Birgit Schilling Biography Publications JoVE Articles Birgit Schilling has not added a biography. If you are Birgit Schilling and would like to personalize this page please email our Author Liaison for assistance. Publications Cytotrophoblast Extracellular Vesicles Enhance Decidual Cell Secretion of Immune Modulators Via TNF-alpha Development (Cambridge, England). Aug, 2020 | Pubmed ID: 32747437 Translational Control of One-carbon Metabolism Underpins Ribosomal Protein Phenotypes in Cell Division and Longevity ELife. May, 2020 | Pubmed ID: 32432546 The Power of Proteomics to Monitor Senescence-associated Secretory Phenotypes and Beyond: Toward Clinical Applications Expert Review of Proteomics. Apr, 2020 | Pubmed ID: 32425074 Abundances of Transcripts, Proteins, and Metabolites in the Cell Cycle of Budding Yeast Reveal Coordinate Control of Lipid Metabolism Molecular Biology of the Cell. 05, 2020 | Pubmed ID: 32129706 Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics Journal of Proteome Research. Apr, 2020 | Pubmed ID: 31984744 Activating Transcription Factor 4 (ATF4) Promotes Skeletal Muscle Atrophy by Forming a Heterodimer with the Transcriptional Regulator C/EBPβ The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31953319 A Proteomic Atlas of Senescence-associated Secretomes for Aging Biomarker Development PLoS Biology. Jan, 2020 | Pubmed ID: 31945054 Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species Scientific Reports. Oct, 2019 | Pubmed ID: 31659173 Dietary Sugars Alter Hepatic Fatty Acid Oxidation Via Transcriptional and Post-translational Modifications of Mitochondrial Proteins Cell Metabolism. Oct, 2019 | Pubmed ID: 31577934 Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect Against AKI Journal of the American Society of Nephrology : JASN. Dec, 2019 | Pubmed ID: 31575700 SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells Cell Reports. Sep, 2019 | Pubmed ID: 31553904 Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity Proteomics. Aug, 2019 | Pubmed ID: 31408259 Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions Frontiers in Microbiology. 2019 | Pubmed ID: 31354686 High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31087289 Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation Molecular Cell. 05, 2019 | Pubmed ID: 31000437 Correction for Christensen Et Al., "Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli" MBio. 04, 2019 | Pubmed ID: 30967468 JNK Modifies Neuronal Metabolism to Promote Proteostasis and Longevity Aging Cell. 06, 2019 | Pubmed ID: 30810280 Global Lysine Acetylation in Results from Growth Conditions That Favor Acetate Fermentation Journal of Bacteriology. 05, 2019 | Pubmed ID: 30782634 Temporal Dynamics of Liver Mitochondrial Protein Acetylation and Succinylation and Metabolites Due to High Fat Diet And/or Excess Glucose or Fructose PloS One. 2018 | Pubmed ID: 30586434 Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli MBio. 10, 2018 | Pubmed ID: 30352934 Identifying Ubiquitinated Proteins and Aggregates Aging. 10, 2018 | Pubmed ID: 30335616 Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves MTOR Malonylation Cell Metabolism. 