Birger Brodin

Publications

• Culture-induced Changes in MRNA Expression Levels of Efflux and SLC-transporters in Brain Endothelial Cells
  Fluids and Barriers of the CNS. Apr, 2020  |   Pubmed ID: 32321539
• The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
  Cells. Mar, 2020  |   Pubmed ID: 32143347
• Effects of Oxygen-glucose Deprivation (OGD) on Barrier Properties and MRNA Transcript Levels of Selected Marker Proteins in Brain Endothelial Cells/astrocyte Co-cultures
  PloS One. 2019  |   Pubmed ID: 31425564
• Evaluating the Involvement of Cerebral Microvascular Endothelial Na/K-ATPase and Na-K-2Cl Co-transporter in Electrolyte Fluxes in an In vitro Blood-brain Barrier Model of Dehydration
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 03, 2019  |   Pubmed ID: 28994331
• Validation of Reference Genes for Normalization of Real-time Quantitative PCR Studies of Gene Expression in Brain Capillary Endothelial Cells Cultured in Vitro
  Molecular and Cellular Neurosciences. 12, 2018  |   Pubmed ID: 30315869
• Stimulation-induced Increases in Cerebral Blood Flow and Local Capillary Vasoconstriction Depend on Conducted Vascular Responses
  Proceedings of the National Academy of Sciences of the United States of America. 06, 2018  |   Pubmed ID: 29866853
• The Insulin Receptor is Expressed and Functional in Cultured Blood-brain Barrier Endothelial Cells but Does Not Mediate Insulin Entry from Blood to Brain
  American Journal of Physiology. Endocrinology and Metabolism. 10, 2018  |   Pubmed ID: 29584446
• Data Demonstrating the Challenges of Determining the Kinetic Parameters of P-gp Mediated Transport of Low-water Soluble Substrates
  Data in Brief. Feb, 2018  |   Pubmed ID: 29541662
• Correction To: Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017
  Fluids and Barriers of the CNS. 01, 2018  |   Pubmed ID: 29329565
• Characterization of the IPEC-J2 MDR1 (iP-gp) Cell Line As a Tool for Identification of P-gp Substrates
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2018  |   Pubmed ID: 29146563
• Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017
  Fluids and Barriers of the CNS. Nov, 2017  |   Pubmed ID: 29110676
• Glutamate Transporters in the Blood-Brain Barrier
  Advances in Neurobiology. 2017  |   Pubmed ID: 28828617
• Routes for Drug Translocation Across the Blood-Brain Barrier: Exploiting Peptides As Delivery Vectors
  Journal of Pharmaceutical Sciences. 09, 2017  |   Pubmed ID: 28501469
• A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics
  Journal of Pharmaceutical Sciences. 09, 2017  |   Pubmed ID: 28438535
• Bidirectional Apical-basal Traffic of the Cation-independent Mannose-6-phosphate Receptor in Brain Endothelial Cells
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jul, 2017  |   Pubmed ID: 28337939
• Characterization of the L-glutamate Clearance Pathways Across the Blood-brain Barrier and the Effect of Astrocytes in an In vitro Blood-brain Barrier Model
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Dec, 2017  |   Pubmed ID: 28145808
• Transferrin Receptor Expression and Role in Transendothelial Transport of Transferrin in Cultured Brain Endothelial Monolayers
  Molecular and Cellular Neurosciences. Oct, 2016  |   Pubmed ID: 27567687
• In Vitro Blood-brain Barrier Permeability Predictions for GABAA Receptor Modulating Piperine Analogs
  European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Jun, 2016  |   Pubmed ID: 27018328
• Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier
  Journal of Pharmaceutical Sciences. Feb, 2016  |   Pubmed ID: 26869407
• In vitro Models of the Blood-brain Barrier: An Overview of Commonly Used Brain Endothelial Cell Culture Models and Guidelines for Their Use
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2016  |   Pubmed ID: 26868179
• The Putative P-gp Inhibitor Telmisartan Does Not Affect the Transcellular Permeability and Cellular Uptake of the Calcium Channel Antagonist Verapamil in the P-glycoprotein Expressing Cell Line MDCK II MDR1
  Pharmacology Research & Perspectives. Aug, 2015  |   Pubmed ID: 26171231
• In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches
  Journal of Pharmaceutical Sciences. Sep, 2015  |   Pubmed ID: 25630899
• Intestinal Absorption of the Antiepileptic Drug Substance Vigabatrin is Altered by Infant Formula in Vitro and in Vivo
