Bente Pakkenberg Research Laboratory for Stereology and Neuroscience Bispebjerg-Frederiksberg Hospital Biography Publications Institution JoVE Articles Bente Pakkenberg has not added a biography. If you are Bente Pakkenberg and would like to personalize this page please email our Author Liaison for assistance. Publications Autoimmune Antibody Decline in Parkinson's Disease and Multiple System Atrophy; a Step Towards Immunotherapeutic Strategies Molecular Neurodegeneration. Jun, 2017 | Pubmed ID: 28592329 Changes in the Cell Population in Brain White Matter in Multiple System Atrophy Movement Disorders : Official Journal of the Movement Disorder Society. Apr, 2017 | Pubmed ID: 28394027 Involvement of Serotonin 2A Receptor Activation in Modulating Medial Prefrontal Cortex and Amygdala Neuronal Activation During Novelty-exposure Behavioural Brain Research. May, 2017 | Pubmed ID: 28263831 Electroconvulsive Stimulation Results in Long-term Survival of Newly Generated Hippocampal Neurons in Rats Hippocampus. Jan, 2017 | Pubmed ID: 27756104 Neocortical Neuronal Loss in Patients with Multiple System Atrophy: A Stereological Study Cerebral Cortex (New York, N.Y. : 1991). Jan, 2017 | Pubmed ID: 26464477 Assessment of Brain Reference Genes for RT-qPCR Studies in Neurodegenerative Diseases Scientific Reports. Nov, 2016 | Pubmed ID: 27853238 Neocortical Development in Brain of Young Children-A Stereological Study Cerebral Cortex (New York, N.Y. : 1991). Oct, 2016 | Pubmed ID: 27733541 Limited Effects of Preterm Birth and the First Enteral Nutrition on Cerebellum Morphology and Gene Expression in Piglets Physiological Reports. 07, 2016 | Pubmed ID: 27462071 Recording, Analysis, and Interpretation of Spreading Depolarizations in Neurointensive Care: Review and Recommendations of the COSBID Research Group Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jun, 2016 | Pubmed ID: 27317657 Altered α-synuclein, Parkin, and Synphilin Isoform Levels in Multiple System Atrophy Brains Journal of Neurochemistry. Jan, 2016 | Pubmed ID: 26465922 Development of the Cell Population in the Brain White Matter of Young Children Cerebral Cortex (New York, N.Y. : 1991). Jan, 2016 | Pubmed ID: 25122465 Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia Cell. Oct, 2015 | Pubmed ID: 26451483 Core and Shell Song Systems Unique to the Parrot Brain PloS One. 2015 | Pubmed ID: 26107173 Aberrant Wnt Signaling Pathway in Medial Temporal Lobe Structures of Alzheimer's Disease Journal of Neural Transmission (Vienna, Austria : 1996). Sep, 2015 | Pubmed ID: 25680440 The Total Number of Leydig and Sertoli Cells in the Testes of Men Across Various Age Groups - a Stereological Study Journal of Anatomy. Feb, 2015 | Pubmed ID: 25545958 Changes in Total Cell Numbers of the Basal Ganglia in Patients with Multiple System Atrophy - A Stereological Study Neurobiology of Disease. Feb, 2015 | Pubmed ID: 25449905 Electroconvulsive Stimulation, but Not Chronic Restraint Stress, Causes Structural Alterations in Adult Rat Hippocampus--a Stereological Study Hippocampus. Jan, 2015 | Pubmed ID: 25139647 Quantitative Relationships in Delphinid Neocortex Frontiers in Neuroanatomy. 2014 | Pubmed ID: 25505387 Stereological Estimation of Total Cell Numbers in the Human Cerebral and Cerebellar Cortex Frontiers in Human Neuroscience. 2014 | Pubmed ID: 25076882 Cerebellar Cytokine Expression in a Rat Model for Fetal Asphyctic Preconditioning and Perinatal Asphyxia Cerebellum (London, England). Aug, 2014 | Pubmed ID: 24771476 Comparison of Quantitative Estimation of Intracerebral Hemorrhage and Infarct Volumes After Thromboembolism in an Embolic Stroke Model International Journal of Stroke : Official Journal of the International Stroke Society. Aug, 2014 | Pubmed ID: 22928632 Expression of Presynaptic Markers in a Neurodevelopmental Animal Model with Relevance to Schizophrenia Neuroreport. Nov, 2013 | Pubmed ID: 24045778 Screening of Toll-like Receptors Expression in Multiple System Atrophy Brains Neurochemical Research. Jun, 2013 | Pubmed ID: 23525968 Application of Stereological Methods to Estimate Post-mortem Brain Surface Area Using 3T MRI Magnetic Resonance Imaging. Apr, 2013 | Pubmed ID: 23238418 Differential Expression of Parvalbumin in Neonatal Phencyclidine-treated Rats and Socially Isolated Rats Journal of Neurochemistry. Feb, 2013 | Pubmed ID: 23083323 Effect of Age on Neocortical Brain Cells in 90+ Year Old Human