Bärbel Rohrer Department of Ophthalmology, Division of Research Medical University of South Carolina Biography Publications Institution JoVE Articles Bärbel Rohrer has not added a biography. If you are Bärbel Rohrer and would like to personalize this page please email our Author Liaison for assistance. Publications Mechanisms of Extracellular Vesicle Uptake in Stressed Retinal Pigment Epithelial Cell Monolayers Biochimica Et Biophysica Acta. Molecular Basis of Disease. Mar, 2020 | Pubmed ID: 31740401 Increased Nonexudative Age-Related Macular Degeneration Diagnosis Among Medicare Beneficiaries With Rheumatoid Arthritis Investigative Ophthalmology & Visual Science. 08, 2019 | Pubmed ID: 31412111 An Improved Method for Isolation of Mitochondria from Cell Lines That Enables Reconstitution of Calcium-dependent Processes Analytical Biochemistry. 07, 2019 | Pubmed ID: 31022379 The Exocyst Acting Through the Primary Cilium is Necessary for Renal Ciliogenesis, Cystogenesis, and Tubulogenesis The Journal of Biological Chemistry. 04, 2019 | Pubmed ID: 30824539 Association of Age-related Macular Degeneration with Complement Activation Products, Smoking, and Single Nucleotide Polymorphisms in South Carolinians of European and African Descent Molecular Vision. 2019 | Pubmed ID: 30820144 Inhibition of the Alternative Complement Pathway Accelerates Repair Processes in the Murine Model of Choroidal Neovascularization Molecular Immunology. 04, 2019 | Pubmed ID: 30763805 Correction: Mechanisms of Bystander Effects in Retinal Pigment Epithelium Cell Networks Cell Death & Disease. Jul, 2018 | Pubmed ID: 30013064 Anaphylatoxin Signaling in Retinal Pigment and Choroidal Endothelial Cells: Characteristics and Relevance to Age-Related Macular Degeneration Advances in Experimental Medicine and Biology. 2018 | Pubmed ID: 29721926 Extracellular Vesicle-mediated Long-range Communication in Stressed Retinal Pigment Epithelial Cell Monolayers Biochimica Et Biophysica Acta. Molecular Basis of Disease. Aug, 2018 | Pubmed ID: 29684588 Encapsulated Cell Technology-Based Delivery of a Complement Inhibitor Reduces Choroidal Neovascularization in a Mouse Model Translational Vision Science & Technology. Mar, 2018 | Pubmed ID: 29576927 Proteome and Metabolome of Subretinal Fluid in Central Serous Chorioretinopathy and Rhegmatogenous Retinal Detachment: A Pilot Case Study Translational Vision Science & Technology. Jan, 2018 | Pubmed ID: 29359109 Delivery of CR2-fH Using AAV Vector Therapy As Treatment Strategy in the Mouse Model of Choroidal Neovascularization Molecular Therapy. Methods & Clinical Development. Jun, 2018 | Pubmed ID: 29234687 The Retinol Binding Protein Receptor 2 (Rbpr2) is Required for Photoreceptor Outer Segment Morphogenesis and Visual Function in Zebrafish Scientific Reports. 11, 2017 | Pubmed ID: 29176573 Mechanisms of Bystander Effects in Retinal Pigment Epithelium Cell Networks Cell Death & Disease. 10, 2017 | Pubmed ID: 28981111 The Exocyst is Required for Photoreceptor Ciliogenesis and Retinal Development The Journal of Biological Chemistry. 09, 2017 | Pubmed ID: 28729419 Anaphylatoxins Activate Ca, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium Frontiers in Immunology. 2017 | Pubmed ID: 28663750 New Insights on Complement Inhibitor CD59 in Mouse Laser-Induced Choroidal Neovascularization: Mislocalization After Injury and Targeted Delivery for Protein Replacement Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. 06, 2017 | Pubmed ID: 28333572 Bystander Effects Elicited by Single-cell Photo-oxidative Blue-light Stimulation in Retinal Pigment Epithelium Cell Networks Cell Death Discovery. 2017 | Pubmed ID: 28179989 Targeting the Tight Junction Protein, Zonula Occludens-1, with the Connexin43 Mimetic Peptide, αCT1, Reduces VEGF-dependent RPE Pathophysiology Journal of Molecular Medicine (Berlin, Germany). 05, 2017 | Pubmed ID: 28132078 Retinal Pre-Conditioning by CD59a Knockout Protects Against Light-Induced Photoreceptor Degeneration PloS One. 2016 | Pubmed ID: 27893831 Calpain Inhibition Reduces Structural and Functional Impairment of Retinal Ganglion Cells in Experimental Optic Neuritis Journal of Neurochemistry. 