  Pharmacology Research & Perspectives. Apr, 2014  |   Pubmed ID: 25505585
• Glutamate Efflux at the Blood-brain Barrier: Cellular Mechanisms and Potential Clinical Relevance
  Archives of Medical Research. Nov, 2014  |   Pubmed ID: 25446623
• An Electrically Tight in Vitro Blood-brain Barrier Model Displays Net Brain-to-blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1
  The AAPS Journal. Sep, 2014  |   Pubmed ID: 24934296
• In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt-DALDA Analogues
  ACS Medicinal Chemistry Letters. Apr, 2014  |   Pubmed ID: 24839540
• Generation of Primary Cultures of Bovine Brain Endothelial Cells and Setup of Cocultures with Rat Astrocytes
  Methods in Molecular Biology (Clifton, N.J.). 2014  |   Pubmed ID: 24510879
• PAT1 (SLC36A1) Shows Nuclear Localization and Affects Growth of Smooth Muscle Cells from Rats
  American Journal of Physiology. Endocrinology and Metabolism. Jan, 2014  |   Pubmed ID: 24222668
• The Absorptive Flux of the Anti-epileptic Drug Substance Vigabatrin is Carrier-mediated Across Caco-2 Cell Monolayers
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2014  |   Pubmed ID: 24008184
• Basolateral Glycylsarcosine (Gly-Sar) Transport in Caco-2 Cell Monolayers is PH Dependent
  The Journal of Pharmacy and Pharmacology. Jul, 2013  |   Pubmed ID: 23738724
• Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, HPEPT1
  International Journal of Peptides. 2012  |   Pubmed ID: 23346117
• In-vitro Evaluation of the P-glycoprotein Interactions of a Series of Potentially CNS-active Amaryllidaceae Alkaloids
  The Journal of Pharmacy and Pharmacology. Nov, 2012  |   Pubmed ID: 23058055
• Carrier-mediated γ-aminobutyric Acid Transport Across the Basolateral Membrane of Human Intestinal Caco-2 Cell Monolayers
  European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Jun, 2012  |   Pubmed ID: 22452873
• In Vitro Evidence for the Brain Glutamate Efflux Hypothesis: Brain Endothelial Cells Cocultured with Astrocytes Display a Polarized Brain-to-blood Transport of Glutamate
  Glia. May, 2012  |   Pubmed ID: 22392649
• Calu-3 Cells Grown Under AIC and LCC Conditions: Implications for Dipeptide Uptake and Transepithelial Transport of Substances
  European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. May, 2011  |   Pubmed ID: 21195173
• Affinity and Translocation Relationships Via HPEPT1 of H-X Aa-Ser-OH Dipeptides: Evaluation of H-Phe-Ser-OH As a Pro-moiety for Ibuprofen and Benzoic Acid Prodrugs
  European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Feb, 2011  |   Pubmed ID: 21147219
• Paracellular Tightness and Claudin-5 Expression is Increased in the BCEC/astrocyte Blood-brain Barrier Model by Increasing Media Buffer Capacity During Growth
  The AAPS Journal. Dec, 2010  |   Pubmed ID: 20967520
• Ibuprofen is a Non-competitive Inhibitor of the Peptide Transporter HPEPT1 (SLC15A1): Possible Interactions Between HPEPT1 Substrates and Ibuprofen
  British Journal of Pharmacology. Dec, 2010  |   Pubmed ID: 20726987
• A Quantitative Structure-activity Relationship for Translocation of Tripeptides Via the Human Proton-coupled Peptide Transporter, HPEPT1 (SLC15A1)
  The AAPS Journal. Sep, 2010  |   Pubmed ID: 20449699
• 5-Hydroxy-L-tryptophan Alters Gaboxadol Pharmacokinetics in Rats: Involvement of PAT1 and ROat1 in Gaboxadol Absorption and Elimination
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2010  |   Pubmed ID: 19900542
• In Vitro Cutaneous Application of ISCOMs on Human Skin Enhances Delivery of Hydrophobic Model Compounds Through the Stratum Corneum
  The AAPS Journal. Dec, 2009  |   Pubmed ID: 19862629
• Discovery of Ligands for the Human Intestinal Di-/Tripeptide Transporter (hPEPT1) Using a QSAR-assisted Virtual Screening Strategy
  ChemMedChem. Sep, 2009  |   Pubmed ID: 19557803
• Cloning of the Pig PEPT2 (pPEPT2) and Characterization of the Effects of Epidermal Growth Factor (EGF) on PPEPT2-mediated Peptide Uptake in the Renal Porcine Cell Line LLC-PK1
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Apr, 2008  |   Pubmed ID: 18295462
• HPEPT1 is Responsible for Uptake and Transport of Gly-Sar in the Human Bronchial Airway Epithelial Cell-line Calu-3
  Pflugers Archiv : European Journal of Physiology. Jun, 2008  |   Pubmed ID: 18094991