Females--a Cell Counting Study Neurobiology of Aging. Jan, 2013 | Pubmed ID: 22878165 Application of Immunohistochemistry in Stereology for Quantitative Assessment of Neural Cell Populations Illustrated in the Göttingen Minipig PloS One. 2012 | Pubmed ID: 22905271 The DJ-1 Concentration in Cerebrospinal Fluid Does Not Differentiate Among Parkinsonian Syndromes Parkinsonism & Related Disorders. Aug, 2012 | Pubmed ID: 22503539 Age-related Degeneration of Corpus Callosum in the 90+ Years Measured with Stereology Neurobiology of Aging. May, 2012 | Pubmed ID: 22118947 Reimplantation of Cultivated Human Bone Cells from the Posterior Maxilla for Sinus Floor Augmentation. Histological Results from a Randomized Controlled Clinical Trial Clinical Oral Implants Research. Sep, 2012 | Pubmed ID: 22092973 Stereological Quantification of the Cerebellum in Patients with Alzheimer's Disease Neurobiology of Aging. Jan, 2012 | Pubmed ID: 20728248 Total Numbers of Neurons and Glial Cells in Cortex and Basal Ganglia of Aged Brains with Down Syndrome--a Stereological Study Cerebral Cortex (New York, N.Y. : 1991). Nov, 2011 | Pubmed ID: 21427166 Stereological Estimate of the Total Number of Neurons in Spinal Segment D9 of the Red-eared Turtle The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011 | Pubmed ID: 21325510 Stereological Estimation of the Total Number of Myelinated Callosal Fibers in Human Subjects Journal of Anatomy. Mar, 2011 | Pubmed ID: 21250987 A Neurological Comparative Study of the Harp Seal (Pagophilus Groenlandicus) and Harbor Porpoise (Phocoena Phocoena) Brain Anatomical Record (Hoboken, N.J. : 2007). Dec, 2010 | Pubmed ID: 21077171 Stereological Brain Volume Changes in Post-weaned Socially Isolated Rats Brain Research. Jul, 2010 | Pubmed ID: 20546705 Spatiotemporal Distribution of PAX6 and MEIS2 Expression and Total Cell Numbers in the Ganglionic Eminence in the Early Developing Human Forebrain Developmental Neuroscience. Jul, 2010 | Pubmed ID: 20523026 Age and Parkinson's Disease-related Neuronal Death in the Substantia Nigra Pars Compacta Journal of Neural Transmission. Supplementum. 2009 | Pubmed ID: 20411779 Application of Stereology to Dermatological Research Experimental Dermatology. Dec, 2009 | Pubmed ID: 19758342 An Empirical Analysis of the Precision of Estimating the Numbers of Neurons and Glia in Human Neocortex Using a Fractionator-design with Sub-sampling Journal of Neuroscience Methods. Sep, 2009 | Pubmed ID: 19520115 Reduced Cell Number in the Neocortical Part of the Human Fetal Brain in Down Syndrome Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft. Nov, 2008 | Pubmed ID: 18722098 The Impact of Maternal Separation on Adult Mouse Behaviour and on the Total Neuron Number in the Mouse Hippocampus Brain Structure & Function. Feb, 2008 | Pubmed ID: 18200448 Validation of in Vitro Probabilistic Tractography NeuroImage. Oct, 2007 | Pubmed ID: 17706434 Severe Cell Reduction in the Future Brain Cortex in Human Growth-restricted Fetuses and Infants American Journal of Obstetrics and Gynecology. Jul, 2007 | Pubmed ID: 17618757 Neocortical and Hippocampal Neuron and Glial Cell Numbers in the Rhesus Monkey Anatomical Record (Hoboken, N.J. : 2007). Mar, 2007 | Pubmed ID: 17525948 Total Neocortical Cell Number in the Mysticete Brain Anatomical Record (Hoboken, N.J. : 2007). Jan, 2007 | Pubmed ID: 17441201 A PET Study of Effects of Chronic 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on Serotonin Markers in Göttingen Minipig Brain Synapse (New York, N.Y.). Jul, 2007 | Pubmed ID: 17415793 No Changes in Neocortical Cell Volumes or Glial Cell Numbers in Chronic Alcoholic Subjects Compared to Control Subjects Alcohol and Alcoholism (Oxford, Oxfordshire). Sep-Oct, 2007 | Pubmed ID: 17341513 Excess of Neurons in the Human Newborn Mediodorsal Thalamus Compared with That of the Adult Cerebral Cortex (New York, N.Y. : 1991). Nov, 2007 | Pubmed ID: 17218480 The Prefrontal Cortex in the Göttingen Minipig Brain Defined by Neural Projection Criteria and Cytoarchitecture Brain Research Bulletin. Oct, 2006 | Pubmed ID: 17027768 The Postnatal Development of Cerebellar Purkinje Cells in the Göttingen Minipig Estimated with a New Stereological Sampling Technique--the Vertical Bar Fractionator Journal of Anatomy. Sep, 2006 | Pubmed ID: 16928201 The Postnatal Development of Neocortical Neurons and Glial Cells in the Göttingen Minipig and the Domestic Pig