12, 2018 | Pubmed ID: 30146486 Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment Proteomics. 09, 2018 | Pubmed ID: 30035354 Removing 4E-BP Enables Synapses to Refine Without Postsynaptic Activity Cell Reports. 04, 2018 | Pubmed ID: 29617653 Protein Turnover in Aging and Longevity Proteomics. Mar, 2018 | Pubmed ID: 29453826 An Acetylatable Lysine Controls CRP Function in E. Coli Molecular Microbiology. Jan, 2018 | Pubmed ID: 29105190 Ancient Regulatory Role of Lysine Acetylation in Central Metabolism MBio. Nov, 2017 | Pubmed ID: 29184018 Characterization of Inner and Outer Membrane Proteins FromStrains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates MBio. Oct, 2017 | Pubmed ID: 29018123 Multi-laboratory Assessment of Reproducibility, Qualitative and Quantitative Performance of SWATH-mass Spectrometry Nature Communications. 08, 2017 | Pubmed ID: 28827567 PIQED: Automated Identification and Quantification of Protein Modifications from DIA-MS Data Nature Methods. Jun, 2017 | Pubmed ID: 28661500 Identification and Characterization of AckA-dependent Protein Acetylation in Neisseria Gonorrhoeae PloS One. 2017 | Pubmed ID: 28654654 MSstatsQC: Longitudinal System Suitability Monitoring and Quality Control for Targeted Proteomic Experiments Molecular & Cellular Proteomics : MCP. Jul, 2017 | Pubmed ID: 28483925 Clinical Applications of Quantitative Proteomics Using Targeted and Untargeted Data-independent Acquisition Techniques Expert Review of Proteomics. 05, 2017 | Pubmed ID: 28436239 Generation of High-Quality SWATHAcquisition Data for Label-free Quantitative Proteomics Studies Using TripleTOFMass Spectrometers Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28188533 Vitamin D Promotes Protein Homeostasis and Longevity Via the Stress Response Pathway Genes Skn-1, Ire-1, and Xbp-1 Cell Reports. 10, 2016 | Pubmed ID: 27783938 Stable Nuclear Expression of ATP8 and ATP6 Genes Rescues a MtDNA Complex V Null Mutant Nucleic Acids Research. Nov, 2016 | Pubmed ID: 27596602 Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH) Journal of the American Society for Mass Spectrometry. Nov, 2016 | Pubmed ID: 27590315 Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4 The Journal of Biological Chemistry. 08, 2016 | Pubmed ID: 27358404 Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss Neuron. 04, 2016 | Pubmed ID: 27041503 Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows Analytical Chemistry. Oct, 2015 | Pubmed ID: 26398777 Critical Role of Acetylation in Tau-mediated Neurodegeneration and Cognitive Deficits Nature Medicine. Oct, 2015 | Pubmed ID: 26390242 Protein Acetylation Dynamics in Response to Carbon Overflow in Escherichia Coli Molecular Microbiology. Dec, 2015 | Pubmed ID: 26264774 SIRT1 Deacetylates RORγt and Enhances Th17 Cell Generation The Journal of Experimental Medicine. May, 2015 | Pubmed ID: 25918343 Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma Molecular & Cellular Proteomics : MCP. Sep, 2015 | Pubmed ID: 25693799 Iron Promotes Protein Insolubility and Aging in C. Elegans Aging. Nov, 