Baljit S. Khakh Department of Physiology, David Geffen School of Medicine University of California Los Angeles Biography Publications Institution JoVE Articles Baljit S. Khakh has not added a biography. If you are Baljit S. Khakh and would like to personalize this page please email our Author Liaison for assistance. Publications Astrocyte-Neuron Interactions in the Striatum: Insights on Identity, Form, and Function Trends in Neurosciences. Sep, 2019 | Pubmed ID: 31351745 The Emerging Nature of Astrocyte Diversity Annual Review of Neuroscience. Jul, 2019 | Pubmed ID: 31283899 Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation Cell Reports. May, 2019 | Pubmed ID: 31116972 Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue Cell. May, 2019 | Pubmed ID: 31031006 A Genetically Encoded Single-wavelength Sensor for Imaging Cytosolic and Cell Surface ATP Nature Communications. 02, 2019 | Pubmed ID: 30755613 Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior Neuron. 09, 2018 | Pubmed ID: 30174118 Active Role of Capillary Pericytes During Stimulation-induced Activity and Spreading Depolarization Brain : a Journal of Neurology. 07, 2018 | Pubmed ID: 30053174 An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales Neuron. Apr, 2018 | Pubmed ID: 29621490 Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence Neuron. Aug, 2017 | Pubmed ID: 28712653 Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease Trends in Neurosciences. 07, 2017 | Pubmed ID: 28578789 New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo Neuron. Dec, 2016 | Pubmed ID: 27939582 P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 08, 2016 | Pubmed ID: 27559172 Astrocyte Scar Formation Aids Central Nervous System Axon Regeneration Nature. Apr, 2016 | Pubmed ID: 27027288 Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2016 | Pubmed ID: 27013675 Probing the Complexities of Astrocyte Calcium Signaling Trends in Cell Biology. Apr, 2016 | Pubmed ID: 26896246 Diversity of Astrocyte Functions and Phenotypes in Neural Circuits Nature Neuroscience. Jul, 2015 | Pubmed ID: 26108722 Ca(2+) Signaling in Astrocytes from Ip3r2(-/-) Mice in Brain Slices and During Startle Responses in Vivo Nature Neuroscience. May, 2015 | Pubmed ID: 25894291 ATP-gated P2X Receptors in Health and Disease Frontiers in Cellular Neuroscience. 2014 | Pubmed ID: 25104924 Slow Neuromodulation Mediated by ATP P2X Receptors Neuron. Jul, 2014 | Pubmed ID: 25033174 Imaging P2X4 Receptor Subcellular Distribution, Trafficking, and Regulation Using P2X4-pHluorin The Journal of General Physiology. Jul, 2014 | Pubmed ID: 24935743 Astrocytes and Huntington's Disease ACS Chemical Neuroscience. Jul, 2014 | Pubmed ID: 24842291 Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway Neuron. Apr, 2014 | Pubmed ID: 24742463 Inhibitory Interactions Between Phosphorylation Sites in the C Terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid-type Glutamate Receptor GluA1 Subunits The Journal of Biological Chemistry. May, 2014 | Pubmed ID: 24706758 Astrocyte Kir4.1 Ion Channel Deficits Contribute to Neuronal Dysfunction in Huntington's Disease Model Mice Nature Neuroscience. May, 2014 | Pubmed ID: 24686787 Tunable Diblock Copolypeptide Hydrogel Depots for Local Delivery of Hydrophobic Molecules in Healthy and Injured Central Nervous System Biomaterials. Feb, 2014 | Pubmed ID: 24314556 TRPA1 Channels Are Regulators of Astrocyte Basal Calcium Levels and Long-term Potentiation Via Constitutive D-serine Release The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2013 | Pubmed ID: 23761909 ATP-gated Ion Channels Mediate Adaptation to Elevated Sound Levels Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23592720 Imaging Calcium Microdomains Within Entire Astrocyte Territories and Endfeet with GCaMPs Expressed Using Adeno-associated Viruses The Journal of General Physiology. May, 2013 | Pubmed ID: 23589582 Genetically Encoded Calcium Indicators and Astrocyte Calcium Microdomains The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Jun, 2013 | Pubmed ID: 23264008 Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-protein-coupled Receptors The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2012 | Pubmed ID: 23077035 Neuromodulation by Extracellular ATP and P2X Receptors in the CNS Neuron. Oct, 2012 | Pubmed ID: 23040806 Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2012 | Pubmed ID: 23035093 Imaging P2X4 Receptor Lateral Mobility in Microglia: Regulation by Calcium and P38 MAPK The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22393055 Allosteric Modulation of Ca2+ Flux in a Ligand-gated Cation Channel (P2X4) by Actions on Lateral Portals The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22219189 TRPA1 Channels Regulate Astrocyte Resting Calcium and Inhibitory Synapse Efficacy Through GAT-3 Nature Neuroscience. Jan, 2012 | Pubmed ID: 22158513 Neuronal P2X2 Receptors Are Mobile ATP Sensors That Explore the Plasma Membrane when Activated The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2011 | Pubmed ID: 22090499 Preferential Use of Unobstructed Lateral Portals As the Access Route to the Pore of Human ATP-gated Ion Channels (P2X Receptors) Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21808018 Bulk Loading of Calcium Indicator Dyes to Study Astrocyte Physiology: Key Limitations and Improvements Using Morphological Maps The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011 | Pubmed ID: 21697385 Monitoring Astrocyte Calcium Microdomains with Improved Membrane Targeted GCaMP Reporters