Birger Brodin Department of Pharmacy, The Faculty of Health and Medical Sciences University of Copenhagen Biography Publications Institution JoVE Articles Birger Brodin has not added a biography. If you are Birger Brodin and would like to personalize this page please email our Author Liaison for assistance. Publications Culture-induced Changes in MRNA Expression Levels of Efflux and SLC-transporters in Brain Endothelial Cells Fluids and Barriers of the CNS. Apr, 2020 | Pubmed ID: 32321539 The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP Cells. Mar, 2020 | Pubmed ID: 32143347 Effects of Oxygen-glucose Deprivation (OGD) on Barrier Properties and MRNA Transcript Levels of Selected Marker Proteins in Brain Endothelial Cells/astrocyte Co-cultures PloS One. 2019 | Pubmed ID: 31425564 Evaluating the Involvement of Cerebral Microvascular Endothelial Na/K-ATPase and Na-K-2Cl Co-transporter in Electrolyte Fluxes in an In vitro Blood-brain Barrier Model of Dehydration Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 03, 2019 | Pubmed ID: 28994331 Validation of Reference Genes for Normalization of Real-time Quantitative PCR Studies of Gene Expression in Brain Capillary Endothelial Cells Cultured in Vitro Molecular and Cellular Neurosciences. 12, 2018 | Pubmed ID: 30315869 Stimulation-induced Increases in Cerebral Blood Flow and Local Capillary Vasoconstriction Depend on Conducted Vascular Responses Proceedings of the National Academy of Sciences of the United States of America. 06, 2018 | Pubmed ID: 29866853 The Insulin Receptor is Expressed and Functional in Cultured Blood-brain Barrier Endothelial Cells but Does Not Mediate Insulin Entry from Blood to Brain American Journal of Physiology. Endocrinology and Metabolism. 10, 2018 | Pubmed ID: 29584446 Data Demonstrating the Challenges of Determining the Kinetic Parameters of P-gp Mediated Transport of Low-water Soluble Substrates Data in Brief. Feb, 2018 | Pubmed ID: 29541662 Correction To: Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017 Fluids and Barriers of the CNS. 01, 2018 | Pubmed ID: 29329565 Characterization of the IPEC-J2 MDR1 (iP-gp) Cell Line As a Tool for Identification of P-gp Substrates European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2018 | Pubmed ID: 29146563 Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017 Fluids and Barriers of the CNS. Nov, 2017 | Pubmed ID: 29110676 Glutamate Transporters in the Blood-Brain Barrier Advances in Neurobiology. 2017 | Pubmed ID: 28828617 Routes for Drug Translocation Across the Blood-Brain Barrier: Exploiting Peptides As Delivery Vectors Journal of Pharmaceutical Sciences. 09, 2017 | Pubmed ID: 28501469 A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics Journal of Pharmaceutical Sciences. 09, 2017 | Pubmed ID: 28438535 Bidirectional Apical-basal Traffic of the Cation-independent Mannose-6-phosphate Receptor in Brain Endothelial Cells Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jul, 2017 | Pubmed ID: 28337939 Characterization of the L-glutamate Clearance Pathways Across the Blood-brain Barrier and the Effect of Astrocytes in an In vitro Blood-brain Barrier Model Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Dec, 2017 | Pubmed ID: 28145808 Transferrin Receptor Expression and Role in Transendothelial Transport of Transferrin in Cultured Brain Endothelial Monolayers Molecular and Cellular Neurosciences. Oct, 2016 | Pubmed ID: 27567687 In Vitro Blood-brain Barrier Permeability Predictions for GABAA Receptor Modulating Piperine Analogs European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Jun, 2016 | Pubmed ID: 27018328 Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier Journal of Pharmaceutical Sciences. Feb, 2016 | Pubmed ID: 26869407 In vitro Models of the Blood-brain Barrier: An Overview of Commonly Used Brain Endothelial Cell Culture Models and Guidelines for Their Use Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2016 | Pubmed ID: 26868179 The Putative P-gp Inhibitor Telmisartan Does Not Affect the Transcellular Permeability and Cellular Uptake of the Calcium Channel Antagonist Verapamil in the P-glycoprotein Expressing Cell Line MDCK II MDR1 Pharmacology Research & Perspectives. Aug, 2015 | Pubmed ID: 26171231 In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches Journal of Pharmaceutical Sciences. Sep, 2015 | Pubmed ID: 25630899 Intestinal Absorption of the Antiepileptic Drug Substance Vigabatrin is Altered by Infant Formula in Vitro and in Vivo Pharmacology Research & Perspectives. Apr, 2014 | Pubmed ID: 25505585 Glutamate Efflux at the Blood-brain Barrier: Cellular Mechanisms and Potential Clinical Relevance Archives of Medical Research. Nov, 2014 | Pubmed ID: 25446623 An Electrically Tight in Vitro Blood-brain Barrier Model Displays Net Brain-to-blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1 The AAPS Journal. Sep, 2014 | Pubmed ID: 24934296 In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt-DALDA Analogues ACS Medicinal Chemistry Letters. Apr, 2014 | Pubmed ID: 24839540 Generation of Primary Cultures of Bovine Brain Endothelial Cells and Setup of Cocultures with Rat Astrocytes Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24510879 PAT1 (SLC36A1) Shows Nuclear Localization and Affects Growth of Smooth Muscle Cells from Rats American Journal of Physiology. Endocrinology and Metabolism. Jan, 2014 | Pubmed ID: 24222668 The Absorptive Flux of the Anti-epileptic Drug Substance Vigabatrin is Carrier-mediated Across Caco-2 Cell Monolayers European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2014 | Pubmed ID: 24008184 Basolateral Glycylsarcosine (Gly-Sar) Transport in Caco-2 Cell Monolayers is PH Dependent The Journal of Pharmacy and Pharmacology. Jul, 2013 | Pubmed ID: 23738724 Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, HPEPT1 International Journal of Peptides. 2012 | Pubmed ID: 23346117 一連の潜在的 CNS アクティブ ヒガンバナ科アルカロイドの P 糖蛋白質の相互作用の in Vitro 評価。 The Journal of Pharmacy and Pharmacology. Nov, 2012 | Pubmed ID: 23058055 Carrier-mediated γ-aminobutyric Acid Transport Across the Basolateral Membrane of Human Intestinal Caco-2 Cell Monolayers European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Jun, 2012 | Pubmed ID: 22452873 In Vitro Evidence for the Brain Glutamate Efflux Hypothesis: Brain Endothelial Cells Cocultured with Astrocytes Display a Polarized Brain-to-blood Transport of Glutamate Glia. May, 2012 | Pubmed ID: 22392649 Calu-3 Cells Grown Under AIC and LCC Conditions: Implications for Dipeptide Uptake and Transepithelial Transport of Substances European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. May, 2011 | Pubmed ID: 21195173 Affinity and Translocation Relationships Via HPEPT1 of H-X Aa-Ser-OH Dipeptides: Evaluation of H-Phe-Ser-OH As a Pro-moiety for Ibuprofen and Benzoic Acid Prodrugs European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Feb, 2011 | Pubmed ID: 21147219 Paracellular Tightness and Claudin-5 Expression is Increased in the BCEC/astrocyte Blood-brain Barrier Model by Increasing Media Buffer Capacity During Growth The AAPS Journal. Dec, 2010 | Pubmed ID: 20967520 Ibuprofen is a Non-competitive Inhibitor of the Peptide Transporter HPEPT1 (SLC15A1): Possible Interactions Between HPEPT1 Substrates and Ibuprofen British Journal of Pharmacology. Dec, 2010 | Pubmed ID: 20726987 A Quantitative Structure-activity Relationship for Translocation of Tripeptides Via the Human Proton-coupled Peptide Transporter, HPEPT1 (SLC15A1) The AAPS Journal. Sep, 2010 | Pubmed ID: 20449699 5-Hydroxy-L-tryptophan Alters Gaboxadol Pharmacokinetics in Rats: Involvement of PAT1 and ROat1 in Gaboxadol Absorption and Elimination European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2010 | Pubmed ID: 19900542 In Vitro Cutaneous Application of ISCOMs on Human Skin Enhances Delivery of Hydrophobic Model Compounds Through the Stratum Corneum The AAPS Journal. Dec, 2009 | Pubmed ID: 19862629 Discovery of Ligands for the Human Intestinal Di-/Tripeptide Transporter (hPEPT1) Using a QSAR-assisted Virtual Screening Strategy ChemMedChem. Sep, 2009 | Pubmed ID: 19557803 Cloning of the Pig PEPT2 (pPEPT2) and Characterization of the Effects of Epidermal Growth Factor (EGF) on PPEPT2-mediated Peptide Uptake in the Renal Porcine Cell Line LLC-PK1 European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Apr, 2008 | Pubmed ID: 18295462 HPEPT1 is Responsible for Uptake and Transport of Gly-Sar in the Human Bronchial Airway Epithelial Cell-line Calu-3 Pflugers Archiv : European Journal of Physiology. Jun, 2008 | Pubmed ID: 18094991 細胞体カルシウム測定とカルシウムイメージング研究のための脳毛細血管培養 Sofie Hørlyck1, Hans Christian Cederberg Helms1, Birger Brodin1 1Department of Pharmacy, The Faculty of Health and Medical Sciences, University of Copenhagen JoVE 61253 Neuroscience
細胞体カルシウム測定とカルシウムイメージング研究のための脳毛細血管培養 Sofie Hørlyck1, Hans Christian Cederberg Helms1, Birger Brodin1 1Department of Pharmacy, The Faculty of Health and Medical Sciences, University of Copenhagen JoVE 61253 Neuroscience