Billy W. Day Department of Pharmaceutical Sciences University of Pittsburgh Biography Publications Institution JoVE Articles Billy W. Day has not added a biography. If you are Billy W. Day and would like to personalize this page please email our Author Liaison for assistance. Publications Synthesis and Biological Evaluation of Neopeltolide and Analogs The Journal of Organic Chemistry. Feb, 2012 | Pubmed ID: 22329423 Efficient Syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, Two Potent New Microtubule-stabilizing Agents Beilstein Journal of Organic Chemistry. 2011 | Pubmed ID: 22043248 Characterization of Inhibitors of Glucocorticoid Receptor Nuclear Translocation: A Model of Cytoplasmic Dynein-Mediated Cargo Transport Assay and Drug Development Technologies. Sep, 2011 | Pubmed ID: 21919741 Total Synthesis and Biological Evaluation of Pederin, Psymberin, and Highly Potent Analogs Journal of the American Chemical Society. Oct, 2011 | Pubmed ID: 21902245 A Simplified Synthesis of Novel Dictyostatin Analogues with in Vitro Activity Against Epothilone B-resistant Cells and Antiangiogenic Activity in Zebrafish Embryos Molecular Cancer Therapeutics. Jun, 2011 | Pubmed ID: 21490306 Characterization and Detection of Cellular and Proteomic Alterations in Stable Stathmin-overexpressing, Taxol-resistant BT549 Breast Cancer Cells Using Offgel IEF/PAGE Difference Gel Electrophoresis Mutation Research. Jun, 2011 | Pubmed ID: 20816848 Theory and Applications of Surface Plasmon Resonance, Resonant Mirror, Resonant Waveguide Grating, and Dual Polarization Interferometry Biosensors Sensors (Basel, Switzerland). 2010 | Pubmed ID: 22163431 Regulation of the Autophagy Protein LC3 by Phosphorylation The Journal of Cell Biology. Aug, 2010 | Pubmed ID: 20713600 Streamlined Syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin Journal of the American Chemical Society. Jul, 2010 | Pubmed ID: 20545347 Inhibition of Histone Deacetylase Expands the Renal Progenitor Cell Population Journal of the American Society of Nephrology : JASN. May, 2010 | Pubmed ID: 20378823 Azide-tetrazole Equilibrium of C-6 Azidopurine Nucleosides and Their Ligation Reactions with Alkynes The Journal of Organic Chemistry. Apr, 2010 | Pubmed ID: 20297785 A Functionalizable Polyester with Free Hydroxyl Groups and Tunable Physiochemical and Biological Properties Biomaterials. Apr, 2010 | Pubmed ID: 20149441 Identification of ATP Citrate Lyase As a Positive Regulator of Glycolytic Function in Glioblastomas International Journal of Cancer. Journal International Du Cancer. May, 2010 | Pubmed ID: 19795461 Chemical Library Screens Targeting an HIV-1 Accessory Factor/host Cell Kinase Complex Identify Novel Antiretroviral Compounds ACS Chemical Biology. Nov, 2009 | Pubmed ID: 19807124 Human Liver Microsomal Metabolism of (+)-discodermolide Journal of Natural Products. Oct, 2009 | Pubmed ID: 19775091 High-content Analysis of Cancer-cell-specific Apoptosis and Inhibition of in Vivo Angiogenesis by Synthetic (-)-pironetin and Analogs Chemical Biology & Drug Design. Oct, 2009 | Pubmed ID: 19691472 Meayamycin Inhibits Pre-messenger RNA Splicing and Exhibits Picomolar Activity Against Multidrug-resistant Cells Molecular Cancer Therapeutics. Aug, 2009 | Pubmed ID: 19671752 Evaluation of Biosensor Surfaces for the Detection of Microtubule Perturbation Biosensors & Bioelectronics. Sep, 2009 | Pubmed ID: 19595587 Zebrafish Chemical Screening Reveals an Inhibitor of Dusp6 That Expands Cardiac Cell Lineages Nature Chemical Biology. Sep, 2009 | Pubmed ID: 19578332 Design and Synthesis of a Library of Tetracyclic Hydroazulenoisoindoles Journal of Combinatorial Chemistry. May-Jun, 2009 | Pubmed ID: 19366169 Biphenyl C-cyclopropylalkylamides: New Scaffolds for Targeting Estrogen Receptor Beta Bioorganic & Medicinal Chemistry Letters. May, 2009 | Pubmed ID: 19356928 Polyhydroxylalkyleneamines: a Class of Hydrophilic Cationic Polymer-based Gene Transfer Agents Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2009 | Pubmed ID: 19332088 Select Pyrimidinones Inhibit the Propagation of the Malarial Parasite, Plasmodium Falciparum Bioorganic & Medicinal Chemistry. Feb, 2009 | Pubmed ID: 19195901 Microtubule Binding and Disruption and Induction of Premature Senescence by Disorazole C(1) The Journal of Pharmacology and Experimental Therapeutics. Mar, 2009 | Pubmed ID: 19066338 APC is Essential for Targeting