Neuron Glia Biology. Dec, 2010 | Pubmed ID: 21205365 A Genetically Targeted Optical Sensor to Monitor Calcium Signals in Astrocyte Processes Nature Neuroscience. Jun, 2010 | Pubmed ID: 20495558 P2X4 Receptors in Activated C8-B4 Cells of Cerebellar Microglial Origin The Journal of General Physiology. Apr, 2010 | Pubmed ID: 20231374 Gated Access to the Pore of a P2X Receptor: Structural Implications for Closed-open Transitions The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 20093367 The Double Life of ATP Scientific American. Dec, 2009 | Pubmed ID: 20058644 ATP-gated P2X Cation-channels Neuropharmacology. Jan, 2009 | Pubmed ID: 18657557 ATP-gated P2X Receptors on Excitatory Nerve Terminals Onto Interneurons Initiate a Form of Asynchronous Glutamate Release Neuropharmacology. Jan, 2009 | Pubmed ID: 18601937 Regulation of P2X2 Receptors by the Neuronal Calcium Sensor VILIP1 Science Signaling. 2008 | Pubmed ID: 18922787 Tunable Calcium Current Through TRPV1 Receptor Channels The Journal of Biological Chemistry. Nov, 2008 | Pubmed ID: 18775990 Patch-clamp Coordinated Spectroscopy Shows P2X2 Receptor Permeability Dynamics Require Cytosolic Domain Rearrangements but Not Panx-1 Channels Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18689682 Molecular Shape, Architecture, and Size of P2X4 Receptors Determined Using Fluorescence Resonance Energy Transfer and Electron Microscopy The Journal of Biological Chemistry. Sep, 2008 | Pubmed ID: 18635539 Two Forms of Astrocyte Calcium Excitability Have Distinct Effects on NMDA Receptor-mediated Slow Inward Currents in Pyramidal Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2008 | Pubmed ID: 18579739 Tracking Transmitter-gated P2X Cation Channel Activation in Vitro and in Vivo Nature Methods. Jan, 2008 | Pubmed ID: 18084300 Vesicular ATP is the Predominant Cause of Intercellular Calcium Waves in Astrocytes The Journal of General Physiology. Jun, 2007 | Pubmed ID: 17504911 Two Forms of Single-vesicle Astrocyte Exocytosis Imaged with Total Internal Reflection Fluorescence Microscopy Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17360502 P2X Receptors As Cell-surface ATP Sensors in Health and Disease Nature. Aug, 2006 | Pubmed ID: 16885977 An Angstrom Scale Interaction Between Plasma Membrane ATP-gated P2X2 and Alpha4beta2 Nicotinic Channels Measured with Fluorescence Resonance Energy Transfer and Total Internal Reflection Fluorescence Microscopy The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2005 | Pubmed ID: 16033901 Contribution of Transmembrane Regions to ATP-gated P2X2 Channel Permeability Dynamics The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15556949 Time-resolved Measurement of State-specific P2X2 Ion Channel Cytosolic Gating Motions The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2004 | Pubmed ID: 15548662 ATP Excites Interneurons and Astrocytes to Increase Synaptic Inhibition in Neuronal Networks The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2004 | Pubmed ID: 15456834 Contribution of Calcium Ions to P2X Channel Responses The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2004 | Pubmed ID: 15056721 ATP-gated P2X Channels Current Biology : CB. Jan, 2004 | Pubmed ID: 14711422 ATP Modulation of Excitatory Synapses Onto Interneurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2003 | Pubmed ID: 12917379 Control of P2X(2) Channel Permeability by the Cytosolic Domain The Journal of General Physiology. Aug, 2002 | Pubmed ID: 12149275 Visualisere Astrocytt morfologi bruke Lucifer Yellow Iontoforese Stefanie L. Moye1, Blanca Diaz-Castro1, Mohitkumar R. Gangwani1, Baljit S. Khakh1,2 1Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, 2Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles JoVE 60225 Neuroscience Å gjøre Testing og bruke kalium Ion selektive Microelectrodes i vev skiver av voksen hjernen J. Christopher Octeau1, Guido Faas2, Istvan Mody1,2, Baljit S. Khakh1,3 1Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, 2Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 3Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles JoVE 57511 Neuroscience Imaging Intracellulær Ca Ruotian Jiang1, Martin D. Haustein1, Michael V. Sofroniew2, Baljit S. Khakh1,2 1Department of Physiology, University of California Los Angeles, 2Department of Neurobiology, University of California Los Angeles Neuroscience Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels JoVE 1178 Biology Measuring Near Plasma Membrane and Global Intracellular Calcium Dynamics in Astrocytes JoVE 1142 Biology
Visualisere Astrocytt morfologi bruke Lucifer Yellow Iontoforese Stefanie L. Moye1, Blanca Diaz-Castro1, Mohitkumar R. Gangwani1, Baljit S. Khakh1,2 1Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, 2Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles JoVE 60225 Neuroscience
Å gjøre Testing og bruke kalium Ion selektive Microelectrodes i vev skiver av voksen hjernen J. Christopher Octeau1, Guido Faas2, Istvan Mody1,2, Baljit S. Khakh1,3 1Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, 2Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 3Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles JoVE 57511 Neuroscience
Imaging Intracellulær Ca Ruotian Jiang1, Martin D. Haustein1, Michael V. Sofroniew2, Baljit S. Khakh1,2 1Department of Physiology, University of California Los Angeles, 2Department of Neurobiology, University of California Los Angeles Neuroscience
Measuring Near Plasma Membrane and Global Intracellular Calcium Dynamics in Astrocytes JoVE 1142 Biology
