfate Promotes Vascular Smooth Muscle Cell Senescence with Upregulation of P53, P21, and Prelamin A Through Oxidative Stress American Journal of Physiology. Cell Physiology. Jul, 2012 | Pubmed ID: 22555846 High Glucose Impairs the Proliferation and Increases the Apoptosis of Endothelial Progenitor Cells by Suppression of Akt Journal of Diabetes Investigation. Aug, 2011 | Pubmed ID: 24843496 Behavioral Alterations Associated with Targeted Disruption of Exons 2 and 3 of the Disc1 Gene in the Mouse Human Molecular Genetics. Dec, 2011 | Pubmed ID: 21903668 NF-κB Plays an Important Role in Indoxyl Sulfate-induced Cellular Senescence, Fibrotic Gene Expression, and Inhibition of Proliferation in Proximal Tubular Cells American Journal of Physiology. Cell Physiology. Nov, 2011 | Pubmed ID: 21832251 Girdin is an Intrinsic Regulator of Neuroblast Chain Migration in the Rostral Migratory Stream of the Postnatal Brain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011 | Pubmed ID: 21632933 NMDA Receptor Regulates Migration of Newly Generated Neurons in the Adult Hippocampus Via Disrupted-In-Schizophrenia 1 (DISC1) Journal of Neurochemistry. Jul, 2011 | Pubmed ID: 21517847 The Actin-binding Protein Girdin and Its Akt-mediated Phosphorylation Regulate Neointima Formation After Vascular Injury Circulation Research. May, 2011 | Pubmed ID: 21415395 [Roles of DISC1-interacting Protein Girdin in Postnatal Development and Adult Neurogenesis in the Dentate Gyrus] Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. Feb, 2011 | Pubmed ID: 21409841 Indoxyl Sulfate Downregulates Renal Expression of Klotho Through Production of ROS and Activation of Nuclear Factor-ĸB American Journal of Nephrology. 2011 | Pubmed ID: 21389697 Analysis of Glial Cell Line-derived Neurotrophic Factor-inducible Zinc Finger Protein 1 Expression in Human Diseased Kidney Human Pathology. Jun, 2011 | Pubmed ID: 21292309 Protective Role of Gipie, a Girdin Family Protein, in Endoplasmic Reticulum Stress Responses in Endothelial Cells Molecular Biology of the Cell. Mar, 2011 | Pubmed ID: 21289099 Loss of Sprouty2 Partially Rescues Renal Hypoplasia and Stomach Hypoganglionosis but Not Intestinal Aganglionosis in Ret Y1062F Mutant Mice Developmental Biology. Jan, 2011 | Pubmed ID: 21070764 Senescence and Dysfunction of Proximal Tubular Cells Are Associated with Activated P53 Expression by Indoxyl Sulfate American Journal of Physiology. Cell Physiology. Nov, 2010 | Pubmed ID: 20720180 Indoxyl Sulfate Upregulates Expression of ICAM-1 and MCP-1 by Oxidative Stress-induced NF-kappaB Activation American Journal of Nephrology. 2010 | Pubmed ID: 20389059 Analysis of DOK-6 Function in Downstream Signaling of RET in Human Neuroblastoma Cells Cancer Science. May, 2010 | Pubmed ID: 20210798 Girding for Migratory Cues: Roles of the Akt Substrate Girdin in Cancer Progression and Angiogenesis Cancer Science. Apr, 2010 | Pubmed ID: 20132219 Roles of Disrupted-in-schizophrenia 1-interacting Protein Girdin in Postnatal Development of the Dentate Gyrus Neuron. Sep, 2009 | Pubmed ID: 19778507 Expression of Ret Finger Protein Correlates with Outcomes in Endometrial Cancer Cancer Science. Oct, 2009 | Pubmed ID: 19650860 Adiponectin Promotes Migration Activities of Endothelial Progenitor Cells Via Cdc42/Rac1 FEBS Letters. Aug, 2009 | Pubmed ID: 19596003 Characterization of the HDAC1 Complex That Regulates the Sensitivity of Cancer Cells to Oxidative Stress Cancer Research. Apr, 2009 | Pubmed ID: 19351825 Cell Biology of the Movement of Breast Cancer Cells: Intracellular Signalling and the Actin Cytoskeleton Cancer Letters. Nov, 2009 | Pubmed ID: 19303207 CD109 Expression in Basal-like Breast Carcinoma Pathology International. May, 2008 | Pubmed ID: 18429827 [Coordination of Actin Cytoskeleton and Membrane Transport in Cell Migration] Seikagaku. The Journal of Japanese Biochemical Society. Mar, 2008 | Pubmed ID: 18411793 GDNF-mediated Signaling Via RET Tyrosine 1062 is Essential for Maintenance of Spermatogonial Stem