10, 2016 | Pubmed ID: 27513991 New Therapeutic and Diagnostic Opportunities for Injured Tissue-specific Targeting of Complement Inhibitors and Imaging Modalities Seminars in Immunology. Jun, 2016 | Pubmed ID: 27282113 A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury Investigative Ophthalmology & Visual Science. Apr, 2016 | Pubmed ID: 27064393 Connecting the Innate and Adaptive Immune Responses in Mouse Choroidal Neovascularization Via the Anaphylatoxin C5a and γδT-cells Scientific Reports. Mar, 2016 | Pubmed ID: 27029558 Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 26427491 Small Molecules That Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 26427445 Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 26427398 Local Production of the Alternative Pathway Component Factor B is Sufficient to Promote Laser-induced Choroidal Neovascularization Investigative Ophthalmology & Visual Science. Jan, 2015 | Pubmed ID: 25593023 Quantitative Analysis of Mitochondrial Morphology and Membrane Potential in Living Cells Using High-content Imaging, Machine Learning, and Morphological Binning Biochimica Et Biophysica Acta. Feb, 2015 | Pubmed ID: 25447550 Activation of Endogenously Expressed Ion Channels by Active Complement in the Retinal Pigment Epithelium Pflugers Archiv : European Journal of Physiology. Oct, 2015 | Pubmed ID: 25427445 A Comparative Analysis of C57BL/6J and 6N Substrains; Chemokine/cytokine Expression and Susceptibility to Laser-induced Choroidal Neovascularization Experimental Eye Research. Dec, 2014 | Pubmed ID: 25305577 Smoke Exposure Causes Endoplasmic Reticulum Stress and Lipid Accumulation in Retinal Pigment Epithelium Through Oxidative Stress and Complement Activation The Journal of Biological Chemistry. May, 2014 | Pubmed ID: 24711457 A Mechanistic Review of Cigarette Smoke and Age-related Macular Degeneration Advances in Experimental Medicine and Biology. 2014 | Pubmed ID: 24664711 Prolonged SRC Kinase Activation, a Mechanism to Turn Transient, Sublytic Complement Activation into a Sustained Pathological Condition in Retinal Pigment Epithelium Cells Advances in Experimental Medicine and Biology. 2014 | Pubmed ID: 24664702 Alternative Complement Pathway Deficiency Ameliorates Chronic Smoke-induced Functional and Morphological Ocular Injury PloS One. 2013 | Pubmed ID: 23825688 The Role of the Immune Response in Age-related Macular Degeneration International Journal of Inflammation. 2013 | Pubmed ID: 23762772 Explant Cultures of Rpe65-/- Mouse Retina: a Model to Investigate Cone Opsin Trafficking Molecular Vision. 2013 | Pubmed ID: 23734084 Detection of Complement Activation Using Monoclonal Antibodies Against C3d The Journal of Clinical Investigation. May, 2013 | Pubmed ID: 23619360 Oxidative Stress Sensitizes Retinal Pigmented Epithelial (RPE) Cells to Complement-mediated Injury in a Natural Antibody-, Lectin Pathway-, and Phospholipid Epitope-dependent Manner The Journal of Biological Chemistry. May, 2013 | Pubmed ID: 23493397 Early Alterations in Mitochondrial Reserve Capacity; a Means to Predict Subsequent Photoreceptor Cell Death Journal of Bioenergetics and Biomembranes. Feb, 2013 | Pubmed ID: 23090843 Revealing Functionally Coherent Subsets Using a Spectral Clustering and an Information Integration Approach BMC Systems Biology. 2012 | Pubmed ID: 23282411 Matrix Metalloproteinase Activity Creates Pro-angiogenic Environment in Primary Human Retinal Pigment Epithelial Cells Exposed to Complement Investigative Ophthalmology & Visual Science. Apr, 2012 | Pubmed ID: 22408008 Systemic Human CR2-targeted Complement Alternative Pathway Inhibitor Ameliorates Mouse Laser-induced Choroidal Neovascularization Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Aug, 2012 | Pubmed ID: 22309197 Sublytic Membrane-attack-complex Activation and VEGF Secretion in Retinal Pigment Epithelial Cells Advances in Experimental Medicine and Biology. 