2014 | Pubmed ID: 25554795 Panorama: a Targeted Proteomics Knowledge Base Journal of Proteome Research. Sep, 2014 | Pubmed ID: 25102069 RPL24: a Potential Therapeutic Target Whose Depletion or Acetylation Inhibits Polysome Assembly and Cancer Cell Growth Oncotarget. Jul, 2014 | Pubmed ID: 24970821 Variation and Quantification Among a Target Set of Phosphopeptides in Human Plasma by Multiple Reaction Monitoring and SWATH-MS2 Data-independent Acquisition Electrophoresis. Dec, 2014 | Pubmed ID: 24853916 Structural, Kinetic and Proteomic Characterization of Acetyl Phosphate-dependent Bacterial Protein Acetylation PloS One. 2014 | Pubmed ID: 24756028 Phosphoprotein Secretome of Tumor Cells As a Source of Candidates for Breast Cancer Biomarkers in Plasma Molecular & Cellular Proteomics : MCP. Apr, 2014 | Pubmed ID: 24505115 Site-specific Acylation Changes in the Lipid A of Escherichia Coli LpxL Mutants Grown at High Temperatures Innate Immunity. Apr, 2014 | Pubmed ID: 23812252 Label-Free Quantitation and Mapping of the ErbB2 Tumor Receptor by Multiple Protease Digestion with Data-Dependent (MS1) and Data-Independent (MS2) Acquisitions International Journal of Proteomics. 2013 | Pubmed ID: 23710360 Label-free Quantitative Proteomics of the Lysine Acetylome in Mitochondria Identifies Substrates of SIRT3 in Metabolic Pathways Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23576753 Ligand Binding Promotes CDK-dependent Phosphorylation of ER-alpha on Hinge Serine 294 but Inhibits Ligand-independent Phosphorylation of Serine 305 Molecular Cancer Research : MCR. Aug, 2012 | Pubmed ID: 22669764 Ubiquitin-specific Peptidase 9, X-linked (USP9X) Modulates Activity of Mammalian Target of Rapamycin (mTOR) The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22544753 Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline: Application to Protein Acetylation and Phosphorylation Molecular & Cellular Proteomics : MCP. May, 2012 | Pubmed ID: 22454539 凝集素色谱/质谱法测定发现工作流标识侵略性乳腺癌指认生物标志的物。 Journal of Proteome Research. Feb, 2012 | Pubmed ID: 22309216 Huntingtin 新型赖氨酸的乙酰化土地的质谱鉴定。 Molecular & Cellular Proteomics : MCP. Oct, 2011 | Pubmed ID: 21685499 ScanRanker： 质量评定的串联质谱通过序列标签。 Journal of Proteome Research. Jul, 2011 | Pubmed ID: 21520941 3-硝基酪氨酸修改质谱数据跨多个质谱平台中的自信标识。 Journal of Proteomics. Oct, 2011 | Pubmed ID: 21514405 针对 Glycosite 特定的与癌症相关的碳水化合物结构胰蛋白酶消化人血浆中凝集素亲和工作流。 Analytical Biochemistry. Jan, 2011 | Pubmed ID: 20705048 新调制器和中非凋亡蛋白改建鉴定程序性细胞死亡。 Journal of Cellular Biochemistry. Dec, 2010 | Pubmed ID: 20830744 特定于站点的半胱氨酸氧化内源性蛋白使用微分烷基化和多个反应监测质谱方法有针对性地定量检测。 Molecular & Cellular Proteomics : MCP. Jul, 2010 | Pubmed ID: 20233844 重复性和重现性的高效液相色谱串联质谱蛋白质组标识。 Journal of Proteome Research. Feb, 2010 | Pubmed ID: 19921851 实验室间研究定性基准液相色谱-质谱平台性能的酵母性能标准。 Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19858499 高效液相色谱串联质谱在蛋白质组学分析系统的性能指标。 Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19837981 结核分枝杆菌牛黄卡介苗 Phagosome 蛋白质组。 Molecular & Cellular Proteomics : MCP. Jan, 2010 | Pubmed ID: 19815536 Α-synuclein 在帕金森病的细胞氧化模型中的酪氨酸 39 优先增加硝化反应。 Analytical Chemistry. Sep, 2009 | Pubmed ID: 19697948 多站点的精度和可重复性的蛋白在血浆中的多个反应基于监测的测量评估。 