Cells Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Apr, 2008 | Pubmed ID: 18363967 An Actin-binding Protein Girdin Regulates the Motility of Breast Cancer Cells Cancer Research. Mar, 2008 | Pubmed ID: 18316593 Regulation of VEGF-mediated Angiogenesis by the Akt/PKB Substrate Girdin Nature Cell Biology. Mar, 2008 | Pubmed ID: 18264090 A Novel GDNF-inducible Gene, BMZF3, Encodes a Transcriptional Repressor Associated with KAP-1 Biochemical and Biophysical Research Communications. Feb, 2008 | Pubmed ID: 18060868 Roles of Organic Anion Transporters in the Progression of Chronic Renal Failure Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. Oct, 2007 | Pubmed ID: 17976081 Nucleolin Modulates the Subcellular Localization of GDNF-inducible Zinc Finger Protein 1 and Its Roles in Transcription and Cell Proliferation Experimental Cell Research. Oct, 2007 | Pubmed ID: 17674968 Sprouty2 Regulates Growth and Differentiation of Human Neuroblastoma Cells Through RET Tyrosine Kinase Cancer Science. Jun, 2007 | Pubmed ID: 17388787 Girdin, a Novel Actin-binding Protein, and Its Family of Proteins Possess Versatile Functions in the Akt and Wnt Signaling Pathways Annals of the New York Academy of Sciences. Nov, 2006 | Pubmed ID: 17185515 Targeted Mutation of Serine 697 in the Ret Tyrosine Kinase Causes Migration Defect of Enteric Neural Crest Cells Development (Cambridge, England). Nov, 2006 | Pubmed ID: 17050626 Dok-4 Regulates GDNF-dependent Neurite Outgrowth Through Downstream Activation of Rap1 and Mitogen-activated Protein Kinase Journal of Cell Science. Aug, 2006 | Pubmed ID: 16820412 RET Receptor Signaling: Dysfunction in Thyroid Cancer and Hirschsprung's Disease Pathology International. Apr, 2006 | Pubmed ID: 16634961 Akt/PKB Regulates Actin Organization and Cell Motility Via Girdin/APE Developmental Cell. Sep, 2005 | Pubmed ID: 16139227 GDNF-inducible Zinc Finger Protein 1 is a Sequence-specific Transcriptional Repressor That Binds to the HOXA10 Gene Regulatory Region Nucleic Acids Research. 2005 | Pubmed ID: 16049025 Activation of C-Jun Amino-terminal Kinase by GDNF Induces G2/M Cell Cycle Delay Linked with Actin Reorganization Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jul, 2005 | Pubmed ID: 15966897 Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma Hiroki Kobayashi1,2,3,4, Krystyna A. Gieniec1,2, Jia Q. Ng1,2, Jarrad Goyne1,2, Tamsin R. M. Lannagan1,2, Elaine M. Thomas1,2, Georgette Radford1,2, Tongtong Wang1,2, Nobumi Suzuki1,2,5, Mari Ichinose1,2, Josephine A. Wright2, Laura Vrbanac1,2, Alastair D. Burt6, Masahide Takahashi3,4,7, Atsushi Enomoto3, Daniel L. Worthley2, Susan L. Woods1,2 1Adelaide Medical School, University of Adelaide, 2South Australian Health and Medical Research Institute (SAHMRI), 3Department of Pathology, Nagoya University Graduate School of Medicine, 4Division of Molecular Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, 5Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 6Translational and Clinical Research Institute, Newcastle University, 7International Center for Cell and Gene Therapy, Fujita Health University JoVE 62630 Cancer Research
Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma Hiroki Kobayashi1,2,3,4, Krystyna A. Gieniec1,2, Jia Q. Ng1,2, Jarrad Goyne1,2, Tamsin R. M. Lannagan1,2, Elaine M. Thomas1,2, Georgette Radford1,2, Tongtong Wang1,2, Nobumi Suzuki1,2,5, Mari Ichinose1,2, Josephine A. Wright2, Laura Vrbanac1,2, Alastair D. Burt6, Masahide Takahashi3,4,7, Atsushi Enomoto3, Daniel L. Worthley2, Susan L. Woods1,2 1Adelaide Medical School, University of Adelaide, 2South Australian Health and Medical Research Institute (SAHMRI), 3Department of Pathology, Nagoya University Graduate School of Medicine, 4Division of Molecular Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, 5Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 6Translational and Clinical Research Institute, Newcastle University, 7International Center for Cell and Gene Therapy, Fujita Health University JoVE 62630 Cancer Research