Binu Tharakan Department of Surgery Texas A&M University Health Science Center College of Medicine Biography Publications Institution JoVE Articles Binu Tharakan has not added a biography. If you are Binu Tharakan and would like to personalize this page please email our Author Liaison for assistance. Publications Blood-brain Barrier Dysfunction Following Traumatic Brain Injury Metabolic Brain Disease. Jan, 2015 | Pubmed ID: 25624154 Tumor Necrosis Factor-α-induced Microvascular Endothelial Cell Hyperpermeability: Role of Intrinsic Apoptotic Signaling Journal of Physiology and Biochemistry. Dec, 2014 | Pubmed ID: 25392259 Tumor Necrosis Factor-α Disruption of Brain Endothelial Cell Barrier is Mediated Through Matrix Metalloproteinase-9 American Journal of Surgery. Dec, 2014 | Pubmed ID: 25312844 The Role of Intrinsic Apoptotic Signaling in Hemorrhagic Shock-induced Microvascular Endothelial Cell Barrier Dysfunction Journal of Cardiovascular Translational Research. Nov, 2014 | Pubmed ID: 25277298 Melatonin Inhibits Thermal Injury-induced Hyperpermeability in Microvascular Endothelial Cells The Journal of Trauma and Acute Care Surgery. Dec, 2014 | Pubmed ID: 25051382 Vascular Hyperpermeability and Aging Aging and Disease. Apr, 2014 | Pubmed ID: 24729937 Reactive Oxygen Species-caspase-3 Relationship in Mediating Blood-brain Barrier Endothelial Cell Hyperpermeability Following Oxygen-glucose Deprivation and Reoxygenation Microcirculation (New York, N.Y. : 1994). Feb, 2014 | Pubmed ID: 24372803 The Effects of Inflammatory Cytokines on Lymphatic Endothelial Barrier Function Angiogenesis. Apr, 2014 | Pubmed ID: 24141404 Doxycycline Attenuates Burn-induced Microvascular Hyperpermeability The Journal of Trauma and Acute Care Surgery. Dec, 2013 | Pubmed ID: 24256679 Regulation of Tumor Necrosis Factor-α-induced Microvascular Endothelial Cell Hyperpermeability by Recombinant B-cell Lymphoma-extra Large The Journal of Surgical Research. Sep, 2013 | Pubmed ID: 23731686 Tumor Necrosis Factor-related Apoptosis-inducing Ligand Promotes Microvascular Endothelial Cell Hyperpermeability Through Phosphatidylinositol 3-kinase Pathway American Journal of Surgery. Apr, 2013 | Pubmed ID: 23375756 Microvascular Endothelial Cell Hyperpermeability Induced by Endogenous Caspase 3 Activator Staurosporine The Journal of Trauma and Acute Care Surgery. Feb, 2013 | Pubmed ID: 23354245 Inhibition of Fas-Fas Ligand Interaction Attenuates Microvascular Hyperpermeability Following Hemorrhagic Shock Shock (Augusta, Ga.). Feb, 2013 | Pubmed ID: 23324886 Marrow Stimulation Improves Meniscal Healing at Early Endpoints in a Rabbit Meniscal Injury Model Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association. Jan, 2013 | Pubmed ID: 23200846 The Effects of Hypothermia and L-arginine on Skeletal Muscle Function in Ischemia-reperfusion Injury Journal of Orthopaedic Trauma. Oct, 2012 | Pubmed ID: 22430525 Differential Effects of Dopaminergic Neurotoxins on DNA Cleavage Life Sciences. Jul, 2012 | Pubmed ID: 22213117 β-Catenin Dynamics in the Regulation of Microvascular Endothelial Cell Hyperpermeability Shock (Augusta, Ga.). Mar, 2012 | Pubmed ID: 22089197 Role of β-catenin in Regulating Microvascular Endothelial Cell Hyperpermeability The Journal of Trauma. Feb, 2011 | Pubmed ID: 21307750 Inhibition of VE-cadherin Proteasomal Degradation Attenuates Microvascular Hyperpermeability Microcirculation (New York, N.Y. : 1994). Jan, 2011 | Pubmed ID: 21166925 Curcumin Inhibits Reactive Oxygen Species Formation and Vascular Hyperpermeability Following Haemorrhagic Shock Clinical and Experimental Pharmacology & Physiology. Sep, 2010 | Pubmed ID: 20528978 Cyclosporine A--protection Against Microvascular Hyperpermeability is Calcineurin Independent American Journal of Surgery. Apr, 2010 | Pubmed ID: 20359571 