2012 | Pubmed ID: 22183311 Sublytic Membrane-attack-complex (MAC) Activation Alters Regulated Rather Than Constitutive Vascular Endothelial Growth Factor (VEGF) Secretion in Retinal Pigment Epithelium Monolayers The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21566137 Central Nervous System Dysfunction in a Mouse Model of FA2H Deficiency Glia. Jul, 2011 | Pubmed ID: 21491498 Differential Effects of Rapamycin on Rods and Cones During Light-induced Stress in Albino Mice Investigative Ophthalmology & Visual Science. May, 2011 | Pubmed ID: 21273550 The Alternative Pathway is Required, but Not Alone Sufficient, for Retinal Pathology in Mouse Laser-induced Choroidal Neovascularization Molecular Immunology. Mar, 2011 | Pubmed ID: 21257205 Gene Therapy Rescues Cone Structure and Function in the 3-month-old Rd12 Mouse: a Model for Midcourse RPE65 Leber Congenital Amaurosis Investigative Ophthalmology & Visual Science. Jan, 2011 | Pubmed ID: 21169527 A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-related Macular Degeneration Advances in Experimental Medicine and Biology. 2010 | Pubmed ID: 20711712 Photoreceptor Structure and Function is Maintained in Organotypic Cultures of Mouse Retinas Molecular Vision. Jun, 2010 | Pubmed ID: 20664685 Self-complementary AAV-mediated Gene Therapy Restores Cone Function and Prevents Cone Degeneration in Two Models of Rpe65 Deficiency Gene Therapy. Jul, 2010 | Pubmed ID: 20237510 Cone Outer Segment Morphology and Cone Function in the Rpe65-/- Nrl-/- Mouse Retina Are Amenable to Retinoid Replacement Investigative Ophthalmology & Visual Science. Oct, 2009 | Pubmed ID: 19407011 Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury The Journal of Biological Chemistry. Jun, 2009 | Pubmed ID: 19386604 A Targeted Inhibitor of the Alternative Complement Pathway Reduces Angiogenesis in a Mouse Model of Age-related Macular Degeneration Investigative Ophthalmology & Visual Science. Jul, 2009 | Pubmed ID: 19264882 Identification of Candidate Genes for Human Retinal Degeneration Loci Using Differentially Expressed Genes from Mouse Photoreceptor Dystrophy Models Molecular Vision. Sep, 2008 | Pubmed ID: 18776951 Eliminating Complement Factor D Reduces Photoreceptor Susceptibility to Light-induced Damage Investigative Ophthalmology & Visual Science. Nov, 2007 | Pubmed ID: 17962484 Paradoxical Role of BDNF: BDNF+/- Retinas Are Protected Against Light Damage-mediated Stress Investigative Ophthalmology & Visual Science. Jun, 2007 | Pubmed ID: 17525224 Apoptosis and Autophagy in Photoreceptors Exposed to Oxidative Stress Autophagy. Sep-Oct, 2007 | Pubmed ID: 17471016 Sustained Elevation of Intracellular CGMP Causes Oxidative Stress Triggering Calpain-mediated Apoptosis in Photoreceptor Degeneration Current Eye Research. Mar, 2007 | Pubmed ID: 17453946 Autophagy is One of the Multiple Mechanisms Active in Photoreceptor Degeneration Autophagy. Jan-Feb, 2007 | Pubmed ID: 17102584 Classical Complement Activation and Acquired Immune Response Pathways Are Not Essential for Retinal Degeneration in the Rd1 Mouse Experimental Eye Research. Jan, 2007 | Pubmed ID: 17069800 Rod and Cone Pigment Regeneration in RPE65-/- Mice Advances in Experimental Medicine and Biology. 2006 | Pubmed ID: 17249562 Multiple, Parallel Cellular Suicide Mechanisms Participate in Photoreceptor Cell Death Experimental Eye Research. Aug, 2006 | Pubmed ID: 16626700 11-cis-retinal Reduces Constitutive Opsin Phosphorylation and Improves Quantum Catch in Retinoid-deficient Mouse Rod Photoreceptors The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12176991 تكنولوجيا الخلية المغلفة لتسليم البيولوجيا إلى العين الماوس Marwa Belhaj1, Balasubramaniam Annamalai2, Nathaniel Parsons2, Andrew Shuler1, Jay Potts1, Bärbel Rohrer2,3,4 1Department of Cell Biology, University of South Carolina, 2Department of Ophthalmology, Division of Research, Medical University of South Carolina, 3Department of Neuroscience, Division of Research, Medical University of South Carolina, 4Division of Research, Ralph H. Johnson VA Medical Center JoVE 60162 Bioengineering
تكنولوجيا الخلية المغلفة لتسليم البيولوجيا إلى العين الماوس Marwa Belhaj1, Balasubramaniam Annamalai2, Nathaniel Parsons2, Andrew Shuler1, Jay Potts1, Bärbel Rohrer2,3,4 1Department of Cell Biology, University of South Carolina, 2Department of Ophthalmology, Division of Research, Medical University of South Carolina, 3Department of Neuroscience, Division of Research, Medical University of South Carolina, 4Division of Research, Ralph H. Johnson VA Medical Center JoVE 60162 Bioengineering