Phosphorylated Beta-catenin to the SCFbeta-TrCP Ubiquitin Ligase Molecular Cell. Dec, 2008 | Pubmed ID: 19061640 Improved Synthesis of 6-epi-dictyostatin and Antitumor Efficacy in Mice Bearing MDA-MB231 Human Breast Cancer Xenografts Journal of Medicinal Chemistry. Nov, 2008 | Pubmed ID: 18839939 Guidelines for Reporting the Use of Gel Electrophoresis in Proteomics Nature Biotechnology. Aug, 2008 | Pubmed ID: 18688234 Mild, Efficient Friedel-Crafts Acylations from Carboxylic Acids Using Cyanuric Chloride and AlCl3 Organic Letters. Jul, 2008 | Pubmed ID: 18512929 (Z)-1,1-Dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane Induces Concentration-dependent Growth Inhibition, Apoptosis, and Coordinates Regulation of Apoptotic Genes in TRAMP Cells Urologic Oncology. Jul-Aug, 2008 | Pubmed ID: 18367102 Tubulin-perturbing Naphthoquinone Spiroketals Chemical Biology & Drug Design. Feb, 2008 | Pubmed ID: 18194192 Pyrimidinone-peptoid Hybrid Molecules with Distinct Effects on Molecular Chaperone Function and Cell Proliferation Bioorganic & Medicinal Chemistry. Mar, 2008 | Pubmed ID: 18164205 Cell-based and Biochemical Structure-activity Analyses of Analogs of the Microtubule Stabilizer Dictyostatin Molecular Pharmacology. Mar, 2008 | Pubmed ID: 18073274 Synthesis and Biological Evaluation of (-)-dictyostatin and Stereoisomers Tetrahedron. Aug, 2007 | Pubmed ID: 18728696 Structure-activity and High-content Imaging Analyses of Novel Tubulysins Chemical Biology & Drug Design. Aug, 2007 | Pubmed ID: 17683369 New Opportunities for Pregnane X Receptor (PXR) Targeting in Drug Development. Lessons from Enantio- and Species-specific PXR Ligands Identified from a Discovery Library of Amino Acid Analogues Mini Reviews in Medicinal Chemistry. Jun, 2007 | Pubmed ID: 17584160 Total Synthesis and Biological Evaluation of C16 Analogs of (-)-dictyostatin Journal of Medicinal Chemistry. Jun, 2007 | Pubmed ID: 17542572 Genotoxicity Assessed by the Comet and GPA Assays Following in Vitro Exposure of Human Lymphoblastoid Cells (H9) or Perinatal Exposure of Mother-child Pairs to AZT or AZT-3TC Environmental and Molecular Mutagenesis. Apr-May, 2007 | Pubmed ID: 17358027 Cyclostreptin Binds Covalently to Microtubule Pores and Lumenal Taxoid Binding Sites Nature Chemical Biology. Feb, 2007 | Pubmed ID: 17206139 Production and Characterization of Monoclonal Antibodies Against Ochratoxin B Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. May, 2007 | Pubmed ID: 17161512 Albumin Marks Pseudopodia of Astrocytoma Cells Responding to Hepatocyte Growth Factor or Serum Laboratory Investigation; a Journal of Technical Methods and Pathology. Nov, 2006 | Pubmed ID: 16969371 Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly Molecular Pharmacology. Nov, 2006 | Pubmed ID: 16887932 Myeloperoxidase-catalyzed Metabolism of Etoposide to Its Quinone and Glutathione Adduct Forms in HL60 Cells Chemical Research in Toxicology. Jul, 2006 | Pubmed ID: 16841962 Synthesis and Biological Evaluation of Purealin and Analogues As Cytoplasmic Dynein Heavy Chain Inhibitors Journal of Medicinal Chemistry. Mar, 2006 | Pubmed ID: 16539395 Altered Expression and Localization of Creatine Kinase B, Heterogeneous Nuclear Ribonucleoprotein F, and High Mobility Group Box 1 Protein in the Nuclear Matrix Associated with Colon Cancer Cancer Research. Jan, 2006 | Pubmed ID: 16424007 Fluorous Mixture Synthesis of (-)-dictyostatin and Three Stereoisomers Organic Letters. Jan, 2006 | Pubmed ID: 16408900 Brisk Production of Nitric Oxide and Associated Formation of S-nitrosothiols in Early Hemorrhage Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2006 | Pubmed ID: 16339342 Rac1 Leads to Phosphorylation-dependent Increase in Stability of the P66shc Adaptor Protein: Role in Rac1-induced Oxidative Stress Molecular Biology of the Cell. Jan, 2006 | Pubmed ID: 16251354 Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells Molecular Endocrinology (Baltimore, Md.). Feb, 2006 | Pubmed ID: 16195250 Systems Cell Biology Knowledge Created from High Content Screening Assay and Drug Development Technologies. Oct, 2005 | Pubmed ID: 16305307 Tubulin Assembly, Taxoid Site Binding, and Cellular Effects of the Microtubule-stabilizing Agent Dictyostatin Biochemistry. Nov, 2005 | Pubmed ID: 16274252 A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-based Approach Journal of Medicinal Chemistry. Sep, 2005 | Pubmed ID: 16162011 Redox Regulation of Cdc25B by Cell-active Quinolinediones Molecular Pharmacology. Dec, 2005 | Pubmed ID: 16155209 Synthesis and Biological Evaluation of (-)-16-normethyldictyostatin: a Potent Analogue of (-)-dictyostatin Organic Letters. Jul, 2005 | Pubmed ID: 15987158 A Pregnane X Receptor Agonist with Unique Species-dependent Stereoselectivity and Its Implications in Drug Development Molecular Pharmacology. Aug, 2005 | Pubmed ID: 15872116 HPRT Gene Alterations in Umbilical Cord Blood T-lymphocytes in Newborns of Mothers Exposed to Tobacco Smoke During Pregnancy Mutation Research. May, 2005 | Pubmed ID: 15790499 Microwave-assisted "libraries from Libraries" Approach Toward the Synthesis of Allyl- and C-cyclopropylalkylamides Journal of Combinatorial Chemistry. Mar-Apr, 2005 | Pubmed ID: 15762763 Proteomic Characterization of Harvested Pseudopodia with Differential Gel Electrophoresis and Specific Antibodies Laboratory Investigation; a Journal of Technical Methods and Pathology. Mar, 2005 | Pubmed ID: 15654357 CoMFA, HQSAR and Molecular Docking Studies of Butitaxel Analogues with Beta-tubulin Journal of Molecular Modeling. Feb, 2005 | Pubmed ID: 15616834 New Antiestrogens from a Library Screen of Homoallylic Amides, Allylic Amides, and C-cyclopropylalkylamides Bioorganic & Medicinal Chemistry. Jan, 2005 | Pubmed ID: 15582460 Small Molecule Modulators of Endogenous and Co-chaperone-stimulated Hsp70 ATPase Activity The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15448148 Inhibition of Estrogen Receptor Alpha-mediated Transcription by Antiestrogenic 1,1-dichloro-2,2,3-triarylcyclopropanes Molecular Pharmacology. Oct, 2004 | Pubmed ID: 15235102 Detection of Conjugated C16 PUFAs in Rat Tissues As Possible Partial Beta-oxidation Products of Naturally Occurring Conjugated Linoleic Acid and Its Metabolites Biochimica Et Biophysica Acta. Jun, 2004 | Pubmed ID: 15158763 Chemistry and Biology of Curacin A Current Pharmaceutical Design. 2004 | Pubmed ID: 15134491 Altered Levels and Regulation of Stathmin in Paclitaxel-resistant Ovarian Cancer Cells Oncogene. Dec, 2003 | Pubmed ID: 14654788 Identification of Structural Components Associated with Cytostatic Activity in MCF-7 but Not in MDA-MB-231 Cells Bioorganic & Medicinal Chemistry. Nov, 2003 | Pubmed ID: 14604689 Synthesis and Biological Assessment of Simplified Analogues of the Potent Microtubule Stabilizer (+)-discodermolide Bioorganic & Medicinal Chemistry. Jul, 2003 | Pubmed ID: 12837544 Simplified Discodermolide Analogues: Synthesis and Biological Evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides As Microtubule-stabilizing Agents Journal of Medicinal Chemistry. Jul, 2003 | Pubmed ID: 12825928 Synthesis and High Content Cell-based Profiling of Simplified Analogues of the Microtubule Stabilizer (+)-discodermolide Molecular Cancer Therapeutics. Dec, 2002 | Pubmed ID: 12516963 The Antisignaling Agent SC-alpha Alpha Delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric Acid, is a Structurally Unique Phospholipid Analogue with Phospholipase C Inhibitory Activity Molecular Cancer Therapeutics. Sep, 2002 | Pubmed ID: 12481409 Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation Organic Letters. Dec, 2002 | Pubmed ID: 12465908 Synthesis and Biological Evaluation of Structurally Highly Modified Analogues of the Antimitotic Natural Product Curacin A Journal of Medicinal Chemistry. Apr, 2002 | Pubmed ID: 11960501 Разработка автоматизированной обработки изображений и анализа для экранов данио химических веществ. Andreas Vogt1, Hiba Codore2, Billy W. Day3,4, Neil A. Hukriede2, Michael Tsang2 1Pharmacology and Chemical Biology, University of Pittsburgh Drug Discovery Institute, 2Department of Microbiology and Molecular Genetics, University of Pittsburgh, 3Department of Pharmaceutical Sciences, University of Pittsburgh, 4Department of Chemistry, University of Pittsburgh JoVE 1900 Biology
Разработка автоматизированной обработки изображений и анализа для экранов данио химических веществ. Andreas Vogt1, Hiba Codore2, Billy W. Day3,4, Neil A. Hukriede2, Michael Tsang2 1Pharmacology and Chemical Biology, University of Pittsburgh Drug Discovery Institute, 2Department of Microbiology and Molecular Genetics, University of Pittsburgh, 3Department of Pharmaceutical Sciences, University of Pittsburgh, 4Department of Chemistry, University of Pittsburgh JoVE 1900 Biology