17beta-estradiol Mediated Protection Against Vascular Leak After Hemorrhagic Shock: Role of Estrogen Receptors and Apoptotic Signaling Shock (Augusta, Ga.). Sep, 2010 | Pubmed ID: 20160663 (-)-Deprenyl Inhibits Vascular Hyperpermeability After Hemorrhagic Shock Shock (Augusta, Ga.). Jan, 2010 | Pubmed ID: 19373132 (-)-Deprenyl Inhibits Thermal Injury-induced Apoptotic Signaling and Hyperpermeability in Microvascular Endothelial Cells Journal of Burn Care & Research : Official Publication of the American Burn Association. Nov-Dec, 2009 | Pubmed ID: 19826263 Cyclosporine A Prevents Vascular Hyperpermeability After Hemorrhagic Shock by Inhibiting Apoptotic Signaling The Journal of Trauma. Apr, 2009 | Pubmed ID: 19359911 Vascular Leak in a Rat Model of Preeclampsia American Journal of Nephrology. 2009 | Pubmed ID: 19194101 17beta-estradiol Mediates Protection Against Microvascular Endothelial Cell Hyperpermeability American Journal of Surgery. Feb, 2009 | Pubmed ID: 19185107 Centella Asiatica Extract Selectively Decreases Amyloid Beta Levels in Hippocampus of Alzheimer's Disease Animal Model Phytotherapy Research : PTR. Jan, 2009 | Pubmed ID: 19048607 Alpha-lipoic Acid Attenuates Hemorrhagic Shock-induced Apoptotic Signaling and Vascular Hyperpermeability Shock (Augusta, Ga.). Nov, 2008 | Pubmed ID: 18923301 Caspases - an Update Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. Sep, 2008 | Pubmed ID: 18602321 Mitochondrial Complex III is Involved in Proapoptotic BAK-induced Microvascular Endothelial Cell Hyperpermeability Shock (Augusta, Ga.). May, 2008 | Pubmed ID: 18414238 Angiopoietin-1 Inhibits Intrinsic Apoptotic Signaling and Vascular Hyperpermeability Following Hemorrhagic Shock American Journal of Physiology. Heart and Circulatory Physiology. May, 2008 | Pubmed ID: 18344375 Alpha Lipoic Acid Attenuates Microvascular Endothelial Cell Hyperpermeability by Inhibiting the Intrinsic Apoptotic Signaling American Journal of Surgery. Feb, 2008 | Pubmed ID: 18096126 Antiparkinson Drug--Mucuna Pruriens Shows Antioxidant and Metal Chelating Activity Phytotherapy Research : PTR. Jan, 2008 | Pubmed ID: 18064727 Anti-Parkinson Botanical Mucuna Pruriens Prevents Levodopa Induced Plasmid and Genomic DNA Damage Phytotherapy Research : PTR. Dec, 2007 | Pubmed ID: 17622977 Neuroprotective Mechanisms of Ayurvedic Antidementia Botanical Bacopa Monniera Phytotherapy Research : PTR. Oct, 2007 | Pubmed ID: 17604373 Apoptotic Signaling Induces Hyperpermeability Following Hemorrhagic Shock American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2007 | Pubmed ID: 17307990 Current Concepts in Apoptosis: the Physiological Suicide Program Revisited Cellular & Molecular Biology Letters. 2006 | Pubmed ID: 16977376 Trichopus Zeylanicus Combats Fatigue Without Amphetamine-mimetic Activity Phytotherapy Research : PTR. Mar, 2006 | Pubmed ID: 16617470 Botanical Therapies in Chronic Fatigue Phytotherapy Research : PTR. Feb, 2006 | Pubmed ID: 16444659 Antioxidant and DNA Protecting Properties of Anti-fatigue Herb Trichopus Zeylanicus Phytotherapy Research : PTR. Aug, 2005 | Pubmed ID: 16177968 Botanical Therapies in Sexual Dysfunction Phytotherapy Research : PTR. Jun, 2005 | Pubmed ID: 16114077 Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction Himakarnika Alluri1,2, Chinchusha Anasooya Shaji2, Matthew L. Davis1,2, Binu Tharakan1,2 1Department of Surgery, Texas A&M University Health Science Center College of Medicine, 2Department of Surgery, Baylor Scott & White Health JoVE 52699 Medicine
Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction Himakarnika Alluri1,2, Chinchusha Anasooya Shaji2, Matthew L. Davis1,2, Binu Tharakan1,2 1Department of Surgery, Texas A&M University Health Science Center College of Medicine, 2Department of Surgery, Baylor Scott & White Health JoVE 52699 Medicine