Brain The Journal of Experimental Biology. Apr, 2006 | Pubmed ID: 16574805 Immunohistochemical Visualization of Neurons and Specific Glial Cells for Stereological Application in the Porcine Neocortex Journal of Neuroscience Methods. Apr, 2006 | Pubmed ID: 16269187 Regulatory Developmental Neurotoxicity Testing: a Model Study Focussing on Conventional Neuropathology Endpoints and Other Perspectives Environmental Toxicology and Pharmacology. May, 2005 | Pubmed ID: 21783551 Measuring Morphological and Cellular Changes in Alzheimer's Dementia: a Review Emphasizing Stereology Current Alzheimer Research. Oct, 2005 | Pubmed ID: 16248850 The Size Distribution of Neurons in the Motor Cortex in Amyotrophic Lateral Sclerosis Journal of Anatomy. Oct, 2005 | Pubmed ID: 16191168 2D and 3D Assessment of Neuropathology in Rat Brain After Prenatal Exposure to Methylazoxymethanol, a Model for Developmental Neurotoxicty Reproductive Toxicology (Elmsford, N.Y.). Sep-Oct, 2005 | Pubmed ID: 15964739 Assessment of in Vivo MR Imaging Compared to Physical Sections in Vitro--a Quantitative Study of Brain Volumes Using Stereology NeuroImage. May, 2005 | Pubmed ID: 15862205 Increased Volume of the Pigmented Neurons in the Locus Coeruleus of Schizophrenic Subjects: a Stereological Study Journal of Psychiatric Research. Jul, 2005 | Pubmed ID: 15804384 Genetic Background Determines the Size and Structure of the Endocrine Pancreas Diabetes. Jan, 2005 | Pubmed ID: 15616020 No Global Loss of Neocortical Neurons in Parkinson's Disease: a Quantitative Stereological Study Movement Disorders : Official Journal of the Movement Disorder Society. Feb, 2005 | Pubmed ID: 15468109 Myelinated Nerve Fibres in the Subcortical White Matter of Cerebral Hemispheres Are Preserved in Alcoholic Subjects Brain Research. Dec, 2004 | Pubmed ID: 15542070 Glial Cell Loss in the Anterior Cingulate Cortex, a Subregion of the Prefrontal Cortex, in Subjects with Schizophrenia The American Journal of Psychiatry. May, 2004 | Pubmed ID: 15121654 The Endocrine Pancreas in Non-diabetic Rats After Short-term and Long-term Treatment with the Long-acting GLP-1 Derivative NN2211 APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Dec, 2003 | Pubmed ID: 14678021 Total Length of Nerve Fibers in Prefrontal and Global White Matter of Chronic Schizophrenics Journal of Psychiatric Research. Nov-Dec, 2003 | Pubmed ID: 14563386 Aging of the Human Cerebellum: a Stereological Study The Journal of Comparative Neurology. Nov, 2003 | Pubmed ID: 14556293 Neocortical Glial Cell Numbers in Alzheimer's Disease. A Stereological Study Dementia and Geriatric Cognitive Disorders. 2003 | Pubmed ID: 14512716 Increased Islet Volume but Unchanged Islet Number in Ob/ob Mice Diabetes. Jul, 2003 | Pubmed ID: 12829638 Marked Loss of Myelinated Nerve Fibers in the Human Brain with Age The Journal of Comparative Neurology. Jul, 2003 | Pubmed ID: 12794739 Stereological Quantitation in Cerebella from People with Schizophrenia The British Journal of Psychiatry : the Journal of Mental Science. Apr, 2003 | Pubmed ID: 12668413 Comparison of MR Imaging Against Physical Sectioning to Estimate the Volume of Human Cerebral Compartments NeuroImage. Feb, 2003 | Pubmed ID: 12595203 Aging and the Human Neocortex Experimental Gerontology. Jan-Feb, 2003 | Pubmed ID: 12543266 The Changing Number of Cells in the Human Fetal Forebrain and Its Subdivisions: a Stereological Analysis Cerebral Cortex (New York, N.Y. : 1991). Feb, 2003 | Pubmed ID: 12507942 Postnatal Development of Beta-cells in Rats. Proposed Explanatory Model APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. May, 2002 | Pubmed ID: 12076254 The Optical Fractionator Technique to Estimate Cell Numbers in a Rat Model of Electroconvulsive Therapy Mikkel Vestergaard Olesen1, Esther Kjær Needham1, Bente Pakkenberg1,2 1Research Laboratory for Stereology and Neuroscience, Bispebjerg-Frederiksberg Hospital, 2Institute of Clinical Medicine, Department of Health and Medical Sciences, University of Copenhagen JoVE 55737 Neuroscience
The Optical Fractionator Technique to Estimate Cell Numbers in a Rat Model of Electroconvulsive Therapy Mikkel Vestergaard Olesen1, Esther Kjær Needham1, Bente Pakkenberg1,2 1Research Laboratory for Stereology and Neuroscience, Bispebjerg-Frederiksberg Hospital, 2Institute of Clinical Medicine, Department of Health and Medical Sciences, University of Copenhagen JoVE 55737 Neuroscience