Avijit Chakrabartty Department of Medical Biophysics University of Toronto Biography Publications Institution JoVE Articles Avijit Chakrabartty has not added a biography. If you are Avijit Chakrabartty and would like to personalize this page please email our Author Liaison for assistance. Publications Quercitrin and Quercetin 3-β-d-glucoside As Chemical Chaperones for the A4V SOD1 ALS-causing Mutant Protein Engineering, Design & Selection : PEDS. May, 2017 | Pubmed ID: 28475686 Transthyretin Amyloidosis: an Under-recognized Neuropathy and Cardiomyopathy Clinical Science (London, England : 1979). Mar, 2017 | Pubmed ID: 28213611 Phase to Phase with TDP-43 Biochemistry. Feb, 2017 | Pubmed ID: 28112502 Corrigendum: Substoichiometric Inhibition of Transthyretin Misfolding by Immune-targeting Sparsely Populated Misfolding Intermediates: a Potential Diagnostic and Therapeutic for TTR Amyloidoses Scientific Reports. Jun, 2016 | Pubmed ID: 27282221 Substoichiometric Inhibition of Transthyretin Misfolding by Immune-targeting Sparsely Populated Misfolding Intermediates: a Potential Diagnostic and Therapeutic for TTR Amyloidoses Scientific Reports. 04, 2016 | Pubmed ID: 27122057 Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation PLoS Biology. Apr, 2016 | Pubmed ID: 27096426 Determining Composition of Micron-scale Protein Deposits in Neurodegenerative Disease by Spatially Targeted Optical Microproteomics ELife. Sep, 2015 | Pubmed ID: 26418743 Low Molecular Weight Species of TDP-43 Generated by Abnormal Splicing Form Inclusions in Amyotrophic Lateral Sclerosis and Result in Motor Neuron Death Acta Neuropathologica. Jul, 2015 | Pubmed ID: 25788357 "Structural Characterization of the Minimal Segment of TDP-43 Competent for Aggregation" Archives of Biochemistry and Biophysics. Mar, 2014 | Pubmed ID: 24440310 Wild-type Cu/Zn Superoxide Dismutase Stabilizes Mutant Variants by Heterodimerization Neurobiology of Disease. Feb, 2014 | Pubmed ID: 24200866 Structure of a Simplified β-hairpin and Its ATP Complex Archives of Biochemistry and Biophysics. Sep, 2013 | Pubmed ID: 23811197 N-terminal Helix-cap in α-helix 2 Modulates β-state Misfolding in Rabbit and Hamster Prion Proteins PloS One. 2013 | Pubmed ID: 23675452 Protein Misfolding in the Late-onset Neurodegenerative Diseases: Common Themes and the Unique Case of Amyotrophic Lateral Sclerosis Proteins. Aug, 2013 | Pubmed ID: 23508986 An Arg-rich Putative Prebiotic Protein is As Stable As Its Lys-rich Variant Archives of Biochemistry and Biophysics. Dec, 2012 | Pubmed ID: 23022061 Targeting of Monomer/misfolded SOD1 As a Therapeutic Strategy for Amyotrophic Lateral Sclerosis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2012 | Pubmed ID: 22745481 Adaptor Protein Self-assembly Drives the Control of a Cullin-RING Ubiquitin Ligase Structure (London, England : 1993). Jul, 2012 | Pubmed ID: 22632832 Early Steps in Oxidation-induced SOD1 Misfolding: Implications for Non-amyloid Protein Aggregation in Familial ALS Journal of Molecular Biology. Aug, 2012 | Pubmed ID: 22542526 Analyzing Complicated Protein Folding Kinetics Rapidly by Analytical Laplace Inversion Using a Tikhonov Regularization Variant Analytical Biochemistry. Feb, 2012 | Pubmed ID: 22119751 Conformation Specificity and Arene Binding in a Peptide Composed Only of Lys, Ile, Ala and Gly European Biophysics Journal : EBJ. Jan, 2012 | Pubmed ID: 22038076 Relative and Regional Stabilities of the Hamster, Mouse, Rabbit, and Bovine Prion Proteins Toward Urea Unfolding Assessed by Nuclear Magnetic Resonance and Circular Dichroism Spectroscopies Biochemistry. Sep, 2011 | Pubmed ID: 21800884 Aβ Behavior on Neuronal Membranes: Aggregation and Toxicities International Journal of Alzheimer's Disease. 2011 | Pubmed ID: 21760987 CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 Homodimerization The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21561863 ALS-causing SOD1 Mutations Promote Production of Copper-deficient Misfolded Species Journal of Molecular Biology. Jun, 2011 | Pubmed ID: 21549128 Multiphoton ANS Fluorescence Microscopy As an in Vivo Sensor for Protein Misfolding Stress Cell Stress & Chaperones. Sep, 2011 | Pubmed ID: 21484286 Cell Surface Binding and Internalization of Aβ Modulated by Degree of Aggregation International Journal of Alzheimer's Disease. Feb, 2011 | Pubmed ID: 21331340 Prion Disease Susceptibility is Affected by Beta-structure Folding Propensity and Local Side-chain Interactions in PrP Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21041683 Putative One-pot Prebiotic Polypeptides with Ribonucleolytic Activity Chemistry (Weinheim an Der Bergstrasse, Germany). May, 2010 | Pubmed ID: 20232309 Amyotrophic Lateral Sclerosis is a Non-amyloid Disease in Which Extensive Misfolding of SOD1 is Unique to the Familial Form Acta Neuropathologica. Mar, 2010 | Pubmed ID: 20111867 Conversion of Abeta42 into a Folded Soluble Native-like Protein Using a Semi-random Library of Amphipathic Helices Journal of Molecular Biology. Mar, 2010 | Pubmed ID: 20026077 Probing Alzheimer Amyloid Peptide Aggregation Using a Cell-free Fluorescent Protein Refolding Method Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Aug, 2009 | Pubmed ID: 19767826 Two Distinct Conformations of Abeta Aggregates on the Surface of Living PC12 Cells Biophysical Journal. May, 2009 | Pubmed ID: 19450496 Denaturational Stress Induces Formation of Zinc-deficient Monomers of Cu,Zn Superoxide Dismutase: Implications for Pathogenesis in Amyotrophic Lateral Sclerosis Journal of Molecular Biology. Nov, 2008 | Pubmed ID: 18761352 Dimerization of the Transmembrane Domain of Amyloid Precursor Proteins and Familial Alzheimer's Disease Mutants BMC Neuroscience. Jan, 2008 | Pubmed ID: 18234110 Metal Ion-dependent, Reversible, Protein Filament Formation by Designed Beta-roll Polypeptides BMC Structural Biology. Oct, 2007 | Pubmed ID: 17908326 Getting Specificity from Simplicity in Putative Proteins from the Prebiotic Earth Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17855563 An Immunological Epitope Selective for Pathological Monomer-misfolded SOD1 in ALS Nature Medicine. Jun, 2007 | Pubmed ID: 17486090 Requirement of Aggregation Propensity of Alzheimer Amyloid Peptides for Neuronal Cell Surface Binding BMC Neuroscience. May, 2007 | Pubmed ID: 17475015 Variants of DsRed Fluorescent Protein: Development of a Copper Sensor Protein Science : a Publication of the Protein Society. Oct, 2006 | Pubmed ID: 17008724 Structure, Folding, and Misfolding of Cu,Zn Superoxide Dismutase in Amyotrophic Lateral Sclerosis Biochimica Et Biophysica Acta. Nov-Dec, 2006 | Pubmed ID: 16814528 NMR-driven Secondary and Tertiary Structure Model of Ca2+-loaded Calexcitin Biochemical and Biophysical Research Communications. May, 2006 | Pubmed ID: 16546129 Charge Substitution Shows That Repulsive Electrostatic Interactions Impede the Oligomerization of Alzheimer Amyloid Peptides FEBS Letters. Jul, 2005 | Pubmed ID: 15964569 Hyperactive Antifreeze Protein from Winter Flounder is a Very Long Rod-like Dimer of Alpha-helices The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15716269 Reversible Assembly of Helical Filaments by De Novo Designed Minimalist Peptides Biopolymers. 2005 | Pubmed ID: 15612048 Alzheimer's Abeta40 Studied by NMR at Low PH Reveals That Sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) Binds and Promotes Beta-ball Oligomerization The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15557279 Interaction of Human and Mouse Abeta Peptides Journal of Neurochemistry. Dec, 2004 | Pubmed ID: 15584916 Identification of Stable Helical Bundles from a Combinatorial Library of Amphipathic Peptides Biopolymers. 2004 | Pubmed ID: 15148684 Interactions of Alzheimer Amyloid Peptides with Cultured Cells and Brain Tissue, and Their Biological Consequences Biopolymers. 2004 | Pubmed ID: 14997469 Monomeric Cu,Zn-superoxide Dismutase is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral Sclerosis The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14734542 Conformational Coupling of Mg2+ and Ca2+ on the Three-state Folding of Calexcitin B Biochemistry. May, 2003 | Pubmed ID: 12731896 Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region Molecular and Cellular Biology. May, 2003 | Pubmed ID: 12697809 Co-incorporation of A Beta 40 and A Beta 42 to Form Mixed Pre-fibrillar Aggregates European Journal of Biochemistry. Feb, 2003 | Pubmed ID: 12581205 Lipopeptide Detergents Designed for the Structural Study of Membrane Proteins Nature Biotechnology. Feb, 2003 | Pubmed ID: 12524549 Alternate Aggregation Pathways of the Alzheimer Beta-amyloid Peptide: Abeta Association Kinetics at Endosomal PH Journal of Molecular Biology. Jan, 2003 | Pubmed ID: 12507477 The PrP-like Protein Doppel Binds Copper The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12482851 Oxidation-induced Misfolding and Aggregation of Superoxide Dismutase and Its Implications for Amyotrophic Lateral Sclerosis The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12356748 Simple Elimination of Background Fluorescence in Formalin-Fixed Human Brain Tissue for Immunofluorescence Microscopy Yulong Sun1, Philbert Ip2, Avijit Chakrabartty1,2 1Department of Medical Biophysics, University of Toronto, 2Department of Biochemistry, University of Toronto JoVE 56188 Biochemistry
Simple Elimination of Background Fluorescence in Formalin-Fixed Human Brain Tissue for Immunofluorescence Microscopy Yulong Sun1, Philbert Ip2, Avijit Chakrabartty1,2 1Department of Medical Biophysics, University of Toronto, 2Department of Biochemistry, University of Toronto JoVE 56188 Biochemistry