Nature Biotechnology. Jul, 2009 | Pubmed ID: 19561596 IDPicker 2.0： 改进的蛋白质组装与高歧视肽鉴定筛选。 Journal of Proteome Research. Aug, 2009 | Pubmed ID: 19522537 在人类的雌激素受体与新型磷酸化站点重点翻译后修改的系统映射。 Molecular & Cellular Proteomics : MCP. Mar, 2009 | Pubmed ID: 18984578 在雌激素受体的 N-末端域中检测到的新型丝氨酸磷酸化站点分离人类乳腺癌细胞。 Journal of the American Society for Mass Spectrometry. May, 2008 | Pubmed ID: 18367407 部分的赖氨酸的乙酰化可提高 Intraprotein 交联。 Analytical Chemistry. Feb, 2008 | Pubmed ID: 18201069 LpxL，已故的土拉弗酰基转移酶的标识。 Infection and Immunity. Nov, 2007 | Pubmed ID: 17724076 线粒体氧化应激会导致 Hyperphosphorylation 的头。 PloS One. 2007 | Pubmed ID: 17579710 细胞色素 C 氧化酶酶活性和金额的高吞吐量多路复用分析的小规模 Immunopurification。 Biotechnology and Applied Biochemistry. Dec, 2007 | Pubmed ID: 17508937 脂质 A 乙酰化模式在土拉弗、 土拉热 Novicida 和土拉 Philomiragia 使用上中间的真空源线性离子阱多级质谱法和基质辅助激光解吸/电离的表征。 Analytical Chemistry. Feb, 2007 | Pubmed ID: 17263332 新型通路与醌诱导乳腺癌细胞在应激相关联。 Drug Metabolism Reviews. 2006 | Pubmed ID: 17145690 Huntingtin 磷酸化站点映射质谱法。调制的劈裂和毒性。 The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16782707 琥珀酸脱氢酶和 Ubiquinol 细胞色素 C 还原 (复合物 II 和 III) 孤立的从牛和鼠标心脏线粒体沉淀的蛋白质组学分析。 Biochimica Et Biophysica Acta. Feb, 2006 | Pubmed ID: 16120479 阿尔茨海默病的淀粉样前体非同小可试点蛋白质组学研究。 Annals of Neurology. Aug, 2005 | Pubmed ID: 16049941 新型磷酸化质谱鉴定网站牛线粒体复合体亚 NDUFA10 单位在我。 FEBS Letters. Apr, 2005 | Pubmed ID: 15848193 快速分离纯化与质谱表征线粒体 NADH 脱氢酶 (复杂我） 从鼠脑和多巴胺能神经元细胞系。 Molecular & Cellular Proteomics : MCP. Jan, 2005 | Pubmed ID: 15591592 新型改性的脂质 A 的土拉弗。 Infection and Immunity. Sep, 2004 | Pubmed ID: 15322031 新型的凝集素，DltA，是需要充分的血清中流感嗜血杆菌 Ducreyi 的耐药表型的表达。 Infection and Immunity. Jun, 2004 | Pubmed ID: 15155648 蛋白质组学和免疫化学表征 Stathmin 成人神经发生中的作用。 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2004 | Pubmed ID: 14769823 由内质网应激激活的细胞死亡途径的分子组件。 The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14561754 惰性标有交联试剂： 交联肽的鉴定的大规模简并的决议。 Bioorganic & Medicinal Chemistry Letters. Nov, 2003 | Pubmed ID: 14592499 Phosphospecific 用于映射站点的蛋白磷酸化蛋白质的降解。 Nature Biotechnology. Sep, 2003 | Pubmed ID: 12923550 MS2Assign，自动分配和串联质谱化学交联肽的命名法。 Journal of the American Society for Mass Spectrometry. Aug, 2003 | Pubmed ID: 12892908 组织蛋白酶 L 在分泌囊泡 Prohormone 加工生产的脑啡肽肽神经递质酶的作用。 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12869695 非自然的唾液酸代谢纳入流感嗜血杆菌 Ducreyi Lipooligosaccharides。 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12615992 从包含 Polylactosamine 的流感嗜血杆菌 Ducreyi Lipooligosaccharides 表征重复。 Journal of the American Society for Mass Spectrometry. Jun, 2002 | Pubmed ID: 12056572 Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology 量化和站点本地化两个翻译后修改的同步亲和力丰富 Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology 用数据无关采集质谱法定量测定点特异蛋白赖氨酸乙酰化和琥珀酰化化学计量学 Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology 一个外源凝集素的高效液相色谱法从复杂生物样品，以丰富的选择性糖基化肽 Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology
量化和站点本地化两个翻译后修改的同步亲和力丰富 Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology
用数据无关采集质谱法定量测定点特异蛋白赖氨酸乙酰化和琥珀酰化化学计量学 Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology
一个外源凝集素的高效液相色谱法从复杂生物样品，以丰富的选择性糖基化肽 Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology
