Birgit Schilling Biography Publications JoVE Articles Birgit Schilling has not added a biography. If you are Birgit Schilling and would like to personalize this page please email our Author Liaison for assistance. Publications Cytotrophoblast Extracellular Vesicles Enhance Decidual Cell Secretion of Immune Modulators Via TNF-alpha Development (Cambridge, England). Aug, 2020 | Pubmed ID: 32747437 Translational Control of One-carbon Metabolism Underpins Ribosomal Protein Phenotypes in Cell Division and Longevity ELife. May, 2020 | Pubmed ID: 32432546 The Power of Proteomics to Monitor Senescence-associated Secretory Phenotypes and Beyond: Toward Clinical Applications Expert Review of Proteomics. Apr, 2020 | Pubmed ID: 32425074 Abundances of Transcripts, Proteins, and Metabolites in the Cell Cycle of Budding Yeast Reveal Coordinate Control of Lipid Metabolism Molecular Biology of the Cell. 05, 2020 | Pubmed ID: 32129706 Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics Journal of Proteome Research. Apr, 2020 | Pubmed ID: 31984744 Activating Transcription Factor 4 (ATF4) Promotes Skeletal Muscle Atrophy by Forming a Heterodimer with the Transcriptional Regulator C/EBPβ The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31953319 A Proteomic Atlas of Senescence-associated Secretomes for Aging Biomarker Development PLoS Biology. Jan, 2020 | Pubmed ID: 31945054 Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species Scientific Reports. Oct, 2019 | Pubmed ID: 31659173 Dietary Sugars Alter Hepatic Fatty Acid Oxidation Via Transcriptional and Post-translational Modifications of Mitochondrial Proteins Cell Metabolism. Oct, 2019 | Pubmed ID: 31577934 Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect Against AKI Journal of the American Society of Nephrology : JASN. Dec, 2019 | Pubmed ID: 31575700 SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells Cell Reports. Sep, 2019 | Pubmed ID: 31553904 Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity Proteomics. Aug, 2019 | Pubmed ID: 31408259 Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions Frontiers in Microbiology. 2019 | Pubmed ID: 31354686 High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31087289 Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation Molecular Cell. 05, 2019 | Pubmed ID: 31000437 Correction for Christensen Et Al., "Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli" MBio. 04, 2019 | Pubmed ID: 30967468 JNK Modifies Neuronal Metabolism to Promote Proteostasis and Longevity Aging Cell. 06, 2019 | Pubmed ID: 30810280 Global Lysine Acetylation in Results from Growth Conditions That Favor Acetate Fermentation Journal of Bacteriology. 05, 2019 | Pubmed ID: 30782634 Temporal Dynamics of Liver Mitochondrial Protein Acetylation and Succinylation and Metabolites Due to High Fat Diet And/or Excess Glucose or Fructose PloS One. 2018 | Pubmed ID: 30586434 Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli MBio. 10, 2018 | Pubmed ID: 30352934 Identifying Ubiquitinated Proteins and Aggregates Aging. 10, 2018 | Pubmed ID: 30335616 Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves MTOR Malonylation Cell Metabolism. 12, 2018 | Pubmed ID: 30146486 Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment Proteomics. 09, 2018 | Pubmed ID: 30035354 Removing 4E-BP Enables Synapses to Refine Without Postsynaptic Activity Cell Reports. 04, 2018 | Pubmed ID: 29617653 Protein Turnover in Aging and Longevity Proteomics. Mar, 2018 | Pubmed ID: 29453826 An Acetylatable Lysine Controls CRP Function in E. Coli Molecular Microbiology. Jan, 2018 | Pubmed ID: 29105190 Ancient Regulatory Role of Lysine Acetylation in Central Metabolism MBio. Nov, 2017 | Pubmed ID: 29184018 Characterization of Inner and Outer Membrane Proteins FromStrains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates MBio. Oct, 2017 | Pubmed ID: 29018123 Multi-laboratory Assessment of Reproducibility, Qualitative and Quantitative Performance of SWATH-mass Spectrometry Nature Communications. 08, 2017 | Pubmed ID: 28827567 PIQED: Automated Identification and Quantification of Protein Modifications from DIA-MS Data Nature Methods. Jun, 2017 | Pubmed ID: 28661500 Identification and Characterization of AckA-dependent Protein Acetylation in Neisseria Gonorrhoeae PloS One. 2017 | Pubmed ID: 28654654 MSstatsQC: Longitudinal System Suitability Monitoring and Quality Control for Targeted Proteomic Experiments Molecular & Cellular Proteomics : MCP. Jul, 2017 | Pubmed ID: 28483925 Clinical Applications of Quantitative Proteomics Using Targeted and Untargeted Data-independent Acquisition Techniques Expert Review of Proteomics. 05, 2017 | Pubmed ID: 28436239 Generation of High-Quality SWATHAcquisition Data for Label-free Quantitative Proteomics Studies Using TripleTOFMass Spectrometers Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28188533 Vitamin D Promotes Protein Homeostasis and Longevity Via the Stress Response Pathway Genes Skn-1, Ire-1, and Xbp-1 Cell Reports. 10, 2016 | Pubmed ID: 27783938 Stable Nuclear Expression of ATP8 and ATP6 Genes Rescues a MtDNA Complex V Null Mutant Nucleic Acids Research. Nov, 2016 | Pubmed ID: 27596602 Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH) Journal of the American Society for Mass Spectrometry. Nov, 2016 | Pubmed ID: 27590315 Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4 The Journal of Biological Chemistry. 08, 2016 | Pubmed ID: 27358404 Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss Neuron. 04, 2016 | Pubmed ID: 27041503 Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows Analytical Chemistry. Oct, 2015 | Pubmed ID: 26398777 Critical Role of Acetylation in Tau-mediated Neurodegeneration and Cognitive Deficits Nature Medicine. Oct, 2015 | Pubmed ID: 26390242 Protein Acetylation Dynamics in Response to Carbon Overflow in Escherichia Coli Molecular Microbiology. Dec, 2015 | Pubmed ID: 26264774 SIRT1 Deacetylates RORγt and Enhances Th17 Cell Generation The Journal of Experimental Medicine. May, 2015 | Pubmed ID: 25918343 Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma Molecular & Cellular Proteomics : MCP. Sep, 2015 | Pubmed ID: 25693799 Iron Promotes Protein Insolubility and Aging in C. Elegans Aging. Nov, 2014 | Pubmed ID: 25554795 Panorama: a Targeted Proteomics Knowledge Base Journal of Proteome Research. Sep, 2014 | Pubmed ID: 25102069 RPL24: a Potential Therapeutic Target Whose Depletion or Acetylation Inhibits Polysome Assembly and Cancer Cell Growth Oncotarget. Jul, 2014 | Pubmed ID: 24970821 Variation and Quantification Among a Target Set of Phosphopeptides in Human Plasma by Multiple Reaction Monitoring and SWATH-MS2 Data-independent Acquisition Electrophoresis. Dec, 2014 | Pubmed ID: 24853916 Structural, Kinetic and Proteomic Characterization of Acetyl Phosphate-dependent Bacterial Protein Acetylation PloS One. 2014 | Pubmed ID: 24756028 Phosphoprotein Secretome of Tumor Cells As a Source of Candidates for Breast Cancer Biomarkers in Plasma Molecular & Cellular Proteomics : MCP. Apr, 2014 | Pubmed ID: 24505115 Site-specific Acylation Changes in the Lipid A of Escherichia Coli LpxL Mutants Grown at High Temperatures Innate Immunity. Apr, 2014 | Pubmed ID: 23812252 Label-Free Quantitation and Mapping of the ErbB2 Tumor Receptor by Multiple Protease Digestion with Data-Dependent (MS1) and Data-Independent (MS2) Acquisitions International Journal of Proteomics. 2013 | Pubmed ID: 23710360 Label-free Quantitative Proteomics of the Lysine Acetylome in Mitochondria Identifies Substrates of SIRT3 in Metabolic Pathways Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23576753 Ligand Binding Promotes CDK-dependent Phosphorylation of ER-alpha on Hinge Serine 294 but Inhibits Ligand-independent Phosphorylation of Serine 305 Molecular Cancer Research : MCR. Aug, 2012 | Pubmed ID: 22669764 Ubiquitin-specific Peptidase 9, X-linked (USP9X) Modulates Activity of Mammalian Target of Rapamycin (mTOR) The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22544753 Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline: Application to Protein Acetylation and Phosphorylation Molecular & Cellular Proteomics : MCP. May, 2012 | Pubmed ID: 22454539 Un Workflow De Découverte De Lectine Chromatography/mass Spectrometry Identifie Des Biomarqueurs Putatifs Des Cancers Du Sein Agressifs Journal of Proteome Research. Feb, 2012 | Pubmed ID: 22309216 Identification Par Spectrométrie De Masse Des Sites Acétylation Roman Lysine Dans La Huntingtine Molecular & Cellular Proteomics : MCP. Oct, 2011 | Pubmed ID: 21685499 ScanRanker : Évaluation De La Qualité Des Spectres De Masse En Tandem Par Séquence De Marquage Journal of Proteome Research. Jul, 2011 | Pubmed ID: 21520941 Identification Confiante De Nitrotyrosine-3 Modifications Dans Les Données De Spectrométrie De Masse Sur Plusieurs Plateformes à La Spectrométrie De Masse Journal of Proteomics. Oct, 2011 | Pubmed ID: 21514405 Un Flux De Travail D'affinité Sur Lectine De Ciblage Glycosite-spécifiques, Des Structures Glucidiques Liés Au Cancer Dans La Trypsine-digéré Du Plasma Humain Analytical Biochemistry. Jan, 2011 | Pubmed ID: 20705048 Identification De Nouveaux Modulateurs Et Altérations De Protéine Non-apoptotique De La Mort Cellulaire Programmée Journal of Cellular Biochemistry. Dec, 2010 | Pubmed ID: 20830744 Ciblées De Quantification De L'oxydation De La Cystéine in Situ Dans Des Protéines Endogènes à L'aide D'une Différentielle Alkylation Et Réaction Multiples Suivi L'approche De La Spectrométrie De Masse Molecular & Cellular Proteomics : MCP. Jul, 2010 | Pubmed ID: 20233844 Répétabilité Et De Reproductibilité Dans Identifications Protéomiques Par Spectrométrie De Liquide Chromatographie De Masse En Tandem Journal of Proteome Research. Feb, 2010 | Pubmed ID: 19921851 Étude Interlaboratoires Caractérisation D'une Norme De Performance Pour La Performance De Levure Plate-forme D'analyse Comparative LC-MS Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19858499 Performance Metrics Pour Chromatographie En Phase Liquide En Tandem Systèmes De Spectrométrie De Masse Dans Les Analyses Protéomiques Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19837981 Le Mycobacterium Bovis Bacille Calmette-Guérin Phagosome Proteome Molecular & Cellular Proteomics : MCP. Jan, 2010 | Pubmed ID: 19815536 Nitration Préférentiellement Une Augmentation De L'alpha-synucléine Tyrosine-39 Dans Un Modèle Cellulaire Oxydatif De La Maladie De Parkinson Analytical Chemistry. Sep, 2009 | Pubmed ID: 19697948 Multi-site D'évaluation De La Précision Et La Reproductibilité Multiples Réaction De Surveillance Des Mesures Basées Sur Des Protéines Dans Le Plasma Nature Biotechnology. Jul, 2009 | Pubmed ID: 19561596 IDPicker 2.0: Assemblée Protéine Améliorée Avec La Haute Identification Peptide Discrimination Filtrage Journal of Proteome Research. Aug, 2009 | Pubmed ID: 19522537 Cartographie Systématique Des Modifications Post-traductionnelles Au Récepteur Des œstrogènes Humains Alpha En Mettant L'accent Sur Les Sites De Phosphorylation Roman Molecular & Cellular Proteomics : MCP. Mar, 2009 | Pubmed ID: 18984578 Un Site De Phosphorylation De Sérine Roman Détecté Dans Le Domaine N-terminal Du Récepteur Des Oestrogènes Isolé Des Cellules Cancéreuses Du Sein Humain Journal of the American Society for Mass Spectrometry. May, 2008 | Pubmed ID: 18367407 Acétylation Partielle Des Résidus Lysine Améliore La Réticulation D'intraprotein Analytical Chemistry. Feb, 2008 | Pubmed ID: 18201069 Identification De LpxL, Une Acyltransférase Fin De Francisella Tularensis Infection and Immunity. Nov, 2007 | Pubmed ID: 17724076 Stress Oxydatif Mitochondrial Provoque Hyperphosphorylation De Tau PloS One. 2007 | Pubmed ID: 17579710 Petite Immunopurification De Cytochrome C Oxydase Pour Une Analyse De Multiplexage Haut Débit De L'activité Enzymatique Et Le Montant Biotechnology and Applied Biochemistry. Dec, 2007 | Pubmed ID: 17508937 Caractérisation Des Patrons D'acylation Lipide A Francisella Tularensis Francisella Novicida Et Francisella Philomiragia à L'aide De La Spectrométrie De Masse De Multiples étapes Et Désorption-ionisation Laser Assistée Par Matrice Sur Un Piège à Ions Intermédiaires Source De Dépression Linéaire Analytical Chemistry. Feb, 2007 | Pubmed ID: 17263332 Nouvelles Voies Associées Au Quinone Induite Par Le Stress Dans Les Cellules Cancéreuses Du Sein Drug Metabolism Reviews. 2006 | Pubmed ID: 17145690 Sites De Phosphorylation De La Huntingtine Mappés Par Spectrométrie De Masse. Modulation De Clivage Et De Toxicité The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16782707 Analyse Protéomique De La Succinate Déshydrogénase Et L'ubiquinol-cytochrome C Réductase (complexe II Et III) Isolée Par Immunoprécipitation Des Mitochondries De Coeur De Bovin Et De La Souris Biochimica Et Biophysica Acta. Feb, 2006 | Pubmed ID: 16120479 Une étude Pilote De La Protéomique Interactiens Précurseur De L'amyloïde Dans La Maladie D'Alzheimer Annals of Neurology. Aug, 2005 | Pubmed ID: 16049941 Identification Par Spectrométrie De Masse D'une Phosphorylation Nouveau Site Dans La Sous-unité NDUFA10 Du Complexe Mitochondrique Bovine J'ai FEBS Letters. Apr, 2005 | Pubmed ID: 15848193 Rapide Purification Et Caractérisation Par Spectrométrie De Masse De Déshydrogénase De NADH Mitochondrique (complexe I) De Cerveau De Rongeur Et Une Ligne De Cellules Neuronales Dopaminergiques Molecular & Cellular Proteomics : MCP. Jan, 2005 | Pubmed ID: 15591592 Nouvelle Modification De Lipide A De Francisella Tularensis Infection and Immunity. Sep, 2004 | Pubmed ID: 15322031 Une Lectine Roman, CLFD, Est Nécessaire à L'expression D'un Phénotype De Résistance De Sérum Intégral à Haemophilus Ducreyi Infection and Immunity. Jun, 2004 | Pubmed ID: 15155648 Protéomique Et Caractérisation Immunochimique D'un Rôle Pour Stathmine Dans La Neurogenèse Adulte FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2004 | Pubmed ID: 14769823 Composants Moléculaires D'une Voie De Mort Cellulaire Activé Par Le Stress Du Réticulum Endoplasmique The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14561754 Isotopiquement étiquetés Réactifs De Réticulation : Résolution De Masse Dégénérescence Dans L'identification De Peptides Réticulé Bioorganic & Medicinal Chemistry Letters. Nov, 2003 | Pubmed ID: 14592499 PHOSPHOSPECIFIQUES La Protéolyse Pour La Cartographie Des Sites De Phosphorylation De La Protéine Nature Biotechnology. Sep, 2003 | Pubmed ID: 12923550 MS2Assign, Automatique Affectation Et Nomenclature Des Spectres De Masse En Tandem De Chimiquement Réticulés De Peptides Journal of the American Society for Mass Spectrometry. Aug, 2003 | Pubmed ID: 12892908 Cathepsine L Dans Des Vésicules Sécrétrices Fonctionne Comme Une Enzyme Prohormone-traitement Pour La Production Du Neurotransmetteur Enképhaline Peptide Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12869695 Incorporation Métabolique Des Acides Sialiques Synthétiques Dans Les Haemophilus Ducreyi Lipooligosaccharides Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12615992 Caractérisation Des Lipooligosaccharides De Haemophilus Ducreyi Contenant Polylactosamine Se Répète Journal of the American Society for Mass Spectrometry. Jun, 2002 | Pubmed ID: 12056572 Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology Enrichissement simultané d’affinité de deux modifications post-traductionnelle pour la quantification et la localisation des sites Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology Quantification des protéines spécifiques au site Lysine acétylation et stoechiométrie Succinylation spectrométrie de masse indépendante des données Acquisition Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology Une méthode CLHP lectine pour enrichir sélectivement peptides glycosylés d'échantillons biologiques complexes Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology
Enrichissement simultané d’affinité de deux modifications post-traductionnelle pour la quantification et la localisation des sites Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology
Quantification des protéines spécifiques au site Lysine acétylation et stoechiométrie Succinylation spectrométrie de masse indépendante des données Acquisition Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology
Une méthode CLHP lectine pour enrichir sélectivement peptides glycosylés d'échantillons biologiques complexes Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology